[go: up one dir, main page]

EE200200617A - (Tio)karbamiidi derivaat, seda sisaldav farmatseutiline preparaat, selle valmistamine ning kasutamine VIIa-teguri inhibiitorina - Google Patents

(Tio)karbamiidi derivaat, seda sisaldav farmatseutiline preparaat, selle valmistamine ning kasutamine VIIa-teguri inhibiitorina

Info

Publication number
EE200200617A
EE200200617A EEP200200617A EEP200200617A EE200200617A EE 200200617 A EE200200617 A EE 200200617A EE P200200617 A EEP200200617 A EE P200200617A EE P200200617 A EEP200200617 A EE P200200617A EE 200200617 A EE200200617 A EE 200200617A
Authority
EE
Estonia
Prior art keywords
thio
preparation
factor viia
urea derivative
viia inhibitor
Prior art date
Application number
EEP200200617A
Other languages
English (en)
Estonian (et)
Inventor
Klingler Otmar
Schudok Manfred
Nestler Hans-Peter
Matter Hans
Schreuder Herman
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of EE200200617A publication Critical patent/EE200200617A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
EEP200200617A 2000-06-06 2001-05-26 (Tio)karbamiidi derivaat, seda sisaldav farmatseutiline preparaat, selle valmistamine ning kasutamine VIIa-teguri inhibiitorina EE200200617A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00112116A EP1162194A1 (en) 2000-06-06 2000-06-06 Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use
PCT/EP2001/006029 WO2001094301A2 (en) 2000-06-06 2001-05-26 Factor viia inhibitory (thio)urea derivatives, their preparation and their use

Publications (1)

Publication Number Publication Date
EE200200617A true EE200200617A (et) 2004-04-15

Family

ID=8168926

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200200617A EE200200617A (et) 2000-06-06 2001-05-26 (Tio)karbamiidi derivaat, seda sisaldav farmatseutiline preparaat, selle valmistamine ning kasutamine VIIa-teguri inhibiitorina

Country Status (29)

Country Link
US (1) US6743790B2 (xx)
EP (2) EP1162194A1 (xx)
JP (1) JP4809570B2 (xx)
KR (1) KR101011345B1 (xx)
CN (1) CN1208314C (xx)
AR (1) AR030936A1 (xx)
AU (2) AU7749401A (xx)
BR (1) BR0111264A (xx)
CA (1) CA2410862C (xx)
CZ (1) CZ20023963A3 (xx)
DE (1) DE60139320D1 (xx)
DK (1) DK1299354T3 (xx)
EE (1) EE200200617A (xx)
ES (1) ES2330412T3 (xx)
HR (1) HRP20020961A2 (xx)
HU (1) HUP0301631A2 (xx)
IL (2) IL153220A0 (xx)
MX (1) MXPA02009789A (xx)
MY (1) MY129363A (xx)
NO (1) NO328546B1 (xx)
NZ (1) NZ522960A (xx)
PL (1) PL359584A1 (xx)
PT (1) PT1299354E (xx)
RU (1) RU2286337C2 (xx)
SK (1) SK17032002A3 (xx)
TW (1) TWI283662B (xx)
WO (1) WO2001094301A2 (xx)
YU (1) YU89202A (xx)
ZA (1) ZA200209018B (xx)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4567439B2 (ja) * 2002-04-27 2010-10-20 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング カルボン酸アミド
AU2003265398A1 (en) * 2002-08-09 2004-02-25 Transtech Pharma, Inc. Aryl and heteroaryl compounds and methods to modulate coagulation
US7273886B2 (en) * 2003-05-20 2007-09-25 Genentech, Inc. Benzofuran inhibitors of factor VIIa
US7250447B2 (en) * 2003-05-20 2007-07-31 Genentech, Inc. Acylsulfamide inhibitors of factor VIIa
WO2005014532A1 (en) * 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions and methods of use
CA2531796A1 (en) * 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
US7208601B2 (en) * 2003-08-08 2007-04-24 Mjalli Adnan M M Aryl and heteroaryl compounds, compositions, and methods of use
EP1810965A4 (en) * 2004-10-13 2009-10-28 Eisai R&D Man Co Ltd HYDRAZIDE DERIVATIVES
TW200630337A (en) * 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
EP1855722A2 (en) * 2005-02-24 2007-11-21 Novo Nordisk Health Care AG Compounds for stabilizing factor vii polypeptide formulations
US20090130085A1 (en) * 2005-02-24 2009-05-21 Novo Nordish Healthcare Ag Amidino-Compounds for Stabilizing Factor VII Polypeptide Formulations
WO2006089953A1 (en) * 2005-02-24 2006-08-31 Novo Nordisk Health Care Ag Compounds for stabilizing factor vii polypeptide formulations
EP1893632B1 (en) 2005-06-17 2015-08-12 Novo Nordisk Health Care AG Selective reduction and derivatization of engineered factor vii proteins comprising at least one non-native cysteine
PT2000465E (pt) 2006-03-24 2011-02-10 Eisai R&D Man Co Ltd Derivado de triazolona
WO2007110449A1 (en) * 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
US8791264B2 (en) * 2006-04-13 2014-07-29 Purdue Pharma L.P. Benzenesulfonamide compounds and their use as blockers of calcium channels
WO2007118854A1 (en) * 2006-04-13 2007-10-25 Euro-Celtique S.A. Benzenesulfonamide compounds and the use thereof
US8399486B2 (en) * 2007-04-09 2013-03-19 Purdue Pharma L.P. Benzenesulfonyl compounds and the use thereof
JPWO2009038157A1 (ja) * 2007-09-21 2011-01-06 エーザイ・アール・アンド・ディー・マネジメント株式会社 ２，３−ジヒドロ−イミノイソインドール誘導体
WO2009040659A2 (en) * 2007-09-28 2009-04-02 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
AU2012329098B2 (en) 2011-10-26 2017-08-03 Allergan, Inc. Amide derivatives of N-urea substituted amino acids as formyl peptide receptor like-1 (FPRL-1) receptor modulators
CA2870356A1 (en) * 2012-04-16 2013-10-24 Allergan, Inc. (2-ureidoacetamido)alkyl derivatives as formyl peptide receptor 2 modulators
WO2014057069A1 (en) * 2012-10-10 2014-04-17 Novo Nordisk Health Care Ag Liquid pharmaceutical composition of factor vii polypeptide
BR112015021392B1 (pt) 2013-03-06 2021-11-16 Allergan, Inc Uso de agonistas do receptor de peptídeo formil 2 para tratar doenças dermatológicas
BR122017004254B1 (pt) 2013-03-06 2021-04-13 Allergan, Inc. Uso de agonistas de receptor de formil peptídeo 2 para tratar doenças inflamatórias oculares

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5273982A (en) * 1990-03-09 1993-12-28 Hoffmann-La Roche Inc. Acetic acid derivatives
US5506134A (en) 1990-10-22 1996-04-09 Corvas International, Inc. Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex
JPH06505978A (ja) * 1991-02-05 1994-07-07 スミスクライン・ビーチャム・コーポレイション 芳香族エステルまたはアミドを含有する抗凝集性ペプチド
US5788965A (en) 1991-02-28 1998-08-04 Novo Nordisk A/S Modified factor VII
US5833982A (en) 1991-02-28 1998-11-10 Zymogenetics, Inc. Modified factor VII
JP3387948B2 (ja) * 1992-12-04 2003-03-17 富山化学工業株式会社 新規なフェニルアラニン誘導体またはその塩
US5314902A (en) 1993-01-27 1994-05-24 Monsanto Company Urea derivatives useful as platelet aggregation inhibitors
DE4309867A1 (de) * 1993-03-26 1994-09-29 Cassella Ag Neue Harnstoffderivate, ihre Herstellung und Verwendung
GB9313268D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Chemical compounds
GB9313269D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Allophanic acid derivatives
WO1995008550A1 (en) * 1993-09-24 1995-03-30 Abbott Laboratories Endothelin antagonists
US5707994A (en) * 1993-10-19 1998-01-13 Sumitomo Pharmaceuticals Company, Limited 2,3-diaminopropionic acid derivative
US5674894A (en) * 1995-05-15 1997-10-07 G.D. Searle & Co. Amidine derivatives useful as platelet aggregation inhibitors and vasodilators
AU712504B2 (en) * 1996-01-30 1999-11-11 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
CN1279668A (zh) * 1997-11-18 2001-01-10 帝人株式会社 环胺衍生物及其作为药物的用途
EP0987274A1 (en) * 1998-09-15 2000-03-22 Hoechst Marion Roussel Deutschland GmbH Factor VIIa Inhibitors

Also Published As

Publication number Publication date
HUP0301631A2 (hu) 2003-09-29
AU7749401A (en) 2001-12-17
NO20025810L (no) 2002-12-03
MXPA02009789A (es) 2003-03-12
JP2003535844A (ja) 2003-12-02
AR030936A1 (es) 2003-09-03
YU89202A (sh) 2006-05-25
AU2001277494B2 (en) 2006-05-04
NO20025810D0 (no) 2002-12-03
RU2286337C2 (ru) 2006-10-27
EP1299354A2 (en) 2003-04-09
DK1299354T3 (da) 2009-11-16
CA2410862A1 (en) 2001-12-13
CN1208314C (zh) 2005-06-29
HK1055941A1 (en) 2004-01-30
IL153220A0 (en) 2003-07-06
HRP20020961A2 (en) 2004-12-31
JP4809570B2 (ja) 2011-11-09
ES2330412T3 (es) 2009-12-10
NO328546B1 (no) 2010-03-15
NZ522960A (en) 2004-05-28
SK17032002A3 (sk) 2003-05-02
CA2410862C (en) 2009-11-10
BR0111264A (pt) 2003-06-17
ZA200209018B (en) 2003-10-08
KR20030007911A (ko) 2003-01-23
PL359584A1 (en) 2004-08-23
WO2001094301A2 (en) 2001-12-13
KR101011345B1 (ko) 2011-01-28
IL153220A (en) 2008-11-03
EP1299354B1 (en) 2009-07-22
TWI283662B (en) 2007-07-11
US6743790B2 (en) 2004-06-01
EP1162194A1 (en) 2001-12-12
PT1299354E (pt) 2009-10-01
CZ20023963A3 (cs) 2003-03-12
CN1427818A (zh) 2003-07-02
US20020052417A1 (en) 2002-05-02
MY129363A (en) 2007-03-30
DE60139320D1 (de) 2009-09-03
WO2001094301A3 (en) 2002-04-04

Similar Documents

Publication Publication Date Title
EE200200617A (et) (Tio)karbamiidi derivaat, seda sisaldav farmatseutiline preparaat, selle valmistamine ning kasutamine VIIa-teguri inhibiitorina
EE201300011A (et) Ksantiini derivaadid, nende valmistamine ja kasutamine ravimina
EE200300327A (et) Uurea derivaadid, nende valmistamismeetodid, kasutamine ja farmatseutiline kompositsioon
EE05107B1 (et) Türosiinkinaasi pärssiv ühend, seda sisaldav farmatseutiline kompositsioon ning ühendi kasutamine
HUP0400202A3 (en) Imidazolidindion derivatives having metalloproteinase inhibitor effect, their use and pharmaceutical compositions containing them
DE60106489D1 (de) Zuckersubstituierte 2-azetidinone verwendbar als hypocholesterdenische arzneimittel
IL155196A0 (en) Benzamide derivatives and pharmaceutical compositions containing the same
IL193234A0 (en) Sulphonamide derivatives, the preparation thereof and the application of same as medicaments
PL375874A1 (pl) Wodne kompozycje farmaceutyczne 2,6-diizopropylofenolu
EE200300311A (et) Ftalasinoon-piperidinoderivaadid, nende kasutamine ja ravim
NO20040702L (no) Kombinerte preparater som inneholder 1,4-benzotiepin-1,1-dioksidderivater og andre aktive substanser og anvendelsen derav
DE60203537D1 (de) 5ht1-rezeptoragonist enthaltendes arzneimittel
EE200200342A (et) Asendatud 8-arüülkinoliinid, nende kasutamine, farmatseutiline kompositsioon ja prekursorühend
NO20040860L (no) Farmasoytisk sammensetning som innbefatter lumiracoxib
DK1216250T3 (da) Thienoisoxazolyl- og thienylpyrazolyl-phenoxy- substituerede propylderivater som D4-antagonister
ATE450652T1 (de) Wässrige zusammensetzung
EE200200109A (et) Asendatud 3-fenüül-5-alkoksü-1,3,4-oksdiasool-2-oon, selle valmistamine ja kasutamine lipaasi inhibiitorina ning seda sisaldav ravim
AU2003271223A1 (en) Novel n-hydroxy thiourea, urea and amide compounds and the pharmaceutical compositions comprising the same
DK1227817T3 (da) Ciclesonid-holdigt vandigt farmaceutisk præparat
DE50112350D1 (de) Arzneimittel enthaltend aktiviertes antithrombin iii
EE05406B1 (et) Memnopeptiidhend, selle valmistamine ja kasutamine ning seda sisaldav farmatseutiline kompositsioon
FR2831440B1 (fr) Composition cosmetique, renfermant un derive de la dhea et un agent apaisant
DE60139306D1 (de) N-deacetylthiocolchin-derivate und diese enthaltende arzneimittel
EE200300466A (et) Püridoindolooni derivaatide kasutamine ravimite valmistamiseks
EE200300564A (et) Püridüülmetüülaminopürimidiiniühendid, nende kasutamine ja ravim