AR030854A1 - Las quimoquinas mutantes en el tratamiento de la esclerosis multiple - Google Patents
Las quimoquinas mutantes en el tratamiento de la esclerosis multipleInfo
- Publication number
- AR030854A1 AR030854A1 ARP010104684A ARP010104684A AR030854A1 AR 030854 A1 AR030854 A1 AR 030854A1 AR P010104684 A ARP010104684 A AR P010104684A AR P010104684 A ARP010104684 A AR P010104684A AR 030854 A1 AR030854 A1 AR 030854A1
- Authority
- AR
- Argentina
- Prior art keywords
- mutant
- treatment
- multiple sclerosis
- chemoquins
- chemokines
- Prior art date
Links
- 201000006417 multiple sclerosis Diseases 0.000 title abstract 2
- 102000019034 Chemokines Human genes 0.000 abstract 2
- 108010012236 Chemokines Proteins 0.000 abstract 2
- 102000001327 Chemokine CCL5 Human genes 0.000 abstract 1
- 108010055166 Chemokine CCL5 Proteins 0.000 abstract 1
- 208000016192 Demyelinating disease Diseases 0.000 abstract 1
- 230000027455 binding Effects 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La quimoquinas mutantes CC, los que, al menos, contienen dos mutaciones en el sitio cationico del aro 40, y los que, en relacion con la molécula de tipo salvaje tienen una actividad de union GAG reducida. Particularmente, se ha descubierto que tales quimoquinas mutantes son efectivas en el tratamiento de la esclerosis multiple y/o en otras enfermedades desmielisantes. El compuesto que muestra los mejores resultados es el triple mutante de RANTES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00121665 | 2000-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR030854A1 true AR030854A1 (es) | 2003-09-03 |
Family
ID=8170011
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010104684A AR030854A1 (es) | 2000-10-04 | 2001-10-04 | Las quimoquinas mutantes en el tratamiento de la esclerosis multiple |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US7402303B2 (es) |
| EP (1) | EP1326628B1 (es) |
| JP (1) | JP3908165B2 (es) |
| KR (1) | KR100837898B1 (es) |
| CN (1) | CN1285381C (es) |
| AR (1) | AR030854A1 (es) |
| AT (1) | ATE265222T1 (es) |
| AU (2) | AU2002215919B2 (es) |
| BG (1) | BG66137B1 (es) |
| BR (1) | BR0114407A (es) |
| CA (1) | CA2423616C (es) |
| CZ (1) | CZ303409B6 (es) |
| DE (1) | DE60103078T2 (es) |
| DK (1) | DK1326628T3 (es) |
| EA (1) | EA006137B1 (es) |
| EE (1) | EE05174B1 (es) |
| ES (1) | ES2217199T3 (es) |
| HR (1) | HRP20030215B1 (es) |
| HU (1) | HUP0302194A3 (es) |
| IL (2) | IL155178A0 (es) |
| MX (1) | MXPA03003008A (es) |
| NO (1) | NO330278B1 (es) |
| PL (1) | PL204231B1 (es) |
| PT (1) | PT1326628E (es) |
| RS (1) | RS50738B (es) |
| SI (1) | SI1326628T1 (es) |
| SK (1) | SK287523B6 (es) |
| UA (1) | UA77950C2 (es) |
| WO (1) | WO2002028419A2 (es) |
| ZA (1) | ZA200302315B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003051921A1 (en) | 2001-12-17 | 2003-06-26 | Applied Research Systems Ars Holding N.V. | Chemokine mutants acting as chemokine antagonists |
| US7335350B2 (en) | 2002-04-04 | 2008-02-26 | Laboratoires Serono Sa | Chemokines mutants having improved oral bioavailability |
| AU2003302755B2 (en) * | 2002-12-23 | 2009-01-08 | Laboratoires Serono Sa | Use of CC-chemokine mutants against liver diseases |
| WO2005040210A2 (en) * | 2003-10-22 | 2005-05-06 | Applied Research Systems Ars Holding N.V. | Novel cxcl8 antagonists |
| AT412785B (de) * | 2003-12-04 | 2005-07-25 | Kungl Andreas J Dr | Gag-bindungsproteine |
| ATE322506T1 (de) * | 2004-01-19 | 2006-04-15 | Ares Trading Sa | Verfahren zur reinigung von in bakterien exprimierten proteinen |
| GB0412400D0 (en) * | 2004-06-03 | 2004-07-07 | Univ Newcastle | Treatment of inflammatory conditions |
| EP2218748B1 (en) * | 2005-09-03 | 2012-10-10 | Samsung SDI Co., Ltd. | Polybenzoxazine-based compound, electrolyte membrane including the same, and fuel cell employing the electrolyte membrane |
| GB0614755D0 (en) | 2006-07-25 | 2006-09-06 | Univ Geneve | Cytokine derivatives |
| JP5624884B2 (ja) | 2007-08-02 | 2014-11-12 | ノビミューンエスアー | 抗ｒａｎｔｅｓ抗体およびその使用の方法 |
| WO2011097640A1 (en) * | 2010-02-08 | 2011-08-11 | The Trustees Of The University Of Pennsylvania | Nucleic acid molecules encoding rantes, and compositions comprising and methods of using the same |
| WO2019229615A1 (en) | 2018-05-28 | 2019-12-05 | Université De Genève | Methods of inhibiting cerebral inflammation |
| WO2022093857A1 (en) * | 2020-10-26 | 2022-05-05 | City Of Hope | Oncolytic virus compositions and methods for the treatment of cancer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5739103A (en) * | 1993-11-12 | 1998-04-14 | Dana-Farber Cancer Institute | Chemokine N-terminal deletion mutations |
| WO1998006751A1 (en) * | 1996-08-16 | 1998-02-19 | Research Corporation Technologies, Inc. | Mcp-3, rantes and mip-1alpha receptor antagonists |
| EP0906954A1 (en) * | 1997-09-29 | 1999-04-07 | Applied Research Systems ARS Holding N.V. | Amino-terminal truncated c-c chemokines as chemokine antagonist |
| CA2316447C (en) | 1997-12-23 | 2009-07-28 | Fondazione Centro San Raffaele Del Monte Tabor | Rantes mutants and therapeutic applications thereof |
| EP1148889A2 (en) | 1999-01-29 | 2001-10-31 | Millennium Pharmaceuticals, Inc. | Method of treating demyelinating inflammatory disease using ccr1 antagonists |
-
2001
- 2001-03-10 UA UA2003044038A patent/UA77950C2/uk unknown
- 2001-10-03 MX MXPA03003008A patent/MXPA03003008A/es active IP Right Grant
- 2001-10-03 HR HR20030215A patent/HRP20030215B1/xx not_active IP Right Cessation
- 2001-10-03 WO PCT/EP2001/011428 patent/WO2002028419A2/en not_active Ceased
- 2001-10-03 ES ES01986265T patent/ES2217199T3/es not_active Expired - Lifetime
- 2001-10-03 RS YUP-257/03A patent/RS50738B/sr unknown
- 2001-10-03 JP JP2002532243A patent/JP3908165B2/ja not_active Expired - Fee Related
- 2001-10-03 AU AU2002215919A patent/AU2002215919B2/en not_active Ceased
- 2001-10-03 KR KR1020037004599A patent/KR100837898B1/ko not_active Expired - Fee Related
- 2001-10-03 DK DK01986265T patent/DK1326628T3/da active
- 2001-10-03 CN CNB018199178A patent/CN1285381C/zh not_active Expired - Fee Related
- 2001-10-03 PL PL362350A patent/PL204231B1/pl not_active IP Right Cessation
- 2001-10-03 BR BR0114407-3A patent/BR0114407A/pt not_active IP Right Cessation
- 2001-10-03 IL IL15517801A patent/IL155178A0/xx unknown
- 2001-10-03 CA CA2423616A patent/CA2423616C/en not_active Expired - Fee Related
- 2001-10-03 PT PT01986265T patent/PT1326628E/pt unknown
- 2001-10-03 EP EP01986265A patent/EP1326628B1/en not_active Expired - Lifetime
- 2001-10-03 EA EA200300439A patent/EA006137B1/ru not_active IP Right Cessation
- 2001-10-03 DE DE60103078T patent/DE60103078T2/de not_active Expired - Lifetime
- 2001-10-03 SK SK406-2003A patent/SK287523B6/sk not_active IP Right Cessation
- 2001-10-03 AT AT01986265T patent/ATE265222T1/de active
- 2001-10-03 US US10/398,457 patent/US7402303B2/en not_active Expired - Fee Related
- 2001-10-03 CZ CZ20030947A patent/CZ303409B6/cs not_active IP Right Cessation
- 2001-10-03 EE EEP200300139A patent/EE05174B1/xx not_active IP Right Cessation
- 2001-10-03 AU AU1591902A patent/AU1591902A/xx active Pending
- 2001-10-03 HU HU0302194A patent/HUP0302194A3/hu unknown
- 2001-10-03 SI SI200130130T patent/SI1326628T1/xx unknown
- 2001-10-03 ZA ZA200302315A patent/ZA200302315B/en unknown
- 2001-10-04 AR ARP010104684A patent/AR030854A1/es unknown
-
2003
- 2003-03-28 BG BG107685A patent/BG66137B1/bg unknown
- 2003-04-01 IL IL155178A patent/IL155178A/en not_active IP Right Cessation
- 2003-04-03 NO NO20031525A patent/NO330278B1/no not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |