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AR030051A1 - Acido nucleico aislado, secuencia aislada, constructo genico, secuencias de aminoacidos, vector y organismo aislado que lo comprende, anticuerpo, molecula de acido nucleico antisentido, procedimiento para preparar acidos grasos poliinsaturados que lo emplea, aceite, lipidos o acidos grasos o una fra - Google Patents

Acido nucleico aislado, secuencia aislada, constructo genico, secuencias de aminoacidos, vector y organismo aislado que lo comprende, anticuerpo, molecula de acido nucleico antisentido, procedimiento para preparar acidos grasos poliinsaturados que lo emplea, aceite, lipidos o acidos grasos o una fra

Info

Publication number
AR030051A1
AR030051A1 ARP010100619A ARP010100619A AR030051A1 AR 030051 A1 AR030051 A1 AR 030051A1 AR P010100619 A ARP010100619 A AR P010100619A AR P010100619 A ARP010100619 A AR P010100619A AR 030051 A1 AR030051 A1 AR 030051A1
Authority
AR
Argentina
Prior art keywords
nucleic acid
sec
delta
isolated
sequence
Prior art date
Application number
ARP010100619A
Other languages
English (en)
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2000105973 external-priority patent/DE10005973A1/de
Priority claimed from DE10023893A external-priority patent/DE10023893A1/de
Priority claimed from DE10063387A external-priority patent/DE10063387A1/de
Application filed by Basf Ag filed Critical Basf Ag
Publication of AR030051A1 publication Critical patent/AR030051A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Acido nucleico aislado que proviene de una planta o alga y que codifica un polipéptido que alarga los ácidos grasos C16, C18 o C20 con al menos dos enlaces dobles en el ácido graso en al menos dos átomos de carbono. Dicho polipéptido puede alargar los ácidos grasos C16, C18, o C20 con al menos dos enlaces dobles en la molécula del ácido graso, seleccionados del grupo compuesto de a) una secuencia de ácido nucleico representada en ID. DE SEC No.1, ID. DE SEC No. 3, ID. DE SEC No. 5, o ID. DE SEC No. 7; b)una secuencia de ácido nucleico, que segun el codigo genético degenerado proviene de la secuencia representada en ID. DE SEC No. 1, ID. DE SEC No. 3, ID. DE SEC No. 5, o ID. DE SEC No. 7; c) derivados de la secuencia representada ID. DE SEC No. 1, ID. DE SEC No. 3, ID. DE SEC No. 5, o ID. DE SEC No. 7, que codifican para polipéptidos de la secuencia de aminoácido representada en ID. DE SEC No. 2, ID. DE SEC No. 4, ID. DE SEC No. 6, o ID. DE SEC No. 8 y que representan al menos un 50% de homología a nivel de los aminoácidos, sin que se reduzca considerablemente la accion enzimática de los polipéptidos. Constructo génico, que comprende el ácido nucleico aislado descripto. El ácido nucleico que codifica para un gen de la biosíntesis del ácido graso, puede estar seleccionado del grupo delta 19-, delta 17-, delta 15-, delta 12-, delta 9-, delta 8-, delta 6-, delta 5-, delta 4- desaturasa, las diferentes hidroxilasas, la delta 12-acetilenasa, las acil-ACP-tioesterasas, las beta- cetoacil-ACP-sintasas o las beta-cetoacil-ACP-reductasas. Secuencia de aminoácidos, que es codificada por dicha secuencia de ácido nucleico aislada o el constructo génico. Vector que comprende el ácido nucleico o el constructo génico. Organismo que comprende al menos un ácido nucleico, el constructo génico de o el vector anteriormente descriptos. Anticuerpo que une específicamente a un polipéptido que es codificado por uno de los ácidos nucleicos descriptos, molécula de ácido nucleico antisentido que comprendo una secuencia complementaria del ácido nucleico de acuerdo con lo descripto y procedimiento para preparar PUFAs. Aceite, lípidos o ácidos grasos o una fraccion de ellos, producidos mediante este procedimiento y composicion de aceite, lípido o ácido graso que contiene PUFAs y que proviene de plantas transgénicas. Uso de la composicion de aceite, lípido o ácido graso anterior en forrajes, alimentos, cosméticos o productos farmacéuticos y composicion que comprende el anticuerpo, el constructo génico, la molécula de ácido nucleico antisentido, el anticuerpo, un antagonista o agonista identificado, la composicion, la secuencia de aminoácidos y/o aceite, lípidos y/o ácidos grasos o una fraccion de ellos. Procedimiento para identificar un antagonista o agonista de elongasas.
ARP010100619A 2000-02-09 2001-02-09 Acido nucleico aislado, secuencia aislada, constructo genico, secuencias de aminoacidos, vector y organismo aislado que lo comprende, anticuerpo, molecula de acido nucleico antisentido, procedimiento para preparar acidos grasos poliinsaturados que lo emplea, aceite, lipidos o acidos grasos o una fra AR030051A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE2000105973 DE10005973A1 (de) 2000-02-09 2000-02-09 Neues Elongasegen und Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren
DE10023893A DE10023893A1 (de) 2000-05-17 2000-05-17 Neues Elongasegen und Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren
DE10063387A DE10063387A1 (de) 2000-12-19 2000-12-19 Neues Elongasegen und Verfahren zur Herstellung mehrfach ungestättigter Fettsäuren

Publications (1)

Publication Number Publication Date
AR030051A1 true AR030051A1 (es) 2003-08-13

Family

ID=27213647

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010100619A AR030051A1 (es) 2000-02-09 2001-02-09 Acido nucleico aislado, secuencia aislada, constructo genico, secuencias de aminoacidos, vector y organismo aislado que lo comprende, anticuerpo, molecula de acido nucleico antisentido, procedimiento para preparar acidos grasos poliinsaturados que lo emplea, aceite, lipidos o acidos grasos o una fra

Country Status (22)

Country Link
US (2) US7544859B2 (es)
EP (1) EP1254238B1 (es)
JP (1) JP4547122B2 (es)
KR (1) KR20020073580A (es)
CN (1) CN1247784C (es)
AR (1) AR030051A1 (es)
AT (1) ATE443146T1 (es)
AU (2) AU3924401A (es)
BR (1) BR0108198A (es)
CA (1) CA2399349C (es)
CZ (1) CZ20022502A3 (es)
DE (1) DE50115107D1 (es)
DK (1) DK1254238T3 (es)
EE (1) EE200200443A (es)
ES (1) ES2331228T3 (es)
HU (1) HUP0300081A3 (es)
IL (2) IL150414A0 (es)
MX (1) MXPA02007078A (es)
NO (1) NO20023757L (es)
PL (1) PL207026B1 (es)
PT (1) PT1254238E (es)
WO (1) WO2001059128A2 (es)

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