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AR039634A1 - Medicamento que contiene betamimeticos y un anticolinergico - Google Patents

Medicamento que contiene betamimeticos y un anticolinergico

Info

Publication number
AR039634A1
AR039634A1 ARP030101266A ARP030101266A AR039634A1 AR 039634 A1 AR039634 A1 AR 039634A1 AR P030101266 A ARP030101266 A AR P030101266A AR P030101266 A ARP030101266 A AR P030101266A AR 039634 A1 AR039634 A1 AR 039634A1
Authority
AR
Argentina
Prior art keywords
alkyl
salts
betamimetics
rent
enantiomers
Prior art date
Application number
ARP030101266A
Other languages
English (en)
Inventor
Gerd Morschhaeuser
Pieper Michael P Dr
Pohl Gerald Dr
Pairet Michel Dr
Helmut Meissner
Montague Christopher John Dr
Konetzki Ingo Dr
Reichl Richard Dr
Speck Georg Dr
Banholzer Rolf Dr
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of AR039634A1 publication Critical patent/AR039634A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Composiciones de medicamentos a base de agonistas beta2 de larga acción y sales de un anticolinérgico, a procedimientos para su preparación, así como a su utilización en la terapia de enfermedades de las vías respiratorias. Aerosol de inhalación. Reivindicación 1: Medicamento, caracterizado por un contenido en una o varias sales de la fórmula (1), en donde: X significa un anión cargado negativamente de forma sencilla, preferiblemente un anión elegido del grupo consistente en cloruro, bromuro, yoduro, sulfato, fosfato, metanosulfonato, nitrato, maleato, acetato, citrato, fumarato, tartrato, oxalato, succinato, benzoato y p-toluenosulfonato, en combinación con uno o varios betamiméticos 2, eventualmente en forma de sus enantiómeros, mezclas de los enantiómeros o en forma de los racematos, eventualmente en forma de los solvatos e hidratos así como eventualmente, junto con un coadyuvante farmacéuticamente compatible. Reivindicación 3: Medicamento según la reivindicación 1 ó 2, caracterizado porque en el caso de los betamiméticos 2 se trata de sales de salmeterol, sales de formoterol o de sales por adición de ácidos de los compuestos de la fórmula (2), en donde R1 y R2, iguales o diferentes, significan hidrógeno o alquilo C1-4; R3 y R4, iguales o diferentes, significan hidrógeno, alquilo C1-4, -O-alquilo C1-4, -alquilen C1-4-O-alquilo C1-4 o R3 y R4, juntos, significan uno de los grupos puenteados -alquilen C1-4- u -O-alquilen C1-4-O-.
ARP030101266A 2002-04-12 2003-04-11 Medicamento que contiene betamimeticos y un anticolinergico AR039634A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10216428 2002-04-12
DE10256317A DE10256317A1 (de) 2002-04-12 2002-12-03 Arzneimittel enthaltend Betamimetika und ein neues Anticholinergikum

Publications (1)

Publication Number Publication Date
AR039634A1 true AR039634A1 (es) 2005-03-02

Family

ID=28458801

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030101266A AR039634A1 (es) 2002-04-12 2003-04-11 Medicamento que contiene betamimeticos y un anticolinergico

Country Status (10)

Country Link
EP (1) EP1586574A1 (es)
KR (1) KR20040108719A (es)
AR (1) AR039634A1 (es)
DE (2) DE10256317A1 (es)
EA (1) EA007048B1 (es)
EC (1) ECSP045357A (es)
MY (1) MY141724A (es)
PE (1) PE20040327A1 (es)
TW (1) TWI296928B (es)
ZA (1) ZA200406881B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004024453A1 (de) * 2004-05-14 2006-01-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue langwirksame Bronchodilatoren zur Behandlung von Atemwegserkrankungen
US7745621B2 (en) 2004-05-14 2010-06-29 Boehringer Ingelheim International Gmbh Long acting bronchodilators for the treatment of respiratory diseases
GB0511066D0 (en) * 2005-05-31 2005-07-06 Novartis Ag Organic compounds
GB0511065D0 (en) * 2005-05-31 2005-07-06 Novartis Ag Organic compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4108393A1 (de) * 1991-03-15 1992-09-17 Boehringer Ingelheim Kg Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln
DE10050994A1 (de) * 2000-10-14 2002-04-18 Boehringer Ingelheim Pharma Neue als Arneimittel einsetzbare Anticholinergika sowie Verfahren zu deren Herstellung
DE10050995A1 (de) * 2000-10-14 2002-04-18 Boehringer Ingelheim Pharma Neue Anticholinergika, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel

Also Published As

Publication number Publication date
EA200401302A1 (ru) 2005-04-28
EA007048B1 (ru) 2006-06-30
DE50301052D1 (de) 2005-09-29
TWI296928B (en) 2008-05-21
MY141724A (en) 2010-06-15
PE20040327A1 (es) 2004-07-12
DE10256317A1 (de) 2003-10-23
KR20040108719A (ko) 2004-12-24
ECSP045357A (es) 2005-01-28
ZA200406881B (en) 2006-06-28
TW200307550A (en) 2003-12-16
EP1586574A1 (de) 2005-10-19

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal