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AR059836A1 - Beta-agonistas enantiomericamente puros, y su uso como medicamentos - Google Patents

Beta-agonistas enantiomericamente puros, y su uso como medicamentos

Info

Publication number
AR059836A1
AR059836A1 ARP070101031A ARP070101031A AR059836A1 AR 059836 A1 AR059836 A1 AR 059836A1 AR P070101031 A ARP070101031 A AR P070101031A AR P070101031 A ARP070101031 A AR P070101031A AR 059836 A1 AR059836 A1 AR 059836A1
Authority
AR
Argentina
Prior art keywords
alkyl
enantiomerically pure
tautomers
haloalkyl
medicines
Prior art date
Application number
ARP070101031A
Other languages
English (en)
Inventor
Uwe Ries
Peter Sieger
Original Assignee
Boehringer Ingelheim Vetmed
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmed filed Critical Boehringer Ingelheim Vetmed
Publication of AR059836A1 publication Critical patent/AR059836A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/5381,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Su preparacion como medicamentos, en especial como medicamentos para el tratamiento de enfermedades de las vías respiratorias. Reivindicacion 1: Compuestos enantioméricamente puros de la formula (1) donde n significa 1, 2, 3 o 4; X CH2, CO, NR2, S u O; B un grupo de enlace doble de la formula CR3R4-O; R1 H, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, haloalquilo C1-6, O-haloalquilo C1-6, halogeno, OH, CN, NO2, O-alquilo C1-6, COOH o COO-alquiIo C1-4-; R2 H, alquilo C1-6, alquilen C1-4-arilo C6-10 o alquilen C1-4-cicloalquilo C3-6, con preferencia H o alquilo C1-6; R3 H o alquilo C1-6, R4 H o alquilo C1-6, Ym- un anion cargado negativamente m veces, con preferencia un anion cargado negativamente m veces seleccionado del grupo compuesto por cloruro, bromuro, yoduro, sulfato, fosfato, metansulfonato, nitrato, maleinato, acetato, benzoato, citrato, salicilato, trifluoroacetato, fumarato, tartrato, oxalato, succinato, etandisulfonato, propandisulfonato, benzoato y p-toluensulfonato, m 1 o 2 eventualmente en forma de sus tautomeros, mezclas de los tautomeros, hidratos o solvatos.
ARP070101031A 2006-03-15 2007-03-14 Beta-agonistas enantiomericamente puros, y su uso como medicamentos AR059836A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP06111191 2006-03-15
EP06111342 2006-03-17
EP06111338 2006-03-17

Publications (1)

Publication Number Publication Date
AR059836A1 true AR059836A1 (es) 2008-04-30

Family

ID=38006901

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070101031A AR059836A1 (es) 2006-03-15 2007-03-14 Beta-agonistas enantiomericamente puros, y su uso como medicamentos

Country Status (16)

Country Link
US (2) US7534789B2 (es)
EP (1) EP1996581A1 (es)
JP (1) JP2009530245A (es)
KR (1) KR20080106973A (es)
AR (1) AR059836A1 (es)
AU (1) AU2007224420A1 (es)
BR (1) BRPI0709601A2 (es)
CA (1) CA2643026A1 (es)
EA (1) EA200801894A1 (es)
EC (1) ECSP088723A (es)
MX (1) MX2008011700A (es)
NO (1) NO20083508L (es)
PE (1) PE20080142A1 (es)
TW (1) TW200804360A (es)
UY (1) UY30207A1 (es)
WO (1) WO2007104772A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
PE20080142A1 (es) * 2006-03-15 2008-04-14 Boehringer Ingelheim Int Beta-agonistas enantiomericamente puros y sus procedimientos de preparacion
CA2926515C (en) 2013-10-31 2020-11-24 Allergan, Inc. Prostamide-containing intraocular implants and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2609645A1 (de) * 1976-03-09 1977-09-15 Boehringer Sohn Ingelheim Aminoalkylheterocyclen
DE10253282A1 (de) * 2002-11-15 2004-05-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittel zur Behandlung von chronisch obstruktiver Lungenerkrankung
US7056916B2 (en) 2002-11-15 2006-06-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
DE102004003428A1 (de) 2004-01-23 2005-08-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue langwirksame Beta-2-Agonisten, und deren Verwendung als Arzneimittel
DE102004024454A1 (de) 2004-05-14 2005-12-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004045648A1 (de) * 2004-09-21 2006-03-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Betamimetika zur Behandlung von Atemwegserkrankungen
BRPI0608411A2 (pt) 2005-03-10 2009-12-29 Basf Ag uso de um composto, composto, processo para preparar compostos, agente, semente, e, processo para combater fungos nocivos fitopatogênicos
JP2009526817A (ja) * 2006-02-16 2009-07-23 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 呼吸器疾患の治療用医薬組成物
PE20080142A1 (es) * 2006-03-15 2008-04-14 Boehringer Ingelheim Int Beta-agonistas enantiomericamente puros y sus procedimientos de preparacion

Also Published As

Publication number Publication date
UY30207A1 (es) 2007-10-31
KR20080106973A (ko) 2008-12-09
TW200804360A (en) 2008-01-16
MX2008011700A (es) 2008-09-24
CA2643026A1 (en) 2007-09-20
EA200801894A1 (ru) 2009-02-27
JP2009530245A (ja) 2009-08-27
PE20080142A1 (es) 2008-04-14
BRPI0709601A2 (pt) 2011-07-19
ECSP088723A (es) 2008-10-31
WO2007104772A1 (de) 2007-09-20
US20070249595A1 (en) 2007-10-25
US7939658B2 (en) 2011-05-10
AU2007224420A1 (en) 2007-09-20
EP1996581A1 (de) 2008-12-03
WO2007104772A9 (de) 2007-11-22
NO20083508L (no) 2008-09-30
US7534789B2 (en) 2009-05-19
US20090306068A1 (en) 2009-12-10

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