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AR038203A1 - Cuerpos de inclusion de fosfolipidos y uso de los mismos en tratamientos medicos - Google Patents

Cuerpos de inclusion de fosfolipidos y uso de los mismos en tratamientos medicos

Info

Publication number
AR038203A1
AR038203A1 ARP030100173A ARP030100173A AR038203A1 AR 038203 A1 AR038203 A1 AR 038203A1 AR P030100173 A ARP030100173 A AR P030100173A AR P030100173 A ARP030100173 A AR P030100173A AR 038203 A1 AR038203 A1 AR 038203A1
Authority
AR
Argentina
Prior art keywords
synthetic
inclusion bodies
groups
bodies
inclusion
Prior art date
Application number
ARP030100173A
Other languages
English (en)
Original Assignee
Vasogen Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vasogen Ireland Ltd filed Critical Vasogen Ireland Ltd
Publication of AR038203A1 publication Critical patent/AR038203A1/es

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G19/00—Compounds of tin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G15/00—Compounds of gallium, indium or thallium
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
    • C09D5/24—Electrically-conducting paints

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Nanotechnology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Dispersion Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)

Abstract

Composiciones sintéticas y semi-sintéticas que presentan actividad biológica y uso de las mismas en el tratamiento y/o la profilaxis de diversos trastornos en pacientes mamíferos. Preparación y el uso de cuerpos de inclusión sintéticos y semi-sintéticos que, después de su introducción en el cuerpo de un paciente, producen efectos benéficos anti-inflamatorios, protectores de órganos e inmunoreguladores. Tratamientos y composiciones para aliviar enfermedades inflamatorias y autoinmunes y los síntomas de las mismas. Reivindicación 1: Una composición de materia que comprende cuerpos de inclusión, que presentan una pluralidad de grupos químicos reactivos que tienen la capacidad para interactuar con los receptores presentes sobre las células del sistema inmune de mamíferos para alterar el perfil de citoquinas del sistema inmune a favor de una anti-inflamación, donde dichos cuerpos de inclusión presentan un tamano de aproximadamente 20-1000 nm, con la condición que cuando dichos grupos son todos del mismo tipo, dichos grupos no son serina-fosfato o glicerol-fosfato.
ARP030100173A 2002-01-21 2003-01-21 Cuerpos de inclusion de fosfolipidos y uso de los mismos en tratamientos medicos AR038203A1 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CA002368656A CA2368656A1 (en) 2002-01-21 2002-01-21 Receptor-ligand pairing for anti-inflammatory response
US5138102A 2002-01-22 2002-01-22
US35142702P 2002-01-28 2002-01-28
US36462002P 2002-03-18 2002-03-18
US37210602P 2002-04-15 2002-04-15
US40085702P 2002-08-02 2002-08-02

Publications (1)

Publication Number Publication Date
AR038203A1 true AR038203A1 (es) 2005-01-05

Family

ID=27617925

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP030100173A AR038203A1 (es) 2002-01-21 2003-01-21 Cuerpos de inclusion de fosfolipidos y uso de los mismos en tratamientos medicos
ARP030100172A AR047005A1 (es) 2002-01-21 2003-01-21 Cuerpos de inclusion que transportan glicerol-fosfato aceptables para uso farmaceutico

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP030100172A AR047005A1 (es) 2002-01-21 2003-01-21 Cuerpos de inclusion que transportan glicerol-fosfato aceptables para uso farmaceutico

Country Status (14)

Country Link
US (3) US20030175334A1 (es)
EP (2) EP1467741A1 (es)
JP (2) JP2005515242A (es)
KR (1) KR20040089118A (es)
CN (1) CN1620301A (es)
AR (2) AR038203A1 (es)
BR (2) BR0307041A (es)
CA (5) CA2368656A1 (es)
EA (1) EA007426B1 (es)
MA (1) MA27168A1 (es)
MX (1) MXPA04007042A (es)
PE (1) PE20030973A1 (es)
TW (2) TW200302281A (es)
WO (3) WO2003061620A2 (es)

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US20050058698A1 (en) * 2002-01-21 2005-03-17 Nolan Yvonne Mairead Pharmaceutically acceptable phosphate-glycerol carrying bodies and uses relating to Parkinson's Disease
WO2004082688A1 (en) * 2003-03-20 2004-09-30 Vasogen Ireland Limited Phosphatidylglycerol (pg) receptor agonists and antagonists
JP2006528136A (ja) * 2003-07-21 2006-12-14 バソジェン アイルランド リミテッド 急性炎症性症状の治療のためのリン酸グリセロール含有リポソーム
US20060008517A1 (en) * 2004-07-09 2006-01-12 Lynch Marina A Treatment of age-related memory impairment
AR052642A1 (es) * 2004-09-15 2007-03-28 Vasogen Ireland Ltd Tratamiento de esclerosis multiple con liposomas que contienen fosfatidilglicerol
WO2006107107A1 (ja) * 2005-04-01 2006-10-12 Fumitaka Ohsuzu リン脂質小胞体を含む心筋保護剤および虚血・再潅流時の心筋障害を予防する方法
AU2006294756A1 (en) * 2005-09-26 2007-04-05 Vasogen Ireland Limited Treatment of inflammation and vascular abnormalities of the eye
EP1933813A4 (en) * 2005-10-11 2013-02-27 Univ Pittsburgh SPHINGOMYELIN LIPOSOME FOR THE TREATMENT OF HYPERACTIVE BLADDER DISORDER
WO2007131329A1 (en) * 2006-05-12 2007-11-22 Vasogen Ireland Limited Treatment of ubiquitin-proteasome system dysfunction related disorders
DE112010003355T5 (de) 2009-08-21 2012-07-12 Targeted Delivery Technologies Ltd. Veskuläre Formulierungen
GB201205642D0 (en) 2012-03-29 2012-05-16 Sequessome Technology Holdings Ltd Vesicular formulations
DK2861214T3 (da) * 2012-06-14 2020-10-12 Univ Bern Tilpassede liposomer til behandling af bakterieinfektioner
JP6417648B2 (ja) * 2013-07-30 2018-11-07 株式会社豊田中央研究所 エタノールアミンリン酸の利用
JP6139781B2 (ja) * 2014-04-04 2017-05-31 国立大学法人大阪大学 リゾリン脂質受容体を活性化する物質を含有する薬剤送達促進剤
JP6103143B1 (ja) * 2015-05-18 2017-03-29 不二製油株式会社 ＩＬ−１β産生抑制作用を有する食品添加用組成物
PT3316857T (pt) 2015-06-30 2021-11-03 Sequessome Tech Holdings Limited Composições multifásicas
CN116549393A (zh) 2017-03-02 2023-08-08 康柏辛股份有限公司 抑制生物膜形成的脂质体
CN115531399A (zh) * 2022-09-15 2022-12-30 首都医科大学 溶血磷脂酰胆碱在治疗阿尔茨海默病中的应用

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CA2471740A1 (en) 2003-07-31
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US20030175334A1 (en) 2003-09-18
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