AR036175A1 - Derivados de la dolastatina 10, composiciones farmaceuticas que los comprenden, el uso de dichos compuestos en la preparacion de medicamentos, procesos para la preparacion de dichos compuestos, e intermediarios utiles en la preparacion de dichos compuestos - Google Patents
Derivados de la dolastatina 10, composiciones farmaceuticas que los comprenden, el uso de dichos compuestos en la preparacion de medicamentos, procesos para la preparacion de dichos compuestos, e intermediarios utiles en la preparacion de dichos compuestosInfo
- Publication number
- AR036175A1 AR036175A1 ARP020102678A ARP020102678A AR036175A1 AR 036175 A1 AR036175 A1 AR 036175A1 AR P020102678 A ARP020102678 A AR P020102678A AR P020102678 A ARP020102678 A AR P020102678A AR 036175 A1 AR036175 A1 AR 036175A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- compounds
- dioxolyl
- alkoxy
- amino
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 7
- OFDNQWIFNXBECV-VFSYNPLYSA-N dolastatin 10 Chemical class CC(C)[C@H](N(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 OFDNQWIFNXBECV-VFSYNPLYSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 carbamoyloxy Chemical group 0.000 abstract 13
- 125000003545 alkoxy group Chemical group 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 7
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 7
- 229910052736 halogen Chemical group 0.000 abstract 7
- 150000002367 halogens Chemical group 0.000 abstract 7
- 125000001424 substituent group Chemical group 0.000 abstract 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 6
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 5
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 5
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 4
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 4
- 125000004001 thioalkyl group Chemical group 0.000 abstract 4
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
- 125000004442 acylamino group Chemical group 0.000 abstract 2
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical group C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
- 206010005003 Bladder cancer Diseases 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 206010008342 Cervix carcinoma Diseases 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 208000005718 Stomach Neoplasms Diseases 0.000 abstract 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 abstract 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 125000001691 aryl alkyl amino group Chemical group 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 201000010881 cervical cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 206010017758 gastric cancer Diseases 0.000 abstract 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000011549 stomach cancer Diseases 0.000 abstract 1
- 201000005112 urinary bladder cancer Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Derivados de la dolastatina 10 de la fórmula (1), en donde R1, R2 y R3 son cada uno independientemente hidrógeno ó alquilo C1-4; R4 es hidrógeno; alquilo sustituido opcionalmente con uno a tres sustituyentes seleccionados del grupo consistente en hidroxilo, alcoxilo, amino, mono- o dialquilamino, carboxilo, alcoxicarbonilo, carbamoiloxilo, alquilcarboniloxilo, carbamoilo o halógeno; alquenilo; alquinilo; cicloalquilo C3-7; arilo sustituido opcionalmente con uno a tres sustituyentes seleccionados del grupo consistente en halógeno, alcoxicarbonilo, carbamoilo, sulfamoilo, alquilcarboniloxilo, ciano, mono- o dialquilamino, alquilo, alcoxilo, fenilo, fenoxilo, trifluorometilo, trifluorometoxilo, tioalquilo, hidroxilo, alquilcarbonilamino, heterociclilo, 1,3-dioxolilo, 1,4-dioxolilo, amino o bencilo; aralquilo con el grupo arilo sustituido opcionalmente con uno a tres sustituyentes seleccionados del grupo consistente en halógeno, alcoxicarbonilo, sulfamoilo, alquilcarboniloxilo, ciano, mono- o dialquilamino, alquilo, alcoxilo, fenilo, fenoxilo, trifluorometilo, trifluorometoxilo, tioalquilo, hidroxilo, alquilcarbonilamino, heterociclilo, 1,3-dioxolilo, 1,4-dioxolilo, amino o bencilo; o heterociclilalquilo; R5 es alquil C1-6-amino; hidroxilo; cicloalquil C3-7-amino sustituido opcionalmente por fenilo o bencilo; arilamino; aralquilamino con alquileno C1-4 y el grupo arilo sustituido opcionalmente con uno a tres sustituyentes seleccionados del grupo consistente en halógeno, alcoxicarbonilo, sulfamoilo, alquilcarboniloxilo, carbamoiloxilo, ciano, mono- o dialquilamino, alquilo, alcoxilo, fenilo, fenoxilo, trifluorometilo, trifluorometoxilo, tioalquilo, hidroxilo, alquilcarbonilamino, heterociclilo, 1,3-dioxolilo, 1,4-dioxolilo, amino o bencilo; alcoxilo C1-4; benzhidrazino; heterociclilo sustituido opcionalmente con uno a tres sustituyentes seleccionados del grupo consistente en bencilo, benzhidrilo, alquilo, hidroxilo, alcoxilo, alquilcarbamoiloxilo, amino, mono- o dialquilamino, acilamino, alcoxicarbonilamino, fenilo o halógeno; heterociclilamino; heterocicloalquilamino con el grupo heterociclilo sustituido opcionalmente con uno a tres sustituyentes seleccionados del grupo consistente en bencilo, benzhidrilo, alquilo, hidroxilo, alcoxilo, alquilcarbamoiloxilo, amino, dialquilamino, acilamino, alcoxicarbonilamino o halógeno; aralquiloxilo y aralquilo ambos sustituidos opcionalmente con uno a tres sustituyentes del grupo consistente en halógeno, alcoxicarbonilo, sulfamoilo, alquilcarboniloxilo, ciano, mono- o dialquilamino, alquilo, alcoxilo, fenilo, fenoxilo, trifluorometilo, trifluorometoxilo, tioalquilo, hidroxilo, alquilcarbonilamino, heterociclilo, 1,3-dioxolilo, 1,4-dioxolilo, amino, aminosulfonilo o bencilo; y n es un número entero de 0, 1 ó 2; y las sales farmacéuticamente aceptables de los mismos. Dichos compuestos tienen actividad antitumoral y son útiles para el tratamiento de enfermedades malignas, particularmente cáncer colorrectal, cáncer de pulmón, cáncer de mama, cáncer de estómago, cáncer cervical y cáncer de vejiga. Composiciones farmacéuticas que los comprenden, uso de dichos compuestos en la preparación de medicamentos, procesos para la preparación de dichos compuestos e intermediarios útiles en la preparación de dichos compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01117410 | 2001-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR036175A1 true AR036175A1 (es) | 2004-08-18 |
Family
ID=8178073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020102678A AR036175A1 (es) | 2001-07-19 | 2002-07-17 | Derivados de la dolastatina 10, composiciones farmaceuticas que los comprenden, el uso de dichos compuestos en la preparacion de medicamentos, procesos para la preparacion de dichos compuestos, e intermediarios utiles en la preparacion de dichos compuestos |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6737409B2 (es) |
| EP (1) | EP1412328B1 (es) |
| JP (1) | JP2004534859A (es) |
| KR (2) | KR20060057652A (es) |
| CN (1) | CN1553897A (es) |
| AR (1) | AR036175A1 (es) |
| AT (1) | ATE341537T1 (es) |
| BR (1) | BR0211289A (es) |
| CA (1) | CA2453987A1 (es) |
| CO (1) | CO5550462A2 (es) |
| DE (1) | DE60215179T2 (es) |
| DK (1) | DK1412328T3 (es) |
| ES (1) | ES2272763T3 (es) |
| GT (1) | GT200200154A (es) |
| HR (1) | HRP20040043A2 (es) |
| HU (1) | HUP0401253A2 (es) |
| IL (1) | IL159890A0 (es) |
| MX (1) | MXPA04000577A (es) |
| MY (1) | MY127718A (es) |
| NO (1) | NO20040198L (es) |
| NZ (1) | NZ530655A (es) |
| PA (1) | PA8551001A1 (es) |
| PE (1) | PE20030258A1 (es) |
| PL (1) | PL367682A1 (es) |
| PT (1) | PT1412328E (es) |
| RU (1) | RU2296750C2 (es) |
| SI (1) | SI1412328T1 (es) |
| UY (1) | UY27388A1 (es) |
| WO (1) | WO2003008378A1 (es) |
| ZA (1) | ZA200400334B (es) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7256257B2 (en) | 2001-04-30 | 2007-08-14 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| US7064211B2 (en) | 2002-03-22 | 2006-06-20 | Eisai Co., Ltd. | Hemiasterlin derivatives and uses thereof |
| KR101208266B1 (ko) | 2002-03-22 | 2012-12-05 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 헤미아스텔린 유도체 및 이의 용도 |
| SI2357006T1 (sl) | 2002-07-31 | 2016-01-29 | Seattle Genetics, Inc. | Konjugati zdravil in njihova uporaba za zdravljenje raka, avtoimunske bolezni ali infekcijske bolezni |
| BR122018071808B8 (pt) | 2003-11-06 | 2020-06-30 | Seattle Genetics Inc | conjugado |
| CA2567914A1 (en) * | 2004-06-02 | 2005-12-15 | F. Hoffmann-La Roche Ag | Synthesis of amino-alkoxy-heptanoic alkyl ester |
| EP3505191A1 (en) | 2004-11-12 | 2019-07-03 | Seattle Genetics, Inc. | Auristatins having an aminobenzoic acid unit at the n terminus |
| JP2008523002A (ja) * | 2004-12-13 | 2008-07-03 | エフ．ホフマン−ラ ロシュ アーゲー | 少なくとも１つのドラスタチン１０誘導体を含有する新規な医薬組成物 |
| EP1828117A1 (en) * | 2004-12-13 | 2007-09-05 | F. Hoffmann-Roche AG | Novel process for the manufacture of 3-pyrrolidin-2-yl-propionic acid derivatives |
| US20060161076A1 (en) * | 2005-01-06 | 2006-07-20 | Diamics, Inc. | Systems and methods for collection of cell clusters |
| US20060189893A1 (en) * | 2005-01-06 | 2006-08-24 | Diamics, Inc. | Systems and methods for detecting abnormal cells |
| WO2006074873A2 (en) * | 2005-01-13 | 2006-07-20 | F. Hoffmann-La Roche Ag | New one-step synthesis of useful disubstituted amines |
| CA2607940C (en) | 2005-05-18 | 2009-12-15 | Aegera Therapeutics Inc. | Bir domain binding compounds |
| EP3498289A1 (en) | 2005-07-07 | 2019-06-19 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus |
| US8871720B2 (en) * | 2005-07-07 | 2014-10-28 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus |
| US7750116B1 (en) | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
| EP2024362A4 (en) | 2006-05-16 | 2012-01-25 | Pharmascience Inc | BINDING COMPOUNDS TO THE IAP BIR DOMAIN |
| US20080003652A1 (en) * | 2006-06-28 | 2008-01-03 | Hans Iding | Novel enzymatic process for the manufacture of Boc-Dap-Oh priority to related application(s) |
| PE20090481A1 (es) | 2007-07-16 | 2009-05-18 | Genentech Inc | Anticuerpos anti-cd79b e inmunoconjugados humanizados y metodos de uso |
| SI2176296T1 (sl) | 2007-07-16 | 2012-05-31 | Genentech Inc | Protitelesa proti CD b in imunokonjugati in postopki za uporabo |
| ES2643239T3 (es) | 2008-01-31 | 2017-11-21 | Genentech, Inc. | Anticuerpos anti-CD79b e inmunoconjugados y métodos de uso |
| PL2265283T3 (pl) | 2008-03-18 | 2015-03-31 | Seattle Genetics Inc | Koniugaty aurystatyny lek łącznik |
| WO2011100403A1 (en) | 2010-02-10 | 2011-08-18 | Immunogen, Inc | Cd20 antibodies and uses thereof |
| US9284350B2 (en) | 2010-02-12 | 2016-03-15 | Pharmascience Inc. | IAP BIR domain binding compounds |
| CA2801971C (en) | 2010-06-10 | 2018-07-24 | Hans-Georg Lerchen | Novel auristatin derivatives and their use |
| JP5933562B2 (ja) | 2010-09-29 | 2016-06-15 | シアトル ジェネティックス， インコーポレイテッド | Ｎ−カルボキシアルキル−アウリスタチンおよびその使用 |
| US9029406B2 (en) | 2011-03-16 | 2015-05-12 | Seattle Genetics, Inc | N-carboxyalkylauristatins and use thereof |
| MX371526B (es) * | 2011-05-27 | 2020-01-31 | Ambrx Inc | Composiciones que contienen, metodos que incluyen, y usos de derivados de dolastatina enlazados a aminoacidos no naturales. |
| EP3470413A3 (en) * | 2011-05-27 | 2019-08-07 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives |
| EP2889287B1 (en) * | 2012-09-20 | 2016-08-31 | Celltrion, Inc. | Dolastatin-10 derivative, method of producing same and anticancer drug composition containing same |
| CN106255513B (zh) | 2013-12-27 | 2022-01-14 | 酵活有限公司 | 用于药物偶联物的含磺酰胺连接系统 |
| EP3689910A3 (en) | 2014-09-23 | 2020-12-02 | F. Hoffmann-La Roche AG | Method of using anti-cd79b immunoconjugates |
| CN105949277B (zh) * | 2015-05-05 | 2019-03-01 | 成都永泰诺科技有限公司 | 一种抗肿瘤化合物及其用途 |
| JP6858348B2 (ja) * | 2016-03-29 | 2021-04-14 | 東レ株式会社 | ペプチド誘導体及びその用途 |
| CN109021065B (zh) * | 2017-06-08 | 2021-10-01 | 复旦大学 | 一种制备海兔毒素Dolastatin10的方法 |
| US20250281630A1 (en) | 2021-09-03 | 2025-09-11 | Toray Industries, Inc. | Pharmaceutical composition for cancer treatment and/or prevention |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2700165B1 (fr) * | 1993-01-07 | 1995-02-17 | Rhone Poulenc Rorer Sa | Dérivés de pyrrolidine, leur préparation et les médicaments les contenant. |
| US6323315B1 (en) | 1999-09-10 | 2001-11-27 | Basf Aktiengesellschaft | Dolastatin peptides |
-
2002
- 2002-07-15 US US10/195,698 patent/US6737409B2/en not_active Expired - Fee Related
- 2002-07-17 CA CA002453987A patent/CA2453987A1/en not_active Abandoned
- 2002-07-17 ES ES02764710T patent/ES2272763T3/es not_active Expired - Lifetime
- 2002-07-17 WO PCT/EP2002/007931 patent/WO2003008378A1/en not_active Ceased
- 2002-07-17 EP EP02764710A patent/EP1412328B1/en not_active Expired - Lifetime
- 2002-07-17 HR HR20040043A patent/HRP20040043A2/hr not_active Application Discontinuation
- 2002-07-17 DK DK02764710T patent/DK1412328T3/da active
- 2002-07-17 MX MXPA04000577A patent/MXPA04000577A/es active IP Right Grant
- 2002-07-17 KR KR1020067008692A patent/KR20060057652A/ko not_active Ceased
- 2002-07-17 PL PL02367682A patent/PL367682A1/xx not_active Application Discontinuation
- 2002-07-17 SI SI200230447T patent/SI1412328T1/sl unknown
- 2002-07-17 AT AT02764710T patent/ATE341537T1/de not_active IP Right Cessation
- 2002-07-17 UY UY27388A patent/UY27388A1/es not_active Application Discontinuation
- 2002-07-17 KR KR1020047000854A patent/KR100611540B1/ko not_active Expired - Fee Related
- 2002-07-17 NZ NZ530655A patent/NZ530655A/en unknown
- 2002-07-17 DE DE60215179T patent/DE60215179T2/de not_active Expired - Fee Related
- 2002-07-17 JP JP2003513938A patent/JP2004534859A/ja active Pending
- 2002-07-17 RU RU2004105145/04A patent/RU2296750C2/ru not_active IP Right Cessation
- 2002-07-17 IL IL15989002A patent/IL159890A0/xx unknown
- 2002-07-17 MY MYPI20022704A patent/MY127718A/en unknown
- 2002-07-17 HU HU0401253A patent/HUP0401253A2/hu unknown
- 2002-07-17 PT PT02764710T patent/PT1412328E/pt unknown
- 2002-07-17 CN CNA028177622A patent/CN1553897A/zh active Pending
- 2002-07-17 AR ARP020102678A patent/AR036175A1/es not_active Application Discontinuation
- 2002-07-17 BR BR0211289-2A patent/BR0211289A/pt not_active IP Right Cessation
- 2002-07-18 GT GT200200154A patent/GT200200154A/es unknown
- 2002-07-18 PA PA20028551001A patent/PA8551001A1/es unknown
- 2002-07-19 PE PE2002000643A patent/PE20030258A1/es not_active Application Discontinuation
-
2004
- 2004-01-15 ZA ZA2004/00334A patent/ZA200400334B/en unknown
- 2004-01-16 NO NO20040198A patent/NO20040198L/no not_active Application Discontinuation
- 2004-01-20 CO CO04003736A patent/CO5550462A2/es not_active Application Discontinuation
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