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CL2004000590A1 - Compuestos derivados de 1,3,4-oxadiazol-3-ona, 1,3,4-tiadiazol-2-ona y de 1,2,4-triazol-3-ona; composicion farmaceutica que los contiene; procedimiento de preparacion y su uso en la preparacion de un medicamento en los que esta relacionado el virus v - Google Patents

Compuestos derivados de 1,3,4-oxadiazol-3-ona, 1,3,4-tiadiazol-2-ona y de 1,2,4-triazol-3-ona; composicion farmaceutica que los contiene; procedimiento de preparacion y su uso en la preparacion de un medicamento en los que esta relacionado el virus v

Info

Publication number
CL2004000590A1
CL2004000590A1 CL200400590A CL2004000590A CL2004000590A1 CL 2004000590 A1 CL2004000590 A1 CL 2004000590A1 CL 200400590 A CL200400590 A CL 200400590A CL 2004000590 A CL2004000590 A CL 2004000590A CL 2004000590 A1 CL2004000590 A1 CL 2004000590A1
Authority
CL
Chile
Prior art keywords
ona
preparation
tiadiazol
oxadiazol
triazol
Prior art date
Application number
CL200400590A
Other languages
English (en)
Inventor
Patrick Dunn Steven Swal James
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2004000590A1 publication Critical patent/CL2004000590A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/13—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

COMPUESTOS HETEROCICLICOS DE LA FORMULA I EN LA QUE R1,R2,R2,R3,X1 y X2 TIENEN LOS SIGNIFICADDOS DEFINIDOS EN LA REIVINDICACIONES Y A SALES Y SOLVATOS FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, A METODOS PARA INHIBIR O MODULAR LA TRANSCRIPTASA INVERSA DEL VIRUS DE LA INMUNODEFICIECNCIA HUMANA (VIH) COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y A PROCEDIMIENTOS DE PREPRACIONE. ESTOS COMPUESTOS SON UTILES PARA TRATAR TRANSTORNOS EN LOS QUE ESTAN IMPLICADOS VIRUS VIH O VIRUS RELACIONADOS GENETICAMENTE.
CL200400590A 2003-03-24 2004-03-22 Compuestos derivados de 1,3,4-oxadiazol-3-ona, 1,3,4-tiadiazol-2-ona y de 1,2,4-triazol-3-ona; composicion farmaceutica que los contiene; procedimiento de preparacion y su uso en la preparacion de un medicamento en los que esta relacionado el virus v CL2004000590A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45713003P 2003-03-24 2003-03-24

Publications (1)

Publication Number Publication Date
CL2004000590A1 true CL2004000590A1 (es) 2005-02-04

Family

ID=33098199

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200400590A CL2004000590A1 (es) 2003-03-24 2004-03-22 Compuestos derivados de 1,3,4-oxadiazol-3-ona, 1,3,4-tiadiazol-2-ona y de 1,2,4-triazol-3-ona; composicion farmaceutica que los contiene; procedimiento de preparacion y su uso en la preparacion de un medicamento en los que esta relacionado el virus v

Country Status (20)

Country Link
US (2) US7208509B2 (es)
EP (1) EP1608633B1 (es)
JP (1) JP4708329B2 (es)
KR (1) KR101122456B1 (es)
CN (1) CN100588650C (es)
AR (1) AR043673A1 (es)
AU (1) AU2004224153B2 (es)
BR (2) BR122016023941B1 (es)
CA (1) CA2518437C (es)
CL (1) CL2004000590A1 (es)
CO (1) CO5601029A2 (es)
ES (1) ES2574580T3 (es)
HR (1) HRP20050830A2 (es)
IL (1) IL170343A (es)
MX (1) MXPA05010210A (es)
NO (1) NO334095B1 (es)
NZ (1) NZ541829A (es)
RU (1) RU2342367C2 (es)
TW (1) TW200505441A (es)
WO (1) WO2004085411A1 (es)

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US8293778B2 (en) 2004-07-27 2012-10-23 Roche Palo Alto Llc Heterocyclic antiviral compounds
JP4675959B2 (ja) * 2004-07-27 2011-04-27 エフ．ホフマン−ラ ロシュ アーゲー 非ヌクレオシド逆転写酵素阻害剤としてのベンジルトリアゾロン化合物
CN101180280A (zh) * 2005-03-24 2008-05-14 弗·哈夫曼-拉罗切有限公司 作为杂环逆转录酶抑制剂的1,2,4-三唑-5-酮化合物
AR057455A1 (es) 2005-07-22 2007-12-05 Merck & Co Inc Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
BRPI0617205A2 (pt) * 2005-09-30 2011-07-19 Hoffmann La Roche inibidores de nnrt
AU2006303368B2 (en) 2005-10-19 2011-05-26 F. Hoffmann-La Roche Ag Non-Nucleoside Reverse Transcriptase Inhibitors
ES2380683T3 (es) * 2005-12-15 2012-05-17 Astrazeneca Ab Difenil-éteres, -amidas, -sulfuros y - metanos sustituidos para el tratamiento de la enfermedad respiratoria
AP2985A (en) 2006-07-07 2014-09-30 Gilead Sciences Inc Modulators of pharmacokinetic properties of therapeutics
CL2007002105A1 (es) * 2006-07-21 2008-02-22 Hoffmann La Roche Compuestos derivados de 2-[3-(3-cianofenoxi)(fenoxi o fenilsulfanil)]-n-fenil acetamida, inhibidores de la transcriptasa inversa del vih; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar u
EP2057125B1 (en) 2006-08-16 2011-03-30 F. Hoffmann-La Roche AG Non-nucleoside reverse transcriptase inhibitors
TW200831085A (en) * 2006-12-13 2008-08-01 Merck & Co Inc Non-nucleoside reverse transcriptase inhibitors
EP2118082B1 (en) * 2007-02-23 2014-10-01 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
CN101679414A (zh) * 2007-04-09 2010-03-24 弗·哈夫曼-拉罗切有限公司 非核苷逆转录酶抑制剂
AU2008257772B2 (en) * 2007-05-30 2013-06-20 F. Hoffmann-La Roche Ag Process for preparing triazolones
CA2687747C (en) 2007-05-30 2015-11-17 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
WO2008157330A1 (en) * 2007-06-14 2008-12-24 Smithkline Beecham Corporation Chemical compounds
WO2008157273A1 (en) * 2007-06-14 2008-12-24 Smithkline Beecham Corporation Chemical compounds
KR20100039348A (ko) * 2007-06-22 2010-04-15 에프. 호프만-라 로슈 아게 비-뉴클레오사이드 역 전사효소 억제제로서 우레아 및 카바메이트 유도체
WO2009005811A1 (en) * 2007-07-03 2009-01-08 Yale University Novel azoles and related derivatives as non-nucleoside reverse transcriptase inhibitors (nnrtis) in antiviral therapy (hiv)
KR101610415B1 (ko) * 2007-12-21 2016-04-07 에프. 호프만-라 로슈 아게 헤테로사이클릭 항바이러스 화합물
KR101421861B1 (ko) * 2010-03-30 2014-07-22 머크 캐나다 인크. 비-뉴클레오시드 역전사효소 억제제
CU23896B1 (es) * 2010-04-01 2013-05-31 Ct De Ingeniería Genética Y Biotecnología Método para inhibir la replicación del vih en células de mamíferos
JO3470B1 (ar) 2012-10-08 2020-07-05 Merck Sharp & Dohme مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv
CN104230929B (zh) * 2013-06-19 2015-11-18 华东师范大学 一种非核苷类hiv-1反转录酶抑制剂
SI3125894T1 (sl) 2014-04-01 2020-12-31 Merck Sharp & Dohme Corp. Predzdravila inhibitorjev reverzne transkriptaze HIV

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Also Published As

Publication number Publication date
CN1759104A (zh) 2006-04-12
BRPI0408767B1 (pt) 2017-10-31
CO5601029A2 (es) 2006-01-31
IL170343A (en) 2014-03-31
AU2004224153A1 (en) 2004-10-07
CA2518437C (en) 2012-07-10
CN100588650C (zh) 2010-02-10
JP2006521319A (ja) 2006-09-21
EP1608633A1 (en) 2005-12-28
NO20054264L (no) 2005-10-14
RU2005132632A (ru) 2006-06-10
NO334095B1 (no) 2013-12-09
US7208509B2 (en) 2007-04-24
BRPI0408767B8 (pt) 2021-05-25
ES2574580T3 (es) 2016-06-20
TW200505441A (en) 2005-02-16
US20040192704A1 (en) 2004-09-30
HRP20050830A2 (en) 2006-09-30
CA2518437A1 (en) 2004-10-07
WO2004085411A1 (en) 2004-10-07
AU2004224153B2 (en) 2009-04-02
JP4708329B2 (ja) 2011-06-22
BRPI0408767A (pt) 2006-03-28
MXPA05010210A (es) 2005-11-23
RU2342367C2 (ru) 2008-12-27
US7348345B2 (en) 2008-03-25
KR20050115294A (ko) 2005-12-07
NZ541829A (en) 2008-11-28
US20070179157A1 (en) 2007-08-02
AR043673A1 (es) 2005-08-03
KR101122456B1 (ko) 2012-04-26
BR122016023941B1 (pt) 2021-10-13
NO20054264D0 (no) 2005-09-15
EP1608633B1 (en) 2016-04-20

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