IL159890A0 - Dolastatin 10 derivatives - Google Patents

Dolastatin 10 derivatives

Info

Publication number: IL159890A0
Authority: IL; Israel
Prior art keywords: dolastatin; derivatives
Prior art date: 2001-07-19

Application number

IL15989002A

Other languages

English (en)

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-19

Filing date

2002-07-17

Publication date

2004-06-20

2002-07-17 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-06-20 Publication of IL159890A0 publication Critical patent/IL159890A0/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Genetics & Genomics (AREA)
Epidemiology (AREA)
Crystallography & Structural Chemistry (AREA)
Biophysics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

IL15989002A 2001-07-19 2002-07-17 Dolastatin 10 derivatives IL159890A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01117410		2001-07-19
PCT/EP2002/007931 WO2003008378A1 (en)	2001-07-19	2002-07-17	Dolastatin 10 derivatives

Publications (1)

Publication Number	Publication Date
IL159890A0 true IL159890A0 (en)	2004-06-20

Family

ID=8178073

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL15989002A IL159890A0 (en)	2001-07-19	2002-07-17	Dolastatin 10 derivatives

Country Status (30)

Country	Link
US (1)	US6737409B2 (es)
EP (1)	EP1412328B1 (es)
JP (1)	JP2004534859A (es)
KR (2)	KR20060057652A (es)
CN (1)	CN1553897A (es)
AR (1)	AR036175A1 (es)
AT (1)	ATE341537T1 (es)
BR (1)	BR0211289A (es)
CA (1)	CA2453987A1 (es)
CO (1)	CO5550462A2 (es)
DE (1)	DE60215179T2 (es)
DK (1)	DK1412328T3 (es)
ES (1)	ES2272763T3 (es)
GT (1)	GT200200154A (es)
HR (1)	HRP20040043A2 (es)
HU (1)	HUP0401253A2 (es)
IL (1)	IL159890A0 (es)
MX (1)	MXPA04000577A (es)
MY (1)	MY127718A (es)
NO (1)	NO20040198L (es)
NZ (1)	NZ530655A (es)
PA (1)	PA8551001A1 (es)
PE (1)	PE20030258A1 (es)
PL (1)	PL367682A1 (es)
PT (1)	PT1412328E (es)
RU (1)	RU2296750C2 (es)
SI (1)	SI1412328T1 (es)
UY (1)	UY27388A1 (es)
WO (1)	WO2003008378A1 (es)
ZA (1)	ZA200400334B (es)

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US7256257B2 (en)	2001-04-30	2007-08-14	Seattle Genetics, Inc.	Pentapeptide compounds and uses related thereto
NZ555951A (en) *	2002-03-22	2009-01-31	Eisai Co Ltd	Hemiasterlin derivatives and uses thereof
US7064211B2 (en)	2002-03-22	2006-06-20	Eisai Co., Ltd.	Hemiasterlin derivatives and uses thereof
EP2353611B1 (en)	2002-07-31	2015-05-13	Seattle Genetics, Inc.	Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
PT2489364E (pt)	2003-11-06	2015-04-16	Seattle Genetics Inc	Compostos de monometilvalina conjugados com anticorpos
EP1756038A1 (en) *	2004-06-02	2007-02-28	F.Hoffmann-La Roche Ag	Synthesis of amino-alkoxy-heptanoic alkyl ester
CA2586909A1 (en)	2004-11-12	2006-12-14	Seattle Genetics, Inc.	Auristatins having an aminobenzoic acid unit at the n terminus
CA2589042A1 (en) *	2004-12-13	2006-06-22	F. Hoffmann-La Roche Ag	Novel process for the manufacture of 3-pyrrolidin-2-yl-propionic acid derivatives
CA2590431A1 (en) *	2004-12-13	2006-06-22	F. Hoffmann-La Roche Ag	Novel pharmaceutical composition containing at least one dolastatin 10 derivative
US20060161076A1 (en) *	2005-01-06	2006-07-20	Diamics, Inc.	Systems and methods for collection of cell clusters
US20060189893A1 (en) *	2005-01-06	2006-08-24	Diamics, Inc.	Systems and methods for detecting abnormal cells
JP2008526908A (ja) *	2005-01-13	2008-07-24	エフ．ホフマン−ラロシュアーゲー	有用な二置換アミンの新規な一段合成法
CA2607940C (en)	2005-05-18	2009-12-15	Aegera Therapeutics Inc.	Bir domain binding compounds
WO2007008848A2 (en)	2005-07-07	2007-01-18	Seattle Genetics, Inc.	Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
EP3498289A1 (en)	2005-07-07	2019-06-19	Seattle Genetics, Inc.	Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus
US7750116B1 (en)	2006-02-18	2010-07-06	Seattle Genetics, Inc.	Antibody drug conjugate metabolites
SG10201407457UA (en)	2006-05-16	2014-12-30	Pharmascience Inc	Iap bir domain binding compounds
US20080003652A1 (en) *	2006-06-28	2008-01-03	Hans Iding	Novel enzymatic process for the manufacture of Boc-Dap-Oh priority to related application(s)
DK2176296T3 (da)	2007-07-16	2012-05-21	Genentech Inc	Anti-CD79B-antistoffer og immunkonjugater og anvendelsesfremgangsmåder.
WO2009012256A1 (en)	2007-07-16	2009-01-22	Genentech, Inc.	Humanized anti-cd79b antibodies and immunoconjugates and methods of use
DK2247620T3 (en)	2008-01-31	2016-08-22	Genentech Inc	ANTI-CD79b ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE
PL2265283T3 (pl)	2008-03-18	2015-03-31	Seattle Genetics Inc	Koniugaty aurystatyny lek łącznik
KR20130009760A (ko)	2010-02-10	2013-01-23	이뮤노젠 아이엔씨	Ｃｄ２０ 항체 및 이의 용도
KR20120140658A (ko)	2010-02-12	2012-12-31	파마사이언스 인크.	Ｉａｐｂｉｒ 도메인 결합 화합물
EP2579887B1 (de)	2010-06-10	2014-11-12	Seattle Genetics, Inc.	Neue auristatin-derivate und ihre verwendung
WO2012041805A1 (de)	2010-09-29	2012-04-05	Bayer Pharma Aktiengesellschaft	N-carboxyalkyl-auristatine und ihre verwendung
WO2012123423A1 (de) *	2011-03-16	2012-09-20	Bayer Pharma Aktiengesellschaft	N-carboxyalkyl-auristatine und ihre verwendung
EP2714684B1 (en)	2011-05-27	2018-09-05	Ambrx, Inc.	Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives
BR112013030362B1 (pt) *	2011-05-27	2022-08-30	Ambrx, Inc	Composto derivado de dolastatina, método para derivatizar o mesmo e composição farmacêutica que compreende o dito composto
WO2014046441A1 (ko)	2012-09-20	2014-03-27	(주)셀트리온	돌라스타틴 10 유도체, 그의 제조방법 및 그를 포함하는 항암제 조성물
EP3086815B1 (en)	2013-12-27	2022-02-09	Zymeworks Inc.	Sulfonamide-containing linkage systems for drug conjugates
AU2015320678B2 (en)	2014-09-23	2021-07-22	Genentech, Inc.	Method of using anti-CD79b immunoconjugates
CN105949277B (zh) *	2015-05-05	2019-03-01	成都永泰诺科技有限公司	一种抗肿瘤化合物及其用途
PT3438118T (pt) *	2016-03-29	2023-06-07	Toray Industries	Derivado de peptídeo e utilização deste
CN109021065B (zh) *	2017-06-08	2021-10-01	复旦大学	一种制备海兔毒素Dolastatin10的方法
US20250281630A1 (en)	2021-09-03	2025-09-11	Toray Industries, Inc.	Pharmaceutical composition for cancer treatment and/or prevention

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2700165B1 (fr) *	1993-01-07	1995-02-17	Rhone Poulenc Rorer Sa	Dérivés de pyrrolidine, leur préparation et les médicaments les contenant.
US6323315B1 (en)	1999-09-10	2001-11-27	Basf Aktiengesellschaft	Dolastatin peptides

2002
- 2002-07-15 US US10/195,698 patent/US6737409B2/en not_active Expired - Fee Related
- 2002-07-17 UY UY27388A patent/UY27388A1/es not_active Application Discontinuation
- 2002-07-17 MX MXPA04000577A patent/MXPA04000577A/es active IP Right Grant
- 2002-07-17 CA CA002453987A patent/CA2453987A1/en not_active Abandoned
- 2002-07-17 WO PCT/EP2002/007931 patent/WO2003008378A1/en not_active Ceased
- 2002-07-17 RU RU2004105145/04A patent/RU2296750C2/ru not_active IP Right Cessation
- 2002-07-17 KR KR1020067008692A patent/KR20060057652A/ko not_active Ceased
- 2002-07-17 AR ARP020102678A patent/AR036175A1/es not_active Application Discontinuation
- 2002-07-17 HU HU0401253A patent/HUP0401253A2/hu unknown
- 2002-07-17 BR BR0211289-2A patent/BR0211289A/pt not_active IP Right Cessation
- 2002-07-17 IL IL15989002A patent/IL159890A0/xx unknown
- 2002-07-17 PL PL02367682A patent/PL367682A1/xx not_active Application Discontinuation
- 2002-07-17 DE DE60215179T patent/DE60215179T2/de not_active Expired - Fee Related
- 2002-07-17 MY MYPI20022704A patent/MY127718A/en unknown
- 2002-07-17 PT PT02764710T patent/PT1412328E/pt unknown
- 2002-07-17 KR KR1020047000854A patent/KR100611540B1/ko not_active Expired - Fee Related
- 2002-07-17 ES ES02764710T patent/ES2272763T3/es not_active Expired - Lifetime
- 2002-07-17 SI SI200230447T patent/SI1412328T1/sl unknown
- 2002-07-17 HR HR20040043A patent/HRP20040043A2/hr not_active Application Discontinuation
- 2002-07-17 CN CNA028177622A patent/CN1553897A/zh active Pending
- 2002-07-17 AT AT02764710T patent/ATE341537T1/de not_active IP Right Cessation
- 2002-07-17 EP EP02764710A patent/EP1412328B1/en not_active Expired - Lifetime
- 2002-07-17 NZ NZ530655A patent/NZ530655A/en unknown
- 2002-07-17 DK DK02764710T patent/DK1412328T3/da active
- 2002-07-17 JP JP2003513938A patent/JP2004534859A/ja active Pending
- 2002-07-18 PA PA20028551001A patent/PA8551001A1/es unknown
- 2002-07-18 GT GT200200154A patent/GT200200154A/es unknown
- 2002-07-19 PE PE2002000643A patent/PE20030258A1/es not_active Application Discontinuation
2004
- 2004-01-15 ZA ZA2004/00334A patent/ZA200400334B/en unknown
- 2004-01-16 NO NO20040198A patent/NO20040198L/no not_active Application Discontinuation
- 2004-01-20 CO CO04003736A patent/CO5550462A2/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
HRP20040043A2 (en)	2004-08-31
CO5550462A2 (es)	2005-08-31
NO20040198L (no)	2004-02-19
MY127718A (en)	2006-12-29
DE60215179T2 (de)	2007-10-18
PT1412328E (pt)	2007-01-31
DE60215179D1 (de)	2006-11-16
KR20040023661A (ko)	2004-03-18
UY27388A1 (es)	2003-01-31
ZA200400334B (en)	2005-06-29
ATE341537T1 (de)	2006-10-15
US20030055002A1 (en)	2003-03-20
GT200200154A (es)	2003-05-16
PE20030258A1 (es)	2003-03-19
AR036175A1 (es)	2004-08-18
WO2003008378A1 (en)	2003-01-30
KR20060057652A (ko)	2006-05-26
PL367682A1 (en)	2005-03-07
KR100611540B1 (ko)	2006-08-10
RU2296750C2 (ru)	2007-04-10
PA8551001A1 (es)	2003-09-17
CN1553897A (zh)	2004-12-08
DK1412328T3 (da)	2007-02-12
US6737409B2 (en)	2004-05-18
SI1412328T1 (sl)	2007-02-28
EP1412328B1 (en)	2006-10-04
MXPA04000577A (es)	2004-04-20
JP2004534859A (ja)	2004-11-18
NZ530655A (en)	2006-08-31
BR0211289A (pt)	2004-08-03
CA2453987A1 (en)	2003-01-30
HUP0401253A2 (hu)	2004-12-28
EP1412328A1 (en)	2004-04-28
RU2004105145A (ru)	2005-07-10
ES2272763T3 (es)	2007-05-01

Publication	Publication Date	Title
IL159890A0 (en)	2004-06-20	Dolastatin 10 derivatives
TW595857U (en)	2004-06-21	091219345
TW539393U (en)	2003-06-21	089204149
IL160701A0 (en)	2004-08-31	3-substituted-4-pyrimidone derivatives
HUP0303186A3 (en)	2007-06-28	4-aminobenzopyran derivatives
HUP0401949A3 (en)	2009-07-28	4-imidazolin-2-one derivatives
HUP0500026A3 (en)	2008-02-28	N-heteroarylnicotinamide derivatives
EP1392317A4 (en)	2005-10-19	SUBSTITUTED 1-BENZAZEPINE AND DERIVATIVES THEREOF
GB0113342D0 (en)	2001-07-25	Novel Heterocycles 1
GB0113344D0 (en)	2001-07-25	Novel heterocycles 3
EP1364954A4 (en)	2009-10-28	Dicarba closo DODECARBORANDERIVATE
GB0113343D0 (en)	2001-07-25	Novel Heterocycles 2
GB0104243D0 (en)	2001-04-11	Floodstoppers 2
AU2002361351A1 (en)	2003-06-10	24 volt-battery device
GB0007203D0 (en)	2000-05-17	Supertrowel 2000
TW539396U (en)	2003-06-21	090220607
GB0118917D0 (en)	2001-09-26	Biopower 3
GB0118315D0 (en)	2001-09-19	Jackit 31
GB0116704D0 (en)	2001-08-29	Unistore 800
TW539394U (en)	2003-06-21	090212946
GB0118177D0 (en)	2001-09-19	July 25
GB0118178D0 (en)	2001-09-19	July 24
GB0125582D0 (en)	2001-12-19	Fotwear designs 4
GB0129650D0 (en)	2002-01-30	'DVT-nomore'
GB0019112D0 (en)	2000-09-27	Biopower 2