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AR035871A1 - Procedimiento para preparar derivados de 9-desoxo-9a-aza-9a-homoeritromicina a 4''-sustituidos, intermediario y procedimiento para la preparacion del mismo - Google Patents

Procedimiento para preparar derivados de 9-desoxo-9a-aza-9a-homoeritromicina a 4''-sustituidos, intermediario y procedimiento para la preparacion del mismo

Info

Publication number
AR035871A1
AR035871A1 ARP020101536A ARP020101536A AR035871A1 AR 035871 A1 AR035871 A1 AR 035871A1 AR P020101536 A ARP020101536 A AR P020101536A AR P020101536 A ARP020101536 A AR P020101536A AR 035871 A1 AR035871 A1 AR 035871A1
Authority
AR
Argentina
Prior art keywords
procedure
formula
preparation
homoeritromicina
desoxo
Prior art date
Application number
ARP020101536A
Other languages
English (en)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR035871A1 publication Critical patent/AR035871A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un procedimiento para preparar un compuesto de fórmula (1) o una de sus sales farmacéuticamente aceptable, que comprende hacer reaccionar un compuesto de fórmula (2) con una amina de fórmula HNR8R15, en un disolvente orgánico que comprende isopropanol; en el que la reacción se lleva a cabo a una temperatura de al menos aproximadamente 40°C; en la que R3 es -CH2NR8R15; R8 es alquilo C1-10; y R15 es H o alquilo C1-10. También se da a conocer un procedimiento para la preparación del compuesto de fórmula (2). Los compuestos de fórmula (1) son agentes antibacterianos que se pueden usar para tratar diferentes infecciones bacterianas y protozoarias.
ARP020101536A 2001-04-27 2002-04-26 Procedimiento para preparar derivados de 9-desoxo-9a-aza-9a-homoeritromicina a 4''-sustituidos, intermediario y procedimiento para la preparacion del mismo AR035871A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28720301P 2001-04-27 2001-04-27

Publications (1)

Publication Number Publication Date
AR035871A1 true AR035871A1 (es) 2004-07-21

Family

ID=23101880

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020101536A AR035871A1 (es) 2001-04-27 2002-04-26 Procedimiento para preparar derivados de 9-desoxo-9a-aza-9a-homoeritromicina a 4''-sustituidos, intermediario y procedimiento para la preparacion del mismo

Country Status (22)

Country Link
US (1) US6825327B2 (es)
EP (2) EP1383780A1 (es)
JP (3) JP4104463B2 (es)
KR (1) KR100474225B1 (es)
CN (4) CN1297564C (es)
AR (1) AR035871A1 (es)
AU (1) AU784362B2 (es)
BR (2) BR0209241A (es)
CA (2) CA2445306C (es)
CZ (1) CZ303716B6 (es)
DK (1) DK1253153T3 (es)
ES (1) ES2608848T3 (es)
HU (1) HU230717B1 (es)
IL (3) IL158059A0 (es)
MX (2) MXPA03009786A (es)
PL (2) PL371766A1 (es)
PT (1) PT1253153T (es)
RU (2) RU2263117C2 (es)
SG (1) SG100789A1 (es)
WO (1) WO2002088158A1 (es)
YU (1) YU29502A (es)
ZA (2) ZA200203252B (es)

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MY145148A (en) 2004-08-13 2011-12-30 Schering Plough Ltd Pharmaceutical formulation comprising an antibiotic, a triazole and a carticosteroid
PE20060693A1 (es) 2004-09-23 2006-09-01 Schering Plough Ltd Nuevos derivados de trifluorometansulfonanilida oxamida eter
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US20080227730A1 (en) * 2005-01-14 2008-09-18 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 9A-Carbamoyl and Thiocarbamoyl Azalides With Antimalarial Activity
AR054380A1 (es) * 2005-06-09 2007-06-20 Schering Plough Ltd Control de parasitos en animales con derivados de n- ((feniloxi) fenil) -1,1,1-trifluorometansulfonamida y de n-(fenilsulfanil) fenil) -1,1,1-trifluorometansulfonamida
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
CN101605756A (zh) * 2006-12-13 2009-12-16 先灵-普劳有限公司 氟苯尼考及其类似物的水溶性前药
WO2008076256A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
SI2182945T1 (sl) 2007-06-27 2015-12-31 E.I. Du Pont De Nemours And Company Metoda za zatiranje škodljivcev pri živalih
TWI401023B (zh) 2008-02-06 2013-07-11 Du Pont 中離子農藥
US8314252B2 (en) * 2008-07-30 2012-11-20 Intervet Inc. Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
WO2010086351A1 (en) * 2009-01-30 2010-08-05 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 3'-n-substituted 9-deoxo-9a-methyl-9a-aza-homoerythromycin having antimalarial activity
WO2011017347A2 (en) 2009-08-05 2011-02-10 E. I. Du Pont De Nemours And Company Mesoionic pesticides
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
US20120122679A1 (en) 2009-08-05 2012-05-17 E. I. Du Pont De Nemours And Company Mesoionic pesticides
MX2012013758A (es) 2010-05-27 2013-01-24 Du Pont Forma cristalina de 4-[5-[3-cloro-5-trifluorometil)fenil]-4,5-dihi dro-5-(trifluorometil)-3-isoxazolil]-n-[2-oxo-2-[(2,2,2-trifluoro etil)amino]etil]-1-naftalenocarboxamida.
EP4324524A2 (en) * 2010-07-01 2024-02-21 Elanco Tiergesundheit AG Antibiotic compositions
CN103080121B (zh) * 2010-09-20 2015-11-25 瑞士诺华动物保健有限公司 用于制备在二脱氧甲基己糖环的C-4”处被环氧基团修饰的9-脱氧-9a-氮杂-9a-高红霉素A的新方法
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
CN102295672B (zh) * 2011-07-13 2014-06-04 武汉回盛生物科技有限公司 一种泰拉菌素的合成方法
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
WO2013013834A1 (en) * 2011-07-27 2013-01-31 Farma Grs, D.O.O. New crystalline forms of tulathromycin
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
CN103965273B (zh) 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
CN108473524B (zh) * 2016-01-18 2021-11-02 浙江海正药业股份有限公司 一种泰拉霉素的制备方法及其中间体
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN106434797A (zh) * 2016-08-25 2017-02-22 艾美科健（中国）生物医药有限公司 一种酶法合成泰拉霉素的工艺
CN106939029B (zh) * 2017-04-28 2020-10-13 艾美科健（中国）生物医药有限公司 一种泰拉霉素的制备方法
CN107400152B (zh) * 2017-08-29 2019-10-15 博瑞生物医药（苏州）股份有限公司 泰拉菌素草酸盐
CN107556351B (zh) * 2017-08-29 2019-10-18 博瑞生物医药（苏州）股份有限公司 一种泰拉菌素的制备方法
CN109535210A (zh) * 2018-12-19 2019-03-29 江苏威凌生化科技有限公司 一种合成纯化泰拉霉素杂质e的方法
KR20210154214A (ko) * 2019-04-18 2021-12-20 아주라 오프탈믹스 엘티디 안구 질병의 치료를 위한 화합물 및 방법
CN111072730B (zh) * 2019-12-16 2021-01-12 浙江国邦药业有限公司 一种泰拉霉素中间体盐的制备方法及应用
CN112225769A (zh) * 2020-09-21 2021-01-15 江苏威凌生化科技有限公司 一种合成纯化泰拉霉素杂质e的方法
CN113493483A (zh) * 2021-07-05 2021-10-12 上海应用技术大学 一种泰拉霉素的合成方法

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Also Published As

Publication number Publication date
CA2445306A1 (en) 2002-11-07
JP2004528353A (ja) 2004-09-16
CA2445306C (en) 2008-02-12
ZA200307506B (en) 2005-01-26
CA2383409C (en) 2007-01-02
CZ20021417A3 (cs) 2003-05-14
CN1715289A (zh) 2006-01-04
PL353633A1 (en) 2002-11-04
AU784362B2 (en) 2006-03-16
WO2002088158A1 (en) 2002-11-07
CA2383409A1 (en) 2002-10-27
RU2233287C2 (ru) 2004-07-27
CN1295240C (zh) 2007-01-17
JP2002326998A (ja) 2002-11-15
EP1383780A1 (en) 2004-01-28
PT1253153T (pt) 2016-12-29
BRPI0201437B1 (pt) 2017-11-28
HK1065803A1 (en) 2005-03-04
ZA200203252B (en) 2003-10-24
EP1253153A1 (en) 2002-10-30
AU3563002A (en) 2002-10-31
CN1167708C (zh) 2004-09-22
CN1297564C (zh) 2007-01-31
CN1503804A (zh) 2004-06-09
MXPA02004231A (es) 2002-11-13
BRPI0201437B8 (pt) 2021-05-25
IL158059A0 (en) 2004-03-28
IL149226A0 (en) 2002-11-10
ES2608848T3 (es) 2017-04-17
MXPA03009786A (es) 2004-01-29
PL213731B1 (pl) 2013-04-30
CN100413879C (zh) 2008-08-27
RU2263117C2 (ru) 2005-10-27
JP4100955B2 (ja) 2008-06-11
US20030064939A1 (en) 2003-04-03
JP4104463B2 (ja) 2008-06-18
HU230717B1 (hu) 2017-11-28
HU0201385D0 (es) 2002-06-29
IL149226A (en) 2008-06-05
HK1050370A1 (en) 2003-06-20
CZ303716B6 (cs) 2013-04-03
RU2003131351A (ru) 2005-02-27
CN1530370A (zh) 2004-09-22
EP1253153B1 (en) 2016-11-02
JP2007091754A (ja) 2007-04-12
PL371766A1 (en) 2005-06-27
DK1253153T3 (da) 2017-01-02
KR100474225B1 (ko) 2005-03-08
YU29502A (sh) 2005-03-15
BR0201437A (pt) 2003-06-10
SG100789A1 (en) 2003-12-26
HUP0201385A2 (hu) 2003-12-29
IL182418A0 (en) 2008-01-06
CN1384108A (zh) 2002-12-11
US6825327B2 (en) 2004-11-30
BR0209241A (pt) 2004-06-15
KR20020083474A (ko) 2002-11-02
IL182418A (en) 2012-07-31

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