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AR035498A1 - Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti-inflamatorios y analgesicos, su uso en la preparacion de medicamentos, intermediarios para su preparacion y composiciones farmaceuticas que los contienen - Google Patents

Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti-inflamatorios y analgesicos, su uso en la preparacion de medicamentos, intermediarios para su preparacion y composiciones farmaceuticas que los contienen

Info

Publication number
AR035498A1
AR035498A1 ARP010104879A ARP010104879A AR035498A1 AR 035498 A1 AR035498 A1 AR 035498A1 AR P010104879 A ARP010104879 A AR P010104879A AR P010104879 A ARP010104879 A AR P010104879A AR 035498 A1 AR035498 A1 AR 035498A1
Authority
AR
Argentina
Prior art keywords
alkyl
alkoxy
halo
substituted
amino
Prior art date
Application number
ARP010104879A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR035498A1 publication Critical patent/AR035498A1/es

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Compuesto de fórmula (1) o las sales farmacéuticamente aceptables del mismo, en la que Y1, Y2, Y3 o Y4 se seleccionan independientemente entre N, CH o C(L); R1 es H, alquilo C1-8, alquenilo C2-8, alquinilo C2-8, cicloalquilo C3-7, alcoxi C1-8, alcoxi C1-8 sustituido con halo, alquil C1-8-S(O)m-, Q1-, pirrolidinilo, piperidilo, oxopirrolidinilo, oxopiperidilo, amino, mono- o di-(alquil C1-8) amino, alquil C1-4-C(=O)-N(R3)- o alquil C1-4-S(O)m-N(R3)-, estando dichos alquilo C1-8, alquenilo C2-8 y alquinilo C2-8 opcionalmente sustituidos con halo, alquilo C1-3, hidroxi, oxo, alcoxi C1-4, alquil C1-4-S(O)m-, cicloalquilo C3-7, ciano, indanilo, 1, 2, 3, 4-tetrahidronaftilo, 1,2-dihidronaftilo, pirrolidinilo, piperidilo, oxopirrolidinilo, oxopiperidilo, Q1-, Q1-C(=O)-, Q1-O-, Q1-S(O)m-, Q1-alquilo C1-4-O-, Q1- alquilo C1-4-S(O)m-, Q1-alquilo C1-4-C(O)-N(R3)-, Q1-alquilo C1-4-N(R3)- o alquilo C1-4-C(O)-N(R3)-; Q1 es un anillo aromático monocíclico o bicíclico de 5 a 12 miembros que contiene opcionalmente hasta 4 heteroátomos seleccionados entre O, N y S, y que está opcionalmente sustituido con halo, alquilo C1-4, alquilo C1-4 sustituido con halo, hidroxi, alcoxi C1-4, alcoxi C1-4 sustituido con halo, alquil C1-4-tio, nitro, amino, mono- o di(alquil C1-4)amino, ciano, HO-alquil C1-4, alcoxi C1-4- alquilo C1-4, alquil C1-4-sulfonilo, aminosulfonilo, alquil C1-4-C(=O)-, HO(O=)C-, alquil C1-4-O(O=)C-, R3N(R4)C(=O)-, alquil C1-4-sulfonilamino, cicloalquilo C3-7, R3C(=O)N(R4)- o NH2(HN=)C-; A es un anillo aromático monocíclico de 5-6 miembros que contiene opcionalmente hasta 3 heteroátomos seleccionados entre O, N y S, estando dicho anillo aromático monocíclico de 5-6 miembros opcionalmente sustituido con hasta 3 sustituyentes seleccionados entre halo, alquilo C1-4- alquilo C1-4 sustituido con halo, hidroxi, alcoxi C1-4, alcoxi C1-4 sustituido con halo, alquil C1-4-tío, nitro, amino, mono- o di-(alquil C1-4)amino, ciano, HO-alquilo C1-4, alcoxi C1-4-alquilo C1-4, alquil C1-4-sulfonilo, aminosulfonilo, acetilo, R3N(R4)C(=O)-, -HO(O=)C-, alquilo C1-4-O(O=)C-, alquil C1-4-sulfonilamino, cicloalquilo C3-7, R3C(=O)N(R4)- y NH2(NH=)C-; B es alquileno C1-6 sustituido con halo, cicloalquileno C3-7, alquileno C2-6, alquinileno C2-6, -O-alquileno C1-5, alquileno C1-2-O-alquileno C1-2 o alquileno C1-6 opcionalmente sustituido con un grupo oxo o alquilo C1-3; W es NH, N-alquilo C1-4, O, S, N-OR5 o un enlace covalente; R2 es H, alquilo c1-4, OH o alcoxi C1-4; Z es un anillo aromático monocíclico o bicíclico de 5 a 12 miembros que contiene opcionalmente hasta 3 heteroátomos seleccionados entre O, N y S, estando dicho anillo aromático monocíclico o bicíclico de 5 a 12 miembros opcionalmente sustituido con halo, alquilo C1-4, alquilo C1-4 sustituido con halo, alquenilo C1-4, alquinilo C1-4, hidroxi, alcoxi C1-4, alcoxi C1-4 sustituido con halo, alquil C1-4-tío, nitro amino, mono- o di-(alquil C1-4) amino, ciano, HO-alquil C1-4, alcoxi C1-4-alquilo, alquil C1-4-sulfonilo, aminosulfonilo, alquil C1-4-C(=O)-, R3C(=O)N(R4)-, HO(O=)C-, alquil C1-4-O(O=)C-, alquil C1-4-sulfonilamino, cicloalquilo C3-7, NH2(HN=)C-, Q2-S(O)m-, Q2-O-, Q2-N(R3)-o Q2-; L es halo, alquilo C1-4, alquilo C1-4 sustituido con halo, hidroxi, alcoxi C1-4, alcoxi C1-4 sustituido con halo, alquil C1-4-tio, nitro, amino, mono-o di- (alquil C1-4) amino, ciano, HO-alquilo C1-4, alcoxi C1-4-alquilo C1-4, alquil C1-4-sulfonilo, aminosulfonilo, alquil C1-4-C(=O)-, HO(O=)C-, alquil C1-4-O(O=)C-, alquil C1-4-sulfonilamino, cicloalquilo C3-7, R3C(=O)N(R4)-, NH2(HN=)C-, R3N(R4)C(=O)-, R3N(R4)S(O)m-, Q2-, Q2-C(=O)-, Q2-O-, Q2-alquilo C1-4-O, o dos grupos L adyacentes están unidos opcionalmente entre sí formando una cadena alquileno que tiene 3 o 4 miembros, en la que uno o dos átomos de carbono (no adyacentes) se ha reemplazado opcionalmente por átomos de oxígeno; m es 0, 1 o 2; R3 y R4 se seleccionan independientemente entre H y alquilo C1-4; R5 es H, alquilo C1-4, alquilo C1-4-(O=)C- o alquilo C1-4-O-(O=)C-; y Q2 es un anillo aromático monocíclico o bicíclico de 5-12 miembros, o un anillo tricíclico de 5-12 miembros, que contiene opcionalmente hasta 3 heteroátomos seleccionados entre O, N y S, estando dicho anillo aromático monocíclico o bicíclico de 5-12 miembros opcionalmente sustituido con halo, alquilo C1-4, alquilo C1-4 sustituido con halo, alquenilo C1-4, alquinilo C1-4, hidroxi, alcoxi C1-4, alcoxi C1-4 sustituido con halo, alquil C1-4-tio, nitro, amino, mono- o di(alquil C1-4) amino, ciano, HO-alquilo C1-4, alcoxi C1-4-alquilo C1-4, alquil C1-4-sulfonilo, aminosulfonilo, alquil C1-4-(O=)C-, R3(R4)C(=O)-N-, HO(O=)C-, alquilo C1-4-O(O=)C-, alquil C1-4-sulfonilamino, cicloalquilo C3-7, alquil C1-4-C(=O)-NH- o NH2(NH=)C-. Estos compuestos son útiles para el tratamiento de afecciones médicas mediadas por prostaglandinas tales como dolor, fiebre o inflamación, etc. También se proporciona una composición farmacéutica que comprende el compuesto anterior y el uso de este compuesto en la preparación de medicamentos para el tratamiento de condiciones mediadas por prostaglandinas e intermediarios útiles en su fabricación.
ARP010104879A 2000-10-19 2001-10-17 Compuestos de imidazol condensado con arilo o heteroarilo como agentes anti-inflamatorios y analgesicos, su uso en la preparacion de medicamentos, intermediarios para su preparacion y composiciones farmaceuticas que los contienen AR035498A1 (es)

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