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AR035306A1 - N-arilamidas de acidos sulfonilamino-carboxilicos sustituidas con azufre, procedimiento para su preparacion y preparado farmaceutico que las contiene - Google Patents

N-arilamidas de acidos sulfonilamino-carboxilicos sustituidas con azufre, procedimiento para su preparacion y preparado farmaceutico que las contiene

Info

Publication number
AR035306A1
AR035306A1 ARP990103265A ARP990103265A AR035306A1 AR 035306 A1 AR035306 A1 AR 035306A1 AR P990103265 A ARP990103265 A AR P990103265A AR P990103265 A ARP990103265 A AR P990103265A AR 035306 A1 AR035306 A1 AR 035306A1
Authority
AR
Argentina
Prior art keywords
alkyl
ring
substituted
different
same
Prior art date
Application number
ARP990103265A
Other languages
English (en)
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19830430A external-priority patent/DE19830430A1/de
Priority claimed from DE19903126A external-priority patent/DE19903126A1/de
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of AR035306A1 publication Critical patent/AR035306A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/38—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atom of at least one amino group being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfones
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    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
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    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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Abstract

N-arilamidas de ácidos sulfonilamino-carboxílicos sustituidas con azufre, de la fórmula (1), en la cual A1 representa un radical bivalente de la serie fenileno, naftileno y heteroarileno, todos los cuales pueden estar sustituidos por uno o más sustituyentes, iguales o diferentes, seleccionados de la serie consistente en: halógeno, alquilo C1-5, fenilo, tolilo, CF3, NO2, OH, -O-C1-5-alquilo, -O-O-C2-4-alquil-O-C1-3-alquilo, C1-2-alquilendioxi, NH2, -NH-C1-3-alquilo, -N(C1-3-alquilo)2, -NH-CHO, -NH-CO-C1-5-alquilo, -CN, -CO-NH2, -CO-C1-3-alquilo, -CO-N(C1-3-alquilo)2, -CO-OH, -CO-O-C1-5-alquilo, heterociclilo, CHO, -CO-(C1-5-alquilo)2, -S(O)n-C1-4-alquilo, -S(O)n-fenilo y -S(O)n-tolilo; el anillo A2, que abarca los átomos de carbono que llevan los grupos C(=X)-NH- y NH-SO2R2, representa un anillo benzol, un anillo naftalina, un carbociclo de 3 a 7 miembros, saturado o parcialmente no saturado, un heterociclo monocíclico de 5 a 7 miembros, saturado, parcialmente no saturado, o aromático, que contiene uno o más heteroátomos de anillo seleccionados de la serie consistente en N, O y S, o un heterociclo bicíclico de 8 a 10 miembros, saturado, parcialmente no saturado, o aromático, que lleva uno o varios heteroátomos de anillo seleccionados de la serie consistente en N, O y S; R1 representa arilo, heterociclilo o C1-18-alquilo, que puede estar sustituido por uno o más radicales R4, iguales o diferentes, o cuando el número n en el grupo R1-S(O)n- vale 2, también representa NR5R6, o cuando el número n en el grupo R1-S(O)n- vale 0, también representa -CN; R2 representa arilo, heterociclilo, NR5R6 o alquilo C1-10 que puede estar sustituido por uno o más radicales R4, iguales o diferentes; R3 representa uno o más radicales, iguales o diferentes, seleccionados de entre la siguiente serie: hidrógeno, halógeno, CF3, OH, -O-C1-7-alquilo, -O-C2-4-alquil-O-C1-7-alquilo, -O-arilo, C1-2-alquilendioxi, NO2, -CN, NR7R8, -CO-NR7R8, -CO-OH, -CO-C1-5-alquilo, heterociclilo, S(O)n-C1-5-alquilo y C1-5-alquilo, que puede estar sustituido por uno o más radicales R4, iguales o diferentes; R4 representa flúor, OH, -O-C1-10-alquilo, -O-C1-4-alquil-O-C1-7-alquilo, -O-arilo, -CN, NR7R8, -CO-NH2, -CO-NH-C1-3-alquilo, -CO-N(C1-3-alquilo)2, -CO-OH, -CO-O-C1-5-alquilo, heterociclilo u oxo; R5 representa hidrógeno, C1-10-alquilo, que puede estar sustituido por uno o más radicales R4, iguales o diferentes y/o por arilo, heterociclilo, -CO-NR7R8, -CO-arilo ó -CO-C1-10-alquilo, pudiendo el radical alquilo estar sustituido por uno o más radicales R4, iguales o diferentes; R6, independientemente de R5, tiene uno de los significados indicados para R5, o R5 y R6 conjuntamente con el átomo de nitrógeno al cual están vinculados, forman un anillo de 5 a 8 miembros, saturado o parcialmente no saturado, que adicionalmente del átomo de nitrógeno que lleva los grupos R5 y R6 también puede contener uno o más heteroátomos de anillo de la serie N, O y S, y que puede estar sustituido por uno o varios sustituyentes, iguales o diferentes, tomados de la serie consistente en: flúor, C1-5-alquilo, hidroxi-C1-3-alquilo, -C1-3-alquil-O-C1-4-alquilo, arilo, CF3, OH, -O-C1-7-alquilo, -O-arilo, -O-C2-4-alquil-C1-7-alquilo, C2-3-alquilendioxi, NR7R8, -CN, -CO-NH2, -CO-NH-C1-3-alquilo, -CO-N(C1-3-alquilo)2, -CO-OH, -CO-O-C1-5-alquilo, CHO, CO-C1-5-alquilo, S(O)n-C1-4-alquilo, S(O)n-NH2, S(O)n-NH-C1-3-alquilo, S(O)n-N(C1-3-alquilo)2, oxo, (CH2)m-NH2, -(CH2)m-NH-C1-4-alquilo y -(CH2)m-N(C1-4-alquilo)2, pudiendo en el sustituyente (CH2)m-N(C1-4-alquilo)2 ambos grupos alquilo estar vinculados mediante un enlace simple y entonces formar conjuntamente con el átomo de nitrógeno que los lleva un anillo de 5 a 7 miembros, que además del átomo de nitrógeno y de los átomos de carbono puede contener también un átomo de oxígeno, un átomo de azufre o un grupo NR5 a título de miembro del anillo; R7 representa hidrógeno o C1-7-alquilo, puede estar sustituido por uno o varios sustituyentes, iguales o diferentes, de la serie: OH, -O-C1-5-alquilo, NH2, -NH-(C1-4-alquilo)2 y N(C1-4-alquilo)2, pudiendo en el sustituyente N(C1-4-alquilo)2 ambos grupos alquilo estar vinculados mediante un enlace simple y entonces formar conjuntamente con el átomo de nitrógeno que los lleva un anillo de 5 a 7 miembros, que además del átomo de nitrógeno y de los átomos de carbono puede contener también un átomo de oxígeno, un átomo de azufre o un grupo NR5 a título de miembro del anillo; R8, independientemente de R7, tiene uno de los significados de R7 o representa -CO-C1-4-alquilo; arilo representa fenilo, naftilo o heteroarilo todos los cuales pueden estar sustituidos por uno o varios sustituyentes, iguales o diferentes, seleccionados de entre el grupo consistente en: halógeno, C1-5-alquilo, fenilo, tolilo, CF3, -O-CF3, NO2, OH, -O-C1-5-alquilo, -O-C2-4-alquil-C1-3-alquilo, C1-2-alquilendioxi, NH2, -NH-C1-3-alquilo, N-(C1-3-alquilo)2, NH-CHO, -NH-CO-C1-5-alquilo, -CN, CO-NH2, -CO-NH-C1-3-alquilo, CO-N(C1-3-alquilo)2, -CO-OH, -CO-O-C1-5-alquilo, heterociclilo, CHO, CO-C1-5-alquilo, S(O)n-C1-4-alquilo, S(O)n-fenilo y S(O)n-tolilo; heteroarilo y heteroarileno representan el radical de un heterociclo aromático monocíclico de 5 o 6 miembros o de un heterociclo aromático bicíclico de 8 a 10 miembros, que en cada caso contienen uno o más heteroátomos de anillo de la serie, N, O y S; heterociclilo representa el radical de un heterociclo monocíclico o policíclico, de 5 a 11 miembros, saturado o parcialmente no saturado, que contiene uno o más heteroátomos de anillo de la serie, N, O y S, y que puede estar sustituido por uno o más sustituyentes, iguales o diferentes, de la serie consistente en: flúor, C1-5-alquilo, OH, O-C1-5-alquilo, -O-C2-4-alquil-O-C1-3-alquilo, NH2, -NH-C1-3-alquilo, -N(C1-3-alquilo)2, -CN, CO-NH2, CO-NH-C1-3-alquilo, CO-N(C1-3-alquilo)2, -CO-OH y CO-O-C1-5-alquilo; n representa 0, 1 ó 2; m representa 2, 3 ó 4; X representa O ó NH, o X representa un átomo de nitrógeno, que por intermedio de un enlace simple está vinculado a un átomo de carbono de anillo en el grupo A1, que está directamente próximo al átomo de carbono portador del grupo -NH-C(=X)- en A1, de manera tal que los grupos -NH-C(=X)- juntamente con los átomos de carbono que los lleva en el grupo A1 forma un anillo imidazol anelado; en todas sus formas estereoisoméricas y mezclas de las mismas en todas las proporciones, como también sus sales fisiológicamente aceptables, excluyéndose el compuesto de la fórmula (1) en la cual simultáneamente el anillo A2, que abarca los átomos de carbono que llevan los grupos C(=X)-NH- y NH-SO2R2, representa un anillo benzol, que en las posiciones 3 y 5 está sustituido con cloro, R2 representa metilo, X representa oxígeno y R1-S(O)n-A1 representa un radical 5-cloro-1-(4-clorofenilmercapto)-fenilo, procedimiento para la preparación de los compuestos de la fórmula (1), y preparado farmacéutico que contiene los compuestos de la fórmula (1). Estos compuestos son valiosas sustancias activas como medicamentos para la terapia y profilaxis de enfermedades, por ejemplo de enfermedades cardio-circulatorias tales como la elevada tensión arterial, angina pectoral, insuficiencia cardíaca, trombosis o aterosclerosis. Los compuestos de la fórmula (1) tienen la capacidad de modular la producción, propia del cuerpo, del monofosfato de guanosina cíclico (cGMP, cyclic guanosinmonophosphat) y en términos generales son adecuados para la terapia y profilaxis de los estados patológicos relacionados con una alteración del metabolismo del cGMP.
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Families Citing this family (121)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19830431A1 (de) * 1998-07-08 2000-01-13 Hoechst Marion Roussel De Gmbh Sulfonylamino-carbonsäure-N-arylamide als Guanylatcyclase-Aktivatoren
HU228111B1 (en) 1998-07-08 2012-11-28 Sanofi Aventis Deutschland Sulfur substituted sulfonylaminocarboxylic acid n-arylamides, their preparation, their use and pharmaceutical preparations comprising them
GB9824579D0 (en) * 1998-11-10 1999-01-06 Novartis Ag Organic compounds
DE19944226A1 (de) 1999-09-15 2001-03-29 Aventis Pharma Gmbh Verfahren zum Nachweis von oxidierten Formen der löslichen Guanylatzyklase und Verfahren zum Screening nach Aktivatoren der löslichen Guanylatzyklase mit oxidiertem Hämeisen
PL211888B1 (pl) * 1999-11-26 2012-07-31 Shionogi & Co Związek będący antagonistą NPY Y5 oraz kompozycja farmaceutyczna zawierająca taki związek
SE0001899D0 (sv) 2000-05-22 2000-05-22 Pharmacia & Upjohn Ab New compounds
GB2365426A (en) * 2000-08-01 2002-02-20 Pantherix Ltd Bactericidal benzamide derivatives
AU2001288518A1 (en) 2000-08-30 2002-03-13 Primecyte, Inc. Methods for treating tumors using sulfonyl compounds
EP1193256A1 (en) * 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Pharmaceutically active benzsulfonamide derivatives as inhibitors of JNK proteins
EP1193267A1 (en) * 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Pharmaceutically active hydrophilic sulfonamide derivatives as inhibitors of protein JunKinases
EP1193268A1 (en) * 2000-09-27 2002-04-03 Applied Research Systems ARS Holding N.V. Pharmaceutically active sulfonamide derivatives bearing both lipophilic and ionisable moieties as inhibitors of protein Junkinases
AU2002213048A1 (en) * 2000-10-05 2002-04-15 Smith Kline Beecham Corporation Phosphate transport inhibitors
US7102009B2 (en) 2001-01-12 2006-09-05 Amgen Inc. Substituted amine derivatives and methods of use
US20030134836A1 (en) 2001-01-12 2003-07-17 Amgen Inc. Substituted arylamine derivatives and methods of use
US7105682B2 (en) 2001-01-12 2006-09-12 Amgen Inc. Substituted amine derivatives and methods of use
US6995162B2 (en) * 2001-01-12 2006-02-07 Amgen Inc. Substituted alkylamine derivatives and methods of use
US6878714B2 (en) 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
DE10128331A1 (de) 2001-06-12 2002-12-19 Aventis Pharma Gmbh Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen
SE0102616D0 (sv) * 2001-07-25 2001-07-25 Astrazeneca Ab Novel compounds
GB2378179A (en) * 2001-08-03 2003-02-05 Pantherix Ltd Aromatic sulfonamides and their use in treating bacterial diseases
DE60229975D1 (de) * 2001-10-04 2009-01-02 Smithkline Beecham Corp Nf-kb-inhibitoren
BR0214344A (pt) * 2001-11-22 2004-09-14 Biovitrum Ab Inibidores de 11 - beta - hidroxi esteróide desidrogenase tipo 1
EA200400707A1 (ru) 2001-11-22 2004-10-28 Биовитрум Аб Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1
US20030130279A1 (en) * 2001-11-22 2003-07-10 Guido Kurz Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
JP2005531608A (ja) * 2002-06-06 2005-10-20 スミスクライン・ビーチャム・コーポレイション ＮＦ−κＢ阻害剤
US7307088B2 (en) 2002-07-09 2007-12-11 Amgen Inc. Substituted anthranilic amide derivatives and methods of use
US20040068012A1 (en) * 2002-10-08 2004-04-08 Comess Kenneth M. Sulfonamides having antiangiogenic and anticancer activity
US7491718B2 (en) * 2002-10-08 2009-02-17 Abbott Laboratories Sulfonamides having antiangiogenic and anticancer activity
US20040157836A1 (en) * 2002-10-08 2004-08-12 Comess Kenneth M. Sulfonamides having antiangiogenic and anticancer activity
US7144911B2 (en) 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
US7279576B2 (en) 2002-12-31 2007-10-09 Deciphera Pharmaceuticals, Llc Anti-cancer medicaments
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
SE0300091D0 (sv) * 2003-01-15 2003-01-15 Astrazeneca Ab Novel compounds
SE0300092D0 (sv) * 2003-01-15 2003-01-15 Astrazeneca Ab Novel compounds
WO2004073634A2 (en) * 2003-02-20 2004-09-02 Encysive Pharmaceuticals Inc. Phenylenediamine urotensin-ii receptor antagonists and ccr-9 antagonists
US7288538B2 (en) * 2003-02-20 2007-10-30 Encysive Pharmaceuticals, Inc. Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists
GB0318094D0 (en) * 2003-08-01 2003-09-03 Pfizer Ltd Novel combination
EP1663193B1 (en) * 2003-09-12 2012-04-04 Merck Serono SA Sulfonamide derivatives for the treatment of diabetes
GB0325291D0 (en) * 2003-10-29 2003-12-03 Pfizer Ltd Novel combination
DE102004009931A1 (de) * 2004-02-26 2005-09-15 Aventis Pharma Deutschland Gmbh Kv1.5-Blocker zur selektiven Steigerung der Vorhofkontraktilität und Behandlung der Herzinsuffizienz
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
NZ552284A (en) 2004-05-24 2010-01-29 Amgen Inc Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
DE102004047272A1 (de) * 2004-09-24 2006-04-06 Schering Ag Inhibitoren der löslichen Adenylatzyklase
TW200615260A (en) * 2004-09-24 2006-05-16 Schering Ag Inhibitors of soluble adenylate cyclase
DE102005000666B3 (de) * 2005-01-04 2006-10-05 Sanofi-Aventis Deutschland Gmbh Sulfonylpyrrolidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE102005031576A1 (de) * 2005-07-06 2007-01-25 Bayer Healthcare Ag Verwendung von Aktivatoren der löslichen Guanylatzyklase zur Behandlung von Reperfusionsschäden
DE102005047945A1 (de) * 2005-07-16 2007-01-18 Bayer Healthcare Ag Verwendung von Aktivatoren der löslichen Guanylatzyklase zur Behandlung von Raynaud Phänomenen
US20100016305A1 (en) * 2005-07-18 2010-01-21 Bayer Healthcare Ag novel use of activators and stimulators of soluble guanylate cyclase for the prevention or treatment of renal disorders
US8247556B2 (en) 2005-10-21 2012-08-21 Amgen Inc. Method for preparing 6-substituted-7-aza-indoles
CA2630718A1 (en) 2005-11-22 2007-05-31 Amgen Inc. Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
GB0526252D0 (en) * 2005-12-22 2006-02-01 Novartis Ag Organic compounds
US20070225284A1 (en) * 2006-03-23 2007-09-27 Bernd Buchmann Inhibitors of soluble adenylate cyclase
JP5606075B2 (ja) * 2007-02-14 2014-10-15 ビーエーエスエフ ソシエタス・ヨーロピア エレクトロルミネッセンス金属錯体
DE102007026392A1 (de) * 2007-06-06 2008-12-11 Bayer Healthcare Ag Lösungen für die Perfusion und Konservierung von Organen und Geweben
WO2009035788A1 (en) * 2007-08-03 2009-03-19 Romark Laboratories L.C. Alkylsulfonyl-substituted thiazolide compounds
JP2010540438A (ja) * 2007-09-20 2010-12-24 アムジエン・インコーポレーテツド 免疫障害を処置するためのｓ１ｐ受容体調節剤としての１−（４−ベンジルベンズアミド）−ベンジル）アゼチジン−３−カルボン酸誘導体および関連化合物
WO2009043495A1 (en) * 2007-10-05 2009-04-09 Sanofi-Aventis Deutschland Gmbh Use of sulfonyl-substituted 2-sulfonylaminobenzoic acid n-phenylamides in the treatment of pain
CA2720343A1 (en) * 2008-04-04 2009-10-08 Takeda Pharmaceutical Company Limited Heterocyclic derivative and use thereof
KR101955651B1 (ko) * 2008-08-22 2019-03-07 사우디 아람코 테크놀로지스 컴퍼니 촉매 및 중합체 합성방법
CN102316870A (zh) * 2009-01-17 2012-01-11 拜耳制药股份公司 sGC刺激剂或sGC活化剂联合PDE5抑制剂用于治疗勃起功能障碍
CA2940954A1 (en) 2009-05-12 2010-11-18 Romark Laboratories L.C. Nitazoxanide and tizoxanide for the treatment of rhinovirus and rhabdovirus infections
MX341877B (es) 2009-06-26 2016-09-06 Romark Laboratories L C * Compuestos y métodos para tratar influenza.
KR101793304B1 (ko) * 2010-02-05 2017-11-02 아드베리오 파마 게엠베하 낭성 섬유증의 치료를 위한, 단독으로의 및 ＰＤＥ5 억제제와 조합된 ｓＧＣ 자극제 또는 ｓＧＣ 활성화제
US20130178475A1 (en) 2010-03-17 2013-07-11 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
WO2011147810A1 (en) 2010-05-26 2011-12-01 Bayer Pharma Aktiengesellschaft THE USE OF sGC STIMULATORS, sGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF SYSTEMIC SCLEROSIS (SSc).
CA2803688A1 (en) 2010-06-25 2011-12-29 Bayer Intellectual Property Gmbh Use of stimulators and activators of soluble guanylate cyclase for treating sickle-cell anemia and conserving blood substitutes
CN107021951B (zh) 2010-06-30 2020-10-20 赛克里翁治疗有限公司 sGC刺激物
ES2572803T3 (es) 2010-11-09 2016-06-02 Ironwood Pharmaceuticals, Inc. Estimuladores de GCs
EP3112363A1 (en) 2011-12-27 2017-01-04 Ironwood Pharmaceuticals, Inc. 2-[1-[(2-fluorophenyl)methyl]-5-(3-isoxazolyl)-1h-pyrazol-3-yl]-pyrimidine derivatives and related compounds as soluble guanylate cyclase (sgc) stimulators for the treatment of pulmonary hypertension
KR101475056B1 (ko) 2012-06-29 2014-12-22 동국대학교 산학협력단 설폰아미드계 화합물을 유효성분으로 포함하는 ｃ형 간염의 예방 또는 치료용 약학적 조성물
US9309235B2 (en) 2012-09-18 2016-04-12 Ironwood Pharmaceuticals, Inc. SGC stimulators
WO2014047325A1 (en) 2012-09-19 2014-03-27 Ironwood Pharmaceuticals, Inc. Sgc stimulators
ES2700989T3 (es) * 2012-12-21 2019-02-20 Mayo Found Medical Education & Res Métodos y materiales para tratar estenosis de la válvula aórtica calcificada
CN109369635B (zh) 2013-03-15 2023-06-30 赛克里翁治疗有限公司 化合物或其药学上可接受的盐及其应用和药物组合物
WO2015011086A1 (en) 2013-07-25 2015-01-29 Bayer Pharma Aktiengesellschaft Sgc stimulators or sgc activators and pde5 inhibitors in combination with additional treatment for the therapy of cystic fibrosis
US20160311826A1 (en) 2013-12-11 2016-10-27 Ironwood Pharmaceuticals, Inc. Sgc stimulators
WO2015106268A1 (en) 2014-01-13 2015-07-16 Ironwood Pharmaceuticals, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS
TW201625586A (zh) 2014-07-02 2016-07-16 諾華公司 環己烯－１－基－吡啶－２－基－１ｈ－吡唑－４－羧酸衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途
TW201625584A (zh) 2014-07-02 2016-07-16 諾華公司 茚滿及吲哚啉衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途
TW201625601A (zh) 2014-07-02 2016-07-16 諾華公司 噻吩－２－基－吡啶－２－基－１ｈ－吡唑－４－羧酸衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途
EP2990403A1 (en) 2014-08-29 2016-03-02 Novartis Tiergesundheit AG Anthranilamides, sulfonamides and nitro analogues derived therefrom as anthelmintics
WO2016044445A2 (en) 2014-09-17 2016-03-24 Ironwood Pharmaceuticals, Inc. sGC STIMULATORS
EP3194382B1 (en) 2014-09-17 2021-09-08 Cyclerion Therapeutics, Inc. Pyrazole derivatives as sgc stimulators
US10844064B2 (en) 2014-09-17 2020-11-24 Cyclerion Therapeutics, Inc. sGC stimulators
AU2016258847A1 (en) 2015-05-06 2017-11-16 Bayer Pharma Aktiengesellschaft The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of Digital Ulcers (DU) concomitant to Systemic Sclerosis (SSc)
WO2017013010A1 (de) 2015-07-23 2017-01-26 Bayer Pharma Aktiengesellschaft Stimulatoren und/oder aktivatoren der löslichen guanylatzyklase (sgc) in kombination mit einem inhibitor der neutralen endopeptidase (nep inhibitor) und/oder einem angiotensin aii-antagonisten und ihre verwendung
CN105152996B (zh) * 2015-08-14 2017-04-12 天津小新医药科技有限公司 一类l‑薄荷醇类p2y12受体拮抗剂及其用途
CN105111118B (zh) * 2015-08-14 2017-04-12 天津小新医药科技有限公司 L‑薄荷醇类p2y12受体拮抗剂、制备方法及其用途
CN105111119B (zh) * 2015-08-14 2017-04-12 天津小新医药科技有限公司 一类卤代苯l‑薄荷醇类p2y12受体拮抗剂及其用途
CN105085346B (zh) * 2015-08-14 2017-03-29 天津小新医药科技有限公司 含胺基的l-薄荷醇类p2y12受体拮抗剂及其用途
CN105085345B (zh) * 2015-08-14 2016-09-14 天津小新医药科技有限公司 含硝基的l-薄荷醇类p2y12受体拮抗剂及其用途
CN108463224A (zh) 2015-12-14 2018-08-28 铁木医药有限公司 sGC刺激剂用于胃肠功能障碍治疗的应用
KR102513343B1 (ko) 2016-07-07 2023-03-22 사이클리온 테라퓨틱스, 인크. sGC 자극제의 인 전구약물
KR102803160B1 (ko) 2016-07-07 2025-04-30 사이클리온 테라퓨틱스, 인크. sGC 자극제의 고체 형태
MY199759A (en) 2016-09-02 2023-11-21 Tisento Therapeutics Inc Fused bicyclic sgc stimulators
EP3525778A1 (de) 2016-10-11 2019-08-21 Bayer Pharma Aktiengesellschaft Kombination enthaltend sgc aktivatoren und mineralocorticoid-rezeptor-antagonisten
AU2017359018C1 (en) 2016-11-08 2023-12-21 Tisento Therapeutics Inc. Treatment of CNS diseases with SGC stimulators
MA46755A (fr) 2016-11-08 2021-06-02 Cyclerion Therapeutics Inc Stimulateurs de sgc
EP3554488A2 (en) 2016-12-13 2019-10-23 Cyclerion Therapeutics, Inc. Use of sgc stimulators for the treatment of esophageal motility disorders
WO2018153899A1 (de) 2017-02-22 2018-08-30 Bayer Pharma Aktiengesellschaft Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit stimulatoren und/oder aktivatoren der löslichen guanylatcyclase (sgc)
WO2019081456A1 (en) 2017-10-24 2019-05-02 Bayer Aktiengesellschaft USE OF SGC ACTIVATORS AND STIMULATORS COMPRISING A BETA2 SUBUNIT
EP3498298A1 (en) 2017-12-15 2019-06-19 Bayer AG The use of sgc stimulators and sgc activators alone or in combination with pde5 inhibitors for the treatment of bone disorders including osteogenesis imperfecta (oi)
JP7337067B2 (ja) 2017-12-19 2023-09-01 サイクレリオン・セラピューティクス，インコーポレーテッド ｓＧＣ刺激薬
EP3762389B1 (en) 2018-03-07 2024-02-28 Tisento Therapeutics Inc. Crystalline forms of an sgc stimulator
WO2019211081A1 (en) 2018-04-30 2019-11-07 Bayer Aktiengesellschaft The use of sgc activators and sgc stimulators for the treatment of cognitive impairment
JOP20200287A1 (ar) 2018-05-15 2020-11-09 Bayer Ag بنزاميدات مستبدلة بـ 3،1- ثيازول-2- يل للمعالجة من أمراض مصاحبة لتحسس الألياف العصبية
US11508483B2 (en) 2018-05-30 2022-11-22 Adverio Pharma Gmbh Method of identifying a subgroup of patients suffering from dcSSc which benefits from a treatment with sGC stimulators and sGC activators in a higher degree than a control group
US12220414B2 (en) 2018-07-11 2025-02-11 Tisento Therapeutics Inc. Use of sGC stimulators for the treatment of mitochondrial disorders
WO2020148379A1 (en) 2019-01-17 2020-07-23 Bayer Aktiengesellschaft Methods to determine whether a subject is suitable of being treated with an agonist of soluble guanylyl cyclase (sgc)
CA3136550A1 (en) 2019-04-10 2020-10-15 Mayo Foundation For Medical Education And Research Methods and materials for gender-dependent treatment of cardiovascular dysfunction
WO2021195403A1 (en) 2020-03-26 2021-09-30 Cyclerion Therapeutics, Inc. Deuterated sgc stimulators
WO2021202546A1 (en) 2020-03-31 2021-10-07 Cyclerion Therapeutics, Inc. Early drug interventions to reduce covid-19 related respiratory distress, need for ventilator assistance and death
EP4011873A1 (en) 2020-12-10 2022-06-15 Bayer Aktiengesellschaft Substituted pyrazolo piperidine carboxylic acids
JP2024516623A (ja) 2021-04-20 2024-04-16 ティセント セラピューティクス インコーポレーテッド ｓＧＣ刺激剤でのＣＮＳ疾患の処置
TW202309038A (zh) 2021-04-20 2023-03-01 美商賽克瑞恩醫療公司 sGC刺激劑
US20240342187A1 (en) 2021-06-14 2024-10-17 Curtails Llc Use of nep inhibitors for the treatment of gastrointestinal sphincter disorders
WO2023018795A1 (en) 2021-08-11 2023-02-16 Curtails Llc Nep inhibitors for the treatment of laminitis
JP2025518350A (ja) 2022-06-09 2025-06-12 バイエル・アクチエンゲゼルシヤフト 女性における駆出率が維持された心不全の治療に使用するための可溶性グアニル酸シクラーゼアクチベーター
WO2024086179A1 (en) 2022-10-18 2024-04-25 Tisento Therapeutics, Inc. Pyrimidine sgc stimulators
WO2024086182A1 (en) 2022-10-18 2024-04-25 Tisento Therapeutics Inc. Treatment of mitochondrial diseases with sgc stimulators
WO2025085848A1 (en) * 2023-10-20 2025-04-24 Arrepath, Inc. Antibacterial compounds

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB876526A (en) 1957-12-24 1961-09-06 Geigy Ag J R Process for the production of new aminobenzoic acid derivatives and their use in pest control
US3737316A (en) 1971-08-31 1973-06-05 Eastman Kodak Co Two-equivalent sulfonamido couplers
FR2201083A1 (en) * 1972-09-28 1974-04-26 Ferlux 6-Phenyl pyrimidine-4-carboxylic acids - analgesics, vasodilators, cardiac stimulants and respiratory analeptics
JPH01206338A (ja) 1988-02-15 1989-08-18 Konica Corp ハロゲン化銀カラー写真感光材料
JPH04285955A (ja) 1991-03-14 1992-10-12 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
JP2673061B2 (ja) 1991-07-23 1997-11-05 富士写真フイルム株式会社 ハロゲン化銀カラー写真感光材料
US6048897A (en) 1993-06-15 2000-04-11 Brigham And Women's Hospital Lipoxin compounds and their use in treating cell proliferative disorders
JPH0756293A (ja) 1993-08-18 1995-03-03 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
US6176874B1 (en) * 1993-10-18 2001-01-23 Masschusetts Institute Of Technology Vascularized tissue regeneration matrices formed by solid free form fabrication techniques
KR100359396B1 (ko) 1995-04-04 2003-03-15 텍사스 바이오테크놀로지 코포레이션 엔도텔린의활성을조절하는티에닐-,푸릴-및피롤릴설폰아미드및이의유도체
JPH0943786A (ja) 1995-07-28 1997-02-14 Fuji Photo Film Co Ltd ハロゲン化銀カラー写真感光材料
IT1285454B1 (it) 1996-01-25 1998-06-08 Mario Ciucani Macchina perfezionata per la cucitura di articoli vari, in particolare articoli di pelle e similari
DE19705133A1 (de) * 1997-02-11 1998-08-13 Hoechst Ag Sulfonamid-substituierte Verbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
SG100767A1 (en) 1997-04-28 2003-12-26 Texas Biotechnology Corp Sulfonamides for treatment of endothelin-mediated disorders
US5783705A (en) 1997-04-28 1998-07-21 Texas Biotechnology Corporation Process of preparing alkali metal salys of hydrophobic sulfonamides
DE19744026A1 (de) * 1997-10-06 1999-04-08 Hoechst Marion Roussel De Gmbh Pyrazol-Derivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
DE19744027A1 (de) 1997-10-06 1999-04-08 Hoechst Marion Roussel De Gmbh Substituierte Pyrazolo[3,4-b]pyridine, ihre Herstellung und Verwendung in Arzneimitteln
DE19749453A1 (de) * 1997-11-10 1999-05-12 Hoechst Marion Roussel De Gmbh Sulfonamid-substituierte anellierte 5-Ring-Verbindungen, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
DE19830431A1 (de) 1998-07-08 2000-01-13 Hoechst Marion Roussel De Gmbh Sulfonylamino-carbonsäure-N-arylamide als Guanylatcyclase-Aktivatoren
HU228111B1 (en) 1998-07-08 2012-11-28 Sanofi Aventis Deutschland Sulfur substituted sulfonylaminocarboxylic acid n-arylamides, their preparation, their use and pharmaceutical preparations comprising them
DE19834629A1 (de) * 1998-07-31 1998-12-03 Novartis Ag Herbizides Mittel
AU754204B2 (en) * 1998-09-01 2002-11-07 Bristol-Myers Squibb Company Potassium channel inhibitors and method

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