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AR029518A1 - El uso de un derivado de alfa-halogeno acriloilo distamicina. - Google Patents

El uso de un derivado de alfa-halogeno acriloilo distamicina.

Info

Publication number
AR029518A1
AR029518A1 ARP010102143A ARP010102143A AR029518A1 AR 029518 A1 AR029518 A1 AR 029518A1 AR P010102143 A ARP010102143 A AR P010102143A AR P010102143 A ARP010102143 A AR P010102143A AR 029518 A1 AR029518 A1 AR 029518A1
Authority
AR
Argentina
Prior art keywords
alfa
halogen
distamycin
dynamicine
derivative
Prior art date
Application number
ARP010102143A
Other languages
English (en)
Inventor
Cristina Geroni
Paolo Cozzi
Italo Beria
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of AR029518A1 publication Critical patent/AR029518A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Los compuestos que son derivados de alfa-acriloilo distamicina de formula 1 donde R1 es un átomo de bromo o cloro; R2 es una distamicina o una estructura tipo distamicina segun lo establecido en la especificacion; o una sal de la misma farmacéuticamente aceptable; son agentes citotoxicos particularmente efectivos en el tratamiento de tumores que sobre-expresan un sistema GSH/GSTs y que responden deficientemente o son incluso resistentes a terapias antitumorales convencionales.
ARP010102143A 2000-05-08 2001-05-07 El uso de un derivado de alfa-halogeno acriloilo distamicina. AR029518A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0011059.3A GB0011059D0 (en) 2000-05-08 2000-05-08 Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione

Publications (1)

Publication Number Publication Date
AR029518A1 true AR029518A1 (es) 2003-07-02

Family

ID=9891173

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010102143A AR029518A1 (es) 2000-05-08 2001-05-07 El uso de un derivado de alfa-halogeno acriloilo distamicina.

Country Status (29)

Country Link
US (1) US7030089B2 (es)
EP (1) EP1280527B1 (es)
JP (1) JP2003532669A (es)
KR (1) KR100776184B1 (es)
CN (1) CN1258362C (es)
AR (1) AR029518A1 (es)
AT (1) ATE300944T1 (es)
AU (2) AU2001260227B2 (es)
BR (1) BR0110628A (es)
CA (1) CA2409664C (es)
CZ (1) CZ300791B6 (es)
DE (1) DE60112423T2 (es)
DK (1) DK1280527T3 (es)
EA (1) EA007506B1 (es)
EE (1) EE200200605A (es)
ES (1) ES2244618T3 (es)
GB (1) GB0011059D0 (es)
HK (1) HK1054193B (es)
HU (1) HUP0301882A2 (es)
IL (2) IL152388A0 (es)
MX (1) MXPA02010962A (es)
NO (1) NO20025303L (es)
NZ (1) NZ522234A (es)
PL (1) PL201289B1 (es)
PT (1) PT1280527E (es)
SK (1) SK286501B6 (es)
TW (1) TWI284643B (es)
WO (1) WO2001085144A2 (es)
ZA (1) ZA200208531B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0011059D0 (en) 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015447D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0015446D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0016447D0 (en) 2000-07-04 2000-08-23 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
IT1318696B1 (it) * 2000-09-15 2003-08-27 Pharmacia & Upjohn Spa Coniugati di glutatione con derivati della distamicina ad attivita'antitumorale.
US6969592B2 (en) 2001-09-26 2005-11-29 Pharmacia Italia S.P.A. Method for predicting the sensitivity to chemotherapy
JP2005527552A (ja) * 2002-04-02 2005-09-15 フアルマシア・イタリア・エツセ・ピー・アー 置換アクリロイルジスタマイシン誘導体および放射線療法を含む腫瘍に対する組合せ治療
AR106352A1 (es) * 2015-10-15 2018-01-03 Advanced Biodesign Compuestos de aminotioléster o las sales farmacéuticamente aceptables del mismo, para usar en el tratamiento del cáncer

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT387013B (de) 1985-07-16 1988-11-25 Erba Farmitalia Verfahren zur herstellung von poly-4-aminopyrrol -2-carboxamidoderivaten
GB8612218D0 (en) 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
EP0265719B1 (en) 1986-10-07 1991-03-06 Boehringer Mannheim Italia S.P.A. Pharmaceutical compositions having antineoplastic activity
GB8906709D0 (en) 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
JP2919867B2 (ja) 1989-09-27 1999-07-19 千寿製薬株式会社 抗腫瘍剤
IT1272234B (it) 1994-05-02 1997-06-16 Consiglio Nazionale Ricerche Derivati glutationici delle antracicline e procedimento per ottenerli.
GB9416005D0 (en) * 1994-08-08 1994-09-28 Erba Carlo Spa Peptidic compounds analogous to distamycin a and process for their preparation
US5880097A (en) 1996-01-04 1999-03-09 Terrapin Techologies, Inc. Tethered prodrugs
WO1997028123A1 (en) 1996-02-02 1997-08-07 Pharmacia & Upjohn S.P.A. Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9610079D0 (en) 1996-05-14 1996-07-17 Pharmacia Spa Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents
GB9615692D0 (en) * 1996-07-25 1996-09-04 Pharmacia Spa Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9623522D0 (en) * 1996-11-11 1997-01-08 Pharmacia & Upjohn Spa Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9727524D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Synergistic antitumor composition containing a biologically active ureido compound
GB9806692D0 (en) * 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents
GB9806689D0 (en) * 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9816652D0 (en) 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9816653D0 (en) 1998-07-30 1998-09-30 Pharmacia & Upjohn Spa Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9928703D0 (en) 1999-12-03 2000-02-02 Pharmacia & Upjohn Spa Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
GB0011059D0 (en) 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione

Also Published As

Publication number Publication date
EE200200605A (et) 2004-04-15
CZ300791B6 (cs) 2009-08-12
EP1280527A2 (en) 2003-02-05
US20030207794A1 (en) 2003-11-06
PL201289B1 (pl) 2009-03-31
WO2001085144A3 (en) 2002-05-16
DK1280527T3 (da) 2005-10-17
DE60112423D1 (de) 2005-09-08
EA007506B1 (ru) 2006-10-27
US7030089B2 (en) 2006-04-18
ZA200208531B (en) 2003-10-22
GB0011059D0 (en) 2000-06-28
ES2244618T3 (es) 2005-12-16
TWI284643B (en) 2007-08-01
HK1054193B (zh) 2007-02-02
PL365831A1 (en) 2005-01-10
AU6022701A (en) 2001-11-20
HUP0301882A2 (hu) 2003-09-29
MXPA02010962A (es) 2003-03-27
IL152388A0 (en) 2003-05-29
BR0110628A (pt) 2003-03-18
HK1054193A1 (en) 2003-11-21
DE60112423T2 (de) 2006-05-24
CA2409664A1 (en) 2001-11-15
CN1427719A (zh) 2003-07-02
NO20025303D0 (no) 2002-11-05
CN1258362C (zh) 2006-06-07
EP1280527B1 (en) 2005-08-03
ATE300944T1 (de) 2005-08-15
JP2003532669A (ja) 2003-11-05
EA200201184A1 (ru) 2003-04-24
CZ20023629A3 (cs) 2003-03-12
IL152388A (en) 2008-04-13
AU2001260227B2 (en) 2005-10-27
SK286501B6 (sk) 2008-11-06
NO20025303L (no) 2002-11-05
KR100776184B1 (ko) 2007-11-16
WO2001085144A2 (en) 2001-11-15
SK16002002A3 (sk) 2003-04-01
PT1280527E (pt) 2005-10-31
KR20030019371A (ko) 2003-03-06
NZ522234A (en) 2004-09-24
CA2409664C (en) 2010-01-12

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