SK286501B6 - Použitie alfa-halogénakryloyl-distamycínového derivátu na výrobu liečiva na liečenie nádorov - Google Patents

Použitie alfa-halogénakryloyl-distamycínového derivátu na výrobu liečiva na liečenie nádorov Download PDF

Info

Publication number: SK286501B6
Authority: SK; Slovakia
Prior art keywords: amino; methyl; carbonyl; pyrrol; gsh
Prior art date: 2000-05-08

Application number

SK1600-2002A

Other languages

English (en)

Slovak (sk)

Other versions

SK16002002A3 (sk

Inventor

Maria Cristina Rosa Geroni

Paolo Cozzi

Italo Beria

Original Assignee

Pharmacia Italia S. P. A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-08

Filing date

2001-04-19

Publication date

2008-11-06

2001-04-19 Application filed by Pharmacia Italia S. P. A. filed Critical Pharmacia Italia S. P. A.

2003-04-01 Publication of SK16002002A3 publication Critical patent/SK16002002A3/sk

2008-11-06 Publication of SK286501B6 publication Critical patent/SK286501B6/sk

Links

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Classifications

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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Pulmonology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pyrrole Compounds (AREA)

SK1600-2002A 2000-05-08 2001-04-19 Použitie alfa-halogénakryloyl-distamycínového derivátu na výrobu liečiva na liečenie nádorov SK286501B6 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0011059.3A GB0011059D0 (en)	2000-05-08	2000-05-08	Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
PCT/EP2001/004470 WO2001085144A2 (en)	2000-05-08	2001-04-19	Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione

Publications (2)

Publication Number	Publication Date
SK16002002A3 SK16002002A3 (sk)	2003-04-01
SK286501B6 true SK286501B6 (sk)	2008-11-06

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ID=9891173

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1600-2002A SK286501B6 (sk)	2000-05-08	2001-04-19	Použitie alfa-halogénakryloyl-distamycínového derivátu na výrobu liečiva na liečenie nádorov

Country Status (29)

Country	Link
US (1)	US7030089B2 (es)
EP (1)	EP1280527B1 (es)
JP (1)	JP2003532669A (es)
KR (1)	KR100776184B1 (es)
CN (1)	CN1258362C (es)
AR (1)	AR029518A1 (es)
AT (1)	ATE300944T1 (es)
AU (2)	AU6022701A (es)
BR (1)	BR0110628A (es)
CA (1)	CA2409664C (es)
CZ (1)	CZ300791B6 (es)
DE (1)	DE60112423T2 (es)
DK (1)	DK1280527T3 (es)
EA (1)	EA007506B1 (es)
EE (1)	EE200200605A (es)
ES (1)	ES2244618T3 (es)
GB (1)	GB0011059D0 (es)
HK (1)	HK1054193B (es)
HU (1)	HUP0301882A2 (es)
IL (2)	IL152388A0 (es)
MX (1)	MXPA02010962A (es)
NO (1)	NO20025303D0 (es)
NZ (1)	NZ522234A (es)
PL (1)	PL201289B1 (es)
PT (1)	PT1280527E (es)
SK (1)	SK286501B6 (es)
TW (1)	TWI284643B (es)
WO (1)	WO2001085144A2 (es)
ZA (1)	ZA200208531B (es)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0011059D0 (en)	2000-05-08	2000-06-28	Pharmacia & Upjohn Spa	Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015447D0 (en) *	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0015446D0 (en) *	2000-06-23	2000-08-16	Pharmacia & Upjohn Spa	Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0016447D0 (en)	2000-07-04	2000-08-23	Pharmacia & Upjohn Spa	Process for preparing distamycin derivatives
IT1318696B1 (it) *	2000-09-15	2003-08-27	Pharmacia & Upjohn Spa	Coniugati di glutatione con derivati della distamicina ad attivita'antitumorale.
US6969592B2 (en)	2001-09-26	2005-11-29	Pharmacia Italia S.P.A.	Method for predicting the sensitivity to chemotherapy
EP1490053B1 (en) *	2002-04-02	2008-01-09	NERVIANO MEDICAL SCIENCES S.r.l.	Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and radiotherapy
SMT202100271T1 (it) *	2015-10-15	2021-07-12	Advanced Biodesign	Composti di amminotiolesteri o relativi sali farmaceuticamente accettabili, per l’uso nel trattamento di un cancro

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SE468642B (sv)	1985-07-16	1993-02-22	Erba Farmitalia	Poly-4-aminopyrrol-2-karboxamidoderivat och foerfarande foer deras framstaellning och en farmaceutisk komposition
GB8612218D0 (en)	1986-05-20	1986-06-25	Erba Farmitalia	Site specific alkylating agents
CA1306693C (en)	1986-10-07	1992-08-25	Sergio Tognella	Pharmaceutical compositions having antineoplastic activity
GB8906709D0 (en)	1989-03-23	1989-05-10	Creighton Andrew M	Acryloyl substituted pyrrole derivatives
JP2919867B2 (ja)	1989-09-27	1999-07-19	千寿製薬株式会社	抗腫瘍剤
IT1272234B (it) *	1994-05-02	1997-06-16	Consiglio Nazionale Ricerche	Derivati glutationici delle antracicline e procedimento per ottenerli.
GB9416005D0 (en) *	1994-08-08	1994-09-28	Erba Carlo Spa	Peptidic compounds analogous to distamycin a and process for their preparation
US5880097A (en) *	1996-01-04	1999-03-09	Terrapin Techologies, Inc.	Tethered prodrugs
WO1997028123A1 (en)	1996-02-02	1997-08-07	Pharmacia & Upjohn S.P.A.	Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9610079D0 (en)	1996-05-14	1996-07-17	Pharmacia Spa	Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents
GB9615692D0 (en) *	1996-07-25	1996-09-04	Pharmacia Spa	Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9623522D0 (en) *	1996-11-11	1997-01-08	Pharmacia & Upjohn Spa	Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9727524D0 (en)	1997-12-31	1998-02-25	Pharmacia & Upjohn Spa	Synergistic antitumor composition containing a biologically active ureido compound
GB9806689D0 (en) *	1998-03-27	1998-05-27	Pharmacia & Upjohn Spa	Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9806692D0 (en) *	1998-03-27	1998-05-27	Pharmacia & Upjohn Spa	Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents
GB9816653D0 (en)	1998-07-30	1998-09-30	Pharmacia & Upjohn Spa	Oxidised sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9816652D0 (en)	1998-07-30	1998-09-30	Pharmacia & Upjohn Spa	Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents
GB9928703D0 (en)	1999-12-03	2000-02-02	Pharmacia & Upjohn Spa	Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
GB0011059D0 (en) *	2000-05-08	2000-06-28	Pharmacia & Upjohn Spa	Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione

2000
- 2000-05-08 GB GBGB0011059.3A patent/GB0011059D0/en not_active Ceased
2001
- 2001-04-19 AU AU6022701A patent/AU6022701A/xx active Pending
- 2001-04-19 EE EEP200200605A patent/EE200200605A/xx unknown
- 2001-04-19 BR BR0110628-7A patent/BR0110628A/pt not_active Application Discontinuation
- 2001-04-19 CN CNB018092039A patent/CN1258362C/zh not_active Expired - Fee Related
- 2001-04-19 DE DE60112423T patent/DE60112423T2/de not_active Expired - Lifetime
- 2001-04-19 AU AU2001260227A patent/AU2001260227B2/en not_active Ceased
- 2001-04-19 NZ NZ522234A patent/NZ522234A/en unknown
- 2001-04-19 HK HK03106491.8A patent/HK1054193B/zh not_active IP Right Cessation
- 2001-04-19 CA CA002409664A patent/CA2409664C/en not_active Expired - Fee Related
- 2001-04-19 CZ CZ20023629A patent/CZ300791B6/cs not_active IP Right Cessation
- 2001-04-19 DK DK01933856T patent/DK1280527T3/da active
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- 2001-04-19 HU HUP0301882 patent/HUP0301882A2/hu unknown
- 2001-04-19 PL PL365831A patent/PL201289B1/pl not_active IP Right Cessation
- 2001-04-19 KR KR1020027015026A patent/KR100776184B1/ko not_active Expired - Fee Related
- 2001-04-19 PT PT01933856T patent/PT1280527E/pt unknown
- 2001-04-19 JP JP2001581798A patent/JP2003532669A/ja not_active Abandoned
- 2001-04-19 IL IL15238801A patent/IL152388A0/xx active IP Right Grant
- 2001-04-19 WO PCT/EP2001/004470 patent/WO2001085144A2/en not_active Ceased
- 2001-04-19 EP EP01933856A patent/EP1280527B1/en not_active Expired - Lifetime
- 2001-04-19 AT AT01933856T patent/ATE300944T1/de not_active IP Right Cessation
- 2001-04-19 ES ES01933856T patent/ES2244618T3/es not_active Expired - Lifetime
- 2001-04-19 EA EA200201184A patent/EA007506B1/ru not_active IP Right Cessation
- 2001-04-19 US US10/258,620 patent/US7030089B2/en not_active Expired - Fee Related
- 2001-04-19 MX MXPA02010962A patent/MXPA02010962A/es active IP Right Grant
- 2001-05-03 TW TW090110601A patent/TWI284643B/zh active
- 2001-05-07 AR ARP010102143A patent/AR029518A1/es unknown
2002
- 2002-10-21 IL IL152388A patent/IL152388A/en not_active IP Right Cessation
- 2002-10-22 ZA ZA200208531A patent/ZA200208531B/en unknown
- 2002-11-05 NO NO20025303A patent/NO20025303D0/no unknown

Also Published As

Publication number	Publication date
GB0011059D0 (en)	2000-06-28
DE60112423D1 (de)	2005-09-08
ATE300944T1 (de)	2005-08-15
CN1258362C (zh)	2006-06-07
CA2409664C (en)	2010-01-12
EA007506B1 (ru)	2006-10-27
HK1054193A1 (en)	2003-11-21
CZ20023629A3 (cs)	2003-03-12
US7030089B2 (en)	2006-04-18
IL152388A0 (en)	2003-05-29
MXPA02010962A (es)	2003-03-27
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WO2001085144A3 (en)	2002-05-16
NO20025303L (no)	2002-11-05
US20030207794A1 (en)	2003-11-06
PT1280527E (pt)	2005-10-31
ES2244618T3 (es)	2005-12-16
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HUP0301882A2 (hu)	2003-09-29
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EA200201184A1 (ru)	2003-04-24
JP2003532669A (ja)	2003-11-05
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