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AR029332A1 - Compuesto derivado de una 2-alquinilpurina y su uso en la preparacion de un medicamento para tratar la respuesta inflamatoria - Google Patents

Compuesto derivado de una 2-alquinilpurina y su uso en la preparacion de un medicamento para tratar la respuesta inflamatoria

Info

Publication number
AR029332A1
AR029332A1 ARP000100433A ARP000100433A AR029332A1 AR 029332 A1 AR029332 A1 AR 029332A1 AR P000100433 A ARP000100433 A AR P000100433A AR P000100433 A ARP000100433 A AR P000100433A AR 029332 A1 AR029332 A1 AR 029332A1
Authority
AR
Argentina
Prior art keywords
alkyl
amino
aryl
inflammatory response
mono
Prior art date
Application number
ARP000100433A
Other languages
English (en)
Inventor
J Lindel
Francis X Sullivan
I Sarembock
T Macdonal
M Okusa
I Kron
W Scheld
Original Assignee
Univ Virginia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/333,387 external-priority patent/US6232297B1/en
Application filed by Univ Virginia filed Critical Univ Virginia
Publication of AR029332A1 publication Critical patent/AR029332A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compuestos y métodos para ser usados en el tratamiento de la actividad inflamatoria en tejidos de mamíferos. Los presentes compuestos comprenden una nueva clase de derivados de 2-alquiladenosina, de formula general (1) donde (a) cada R es en forma individual hidrogeno, C1-6 alquilo, C3-7 cicloalquilo, fenilo o fenil (C1-3) alquilo, (b) X es ûCH2OH, -CO2R2, -OC(O)R2, CH2OC(O)R2 o C(O)NR3R4, (c) cada uno de R2, R3 y R4 es en forma individual H, C1,-6 alquilo, C1-6 alquilo sustituido con 1 a 3 C1-6 alcoxilo, C3-7 cicloalquilo, C1-6 alquitilo, halogeno, hidroxilo, amino, mono (C1-6 alquil) amino, di (C1-6 alquil) amino o C6-10 arilo, donde el arilo puede estar sustituido con 1 a 3 halogenos, C1-6 alquilo, hidroxilo, amino, mono (C1-6 alquil) amino o di(C1-6 alquil)amino, C6-10 arilo o C6-10 arilo sustituido con 1 a 3 halogeno, hidroxilo, amino, mono (C1-6 alquil) amino, di (C1-6alquil)amino o C1-6 alquilo. (d) Z y Z' son en forma individual (C1-6) alquilo, opcionalmente interrumpidos por 1 a 3 S u O no peroxido, o están ausentes, y n es 1 a 3, o una sal del mismo aceptable para el uso farmacéutico. Se provee un compuesto de formula (1) para su uso en terapia médica, preferiblemente para su uso en el tratamiento o en la proteccion del tejido de inflamacion, por ejemplo, de una respuesta inflamatoria, así como el uso de un compuesto de formula (1) para la fabricacion de una medicamento para el tratamiento de una respuesta inflamatoria debida a una condicion o a un síntoma patologico de un mamífero, tal como un humano que ese asocia con la inflamacion de distintos orígenes.
ARP000100433A 1999-02-01 2000-02-01 Compuesto derivado de una 2-alquinilpurina y su uso en la preparacion de un medicamento para tratar la respuesta inflamatoria AR029332A1 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US11802999P 1999-02-01 1999-02-01
US12431699P 1999-03-12 1999-03-12
US13337499P 1999-05-10 1999-05-10
US13557399P 1999-05-24 1999-05-24
US09/333,387 US6232297B1 (en) 1999-02-01 1999-06-15 Methods and compositions for treating inflammatory response
US15141299P 1999-08-30 1999-08-30

Publications (1)

Publication Number Publication Date
AR029332A1 true AR029332A1 (es) 2003-06-25

Family

ID=27557920

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000100433A AR029332A1 (es) 1999-02-01 2000-02-01 Compuesto derivado de una 2-alquinilpurina y su uso en la preparacion de un medicamento para tratar la respuesta inflamatoria

Country Status (25)

Country Link
EP (1) EP1150991B1 (es)
JP (1) JP4837831B2 (es)
KR (1) KR100668006B1 (es)
CN (1) CN1191266C (es)
AR (1) AR029332A1 (es)
AT (1) ATE263777T1 (es)
AU (2) AU778870B2 (es)
BR (1) BR0007864A (es)
CA (1) CA2361614C (es)
CZ (1) CZ296404B6 (es)
DE (1) DE60009665T2 (es)
DK (1) DK1150991T3 (es)
EE (1) EE05185B1 (es)
ES (1) ES2215609T3 (es)
HU (1) HU228937B1 (es)
IL (2) IL144188A0 (es)
MX (1) MXPA01007850A (es)
MY (1) MY129445A (es)
NO (1) NO321216B1 (es)
NZ (1) NZ513096A (es)
PL (1) PL199953B1 (es)
PT (1) PT1150991E (es)
SK (1) SK284877B6 (es)
UA (1) UA72912C2 (es)
WO (1) WO2000044763A2 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6448235B1 (en) 1994-07-11 2002-09-10 University Of Virginia Patent Foundation Method for treating restenosis with A2A adenosine receptor agonists
US6514949B1 (en) 1994-07-11 2003-02-04 University Of Virginia Patent Foundation Method compositions for treating the inflammatory response
US7378400B2 (en) 1999-02-01 2008-05-27 University Of Virginia Patent Foundation Method to reduce an inflammatory response from arthritis
US6232297B1 (en) 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
US7427606B2 (en) 1999-02-01 2008-09-23 University Of Virginia Patent Foundation Method to reduce inflammatory response in transplanted tissue
US6322771B1 (en) * 1999-06-18 2001-11-27 University Of Virginia Patent Foundation Induction of pharmacological stress with adenosine receptor agonists
IL133680A0 (en) * 1999-09-10 2001-04-30 Can Fite Technologies Ltd Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist
AU2002362443B2 (en) 2001-10-01 2008-05-15 University Of Virginia Patent Foundation 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof
US20050033044A1 (en) 2003-05-19 2005-02-10 Bristol-Myers Squibb Pharma Company Methods for preparing 2-alkynyladenosine derivatives
WO2005097140A2 (en) * 2004-04-02 2005-10-20 Adenosine Therapeutics, Llc Selective antagonists of a2a adenosine receptors
EP1746885A4 (en) * 2004-05-03 2010-09-08 Univ Virginia AGONISTS OF A2A ADENOSINE RECEPTORS FOR THE TREATMENT OF NEEDLE INJURY IN DIABETES
WO2006028618A1 (en) 2004-08-02 2006-03-16 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
EP1778712B1 (en) 2004-08-02 2013-01-30 University Of Virginia Patent Foundation 2-propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
WO2006023272A1 (en) 2004-08-02 2006-03-02 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having a2a agonist activity
US8178509B2 (en) 2006-02-10 2012-05-15 University Of Virginia Patent Foundation Method to treat sickle cell disease
EP2021350B1 (en) 2006-03-21 2016-12-21 Rheinische Friedrich-Wilhelms-Universität Bonn Phosphorylated a2a receptor agonists
US8188063B2 (en) 2006-06-19 2012-05-29 University Of Virginia Patent Foundation Use of adenosine A2A modulators to treat spinal cord injury
RU2441875C2 (ru) * 2006-06-27 2012-02-10 СиБиТи ДЕВЕЛОПМЕНТ ЛИМИТЕД Терапевтические соединения
US8058259B2 (en) 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
PL2306971T3 (pl) * 2008-07-03 2015-07-31 Univ Virginia Patent Foundation Dawka jednostkowa apadenozonu
KR20120107065A (ko) 2009-06-30 2012-09-28 포레스트 래보러토리즈 홀딩스 리미티드 Ａ２ａｒ 효현제용 알콕시 카르보닐 아미노 알키닐 아데노신 화합물 및 그 유도체
FR2960876B1 (fr) 2010-06-03 2012-07-27 Sanofi Aventis Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.
US20220363710A1 (en) * 2019-06-21 2022-11-17 Academy Of Military Medical Sciences Small-molecule compound having a2a adenosine receptor antagonism

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3537228A1 (de) * 1985-10-19 1987-04-23 Huels Chemische Werke Ag Verfahren zur herstellung von cyclohexylverbindungen
JPS6299330A (ja) * 1985-10-25 1987-05-08 Yamasa Shoyu Co Ltd 抗高血圧剤
DE68916036T2 (de) * 1988-11-15 1994-09-29 Toa Eiyo Ltd Mittel zur behandlung und prophylaxe koronarer und zerebraler ischämischer erkrankungen.
US5283327A (en) * 1989-06-20 1994-02-01 Yamasa Shoyu Kabushiki Kaisha Tri-O-acetyl-2-alkynyladenosines
WO1991009864A1 (fr) * 1990-01-04 1991-07-11 Yamasa Shoyu Kabushiki Kaisha Medicament pour le traitement d'affections ischemiques du c×ur ou du cerveau
JPH03287537A (ja) * 1990-03-31 1991-12-18 Yamasa Shoyu Co Ltd 抗動脈硬化症剤
JP3025559B2 (ja) * 1990-07-19 2000-03-27 ヤマサ醤油株式会社 アデノシン誘導体
JP3025557B2 (ja) * 1991-06-28 2000-03-27 ヤマサ醤油株式会社 ２‐アルキニルアデノシン誘導体
JP3053908B2 (ja) * 1991-06-28 2000-06-19 ヤマサ醤油株式会社 ２‐アルキニルアデノシン誘導体
IT1254915B (it) * 1992-04-24 1995-10-11 Gloria Cristalli Derivati di adenosina ad attivita' a2 agonista
EP0983768A1 (en) * 1997-05-23 2000-03-08 Nippon Shinyaku Co., Ltd. Medicinal composition for prevention or treatment of hepatopathy
JP2002505687A (ja) * 1997-06-18 2002-02-19 ディスカバリー セラピューティクス，インコーポレイテッド 脈管再生手順の後の再狭窄を防止するための組成物および方法
JPH11335302A (ja) * 1998-05-26 1999-12-07 Toa Eiyo Ltd 安定な医薬組成物
JP3619017B2 (ja) * 1998-06-24 2005-02-09 日本臓器製薬株式会社 新規アラビノシルアデニン誘導体
JP2002173427A (ja) * 1998-09-01 2002-06-21 Yamasa Shoyu Co Ltd 眼疾患治療用医薬組成物

Also Published As

Publication number Publication date
AU2005201255A1 (en) 2005-04-21
CA2361614C (en) 2008-08-26
CA2361614A1 (en) 2000-08-03
CN1191266C (zh) 2005-03-02
ES2215609T3 (es) 2004-10-16
DE60009665D1 (de) 2004-05-13
HUP0200224A2 (en) 2002-06-29
SK10972001A3 (sk) 2002-01-07
DE60009665T2 (de) 2004-08-19
ATE263777T1 (de) 2004-04-15
MXPA01007850A (es) 2002-08-20
IL144188A (en) 2008-12-29
PT1150991E (pt) 2004-08-31
BR0007864A (pt) 2001-11-06
AU2745400A (en) 2000-08-18
WO2000044763A3 (en) 2000-12-14
CN1357002A (zh) 2002-07-03
UA72912C2 (uk) 2005-05-16
WO2000044763A2 (en) 2000-08-03
EE200100397A (et) 2002-08-15
NO321216B1 (no) 2006-04-03
HK1047288A1 (en) 2003-02-14
KR100668006B1 (ko) 2007-01-15
DK1150991T3 (da) 2004-06-07
IL144188A0 (en) 2002-05-23
SK284877B6 (sk) 2006-01-05
HU228937B1 (en) 2013-06-28
EP1150991B1 (en) 2004-04-07
NO20013507D0 (no) 2001-07-13
MY129445A (en) 2007-04-30
KR20020013494A (ko) 2002-02-20
HUP0200224A3 (en) 2005-02-28
JP4837831B2 (ja) 2011-12-14
NO20013507L (no) 2001-09-18
PL199953B1 (pl) 2008-11-28
EE05185B1 (et) 2009-06-15
CZ296404B6 (cs) 2006-03-15
JP2002536300A (ja) 2002-10-29
EP1150991A2 (en) 2001-11-07
AU2005201255B2 (en) 2008-02-28
CZ20012781A3 (cs) 2002-01-16
CA2361614E (en) 2000-08-03
NZ513096A (en) 2003-01-31
AU778870B2 (en) 2004-12-23

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