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BR9910849A - Composto, processo para a profilaxia ou tratamento de uma condição clìnica em um mamìfero, tal como um humano, formulação farmacêutica, uso de um composto, processo para preparação do composto, e, derivado protegido. - Google Patents

Composto, processo para a profilaxia ou tratamento de uma condição clìnica em um mamìfero, tal como um humano, formulação farmacêutica, uso de um composto, processo para preparação do composto, e, derivado protegido.

Info

Publication number
BR9910849A
BR9910849A BR9910849-6A BR9910849A BR9910849A BR 9910849 A BR9910849 A BR 9910849A BR 9910849 A BR9910849 A BR 9910849A BR 9910849 A BR9910849 A BR 9910849A
Authority
BR
Brazil
Prior art keywords
compound
prophylaxis
preparing
human
treatment
Prior art date
Application number
BR9910849-6A
Other languages
English (en)
Inventor
Paul John Beswick
Savvas Kleanthous
Robert John Young
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BR9910849A publication Critical patent/BR9910849A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"COMPOSTO, PROCESSO PARA A PROFILAXIA OU TRATAMENTO DE UMA CONDIçãO CLìNICA EM UM MAMìFERO, TAL COMO UM HUMANO, FORMULAçãO FARMACêUTICA, USO DE UM COMPOSTO, PROCESSO PARA PREPARAçãO DO COMPOSTO, E, DERIVADO PROTEGIDO". A presente invenção refere-se a novos compostos de amidino de fórmula (I) ou um sal, solvato ou derivado fisiologicamente funcional dos mesmos, em que R. é selecionado dentre alquila C~ 1-4~, cicloalquila C~ 3-4~, hidroxialquila C~ 1-4~, e haloalquila C~ 1-4~; a um processo para sua fabricação, a composições farmacêuticas contendo os mesmos, e a seu uso em terapia, particularmente seu uso como inibidores seletivos de óxido nítrico sintase indutível.
BR9910849-6A 1998-05-30 1999-05-27 Composto, processo para a profilaxia ou tratamento de uma condição clìnica em um mamìfero, tal como um humano, formulação farmacêutica, uso de um composto, processo para preparação do composto, e, derivado protegido. BR9910849A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9811599.1A GB9811599D0 (en) 1998-05-30 1998-05-30 Nitric oxide synthase inhibitors
PCT/EP1999/003583 WO1999062875A1 (en) 1998-05-30 1999-05-27 Nitric oxide synthase inhibitors

Publications (1)

Publication Number Publication Date
BR9910849A true BR9910849A (pt) 2001-02-20

Family

ID=10832929

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9910849-6A BR9910849A (pt) 1998-05-30 1999-05-27 Composto, processo para a profilaxia ou tratamento de uma condição clìnica em um mamìfero, tal como um humano, formulação farmacêutica, uso de um composto, processo para preparação do composto, e, derivado protegido.

Country Status (30)

Country Link
US (2) US6355689B1 (pt)
EP (1) EP1084104B1 (pt)
JP (1) JP3839256B2 (pt)
KR (1) KR20010043920A (pt)
CN (1) CN1218940C (pt)
AP (1) AP1382A (pt)
AT (1) ATE245142T1 (pt)
AU (1) AU757042B2 (pt)
BR (1) BR9910849A (pt)
CA (1) CA2333322C (pt)
CZ (1) CZ297473B6 (pt)
DE (1) DE69909625T2 (pt)
DK (1) DK1084104T3 (pt)
EA (1) EA003026B1 (pt)
EE (1) EE04149B1 (pt)
ES (1) ES2203147T3 (pt)
GB (1) GB9811599D0 (pt)
HU (1) HUP0102472A3 (pt)
ID (1) ID26790A (pt)
IL (1) IL139697A (pt)
IS (1) IS2442B (pt)
NO (1) NO20006044L (pt)
NZ (1) NZ508222A (pt)
PL (1) PL194784B1 (pt)
PT (1) PT1084104E (pt)
RS (1) RS49984B (pt)
SK (1) SK18052000A3 (pt)
TR (1) TR200003539T2 (pt)
WO (1) WO1999062875A1 (pt)
ZA (1) ZA200006847B (pt)

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IS5723A (is) 2000-11-21
DE69909625D1 (en) 2003-08-21
CN1303367A (zh) 2001-07-11
GB9811599D0 (en) 1998-07-29
ZA200006847B (en) 2001-11-22
TR200003539T2 (tr) 2001-06-21
IS2442B (is) 2008-11-15
CZ20004450A3 (en) 2001-05-16
RS49984B (sr) 2008-09-29
CA2333322A1 (en) 1999-12-09
ID26790A (id) 2001-02-08
IL139697A (en) 2005-12-18
EP1084104A1 (en) 2001-03-21
CN1218940C (zh) 2005-09-14
NO20006044L (no) 2001-01-29
AP1382A (en) 2005-04-01
ES2203147T3 (es) 2004-04-01
EP1084104B1 (en) 2003-07-16
JP2002516901A (ja) 2002-06-11
NZ508222A (en) 2003-02-28
EA003026B1 (ru) 2002-12-26
HUP0102472A3 (en) 2002-12-28
DK1084104T3 (da) 2003-10-27
HUP0102472A2 (hu) 2002-03-28
JP3839256B2 (ja) 2006-11-01
KR20010043920A (ko) 2001-05-25
EE04149B1 (et) 2003-10-15
WO1999062875A1 (en) 1999-12-09
PL344368A1 (en) 2001-11-05
AU4367199A (en) 1999-12-20
DE69909625T2 (de) 2004-06-24
NO20006044D0 (no) 2000-11-29
PT1084104E (pt) 2003-11-28
EE200000716A (et) 2002-04-15
CA2333322C (en) 2008-01-22
YU74600A (sh) 2002-12-10
US6355689B1 (en) 2002-03-12
IL139697A0 (en) 2002-02-10
HK1034241A1 (en) 2001-10-19
SK18052000A3 (sk) 2001-06-11
AP2000001998A0 (en) 2000-12-31
US6495606B1 (en) 2002-12-17
CZ297473B6 (cs) 2006-12-13
ATE245142T1 (de) 2003-08-15
EA200001122A1 (ru) 2001-06-25
AU757042B2 (en) 2003-01-30
PL194784B1 (pl) 2007-07-31

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