AR008095A1 - Indanilidinacetilguanidinas sustituidas, procedimiento para su preparacion, su uso en la preparacion de medicamentos o agentes de diagnosticoasi como medicamento que las contienen - Google Patents
Indanilidinacetilguanidinas sustituidas, procedimiento para su preparacion, su uso en la preparacion de medicamentos o agentes de diagnosticoasi como medicamento que las contienenInfo
- Publication number
- AR008095A1 AR008095A1 ARP970103414A ARP970103414A AR008095A1 AR 008095 A1 AR008095 A1 AR 008095A1 AR P970103414 A ARP970103414 A AR P970103414A AR P970103414 A ARP970103414 A AR P970103414A AR 008095 A1 AR008095 A1 AR 008095A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- substituted
- procedure
- indanilidineacetilguanidines
- medicines
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 4
- 229940079593 drug Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 229940039227 diagnostic agent Drugs 0.000 title 1
- 239000000032 diagnostic agent Substances 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000007530 Essential hypertension Diseases 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 102000050381 Na+/H+ exchanger Human genes 0.000 abstract 1
- 108091006672 Sodium–hydrogen antiporter Proteins 0.000 abstract 1
- 230000002337 anti-port Effects 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 210000003743 erythrocyte Anatomy 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 abstract 1
- 230000037356 lipid metabolism Effects 0.000 abstract 1
- 238000002483 medication Methods 0.000 abstract 1
- NGGXACLSAZXJGM-UHFFFAOYSA-N n-(diaminomethylidene)acetamide Chemical class CC(=O)N=C(N)N NGGXACLSAZXJGM-UHFFFAOYSA-N 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C327/54—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Indanilidinacetilguanidinas sustituidas de la fórmula (I) y sus sales farmacéuticamente aceptables, en las que X es O, S o NH y R1, R2, R3, R4, R5,R6, R7, R8, R9, R10 tienen los significados dados en las reivindicaciones, son inhibidoresefect ivos del antiporte celular sodio/protón (intercambiador Na+/H+) que en numerosas enfermedades (hipertensión esencial, aterosclorosis, diabetes y similares) está también incrementado en aquellas células que sonfácilmente accesibles paramedidas, tales como, por ejemplo, en eritrocitos, plaquetas o leucocitos. También son útiles para la preparación de unmedicamento para el tratamiento o profilaxis de trastornos del metabolismo de los lípidos. Se describe un procedimientopara su prep aración ymedicamentos que las contienen.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96112275A EP0837055A1 (en) | 1996-07-30 | 1996-07-30 | Substituted Indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR008095A1 true AR008095A1 (es) | 1999-12-09 |
Family
ID=8223055
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970103414A AR008095A1 (es) | 1996-07-30 | 1997-07-28 | Indanilidinacetilguanidinas sustituidas, procedimiento para su preparacion, su uso en la preparacion de medicamentos o agentes de diagnosticoasi como medicamento que las contienen |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US5900436A (es) |
| EP (2) | EP0837055A1 (es) |
| JP (1) | JP4039589B2 (es) |
| KR (1) | KR980009236A (es) |
| CN (1) | CN1064351C (es) |
| AR (1) | AR008095A1 (es) |
| AT (1) | ATE207888T1 (es) |
| AU (1) | AU715187B2 (es) |
| BR (1) | BR9704131A (es) |
| CA (1) | CA2211982C (es) |
| CZ (1) | CZ241197A3 (es) |
| DE (1) | DE69707777T2 (es) |
| DK (1) | DK0822182T3 (es) |
| ES (1) | ES2164283T3 (es) |
| HR (1) | HRP970424B1 (es) |
| HU (1) | HUP9701316A3 (es) |
| ID (1) | ID17565A (es) |
| IL (1) | IL121407A0 (es) |
| MX (1) | MX9705737A (es) |
| NO (1) | NO308213B1 (es) |
| NZ (1) | NZ328440A (es) |
| PL (1) | PL321392A1 (es) |
| PT (1) | PT822182E (es) |
| RU (1) | RU2176638C2 (es) |
| SI (1) | SI0822182T1 (es) |
| SK (1) | SK282128B6 (es) |
| TR (1) | TR199700704A2 (es) |
| TW (1) | TW445251B (es) |
| ZA (1) | ZA976735B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| SI2384318T1 (en) | 2008-12-31 | 2018-03-30 | Ardelyx, Inc. | MEASURES AND PROCEDURES FOR THE INHIBITION OF ANTIPORT INHIBITED BY NHE IN THE TREATMENT OF DISEASES RELATED TO STRENGTH OF FLAMMABILITY OR TRADEMARITY WITH SOLO, AND THE EMISSION OF GASTROINTESTINAL TREATMENT |
| GB0916163D0 (en) * | 2009-09-15 | 2009-10-28 | Shire Llc | Prodrugs of guanfacine |
| MX382203B (es) | 2013-04-12 | 2025-03-11 | Ardelyx Inc | Compuestos de union a nhe3 (intercambiador de sodio-hidrogeno 3) y metodos para inhibir transporte de fosfato. |
| UA126283C2 (uk) | 2017-01-09 | 2022-09-14 | Арделікс, Інк. | Сполуки, придатні для лікування розладів шлунково-кишкового тракту |
| JP2020505333A (ja) | 2017-01-09 | 2020-02-20 | アルデリックス， インコーポレイテッド | Ｎｈｅ媒介性アンチポートの阻害薬 |
| WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
| CN116492469A (zh) * | 2023-05-22 | 2023-07-28 | 遵义医科大学附属医院 | 一种通道阻滞剂在制备治疗和/或预防肝纤维疾病药物中的应用 |
| CN119118881B (zh) * | 2024-07-25 | 2026-01-02 | 中国农业大学 | 含胍基的5-氯茚满化合物及其制备方法与应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
| DE4421536A1 (de) * | 1994-06-20 | 1995-12-21 | Hoechst Ag | Perfluoralkylgruppen tragende phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| SI0738712T1 (en) * | 1995-04-18 | 1999-12-31 | Hoechst Aktiengesellschaft | Anti-arrhythmic and cardioprotective substituted indenoylguanidines |
-
1996
- 1996-07-30 EP EP96112275A patent/EP0837055A1/en not_active Withdrawn
-
1997
- 1997-05-23 TW TW086106928A patent/TW445251B/zh active
- 1997-07-14 ID IDP972422A patent/ID17565A/id unknown
- 1997-07-24 PT PT97112674T patent/PT822182E/pt unknown
- 1997-07-24 ES ES97112674T patent/ES2164283T3/es not_active Expired - Lifetime
- 1997-07-24 DK DK97112674T patent/DK0822182T3/da active
- 1997-07-24 DE DE69707777T patent/DE69707777T2/de not_active Expired - Lifetime
- 1997-07-24 AT AT97112674T patent/ATE207888T1/de not_active IP Right Cessation
- 1997-07-24 SI SI9730260T patent/SI0822182T1/xx unknown
- 1997-07-24 EP EP97112674A patent/EP0822182B1/en not_active Expired - Lifetime
- 1997-07-28 TR TR97/00704A patent/TR199700704A2/xx unknown
- 1997-07-28 IL IL12140797A patent/IL121407A0/xx unknown
- 1997-07-28 US US08/901,099 patent/US5900436A/en not_active Expired - Lifetime
- 1997-07-28 AU AU31554/97A patent/AU715187B2/en not_active Ceased
- 1997-07-28 CZ CZ972411A patent/CZ241197A3/cs unknown
- 1997-07-28 SK SK1034-97A patent/SK282128B6/sk unknown
- 1997-07-28 CN CN97114777A patent/CN1064351C/zh not_active Expired - Fee Related
- 1997-07-28 KR KR1019970035527A patent/KR980009236A/ko not_active Ceased
- 1997-07-28 NZ NZ328440A patent/NZ328440A/en unknown
- 1997-07-28 AR ARP970103414A patent/AR008095A1/es unknown
- 1997-07-29 MX MX9705737A patent/MX9705737A/es not_active IP Right Cessation
- 1997-07-29 NO NO973486A patent/NO308213B1/no not_active IP Right Cessation
- 1997-07-29 JP JP20275697A patent/JP4039589B2/ja not_active Expired - Fee Related
- 1997-07-29 PL PL97321392A patent/PL321392A1/xx unknown
- 1997-07-29 RU RU97113146/04A patent/RU2176638C2/ru not_active IP Right Cessation
- 1997-07-29 BR BR9704131A patent/BR9704131A/pt active Search and Examination
- 1997-07-29 HR HR970424A patent/HRP970424B1/xx not_active IP Right Cessation
- 1997-07-29 HU HU9701316A patent/HUP9701316A3/hu unknown
- 1997-07-29 CA CA002211982A patent/CA2211982C/en not_active Expired - Fee Related
- 1997-07-29 ZA ZA9706735A patent/ZA976735B/xx unknown
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