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AR029226A1 - Tioamidas, composiciones farmaceuticas y el uso de la misma para la fabricacion de compuestos medicinales - Google Patents

Tioamidas, composiciones farmaceuticas y el uso de la misma para la fabricacion de compuestos medicinales

Info

Publication number
AR029226A1
AR029226A1 ARP010100602A ARP010100602A AR029226A1 AR 029226 A1 AR029226 A1 AR 029226A1 AR P010100602 A ARP010100602 A AR P010100602A AR P010100602 A ARP010100602 A AR P010100602A AR 029226 A1 AR029226 A1 AR 029226A1
Authority
AR
Argentina
Prior art keywords
manufacture
pharmaceutical compositions
thioamids
same
medicinal compounds
Prior art date
Application number
ARP010100602A
Other languages
English (en)
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of AR029226A1 publication Critical patent/AR029226A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se proporciona tioamidas que comprenden un compuesto de formula (1) en donde R2, R3, R4 A y W tienen los significados dados en la memoria descriptiva que tienen potentes actividades contra bacterias gram-positivas y gram-negativas. También se describen composiciones farmacéuticas que los comprenden y el uso de los mismos para la fabricacion de compuestos medicinales destinados al tratamiento de infecciones microbianas en un mamífero.
ARP010100602A 2000-02-10 2001-02-09 Tioamidas, composiciones farmaceuticas y el uso de la misma para la fabricacion de compuestos medicinales AR029226A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18164000P 2000-02-10 2000-02-10

Publications (1)

Publication Number Publication Date
AR029226A1 true AR029226A1 (es) 2003-06-18

Family

ID=22665142

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010100602A AR029226A1 (es) 2000-02-10 2001-02-09 Tioamidas, composiciones farmaceuticas y el uso de la misma para la fabricacion de compuestos medicinales

Country Status (17)

Country Link
US (1) US20010047004A1 (es)
EP (1) EP1263742B1 (es)
JP (1) JP2003522763A (es)
KR (1) KR20020072311A (es)
CN (1) CN1395569A (es)
AR (1) AR029226A1 (es)
AT (1) ATE302762T1 (es)
AU (1) AU2001234428A1 (es)
BR (1) BR0107645A (es)
CA (1) CA2395648A1 (es)
CO (1) CO5271737A1 (es)
DE (1) DE60112903T2 (es)
ES (1) ES2248284T3 (es)
MX (1) MXPA02007719A (es)
NZ (1) NZ520696A (es)
PE (1) PE20011089A1 (es)
WO (1) WO2001058885A1 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
US6465456B2 (en) * 2000-06-29 2002-10-15 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
EP1328509B1 (en) * 2000-10-17 2006-03-22 Pharmacia & Upjohn Company LLC Methods of producing oxazolidinone compounds
CN1653064A (zh) 2002-02-28 2005-08-10 阿斯特拉曾尼卡有限公司 噁唑烷酮衍生物、其制备方法以及包含它们的药用组合物
PL372191A1 (en) 2002-02-28 2005-07-11 Astrazeneca Ab 3-cyclyl-5-(nitrogen-containing 5-membered ring) methyl-oxazolidinone derivatives and their use as antibacterial agents
BR0308837A (pt) * 2002-04-01 2005-02-01 Cadila Healthcare Ltd Composto, composição, método e medicamento para o tratamento de infecções bacterianas, psorìase ou artrite em mamìferos, método e medicamento para o tratamento de toxicidade devido a quimioterapia em um paciente, composição farmacêutica, processo para a preparação de um composto e processo para a conversão dos compostos da fórmula (i) em compostos adicionais da fórmula (i)
TW200404069A (en) * 2002-06-28 2004-03-16 Upjohn Co Difluorothioacetamides of oxazolidinones with a glycoloylpiperazine substituent
TW200403240A (en) 2002-06-28 2004-03-01 Upjohn Co Difluorothioacetamides of oxazolidinones as antibacterial agents
US20040235900A1 (en) * 2002-07-11 2004-11-25 Yati Chugh Antimicrobial oxazolifinones with improved pharmacokinetic profile and safety advantages
CA2492194A1 (en) * 2002-07-11 2004-01-22 Wockhardt Limited Antibacterial cyano-(substituted)-methylenepiperidinophenyl oxazolidinones targeting multiple ribonucleoproteins sites
CA2513416A1 (en) * 2002-08-22 2004-03-04 Orchid Chemicals & Pharmaceuticals Ltd. Novel antibacterial agents
US7091196B2 (en) * 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
ATE344036T1 (de) * 2002-11-21 2006-11-15 Pharmacia & Upjohn Co Llc N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinon-5- carbonsäureamid-derivate und verwandte verbindungen als antibakterielle mittel
EP1646629B1 (en) 2003-07-02 2010-06-23 Merck Sharp & Dohme Corp. Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
JP2007521283A (ja) * 2003-07-02 2007-08-02 メルク アンド カンパニー インコーポレーテッド シクロプロピル基で置換されたオキサゾリジノン系抗生物質およびその誘導体
US8202843B2 (en) 2004-02-27 2012-06-19 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
JP2009506063A (ja) 2005-08-24 2009-02-12 リブ−エックス ファーマシューティカルズ，インコーポレイテッド トリアゾール化合物ならびにこれを作製する方法および使用する方法
EP3290427A1 (en) 2005-08-24 2018-03-07 Melinta Therapeutics, Inc. Triazole compounds and methods of making and using the same
US20100210602A1 (en) * 2006-12-12 2010-08-19 The Johns Hopkins University PhoU (PerF), A PERSISTENCE SWITCH INVOLVED IN PERSISTER FORMATION AND TOLERANCE TO MULTIPLE ANTIBIOTICS AND STRESSES AS A DRUG TARGET FOR PERSISTER BACTERIA
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
US8835437B2 (en) * 2007-06-08 2014-09-16 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
AU2008258487B2 (en) 2007-06-08 2012-11-15 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
ES2483898T3 (es) 2007-06-08 2014-08-08 Janssen Pharmaceutica, N.V. Derivados de piperidina/piperazina
WO2009001192A2 (en) * 2007-06-22 2008-12-31 Orchid Research Laboratories Limited Novel compounds and their use
JP5579170B2 (ja) 2008-06-05 2014-08-27 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｄｇａｔ阻害剤とｐｐａｒ作動薬を含有する薬剤組み合わせ物
CN115466253B (zh) * 2021-06-16 2024-08-20 沈阳药科大学 含二硫代氨基甲酸酯结构的噁唑烷酮类化合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR76701B (es) * 1981-09-08 1984-08-29 Lilly Co Eli
ES2242280T3 (es) * 1997-05-30 2005-11-01 PHARMACIA & UPJOHN COMPANY LLC Agentes antibacterianos de oxazolidinona que contienen funcionalidad tiocarbonilo.
WO1999012914A1 (en) * 1997-09-11 1999-03-18 Hokuriku Seiyaku Co., Ltd. Thiourea derivatives
JPH11322729A (ja) * 1998-03-09 1999-11-24 Hokuriku Seiyaku Co Ltd ジチオカルバミド酸誘導体
JP2000204084A (ja) * 1998-11-11 2000-07-25 Hokuriku Seiyaku Co Ltd チオカルバミド酸誘導体
ATE246189T1 (de) * 1999-05-27 2003-08-15 Upjohn Co Bizyklische oxazolidinone als antibakterielle mittel

Also Published As

Publication number Publication date
MXPA02007719A (es) 2002-10-11
BR0107645A (pt) 2002-10-08
AU2001234428A1 (en) 2001-08-20
EP1263742A1 (en) 2002-12-11
CO5271737A1 (es) 2003-04-30
ES2248284T3 (es) 2006-03-16
NZ520696A (en) 2004-03-26
EP1263742B1 (en) 2005-08-24
DE60112903D1 (de) 2005-09-29
DE60112903T2 (de) 2006-06-14
JP2003522763A (ja) 2003-07-29
CN1395569A (zh) 2003-02-05
CA2395648A1 (en) 2001-08-16
PE20011089A1 (es) 2001-10-04
US20010047004A1 (en) 2001-11-29
ATE302762T1 (de) 2005-09-15
KR20020072311A (ko) 2002-09-14
WO2001058885A1 (en) 2001-08-16

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