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DE60112903D1 - Oxazolidinon-thioamide mit piperazinamid-substituenten - Google Patents

Oxazolidinon-thioamide mit piperazinamid-substituenten

Info

Publication number
DE60112903D1
DE60112903D1 DE60112903T DE60112903T DE60112903D1 DE 60112903 D1 DE60112903 D1 DE 60112903D1 DE 60112903 T DE60112903 T DE 60112903T DE 60112903 T DE60112903 T DE 60112903T DE 60112903 D1 DE60112903 D1 DE 60112903D1
Authority
DE
Germany
Prior art keywords
piperazinamide
thioamide
oxazolidinone
substituents
piperazinamide substituents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60112903T
Other languages
English (en)
Other versions
DE60112903T2 (de
Inventor
B Hester
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Application granted granted Critical
Publication of DE60112903D1 publication Critical patent/DE60112903D1/de
Publication of DE60112903T2 publication Critical patent/DE60112903T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE60112903T 2000-02-10 2001-02-07 Oxazolidinon-thioamide mit piperazinamid-substituenten Expired - Fee Related DE60112903T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18164000P 2000-02-10 2000-02-10
PCT/US2001/000682 WO2001058885A1 (en) 2000-02-10 2001-02-07 Oxazolidinone thioamides with piperazine amide substituents

Publications (2)

Publication Number Publication Date
DE60112903D1 true DE60112903D1 (de) 2005-09-29
DE60112903T2 DE60112903T2 (de) 2006-06-14

Family

ID=22665142

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60112903T Expired - Fee Related DE60112903T2 (de) 2000-02-10 2001-02-07 Oxazolidinon-thioamide mit piperazinamid-substituenten

Country Status (17)

Country Link
US (1) US20010047004A1 (de)
EP (1) EP1263742B1 (de)
JP (1) JP2003522763A (de)
KR (1) KR20020072311A (de)
CN (1) CN1395569A (de)
AR (1) AR029226A1 (de)
AT (1) ATE302762T1 (de)
AU (1) AU2001234428A1 (de)
BR (1) BR0107645A (de)
CA (1) CA2395648A1 (de)
CO (1) CO5271737A1 (de)
DE (1) DE60112903T2 (de)
ES (1) ES2248284T3 (de)
MX (1) MXPA02007719A (de)
NZ (1) NZ520696A (de)
PE (1) PE20011089A1 (de)
WO (1) WO2001058885A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
US6465456B2 (en) * 2000-06-29 2002-10-15 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
ATE321024T1 (de) * 2000-10-17 2006-04-15 Pharmacia & Upjohn Co Llc Verfahren zur herstellung von oxazolidinonverbindungen
BR0308018A (pt) * 2002-02-28 2005-01-04 Astrazeneca Ab Composto ou um seu sal farmaceuticamente aceitável ou um seu éster hidrolisável in vivo, pró-droga, método para produzir um efeito antibacteriano em um animal de sangue quente, uso de um composto ou um seu sal farmaceuticamente aceitável ou um seu éster hirolisável in vivo, composição farmacêutica, e, processo para a preparação de um composto ou um seu sal farmaceuticamente aceitável ou um seu éster hidrolisável in vivo
AU2003207340A1 (en) 2002-02-28 2003-09-09 Astrazeneca Ab 3-cyclyl-5-(nitrogen-containing 5-membered ring) methyl-oxazolidinone derivatives and their use as antibacterial agents
EA200401289A1 (ru) * 2002-04-01 2005-04-28 Кадила Хелзкэр Лимитед Новые противоинфекционные соединения, способы их получения и фармацевтические композиции, содержащие эти соединения
TW200403240A (en) 2002-06-28 2004-03-01 Upjohn Co Difluorothioacetamides of oxazolidinones as antibacterial agents
TW200404069A (en) * 2002-06-28 2004-03-16 Upjohn Co Difluorothioacetamides of oxazolidinones with a glycoloylpiperazine substituent
EP1546140A2 (de) * 2002-07-11 2005-06-29 Wockhardt Limited Antimikrobielle oxazolidinone, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen
CA2492194A1 (en) * 2002-07-11 2004-01-22 Wockhardt Limited Antibacterial cyano-(substituted)-methylenepiperidinophenyl oxazolidinones targeting multiple ribonucleoproteins sites
US7217726B2 (en) * 2002-08-22 2007-05-15 Orchid Chemicals & Pharmaceuticals Limited Antibacterial agents
US7091196B2 (en) * 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
AR042086A1 (es) 2002-11-21 2005-06-08 Upjohn Co N-aril-2- oxazolidinon -5- carboxamidas y sus derivados, usados como agentes antibacterianos
WO2005005398A2 (en) 2003-07-02 2005-01-20 Merck & Co., Inc. Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
US20070185132A1 (en) * 2003-07-02 2007-08-09 Yasumichi Fukuda Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereo
WO2005085266A2 (en) 2004-02-27 2005-09-15 Rib-X Pharmaceuticals, Inc. Macrocyclic compounds and methods of making and using the same
WO2007025089A2 (en) 2005-08-24 2007-03-01 Rib-X Pharmaceutical, Inc. Triazole compounds and methods of making and using the same
WO2007025098A2 (en) 2005-08-24 2007-03-01 Rib-X Pharmaceuticals, Inc. Triazole compounds and methods of making and using the same
WO2008073444A2 (en) * 2006-12-12 2008-06-19 The Johns Hopkins University Phou (perf), a persistence switch involved in persister formation as a drug target for persister bacteria
AU2008258549B2 (en) 2007-06-08 2013-11-14 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
ES2483898T3 (es) 2007-06-08 2014-08-08 Janssen Pharmaceutica, N.V. Derivados de piperidina/piperazina
CN101678019B (zh) 2007-06-08 2016-03-30 詹森药业有限公司 哌啶/哌嗪衍生物
CA2692255A1 (en) * 2007-06-22 2008-12-31 Orchid Research Laboratories Limited Novel compounds and their use
ES2617619T3 (es) 2008-06-05 2017-06-19 Janssen Pharmaceutica, N.V. Combinaciones de fármacos que comprenden un inhibidor de DGAT y un agonista de PPAR
CN115466253B (zh) * 2021-06-16 2024-08-20 沈阳药科大学 含二硫代氨基甲酸酯结构的噁唑烷酮类化合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR76701B (de) * 1981-09-08 1984-08-29 Lilly Co Eli
DE69829846T2 (de) * 1997-05-30 2006-02-23 Pharmacia & Upjohn Co. Llc, Kalamazoo Antibakteriell wirksam oxazolidinone mit einer thiocarbonylfunktionalität
AU9001598A (en) * 1997-09-11 1999-03-29 Hokuriku Seiyaku Co. Ltd Thiourea derivatives
JPH11322729A (ja) * 1998-03-09 1999-11-24 Hokuriku Seiyaku Co Ltd ジチオカルバミド酸誘導体
JP2000204084A (ja) * 1998-11-11 2000-07-25 Hokuriku Seiyaku Co Ltd チオカルバミド酸誘導体
BR0010982A (pt) * 1999-05-27 2002-03-05 Upjohn Co Novas oxazolidinonas bicìclicas como agentes antibacterianos

Also Published As

Publication number Publication date
ES2248284T3 (es) 2006-03-16
PE20011089A1 (es) 2001-10-04
AU2001234428A1 (en) 2001-08-20
EP1263742A1 (de) 2002-12-11
BR0107645A (pt) 2002-10-08
JP2003522763A (ja) 2003-07-29
NZ520696A (en) 2004-03-26
DE60112903T2 (de) 2006-06-14
EP1263742B1 (de) 2005-08-24
KR20020072311A (ko) 2002-09-14
ATE302762T1 (de) 2005-09-15
CN1395569A (zh) 2003-02-05
AR029226A1 (es) 2003-06-18
WO2001058885A1 (en) 2001-08-16
MXPA02007719A (es) 2002-10-11
US20010047004A1 (en) 2001-11-29
CA2395648A1 (en) 2001-08-16
CO5271737A1 (es) 2003-04-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee