PE20011089A1 - Tioamidas de oxazolidinona con sustituyentes de piperazin-amida - Google Patents
Tioamidas de oxazolidinona con sustituyentes de piperazin-amidaInfo
- Publication number
- PE20011089A1 PE20011089A1 PE2001000132A PE2001000132A PE20011089A1 PE 20011089 A1 PE20011089 A1 PE 20011089A1 PE 2001000132 A PE2001000132 A PE 2001000132A PE 2001000132 A PE2001000132 A PE 2001000132A PE 20011089 A1 PE20011089 A1 PE 20011089A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- piperazin
- phenyl
- thioamides
- oxazolidinone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A TIOAMIDAS DE OXAZOLIDINONA CON SUBSTITUYENTES DE PIPERAZIN-AMIDA DE FORMULA I DONDE A ES EL GRUPO i, ii ENTRE OTROS; W ES NHC(=S)R1, -Y-het SIEMPRE QUE A ES UNA ESTRUCTURA iv, W NO ES -Y-HET; Y ES NH, O, S; R1 ES H, NH2, NH-ALQUILO C1-C4, ALQUENILO C1-C4, 0-ALQUILO C1-C4, ENTRE OTROS; R2 Y R3 SON H, F, Cl, ALQUILO C1-C2; R4 ES -C(=O)-CR5R6-O-R7, -C(=O)-CH2S(O)n-CH3, ENTRE OTROS; R5 ES H; R6 ES FENILO, BENCILO, CH2OH, CH2OCH3; R5 Y R6 SON CICLOALQUILO C3-C5; R7 ES H, CH3, ALCANOILO C1-C4. SON COMPUESTOS PREFERIDOS N{[5S)-3-(3-FLUORO-4-}4-[2-(METILSULFINIL)ACETIL]-1-PIPERAZINIL}FENIL)-2-OXO-1,3-OXAZOLIDIN-5-IL]METIL}PROPANTIOAMIDA, N{[5S)-3-(3-FLUORO-4-}4-[2-(METILSULFANIL)ACETIL]-1-PIPERAZINIL}FENIL)-2-OXO-1,3-OXAZOLIDIN-5-IL]METIL}PROPANTIOAMIDA, ENTRE OTROS. LOS COMPUESTOS DE FORMULA I TIENEN ACTIVIDAD ANTIBACTERIANA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18164000P | 2000-02-10 | 2000-02-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20011089A1 true PE20011089A1 (es) | 2001-10-04 |
Family
ID=22665142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000132A PE20011089A1 (es) | 2000-02-10 | 2001-02-07 | Tioamidas de oxazolidinona con sustituyentes de piperazin-amida |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20010047004A1 (es) |
| EP (1) | EP1263742B1 (es) |
| JP (1) | JP2003522763A (es) |
| KR (1) | KR20020072311A (es) |
| CN (1) | CN1395569A (es) |
| AR (1) | AR029226A1 (es) |
| AT (1) | ATE302762T1 (es) |
| AU (1) | AU2001234428A1 (es) |
| BR (1) | BR0107645A (es) |
| CA (1) | CA2395648A1 (es) |
| CO (1) | CO5271737A1 (es) |
| DE (1) | DE60112903T2 (es) |
| ES (1) | ES2248284T3 (es) |
| MX (1) | MXPA02007719A (es) |
| NZ (1) | NZ520696A (es) |
| PE (1) | PE20011089A1 (es) |
| WO (1) | WO2001058885A1 (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| US6465456B2 (en) * | 2000-06-29 | 2002-10-15 | Bristol-Myers Squibb Company | Isoxazolinone antibacterial agents |
| ATE321024T1 (de) * | 2000-10-17 | 2006-04-15 | Pharmacia & Upjohn Co Llc | Verfahren zur herstellung von oxazolidinonverbindungen |
| BR0308018A (pt) * | 2002-02-28 | 2005-01-04 | Astrazeneca Ab | Composto ou um seu sal farmaceuticamente aceitável ou um seu éster hidrolisável in vivo, pró-droga, método para produzir um efeito antibacteriano em um animal de sangue quente, uso de um composto ou um seu sal farmaceuticamente aceitável ou um seu éster hirolisável in vivo, composição farmacêutica, e, processo para a preparação de um composto ou um seu sal farmaceuticamente aceitável ou um seu éster hidrolisável in vivo |
| AU2003207340A1 (en) | 2002-02-28 | 2003-09-09 | Astrazeneca Ab | 3-cyclyl-5-(nitrogen-containing 5-membered ring) methyl-oxazolidinone derivatives and their use as antibacterial agents |
| EA200401289A1 (ru) * | 2002-04-01 | 2005-04-28 | Кадила Хелзкэр Лимитед | Новые противоинфекционные соединения, способы их получения и фармацевтические композиции, содержащие эти соединения |
| TW200403240A (en) | 2002-06-28 | 2004-03-01 | Upjohn Co | Difluorothioacetamides of oxazolidinones as antibacterial agents |
| TW200404069A (en) * | 2002-06-28 | 2004-03-16 | Upjohn Co | Difluorothioacetamides of oxazolidinones with a glycoloylpiperazine substituent |
| EP1546140A2 (en) * | 2002-07-11 | 2005-06-29 | Wockhardt Limited | Antimicrobial oxazolidinones, process of their preparation, and pharmaceutical compositions containing them |
| CA2492194A1 (en) * | 2002-07-11 | 2004-01-22 | Wockhardt Limited | Antibacterial cyano-(substituted)-methylenepiperidinophenyl oxazolidinones targeting multiple ribonucleoproteins sites |
| US7217726B2 (en) * | 2002-08-22 | 2007-05-15 | Orchid Chemicals & Pharmaceuticals Limited | Antibacterial agents |
| US7091196B2 (en) * | 2002-09-26 | 2006-08-15 | Rib-X Pharmaceuticals, Inc. | Bifunctional heterocyclic compounds and methods of making and using same |
| AR042086A1 (es) | 2002-11-21 | 2005-06-08 | Upjohn Co | N-aril-2- oxazolidinon -5- carboxamidas y sus derivados, usados como agentes antibacterianos |
| WO2005005398A2 (en) | 2003-07-02 | 2005-01-20 | Merck & Co., Inc. | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof |
| US20070185132A1 (en) * | 2003-07-02 | 2007-08-09 | Yasumichi Fukuda | Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereo |
| WO2005085266A2 (en) | 2004-02-27 | 2005-09-15 | Rib-X Pharmaceuticals, Inc. | Macrocyclic compounds and methods of making and using the same |
| WO2007025089A2 (en) | 2005-08-24 | 2007-03-01 | Rib-X Pharmaceutical, Inc. | Triazole compounds and methods of making and using the same |
| WO2007025098A2 (en) | 2005-08-24 | 2007-03-01 | Rib-X Pharmaceuticals, Inc. | Triazole compounds and methods of making and using the same |
| WO2008073444A2 (en) * | 2006-12-12 | 2008-06-19 | The Johns Hopkins University | Phou (perf), a persistence switch involved in persister formation as a drug target for persister bacteria |
| AU2008258549B2 (en) | 2007-06-08 | 2013-11-14 | Janssen Pharmaceutica N.V. | Piperidine/piperazine derivatives |
| JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
| ES2483898T3 (es) | 2007-06-08 | 2014-08-08 | Janssen Pharmaceutica, N.V. | Derivados de piperidina/piperazina |
| CN101678019B (zh) | 2007-06-08 | 2016-03-30 | 詹森药业有限公司 | 哌啶/哌嗪衍生物 |
| CA2692255A1 (en) * | 2007-06-22 | 2008-12-31 | Orchid Research Laboratories Limited | Novel compounds and their use |
| ES2617619T3 (es) | 2008-06-05 | 2017-06-19 | Janssen Pharmaceutica, N.V. | Combinaciones de fármacos que comprenden un inhibidor de DGAT y un agonista de PPAR |
| CN115466253B (zh) * | 2021-06-16 | 2024-08-20 | 沈阳药科大学 | 含二硫代氨基甲酸酯结构的噁唑烷酮类化合物及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR76701B (es) * | 1981-09-08 | 1984-08-29 | Lilly Co Eli | |
| DE69829846T2 (de) * | 1997-05-30 | 2006-02-23 | Pharmacia & Upjohn Co. Llc, Kalamazoo | Antibakteriell wirksam oxazolidinone mit einer thiocarbonylfunktionalität |
| AU9001598A (en) * | 1997-09-11 | 1999-03-29 | Hokuriku Seiyaku Co. Ltd | Thiourea derivatives |
| JPH11322729A (ja) * | 1998-03-09 | 1999-11-24 | Hokuriku Seiyaku Co Ltd | ジチオカルバミド酸誘導体 |
| JP2000204084A (ja) * | 1998-11-11 | 2000-07-25 | Hokuriku Seiyaku Co Ltd | チオカルバミド酸誘導体 |
| BR0010982A (pt) * | 1999-05-27 | 2002-03-05 | Upjohn Co | Novas oxazolidinonas bicìclicas como agentes antibacterianos |
-
2001
- 2001-02-07 WO PCT/US2001/000682 patent/WO2001058885A1/en not_active Ceased
- 2001-02-07 BR BR0107645-0A patent/BR0107645A/pt not_active IP Right Cessation
- 2001-02-07 AU AU2001234428A patent/AU2001234428A1/en not_active Abandoned
- 2001-02-07 AT AT01906529T patent/ATE302762T1/de not_active IP Right Cessation
- 2001-02-07 EP EP01906529A patent/EP1263742B1/en not_active Expired - Lifetime
- 2001-02-07 MX MXPA02007719A patent/MXPA02007719A/es unknown
- 2001-02-07 US US09/778,603 patent/US20010047004A1/en not_active Abandoned
- 2001-02-07 ES ES01906529T patent/ES2248284T3/es not_active Expired - Lifetime
- 2001-02-07 CN CN01803631A patent/CN1395569A/zh active Pending
- 2001-02-07 KR KR1020027010298A patent/KR20020072311A/ko not_active Withdrawn
- 2001-02-07 PE PE2001000132A patent/PE20011089A1/es not_active Application Discontinuation
- 2001-02-07 JP JP2001558436A patent/JP2003522763A/ja active Pending
- 2001-02-07 CA CA002395648A patent/CA2395648A1/en not_active Abandoned
- 2001-02-07 DE DE60112903T patent/DE60112903T2/de not_active Expired - Fee Related
- 2001-02-07 NZ NZ520696A patent/NZ520696A/en unknown
- 2001-02-08 CO CO01009443A patent/CO5271737A1/es not_active Application Discontinuation
- 2001-02-09 AR ARP010100602A patent/AR029226A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2248284T3 (es) | 2006-03-16 |
| AU2001234428A1 (en) | 2001-08-20 |
| EP1263742A1 (en) | 2002-12-11 |
| BR0107645A (pt) | 2002-10-08 |
| JP2003522763A (ja) | 2003-07-29 |
| NZ520696A (en) | 2004-03-26 |
| DE60112903T2 (de) | 2006-06-14 |
| EP1263742B1 (en) | 2005-08-24 |
| KR20020072311A (ko) | 2002-09-14 |
| DE60112903D1 (de) | 2005-09-29 |
| ATE302762T1 (de) | 2005-09-15 |
| CN1395569A (zh) | 2003-02-05 |
| AR029226A1 (es) | 2003-06-18 |
| WO2001058885A1 (en) | 2001-08-16 |
| MXPA02007719A (es) | 2002-10-11 |
| US20010047004A1 (en) | 2001-11-29 |
| CA2395648A1 (en) | 2001-08-16 |
| CO5271737A1 (es) | 2003-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |