AR025482A1 - Secuencia de adn que codifica una proteina capaz de ligarse a traf; vector que comprende dicha secuencia; celulas huespedes transformadas con dicho vector;proteinas iren codificadas por dicha secuencia; metodo para producir dicha proteina; anticuerpos especificos para dichas proteinas; metodo para m - Google Patents
Secuencia de adn que codifica una proteina capaz de ligarse a traf; vector que comprende dicha secuencia; celulas huespedes transformadas con dicho vector;proteinas iren codificadas por dicha secuencia; metodo para producir dicha proteina; anticuerpos especificos para dichas proteinas; metodo para mInfo
- Publication number
- AR025482A1 AR025482A1 ARP000104593A ARP000104593A AR025482A1 AR 025482 A1 AR025482 A1 AR 025482A1 AR P000104593 A ARP000104593 A AR P000104593A AR P000104593 A ARP000104593 A AR P000104593A AR 025482 A1 AR025482 A1 AR 025482A1
- Authority
- AR
- Argentina
- Prior art keywords
- sequence
- proteins
- protein
- vector
- iren
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 7
- 108090000623 proteins and genes Proteins 0.000 title abstract 7
- 108091028043 Nucleic acid sequence Proteins 0.000 title abstract 4
- XAEWZDYWZHIUCT-UHFFFAOYSA-N desipramine hydrochloride Chemical compound [H+].[Cl-].C1CC2=CC=CC=C2N(CCCNC)C2=CC=CC=C21 XAEWZDYWZHIUCT-UHFFFAOYSA-N 0.000 title abstract 2
- 101001059240 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Site-specific recombinase Flp Proteins 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 102000004393 TNF receptor-associated factor 2 Human genes 0.000 abstract 3
- 108090000925 TNF receptor-associated factor 2 Proteins 0.000 abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 3
- 239000002299 complementary DNA Substances 0.000 abstract 3
- 239000002773 nucleotide Substances 0.000 abstract 3
- 125000003729 nucleotide group Chemical group 0.000 abstract 3
- 108020004414 DNA Proteins 0.000 abstract 1
- 102000023732 binding proteins Human genes 0.000 abstract 1
- 108091008324 binding proteins Proteins 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000002068 genetic effect Effects 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Se trata de secuencias de ADN codificado proteínas de enlace TRAF, proteínas codificadas por la misma, y uso en el tratamiento o prevencion de condicionespatologicas asociadas con la induccion de NF-kB, o una actividad en la que interviene un TRAF.Específicamente se trata de una secuencia que comprende: (g)unasecuencia de cADN de la aquí denominada IREN que comprende la secuencia de nucleotido descripta en la figura 3; (h)una secuencia de cADN de la aquídenominada IREN-10B que comprende la secuencia de nucleotido descripta en la figura 4; (i)una secuencia de cADN de la aquí denominada IREN-E que comprende lasecuencia de nucléotido descripta en la figura 5; (j)un fragmento de una secuencia (a) - (c) la cual codifica una proteína biologicamente activa capaz de ligara al menos la secuencia de aminoácido 225-501 de TRAF2; (k)una secuencia de ADN capaz de hibridizacion a una secuencia de (a) - (d) bajo condicionesmoderadamente estringentes y la cual codifica una proteína biologicamente activa capaz de ligar al menos la secuencia de aminoácidos 225-501 de TRAF2; y unasecuencia de ADN la cual se degenera como un resultado del codigo genético a las secuencias de ADN definidas en (a) - (e) y la cual codifica una proteínabiologicamente activa capaz de ligar al menos la secuencia de aminoácido 225-501 de TRAF2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL13171999A IL131719A0 (en) | 1999-09-02 | 1999-09-02 | Iren protein its preparation and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR025482A1 true AR025482A1 (es) | 2002-11-27 |
Family
ID=11073213
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000104593A AR025482A1 (es) | 1999-09-02 | 2000-09-01 | Secuencia de adn que codifica una proteina capaz de ligarse a traf; vector que comprende dicha secuencia; celulas huespedes transformadas con dicho vector;proteinas iren codificadas por dicha secuencia; metodo para producir dicha proteina; anticuerpos especificos para dichas proteinas; metodo para m |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7429648B1 (es) |
| EP (1) | EP1208197A1 (es) |
| JP (1) | JP2003508053A (es) |
| KR (1) | KR100820526B1 (es) |
| CN (1) | CN100482795C (es) |
| AR (1) | AR025482A1 (es) |
| AU (1) | AU784582B2 (es) |
| BR (1) | BR0014167A (es) |
| CA (1) | CA2383606A1 (es) |
| EA (1) | EA005775B1 (es) |
| EE (1) | EE200200096A (es) |
| IL (2) | IL131719A0 (es) |
| MX (1) | MXPA02002391A (es) |
| NO (1) | NO20020919L (es) |
| WO (1) | WO2001016314A1 (es) |
| ZA (1) | ZA200201401B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1578920A4 (en) * | 2002-02-08 | 2007-11-21 | Wyeth Corp | COMPOSITION AND METHOD FOR MODULATING AN INFLAMMATORY REACTION |
| AU2003234840A1 (en) * | 2002-05-29 | 2003-12-12 | Anges Mg, Inc. | Decoy composition for treating and preventing inflammatory disease |
| US8400998B2 (en) | 2006-08-23 | 2013-03-19 | Motorola Mobility Llc | Downlink control channel signaling in wireless communication systems |
| AU2014247991B2 (en) * | 2013-04-05 | 2019-05-09 | Qiagen Sciences, Llc | Kits and methods for isolating protein from biological and environmental samples |
| CN105986001B (zh) * | 2015-02-12 | 2019-12-03 | 上海交通大学 | 一种基于膜结合蛋白和荧光互补的高通量猎物拮抗剂筛选方法 |
| CN105985979B (zh) * | 2015-02-12 | 2020-03-24 | 上海交通大学 | 一种用于高通量受体基因筛查的新型膜蛋白酵母双杂交方法 |
| EP3344643B1 (en) | 2015-09-04 | 2025-07-02 | Qiagen Sciences LLC | Methods for co-isolation of nucleic acids and proteins |
| CN112313344A (zh) | 2018-04-24 | 2021-02-02 | 凯杰科技有限公司 | 从复杂样品中分离核酸并去除抑制剂 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA71889C2 (uk) * | 1996-04-02 | 2005-01-17 | Йєда Рісерч Енд Дівелопмент Ко. Лтд. | Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування |
| KR100552547B1 (ko) * | 1996-04-02 | 2006-05-12 | 에다 리서치 앤드 디벨럽먼트 컴퍼니 리미티드 | Tnf수용체연합된인자(traf)조절물질,이의제조및이의용도 |
-
1999
- 1999-09-02 IL IL13171999A patent/IL131719A0/xx unknown
-
2000
- 2000-08-31 BR BR0014167-4A patent/BR0014167A/pt not_active Application Discontinuation
- 2000-08-31 CA CA002383606A patent/CA2383606A1/en not_active Abandoned
- 2000-08-31 US US10/070,255 patent/US7429648B1/en not_active Expired - Fee Related
- 2000-08-31 IL IL14844600A patent/IL148446A0/xx unknown
- 2000-08-31 MX MXPA02002391A patent/MXPA02002391A/es unknown
- 2000-08-31 EA EA200200319A patent/EA005775B1/ru not_active IP Right Cessation
- 2000-08-31 WO PCT/IL2000/000517 patent/WO2001016314A1/en not_active Ceased
- 2000-08-31 EE EEP200200096A patent/EE200200096A/xx unknown
- 2000-08-31 JP JP2001520861A patent/JP2003508053A/ja active Pending
- 2000-08-31 EP EP00954882A patent/EP1208197A1/en not_active Withdrawn
- 2000-08-31 CN CNB008150133A patent/CN100482795C/zh not_active Expired - Fee Related
- 2000-08-31 KR KR1020027002840A patent/KR100820526B1/ko not_active Expired - Fee Related
- 2000-08-31 AU AU67231/00A patent/AU784582B2/en not_active Ceased
- 2000-09-01 AR ARP000104593A patent/AR025482A1/es unknown
-
2002
- 2002-02-19 ZA ZA200201401A patent/ZA200201401B/en unknown
- 2002-02-25 NO NO20020919A patent/NO20020919L/no not_active Application Discontinuation
-
2008
- 2008-09-09 US US12/207,269 patent/US20090075889A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN100482795C (zh) | 2009-04-29 |
| EA005775B1 (ru) | 2005-06-30 |
| ZA200201401B (en) | 2003-05-28 |
| NO20020919D0 (no) | 2002-02-25 |
| IL148446A0 (en) | 2002-09-12 |
| KR20020059386A (ko) | 2002-07-12 |
| AU784582B2 (en) | 2006-05-04 |
| JP2003508053A (ja) | 2003-03-04 |
| EP1208197A1 (en) | 2002-05-29 |
| EA200200319A1 (ru) | 2002-08-29 |
| US20090075889A1 (en) | 2009-03-19 |
| BR0014167A (pt) | 2002-05-07 |
| CN1384878A (zh) | 2002-12-11 |
| KR100820526B1 (ko) | 2008-04-07 |
| CA2383606A1 (en) | 2001-03-08 |
| AU6723100A (en) | 2001-03-26 |
| NO20020919L (no) | 2002-04-25 |
| MXPA02002391A (es) | 2002-08-20 |
| WO2001016314A1 (en) | 2001-03-08 |
| IL131719A0 (en) | 2001-03-19 |
| US7429648B1 (en) | 2008-09-30 |
| HK1051876A1 (en) | 2003-08-22 |
| EE200200096A (et) | 2003-04-15 |
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| FB | Suspension of granting procedure |