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AR003469A1 - 2-(4-sustituido)-bencilamino-2-metil-propanamidas, su uso, procedimiento para su preparación y composiciones farmaceuticas que las contienen. - Google Patents

2-(4-sustituido)-bencilamino-2-metil-propanamidas, su uso, procedimiento para su preparación y composiciones farmaceuticas que las contienen.

Info

Publication number
AR003469A1
AR003469A1 ARP960103752A AR10375296A AR003469A1 AR 003469 A1 AR003469 A1 AR 003469A1 AR P960103752 A ARP960103752 A AR P960103752A AR 10375296 A AR10375296 A AR 10375296A AR 003469 A1 AR003469 A1 AR 003469A1
Authority
AR
Argentina
Prior art keywords
propanamides
substituted
methyl
contain
preparation
Prior art date
Application number
ARP960103752A
Other languages
English (en)
Inventor
Paolo Pevarello
Mario Varasi
Alberto Bonsignori
Patricia Salvati
Raffaella Amici
Original Assignee
Newron Pharm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10778352&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR003469(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Newron Pharm Spa filed Critical Newron Pharm Spa
Publication of AR003469A1 publication Critical patent/AR003469A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C07C321/28—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C07C321/30—Sulfides having the sulfur atom of at least one thio group bound to two carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/33—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring
    • C07C323/35—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group
    • C07C323/36—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group the sulfur atom of the sulfide group being further bound to an acyclic carbon atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se presentan nuevas 2-(4-sustituido)-bencilamino-2-metil-propanamidas, con actividad CNS, de la fórmula general (I), donde:n es cero, 1, 2 ó 3; X es -O-,-S-, -CH2- ó -NH-; cada uno de R y R1 es independientemente hidrógeno, alquilo C1-C6,halógeno, hidroxi, alcoxi C1-C4 o trifluorometilo; cada una de R2, R3,y R4 es independientemente hidrógeno, alquilo C1-C6 o cicloalquilo C3-C7, y sus sales farmacológicamente aceptables. Se refiere también a un procedimiento parasu preparación y acomposicion es farmacéuticas que las contienen.
ARP960103752A 1995-07-27 1996-07-26 2-(4-sustituido)-bencilamino-2-metil-propanamidas, su uso, procedimiento para su preparación y composiciones farmaceuticas que las contienen. AR003469A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9515412.6A GB9515412D0 (en) 1995-07-27 1995-07-27 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives

Publications (1)

Publication Number Publication Date
AR003469A1 true AR003469A1 (es) 1998-08-05

Family

ID=10778352

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960103752A AR003469A1 (es) 1995-07-27 1996-07-26 2-(4-sustituido)-bencilamino-2-metil-propanamidas, su uso, procedimiento para su preparación y composiciones farmaceuticas que las contienen.

Country Status (27)

Country Link
US (1) US5945454A (es)
EP (1) EP0842143B3 (es)
JP (1) JP4040089B2 (es)
KR (1) KR100412747B1 (es)
CN (1) CN1085659C (es)
AR (1) AR003469A1 (es)
AT (1) ATE202078T1 (es)
AU (1) AU711309B2 (es)
BR (1) BR9609849B1 (es)
CA (1) CA2226894C (es)
DE (2) DE69613377D1 (es)
DK (1) DK0842143T5 (es)
EA (1) EA001322B1 (es)
ES (1) ES2159749T7 (es)
GB (1) GB9515412D0 (es)
GR (1) GR3036559T3 (es)
HU (1) HU227806B1 (es)
IL (1) IL122705A (es)
MX (1) MX9800718A (es)
NO (1) NO324273B1 (es)
NZ (1) NZ313185A (es)
PL (1) PL184302B1 (es)
PT (1) PT842143E (es)
SI (1) SI0842143T1 (es)
UA (1) UA44331C2 (es)
WO (1) WO1997005102A1 (es)
ZA (1) ZA965998B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
WO1999026614A1 (en) 1997-11-21 1999-06-03 Euro-Celtique S.A. Substituted 2-aminoacetamides and the use thereof
GB9727523D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Alpha-aminoamide derivatives useful as analgesic agents
US6281211B1 (en) 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
EP1169060B1 (en) 1999-04-09 2005-08-31 Euro-Celtique S.A. Sodium channel blocker compositions and the use thereof
US6335354B2 (en) 2000-03-31 2002-01-01 Cocensys Inc. Aminopyridines and methods of using thereof
WO2003020273A2 (en) * 2001-09-03 2003-03-13 Newron Pharmaceuticals Spa Pharmaceutical composition comprising gabapentin or an analogue thereof and an $g(a)-aminoamide and its analgesic use
US6667327B2 (en) 2002-02-04 2003-12-23 Hoffmann-La Roche Inc. Pyridine amido derivatives
EP1438956A1 (en) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful as antimigraine agents
AR044007A1 (es) * 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
EP1524267A1 (en) * 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Substituted benzylaminoalkylene heterocycles
EP1680127B1 (en) 2003-10-23 2008-10-15 F. Hoffmann-La Roche Ag Benzazepine derivatives as mao-b inhibitors
EP1557166A1 (en) * 2004-01-21 2005-07-27 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders
EP1588704A1 (en) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of restless legs syndrome and addictive disorders
BRPI0515154A (pt) * 2004-09-10 2008-07-08 Newron Pharm Spa uso de (halobenzilóxi)benzilamino-propanamidas para a fabricação de medicamentos ativos, compostos e composição farmacêutica
KR20080066821A (ko) * 2005-10-26 2008-07-16 베링거 인겔하임 인터내셔날 게엠베하 Ｍｃｈ 길항 활성을 가진 (헤테로)아릴 화합물 및 당해화합물을 포함하는 약제
PL1963280T3 (pl) 2005-12-22 2016-04-29 Newron Pharm Spa Pochodne 2-fenyloetyloaminowe jako modulatory kanału wapniowego i/lub sodowego
EP1870097A1 (en) * 2006-06-15 2007-12-26 Newron Pharmaceuticals S.p.A. Alpha-aminoamide derivatives useful in the treatment of cognitive disorders
MX2009000792A (es) * 2006-07-28 2009-02-03 Alcon Res Ltd Inhibidores de monoamina oxidasa utiles para tratar trastornos de la retina externa.
RS56780B1 (sr) 2007-06-15 2018-04-30 Newron Pharm Spa Substituisani derivati 2-[2-(fenil) etilamino]alkanamida i njihova upotreba kao modulatora kanala za natrijum i/ili kalcijum
US9505708B2 (en) * 2010-04-27 2016-11-29 Newron Pharmaceuticals S.P.A. Process for the production of ralfinamide salts substantially free from impurities having genotoxic effects
CN107709314A (zh) 2015-06-11 2018-02-16 巴斯利尔药物国际股份公司 外排泵抑制剂及其治疗性用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL94466A (en) * 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
GB9306886D0 (en) * 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylakoxybenzyl) aminopropanamide derivatives and process for their preparation
GB9306899D0 (en) * 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation

Also Published As

Publication number Publication date
KR19990035843A (ko) 1999-05-25
KR100412747B1 (ko) 2004-04-28
CN1192199A (zh) 1998-09-02
US5945454A (en) 1999-08-31
EA199800170A1 (ru) 1998-08-27
GR3036559T3 (en) 2001-12-31
AU6418796A (en) 1997-02-26
NO980290D0 (no) 1998-01-22
MX9800718A (es) 1998-04-30
HUP9900351A3 (en) 1999-11-29
NZ313185A (en) 2000-05-26
AU711309C (en) 1997-02-26
IL122705A (en) 2001-01-28
EA001322B1 (ru) 2001-02-26
EP0842143B3 (en) 2009-02-18
HU227806B1 (en) 2012-03-28
PL184302B1 (pl) 2002-09-30
IL122705A0 (en) 1998-08-16
DE69613377D1 (de) 2001-07-19
AU711309B2 (en) 1999-10-07
CA2226894A1 (en) 1997-02-13
ZA965998B (en) 1997-01-31
NO980290L (no) 1998-01-22
CN1085659C (zh) 2002-05-29
JP4040089B2 (ja) 2008-01-30
ATE202078T1 (de) 2001-06-15
NO324273B1 (no) 2007-09-17
PT842143E (pt) 2001-10-30
DK0842143T3 (da) 2001-07-23
JP2000500732A (ja) 2000-01-25
SI0842143T1 (es) 2001-08-31
BR9609849A (pt) 1999-03-16
EP0842143B1 (en) 2001-06-13
HUP9900351A2 (hu) 1999-06-28
DE69613377T2 (de) 2001-09-20
BR9609849B1 (pt) 2010-05-18
DE69613377T4 (de) 2009-08-13
CA2226894C (en) 2009-03-31
UA44331C2 (uk) 2002-02-15
PL324639A1 (en) 1998-06-08
ES2159749T3 (es) 2001-10-16
ES2159749T7 (es) 2009-06-18
GB9515412D0 (en) 1995-09-27
EP0842143A1 (en) 1998-05-20
WO1997005102A1 (en) 1997-02-13
DK0842143T5 (da) 2009-06-02

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