AR003456A1 - Un compuesto analogo de distamicina y sus sales, procedimiento para su preparacion, composicion farmaceutica que lo contiene y usos del mismo. - Google Patents
Un compuesto analogo de distamicina y sus sales, procedimiento para su preparacion, composicion farmaceutica que lo contiene y usos del mismo.Info
- Publication number
- AR003456A1 AR003456A1 ARP960103583A AR10358396A AR003456A1 AR 003456 A1 AR003456 A1 AR 003456A1 AR P960103583 A ARP960103583 A AR P960103583A AR 10358396 A AR10358396 A AR 10358396A AR 003456 A1 AR003456 A1 AR 003456A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- pharmaceutical composition
- salts
- distamicine
- procedure
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- UPBAOYRENQEPJO-UHFFFAOYSA-N n-[5-[[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-formamido-1-methylpyrrole-2-carboxamide Chemical compound CN1C=C(NC=O)C=C1C(=O)NC1=CN(C)C(C(=O)NC2=CN(C)C(C(=O)NCCC(N)=N)=C2)=C1 UPBAOYRENQEPJO-UHFFFAOYSA-N 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 108010042747 stallimycin Proteins 0.000 abstract 1
- 229950009902 stallimycin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
Abstract
Se presentan nuevos compuestos antitumorales y antivirales análogos a distamicina A de fórmula (I), donde n es 2, 3 ó 4; uno de R y R1 es hidrógeno,alquilo C1-C4, CF3 o alcoxi C1-C4 y la otra es independientemente CF3, alquilo C1-C4 o alcoxi C1-C4; y X es halógeno;y sus sales farmacéuticamente aceptables.Además, la presente invención se refiere a un proceso de preparación de dichos compuestos; a una composición farmacéutica y un producto que lo contiene y ausos de dichos compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9514993.6A GB9514993D0 (en) | 1995-07-21 | 1995-07-21 | Site specific phenyl nitrogen mustards |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR003456A1 true AR003456A1 (es) | 1998-08-05 |
Family
ID=10778062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960103583A AR003456A1 (es) | 1995-07-21 | 1996-07-15 | Un compuesto analogo de distamicina y sus sales, procedimiento para su preparacion, composicion farmaceutica que lo contiene y usos del mismo. |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0787126A1 (es) |
| JP (1) | JPH10506410A (es) |
| KR (1) | KR970706251A (es) |
| CN (1) | CN1159183A (es) |
| AR (1) | AR003456A1 (es) |
| AU (1) | AU6357996A (es) |
| BR (1) | BR9606528A (es) |
| CA (1) | CA2199635A1 (es) |
| EA (1) | EA000033B1 (es) |
| GB (1) | GB9514993D0 (es) |
| HU (1) | HUP9702393A3 (es) |
| IL (1) | IL120342A0 (es) |
| MX (1) | MX9701949A (es) |
| NO (1) | NO971142L (es) |
| PL (1) | PL319352A1 (es) |
| TW (1) | TW367325B (es) |
| WO (1) | WO1997003957A1 (es) |
| ZA (1) | ZA965028B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6635417B1 (en) | 1996-07-31 | 2003-10-21 | California Institute Of Technology | Complex formation between DSDNA and oligomer of cyclic heterocycles |
| JP2001513759A (ja) | 1996-02-26 | 2001-09-04 | カリフォルニア・インスティチュート・オブ・テクノロジー | 二本鎖ｄｎａの副溝において結合する改良されたポリアミド |
| US5998140A (en) | 1996-07-31 | 1999-12-07 | The Scripps Research Institute | Complex formation between dsDNA and oligomer of cyclic heterocycles |
| GB9623522D0 (en) * | 1996-11-11 | 1997-01-08 | Pharmacia & Upjohn Spa | Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents |
| GB9816652D0 (en) * | 1998-07-30 | 1998-09-30 | Pharmacia & Upjohn Spa | Sulfurated distamycin derivatives process for preparing them and their use as antitumor agents |
| GB9907414D0 (en) | 1999-03-31 | 1999-05-26 | Cancer Res Campaign Tech | Improvements relating to prodrugs |
| US6559125B1 (en) | 2000-01-28 | 2003-05-06 | California Institute Of Technology | Polyamide-alkylator conjugates and related products and method |
| WO2002101007A2 (en) | 2001-06-13 | 2002-12-19 | Genesoft Pharmaceuticals, Inc | Antipathogenic benzamide compounds |
| AU2003258022A1 (en) | 2002-08-02 | 2004-02-23 | Genesoft Pharmaceuticals, Inc. | Biaryl compounds having anti-infective activity |
| AU2003285958A1 (en) | 2002-10-25 | 2004-05-25 | Genesoft Pharmaceuticals, Inc. | Anti-infective biaryl compounds |
| EP1587529A4 (en) | 2002-12-10 | 2009-08-12 | Oscient Pharmaceuticals Corp | ANTIBACTERIAL COMPOUNDS WITH (PYROCARBOXAMIDE) - (BENZAMID) - (IMIDAZOLE CARBOXAMIDE) MOTIVE |
| EP2792355A1 (en) | 2013-04-17 | 2014-10-22 | Albert-Ludwigs-Universität Freiburg | Compounds for use as bromodomain inhibitors |
| CN115414356A (zh) * | 2022-09-27 | 2022-12-02 | 广西科技大学 | 一种茚并吡咯类衍生物在制备抗肿瘤药物组合物中的应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8612218D0 (en) * | 1986-05-20 | 1986-06-25 | Erba Farmitalia | Site specific alkylating agents |
-
1995
- 1995-07-21 GB GBGB9514993.6A patent/GB9514993D0/en active Pending
-
1996
- 1996-06-13 ZA ZA965028A patent/ZA965028B/xx unknown
- 1996-06-18 TW TW085107334A patent/TW367325B/zh active
- 1996-06-19 JP JP9506209A patent/JPH10506410A/ja active Pending
- 1996-06-19 PL PL96319352A patent/PL319352A1/xx unknown
- 1996-06-19 EA EA199700046A patent/EA000033B1/ru not_active IP Right Cessation
- 1996-06-19 AU AU63579/96A patent/AU6357996A/en not_active Abandoned
- 1996-06-19 WO PCT/EP1996/002659 patent/WO1997003957A1/en not_active Ceased
- 1996-06-19 CN CN96190784A patent/CN1159183A/zh active Pending
- 1996-06-19 IL IL12034296A patent/IL120342A0/xx unknown
- 1996-06-19 BR BR9606528A patent/BR9606528A/pt not_active Application Discontinuation
- 1996-06-19 EP EP96922849A patent/EP0787126A1/en not_active Withdrawn
- 1996-06-19 CA CA002199635A patent/CA2199635A1/en not_active Abandoned
- 1996-06-19 MX MX9701949A patent/MX9701949A/es unknown
- 1996-06-19 HU HU9702393A patent/HUP9702393A3/hu unknown
- 1996-07-15 AR ARP960103583A patent/AR003456A1/es unknown
- 1996-09-19 KR KR1019970701796A patent/KR970706251A/ko not_active Withdrawn
-
1997
- 1997-03-12 NO NO971142A patent/NO971142L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA965028B (en) | 1997-01-23 |
| IL120342A0 (en) | 1997-06-10 |
| WO1997003957A1 (en) | 1997-02-06 |
| JPH10506410A (ja) | 1998-06-23 |
| EP0787126A1 (en) | 1997-08-06 |
| BR9606528A (pt) | 1997-12-23 |
| PL319352A1 (en) | 1997-08-04 |
| HUP9702393A3 (en) | 1998-05-28 |
| GB9514993D0 (en) | 1995-09-20 |
| NO971142D0 (no) | 1997-03-12 |
| HUP9702393A2 (hu) | 1998-04-28 |
| CA2199635A1 (en) | 1997-02-06 |
| AU6357996A (en) | 1997-02-18 |
| EA000033B1 (ru) | 1998-02-26 |
| NO971142L (no) | 1997-03-12 |
| EA199700046A1 (ru) | 1997-12-30 |
| MX9701949A (es) | 1997-06-28 |
| CN1159183A (zh) | 1997-09-10 |
| KR970706251A (ko) | 1997-11-03 |
| TW367325B (en) | 1999-08-21 |
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