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BRPI0515154A - uso de (halobenzilóxi)benzilamino-propanamidas para a fabricação de medicamentos ativos, compostos e composição farmacêutica - Google Patents

uso de (halobenzilóxi)benzilamino-propanamidas para a fabricação de medicamentos ativos, compostos e composição farmacêutica

Info

Publication number
BRPI0515154A
BRPI0515154A BRPI0515154-6A BRPI0515154A BRPI0515154A BR PI0515154 A BRPI0515154 A BR PI0515154A BR PI0515154 A BRPI0515154 A BR PI0515154A BR PI0515154 A BRPI0515154 A BR PI0515154A
Authority
BR
Brazil
Prior art keywords
halobenzyloxy
benzylamino
manufacture
disorders
pharmaceutically acceptable
Prior art date
Application number
BRPI0515154-6A
Other languages
English (en)
Inventor
Elena Barbanti
Florian Thaler
Carla Caccia
Ruggero Fariello
Patricia Salvati
Original Assignee
Newron Pharm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newron Pharm Spa filed Critical Newron Pharm Spa
Publication of BRPI0515154A publication Critical patent/BRPI0515154A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

USO DE (HALOBENZILóXI)BENZILAMINO-PROPANAMIDAS PARA A FABRICAçãO DE MEDICAMENTOS ATIVOS, COMPOSTOS E COMPOSIçãO FARMACêUTICA A presente invenção refere-se ao uso de selecionadas (R)-2- ¢(halobenzilóxi)benzilamino!propanamidas e os sais farmaceuticamente aceitáveis das mesmas, para a fabricação de medicamentos, que são seletivamente ativos como moduladores do canal de sódio e/ou cálcio e, portanto, de utilidade na prevenção, alívio e cura de uma ampla faixa de patologias, incluindo, dor, enxaqueca, doenças periféricas, doenças cardiovasculares, processos inflamatórios que afetam todos os sistemas do corpo, distúrbios que afetam a pele e tecidos relacionados, distúrbios do sistema respiratório, distúrbios dos sistemas imune e endocrinológico, distúrbios gastrointestinais, urogenitais, metabólicos e de convulsão, onde os mecanismos acima, conforme descrito, desempenham uma função patológica.
BRPI0515154-6A 2004-09-10 2005-07-28 uso de (halobenzilóxi)benzilamino-propanamidas para a fabricação de medicamentos ativos, compostos e composição farmacêutica BRPI0515154A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04021525 2004-09-10
PCT/EP2005/008200 WO2006027052A2 (en) 2004-09-10 2005-07-28 (halobenzyloxy) benzylamino-propanamides as sodium and/or calcium channel selective modulators

Publications (1)

Publication Number Publication Date
BRPI0515154A true BRPI0515154A (pt) 2008-07-08

Family

ID=34926488

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515154-6A BRPI0515154A (pt) 2004-09-10 2005-07-28 uso de (halobenzilóxi)benzilamino-propanamidas para a fabricação de medicamentos ativos, compostos e composição farmacêutica

Country Status (27)

Country Link
US (2) US20080096965A1 (pt)
EP (1) EP1809271B9 (pt)
JP (1) JP5319920B2 (pt)
KR (1) KR101277520B1 (pt)
CN (1) CN101018546B (pt)
AR (1) AR050638A1 (pt)
AT (1) ATE471147T1 (pt)
AU (1) AU2005282028B2 (pt)
BR (1) BRPI0515154A (pt)
CA (1) CA2577408C (pt)
CY (1) CY1110770T1 (pt)
DE (1) DE602005021907D1 (pt)
DK (1) DK1809271T5 (pt)
ES (1) ES2347581T3 (pt)
HR (1) HRP20100400T1 (pt)
IL (1) IL181445A (pt)
ME (1) ME01801B (pt)
MX (1) MX2007002713A (pt)
NO (1) NO338713B1 (pt)
NZ (1) NZ553970A (pt)
PL (1) PL1809271T3 (pt)
PT (1) PT1809271E (pt)
RS (1) RS51411B (pt)
RU (1) RU2391973C2 (pt)
SI (1) SI1809271T1 (pt)
TW (1) TWI351950B (pt)
WO (1) WO2006027052A2 (pt)

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NZ567540A (en) * 2005-12-22 2010-07-30 Newron Pharm Spa 2-Phenylethylamino derivatives as calcium and/or sodium channel modulators
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EA019898B1 (ru) * 2007-12-11 2014-07-30 Ньюрон Фармасьютикалс С.П.А. Способ получения 2-[4-(3- или 2-фторбензилокси)бензиламино]пропанамидов с высокой степенью чистоты
JP5736175B2 (ja) * 2007-12-19 2015-06-17 ニユーロン・フアーマシユーテイカルズ・エツセ・ピー・アー 精神障害の治療に有用なα−アミノアミド誘導体
WO2009109334A1 (en) * 2008-03-07 2009-09-11 Newron Pharmaceuticals S.P.A. (s)-(+)-2-[4-fluorbenzyloxy)benzylamino]propanamide for use in the treatment of mixed or combined pain
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US9505708B2 (en) * 2010-04-27 2016-11-29 Newron Pharmaceuticals S.P.A. Process for the production of ralfinamide salts substantially free from impurities having genotoxic effects
PL2723710T3 (pl) 2011-06-27 2017-02-28 Newron Pharmaceuticals S.P.A. Fluorowane pochodne aryloalkiloaminokarboksyamidowe
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DK1809271T5 (da) * 2004-09-10 2010-12-06 Newron Pharm Spa Anvendelse af (R)-(halogenbenzyloxy)benzylaminopropanamider som natrium- og/eller calciumkanalselektive modulatorer

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EP1809271B9 (en) 2010-09-22
CA2577408C (en) 2013-07-09
CN101018546A (zh) 2007-08-15
US20110184068A1 (en) 2011-07-28
ME01801B (me) 2011-02-28
PL1809271T3 (pl) 2010-10-29
NZ553970A (en) 2010-01-29
DE602005021907D1 (de) 2010-07-29
WO2006027052A2 (en) 2006-03-16
RS51411B (sr) 2011-02-28
TW200612894A (en) 2006-05-01
SI1809271T1 (sl) 2010-10-29
IL181445A0 (en) 2007-07-04
DK1809271T5 (da) 2010-12-06
US20080096965A1 (en) 2008-04-24
NO338713B1 (no) 2016-10-03
AU2005282028B2 (en) 2011-03-24
AU2005282028A2 (en) 2006-03-16
HRP20100400T1 (hr) 2010-09-30
MX2007002713A (es) 2007-05-23
EP1809271A2 (en) 2007-07-25
CA2577408A1 (en) 2006-03-16
TWI351950B (en) 2011-11-11
KR20070061863A (ko) 2007-06-14
RU2007113190A (ru) 2008-10-27
ATE471147T1 (de) 2010-07-15
JP5319920B2 (ja) 2013-10-16
WO2006027052A3 (en) 2006-05-26
EP1809271B1 (en) 2010-06-16
DK1809271T3 (da) 2010-09-20
HK1105359A1 (en) 2008-02-15
JP2008512405A (ja) 2008-04-24
NO20071792L (no) 2007-06-11
ES2347581T3 (es) 2010-11-02
RU2391973C2 (ru) 2010-06-20
CN101018546B (zh) 2013-06-12
AR050638A1 (es) 2006-11-08
PT1809271E (pt) 2010-08-30
KR101277520B1 (ko) 2013-06-21
AU2005282028A1 (en) 2006-03-16
CY1110770T1 (el) 2015-06-10
IL181445A (en) 2014-03-31

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Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: A61K 31/165 , A61K 31/00 , A61K 45/06 , A61P 29/00 , A61P 25/06 , A61P 25/02 , A61P 9/00 , A61P 13/00 , A61P 3/00 , A61P 1/00 , A61P 17/00 , A61P 11/00 , A61P 37/00 , A61P 25/08 , A61P 5/00

Ipc: A61K 45/06 (2006.01), A61P 29/00 (2006.01), A61P 2

B09B Patent application refused [chapter 9.2 patent gazette]
B25G Requested change of headquarter approved

Owner name: NEWRON PHARMACEUTICALS S.P.A. (IT)

B12B Appeal against refusal [chapter 12.2 patent gazette]