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AR002039A1 - Pirido[3.2-e]pirazinonas con efecto antiasmatico, y procedimiento para su preparacion y los medicamentos que los contienen y su preparación - Google Patents

Pirido[3.2-e]pirazinonas con efecto antiasmatico, y procedimiento para su preparacion y los medicamentos que los contienen y su preparación

Info

Publication number
AR002039A1
AR002039A1 ARP960101871A AR10187196A AR002039A1 AR 002039 A1 AR002039 A1 AR 002039A1 AR P960101871 A ARP960101871 A AR P960101871A AR 10187196 A AR10187196 A AR 10187196A AR 002039 A1 AR002039 A1 AR 002039A1
Authority
AR
Argentina
Prior art keywords
preparation
pirazinonas
asmatic
pirido
procedure
Prior art date
Application number
ARP960101871A
Other languages
English (en)
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of AR002039A1 publication Critical patent/AR002039A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención se refiere a nuevos pirido[3.2-e] pirazinonas, a procedimientos para su preparación, y a su utilización farmacéutica. Loscompuestos presentan efectos anti-asmáticos y anti-alérgicos.
ARP960101871A 1995-03-24 1996-03-22 Pirido[3.2-e]pirazinonas con efecto antiasmatico, y procedimiento para su preparacion y los medicamentos que los contienen y su preparación AR002039A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19510965A DE19510965A1 (de) 1995-03-24 1995-03-24 Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung

Publications (1)

Publication Number Publication Date
AR002039A1 true AR002039A1 (es) 1998-01-07

Family

ID=7757727

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960101871A AR002039A1 (es) 1995-03-24 1996-03-22 Pirido[3.2-e]pirazinonas con efecto antiasmatico, y procedimiento para su preparacion y los medicamentos que los contienen y su preparación

Country Status (30)

Country Link
US (1) US5723463A (es)
EP (1) EP0736532B1 (es)
JP (1) JP4124280B2 (es)
KR (1) KR100401395B1 (es)
CN (1) CN1058968C (es)
AR (1) AR002039A1 (es)
AT (1) ATE217624T1 (es)
AU (1) AU697908B2 (es)
BR (1) BR9601093A (es)
CA (1) CA2172472C (es)
CZ (1) CZ290784B6 (es)
DE (2) DE19510965A1 (es)
DK (1) DK0736532T3 (es)
ES (1) ES2174989T3 (es)
HR (1) HRP960129B1 (es)
HU (1) HUP9600731A3 (es)
IL (1) IL117621A (es)
MX (1) MX9601069A (es)
NO (1) NO307091B1 (es)
NZ (1) NZ286232A (es)
PL (1) PL184800B1 (es)
PT (1) PT736532E (es)
RU (1) RU2143433C1 (es)
SG (1) SG43249A1 (es)
SI (1) SI0736532T1 (es)
SK (1) SK36596A3 (es)
TR (1) TR199600217A2 (es)
TW (1) TW426682B (es)
UA (1) UA45319C2 (es)
ZA (1) ZA962270B (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2137113B1 (es) * 1997-07-29 2000-09-16 Almirall Prodesfarma Sa Nuevos derivados de triazolo-piridazinas heterociclicos.
AU2291200A (en) * 1999-01-20 2000-08-07 Arzneimittelwerk Dresden Gmbh Use of imidazo(1,5-a)-pyrido(3,2-e)-pyrazinones as medicaments
DE19961302A1 (de) * 1999-12-18 2001-06-21 Dresden Arzneimittel Verwendung von Imidazo(1,5-a)-pyrido(3,2-e)-pyrazinonen als duale Inhibitoren der Phosphodiesterase 5 und der Phosphodiesterase 3 zur Therapie der Herzinsuffizienz, von pulmonaler Hypertonie und Gefäßerkrankungen, die mit einer Minderdurchblutung einhergehen
EP1671651B1 (en) 1999-08-21 2009-11-11 Nycomed GmbH Synergistic combination of pumafentrine and salmeterol
DE10012373A1 (de) * 2000-03-14 2001-09-20 Dresden Arzneimittel Verwendung von Pyrido[3,2-e]-pyrazinonen als Inhibitoren der Phosphodiesterase 5 zur Therapie von erektiler Dysfunktion
US6465465B1 (en) 2000-03-14 2002-10-15 Arzneimittelwerk Dresden Gmbh Process for the treatment of erectile dysfunction and product therefor
CN1293078C (zh) * 2002-04-03 2007-01-03 霍夫曼-拉罗奇有限公司 咪唑并稠合化合物
EP1558614B1 (en) * 2002-10-30 2010-09-01 Merck Frosst Canada Ltd. Pyridopyrrolizine and pyridoindolizine derivatives
WO2004087211A2 (en) 2003-04-01 2004-10-14 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
TWI417095B (zh) 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
TW200817400A (en) * 2006-05-30 2008-04-16 Elbion Ag Pyrido [3,2-e] pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them
ES2599054T3 (es) * 2006-12-13 2017-01-31 Aska Pharmaceutical Co., Ltd. Derivados de quinoxalina
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) * 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
CA2697399C (en) 2007-09-14 2016-01-19 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. 1,3-disubstituted 4-(aryl-x-phenyl)-1h-pyridin-2-ones
NZ584148A (en) * 2007-09-14 2011-05-27 Ortho Mcneil Janssen Pharm 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones
MY152078A (en) 2007-09-14 2014-08-15 Ortho Mcneil Janssen Pharm 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones
RU2492170C9 (ru) * 2007-11-14 2013-12-27 Орто-Макнейл-Янссен Фармасьютикалз, Инк. Имидазо[1,2-а]пиридиновые производные и их применение в качестве положительных аллостерических модуляторов рецепторов mglur2
EP2227472A1 (en) * 2007-11-30 2010-09-15 Elbion Gmbh Aryl and heteroaryl fused imidazo (1,5-a) pyrazines as inhibitors of phosphodiesterase 10
WO2009070584A1 (en) 2007-11-30 2009-06-04 Wyeth Aryl and heteroaryl fused imidazo[1,5-a]pyrazines as inhibitors of phosphodiesterase 10
AU2009289784B2 (en) 2008-09-02 2012-03-22 Addex Pharma S.A. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
ES2466341T3 (es) 2008-10-16 2014-06-10 Janssen Pharmaceuticals, Inc. Derivados de indol y benzomorfolina como moduladores de receptores de glutamato metabotrópicos
WO2010060589A1 (en) 2008-11-28 2010-06-03 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
NZ596053A (en) 2009-05-12 2013-05-31 Janssen Pharmaceuticals Inc 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
AU2010246609B2 (en) 2009-05-12 2013-09-05 Addex Pharma S.A. 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
EP2661435B1 (en) 2010-11-08 2015-08-19 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
CN103298810B (zh) 2010-11-08 2016-03-16 杨森制药公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
EP2643320B1 (en) 2010-11-08 2015-03-04 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
KR20220038826A (ko) 2014-01-21 2022-03-29 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
DK3096790T3 (da) 2014-01-21 2019-10-07 Janssen Pharmaceutica Nv Kombinationer omfattende positive allosteriske modulatorer eller orthosteriske agonister af metabotrop glutamaterg subtype 2-receptor og anvendelse af disse

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055465A (en) * 1989-05-31 1991-10-08 Berlex Laboratories, Inc. Imidazoquinoxalinones, their aza analogs and process for their preparation
US5166344A (en) * 1989-05-31 1992-11-24 Berlex Laboratories, Inc. Process for the preparation of imidazoquinoxalinones
US5153196A (en) * 1991-06-05 1992-10-06 Eli Lilly And Company Excitatory amino acid receptor antagonists and methods for the use thereof
EP0590022A1 (en) * 1991-06-14 1994-04-06 PHARMACIA & UPJOHN COMPANY IMIDAZO 1,5-a]QUINOXALINES
US5182386A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands
WO1993020077A1 (fr) * 1992-04-03 1993-10-14 Yamanouchi Pharmaceutical Co., Ltd. Derive de quinoxalinone fondue et composition pharmaceutique le contenant
DE4228095A1 (de) * 1992-08-24 1994-03-03 Asta Medica Ag Neue 4,5-Dihydro-4-oxo-pyrrolo[1,2-a]chinoxaline und entsprechende Aza-analoga und Verfahren zu deren Herstellung
JP3252483B2 (ja) * 1992-10-20 2002-02-04 東レ株式会社 ３環性トリアゾロ誘導体の製造方法
JP3252484B2 (ja) * 1992-10-20 2002-02-04 東レ株式会社 ４，５−ジヒドロ［１，２，４］トリアゾロ［４，３−ａ］キノキサリン誘導体の製造方法
DE4329970A1 (de) * 1993-03-31 1994-10-06 Basf Ag Neue Imidazolo-chinoxalinone, ihre Hestellung und Verwendung
FR2704547B1 (fr) * 1993-04-30 1995-06-09 Adir Nouveaux composés pyrrolopyraziniques, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
DK0698024T3 (da) * 1993-05-06 1997-07-28 Novo Nordisk As 1,2,4 triazolo 4,3-a quinoxalinforbindelser, deres fremstilling og anvendelse
CA2112290C (en) * 1993-12-23 2004-06-01 John R. Francis A clock recovery circuit for serial digital video
JP3240462B2 (ja) * 1996-05-24 2001-12-17 株式会社ケンウッド 光ディスク装置の光ピックアップサーボ装置

Also Published As

Publication number Publication date
PL313434A1 (en) 1996-09-30
RU2143433C1 (ru) 1999-12-27
JPH08269059A (ja) 1996-10-15
AU697908B2 (en) 1998-10-22
NO307091B1 (no) 2000-02-07
AU4825796A (en) 1996-10-03
ES2174989T3 (es) 2002-11-16
IL117621A0 (en) 1996-07-23
PT736532E (pt) 2002-10-31
ZA962270B (en) 1996-09-30
HUP9600731A2 (en) 1997-01-28
CA2172472C (en) 2000-01-18
PL184800B1 (pl) 2002-12-31
TW426682B (en) 2001-03-21
SK36596A3 (en) 1997-02-05
UA45319C2 (uk) 2002-04-15
KR100401395B1 (ko) 2003-12-24
SG43249A1 (en) 1997-10-17
NO961173L (no) 1996-09-25
CZ74796A3 (en) 1996-10-16
HRP960129B1 (en) 2002-12-31
MX9601069A (es) 1997-02-28
HUP9600731A3 (en) 1997-04-28
IL117621A (en) 1999-05-09
DE59609201D1 (de) 2002-06-20
ATE217624T1 (de) 2002-06-15
CZ290784B6 (cs) 2002-10-16
NO961173D0 (no) 1996-03-22
DK0736532T3 (da) 2002-09-02
DE19510965A1 (de) 1996-09-26
KR960034204A (ko) 1996-10-22
SI0736532T1 (en) 2002-08-31
JP4124280B2 (ja) 2008-07-23
EP0736532A1 (de) 1996-10-09
HU9600731D0 (en) 1996-05-28
CA2172472A1 (en) 1996-09-25
CN1140173A (zh) 1997-01-15
EP0736532B1 (de) 2002-05-15
TR199600217A2 (tr) 1996-10-21
US5723463A (en) 1998-03-03
NZ286232A (en) 1996-10-28
BR9601093A (pt) 1998-01-06
CN1058968C (zh) 2000-11-29
HRP960129A2 (en) 1997-08-31

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