[go: up one dir, main page]

PT736532E - Pirido¬3,2-e|pirazinonas com actividade anti-asmatica e processos para a sua preparacao - Google Patents

Pirido¬3,2-e|pirazinonas com actividade anti-asmatica e processos para a sua preparacao

Info

Publication number
PT736532E
PT736532E PT96103855T PT96103855T PT736532E PT 736532 E PT736532 E PT 736532E PT 96103855 T PT96103855 T PT 96103855T PT 96103855 T PT96103855 T PT 96103855T PT 736532 E PT736532 E PT 736532E
Authority
PT
Portugal
Prior art keywords
asmatic
pyrazinones
activity
processes
preparation
Prior art date
Application number
PT96103855T
Other languages
English (en)
Inventor
Bernhard Kutscher
Szelenyi Prof Stefan
Norbert Hofgen
Homas Buchner
Ute Achterrath-Tuckermann
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of PT736532E publication Critical patent/PT736532E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT96103855T 1995-03-24 1996-03-12 Pirido¬3,2-e|pirazinonas com actividade anti-asmatica e processos para a sua preparacao PT736532E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19510965A DE19510965A1 (de) 1995-03-24 1995-03-24 Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung

Publications (1)

Publication Number Publication Date
PT736532E true PT736532E (pt) 2002-10-31

Family

ID=7757727

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96103855T PT736532E (pt) 1995-03-24 1996-03-12 Pirido¬3,2-e|pirazinonas com actividade anti-asmatica e processos para a sua preparacao

Country Status (30)

Country Link
US (1) US5723463A (pt)
EP (1) EP0736532B1 (pt)
JP (1) JP4124280B2 (pt)
KR (1) KR100401395B1 (pt)
CN (1) CN1058968C (pt)
AR (1) AR002039A1 (pt)
AT (1) ATE217624T1 (pt)
AU (1) AU697908B2 (pt)
BR (1) BR9601093A (pt)
CA (1) CA2172472C (pt)
CZ (1) CZ290784B6 (pt)
DE (2) DE19510965A1 (pt)
DK (1) DK0736532T3 (pt)
ES (1) ES2174989T3 (pt)
HR (1) HRP960129B1 (pt)
HU (1) HUP9600731A3 (pt)
IL (1) IL117621A (pt)
MX (1) MX9601069A (pt)
NO (1) NO307091B1 (pt)
NZ (1) NZ286232A (pt)
PL (1) PL184800B1 (pt)
PT (1) PT736532E (pt)
RU (1) RU2143433C1 (pt)
SG (1) SG43249A1 (pt)
SI (1) SI0736532T1 (pt)
SK (1) SK36596A3 (pt)
TR (1) TR199600217A2 (pt)
TW (1) TW426682B (pt)
UA (1) UA45319C2 (pt)
ZA (1) ZA962270B (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2137113B1 (es) * 1997-07-29 2000-09-16 Almirall Prodesfarma Sa Nuevos derivados de triazolo-piridazinas heterociclicos.
EA200100792A1 (ru) * 1999-01-20 2002-10-31 Арцнаймиттельверк Дрезден Гмбх Применение имидазо[1,5-a]-пиридо[3,2-e]-пиразинонов в качестве лекарственных средств
DE19961302A1 (de) * 1999-12-18 2001-06-21 Dresden Arzneimittel Verwendung von Imidazo(1,5-a)-pyrido(3,2-e)-pyrazinonen als duale Inhibitoren der Phosphodiesterase 5 und der Phosphodiesterase 3 zur Therapie der Herzinsuffizienz, von pulmonaler Hypertonie und Gefäßerkrankungen, die mit einer Minderdurchblutung einhergehen
SK287231B6 (sk) 1999-08-21 2010-04-07 Nycomed Gmbh Liečivo zahŕňajúce PDE inhibítor a agonistu beta2 adrenoreceptora
US6465465B1 (en) 2000-03-14 2002-10-15 Arzneimittelwerk Dresden Gmbh Process for the treatment of erectile dysfunction and product therefor
DE10012373A1 (de) * 2000-03-14 2001-09-20 Dresden Arzneimittel Verwendung von Pyrido[3,2-e]-pyrazinonen als Inhibitoren der Phosphodiesterase 5 zur Therapie von erektiler Dysfunktion
EP1492790A1 (en) * 2002-04-03 2005-01-05 F. Hoffmann-La Roche Ag Imidazo fused compounds
WO2004039807A1 (en) * 2002-10-30 2004-05-13 Merck Frosst Canada & Co. Pyridopyrrolizine and pyridoindolizine derivatives
AU2004226353A1 (en) 2003-04-01 2004-10-14 Laboratoires Serono Sa Inhibitors of phosphodiesterases in infertility
GB0420722D0 (en) * 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200817400A (en) * 2006-05-30 2008-04-16 Elbion Ag Pyrido [3,2-e] pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them
ES2599054T3 (es) * 2006-12-13 2017-01-31 Aska Pharmaceutical Co., Ltd. Derivados de quinoxalina
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) * 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
WO2009033703A1 (en) * 2007-09-14 2009-03-19 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones
BRPI0816767B8 (pt) 2007-09-14 2021-05-25 Addex Pharmaceuticals Sa composto 4-fenil-3,4,5,6-tetra-hidro-2h,1'h-[1,4']bipiridi¬nil-2'-onas 1',3'-dissubstituídas, composição farmacêutica e uso dos mesmos
ES2365966T3 (es) 2007-09-14 2011-10-14 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. 4-(aril-x-fenil)-1h-piridin-2-onas 1,3-disustituidas.
ES2637794T3 (es) * 2007-11-14 2017-10-17 Janssen Pharmaceuticals, Inc. Derivados de imidazo[1,2-A]piridina y su uso como moduladores alostéricos positivos de receptores MGLUR2
JP2011504892A (ja) * 2007-11-30 2011-02-17 ビオティエ セラピーズ ゲゼルシャフト ミット ベシュレンクテル ハフツング ホスホジエステラーゼ１０の阻害剤としてのアリール及びヘテロアリール縮合イミダゾ（１，５−ａ）ピラジン
CN101918408A (zh) 2007-11-30 2010-12-15 惠氏有限责任公司 作为磷酸二酯酶10的抑制剂的芳基和杂芳基稠合的咪唑并[1,5-a]吡嗪
JP5547194B2 (ja) 2008-09-02 2014-07-09 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体の調節因子としての３−アザビシクロ［３．１．０］ヘキシル誘導体
BRPI0920354A2 (pt) 2008-10-16 2017-06-27 Addex Pharmaceuticals Sa derivados de indol e benzomorfolina como moduladores de receptores de glutamato metabotrópicos
CN102232074B (zh) 2008-11-28 2014-12-03 奥梅-杨森制药有限公司 作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
SG176021A1 (en) 2009-05-12 2011-12-29 Janssen Pharmaceuticals Inc 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
BRPI1010831A2 (pt) 2009-05-12 2016-04-05 Addex Pharmaceuticals Sa derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2
CN103261195B (zh) 2010-11-08 2015-09-02 杨森制药公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
AU2011328203B2 (en) 2010-11-08 2015-03-19 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
PT2649069E (pt) 2010-11-08 2015-11-20 Janssen Pharmaceuticals Inc Derivados de 1,2,4-triazolo[4,3-a]piridina e sua utilização como moduladores alostéricos positivos de recetores mglur2
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
HUE045610T2 (hu) 2014-01-21 2020-01-28 Janssen Pharmaceutica Nv 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait vagy ortosztérikus agonistáit tartalmazó kombinációk és alkalmazásuk
PH12021552653A1 (en) 2014-01-21 2023-07-17 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166344A (en) * 1989-05-31 1992-11-24 Berlex Laboratories, Inc. Process for the preparation of imidazoquinoxalinones
US5055465A (en) * 1989-05-31 1991-10-08 Berlex Laboratories, Inc. Imidazoquinoxalinones, their aza analogs and process for their preparation
US5153196A (en) * 1991-06-05 1992-10-06 Eli Lilly And Company Excitatory amino acid receptor antagonists and methods for the use thereof
AU657986B2 (en) * 1991-06-14 1995-03-30 Pharmacia & Upjohn Company Imidazo(1,5-a)quinoxalines
US5182386A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands
WO1993020077A1 (fr) * 1992-04-03 1993-10-14 Yamanouchi Pharmaceutical Co., Ltd. Derive de quinoxalinone fondue et composition pharmaceutique le contenant
DE4228095A1 (de) * 1992-08-24 1994-03-03 Asta Medica Ag Neue 4,5-Dihydro-4-oxo-pyrrolo[1,2-a]chinoxaline und entsprechende Aza-analoga und Verfahren zu deren Herstellung
JP3252483B2 (ja) * 1992-10-20 2002-02-04 東レ株式会社 ３環性トリアゾロ誘導体の製造方法
JP3252484B2 (ja) * 1992-10-20 2002-02-04 東レ株式会社 ４，５−ジヒドロ［１，２，４］トリアゾロ［４，３−ａ］キノキサリン誘導体の製造方法
DE4329970A1 (de) * 1993-03-31 1994-10-06 Basf Ag Neue Imidazolo-chinoxalinone, ihre Hestellung und Verwendung
FR2704547B1 (fr) * 1993-04-30 1995-06-09 Adir Nouveaux composés pyrrolopyraziniques, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
CN1041931C (zh) * 1993-05-06 1999-02-03 诺沃-诺迪斯克有限公司 [1,2,4]三唑并[4,3－a]喹喔啉化合物,它们的制备及其应用
CA2112290C (en) * 1993-12-23 2004-06-01 John R. Francis A clock recovery circuit for serial digital video
JP3240462B2 (ja) * 1996-05-24 2001-12-17 株式会社ケンウッド 光ディスク装置の光ピックアップサーボ装置

Also Published As

Publication number Publication date
IL117621A0 (en) 1996-07-23
JPH08269059A (ja) 1996-10-15
DK0736532T3 (da) 2002-09-02
ES2174989T3 (es) 2002-11-16
PL313434A1 (en) 1996-09-30
MX9601069A (es) 1997-02-28
TW426682B (en) 2001-03-21
CN1058968C (zh) 2000-11-29
HRP960129A2 (en) 1997-08-31
HU9600731D0 (en) 1996-05-28
SK36596A3 (en) 1997-02-05
HUP9600731A2 (en) 1997-01-28
AR002039A1 (es) 1998-01-07
CN1140173A (zh) 1997-01-15
ATE217624T1 (de) 2002-06-15
CZ290784B6 (cs) 2002-10-16
UA45319C2 (uk) 2002-04-15
NO961173L (no) 1996-09-25
NZ286232A (en) 1996-10-28
PL184800B1 (pl) 2002-12-31
CZ74796A3 (en) 1996-10-16
KR960034204A (ko) 1996-10-22
NO307091B1 (no) 2000-02-07
DE59609201D1 (de) 2002-06-20
KR100401395B1 (ko) 2003-12-24
BR9601093A (pt) 1998-01-06
JP4124280B2 (ja) 2008-07-23
DE19510965A1 (de) 1996-09-26
EP0736532B1 (de) 2002-05-15
EP0736532A1 (de) 1996-10-09
IL117621A (en) 1999-05-09
TR199600217A2 (tr) 1996-10-21
NO961173D0 (no) 1996-03-22
SI0736532T1 (en) 2002-08-31
HRP960129B1 (en) 2002-12-31
HUP9600731A3 (en) 1997-04-28
CA2172472A1 (en) 1996-09-25
ZA962270B (en) 1996-09-30
SG43249A1 (en) 1997-10-17
AU697908B2 (en) 1998-10-22
RU2143433C1 (ru) 1999-12-27
AU4825796A (en) 1996-10-03
US5723463A (en) 1998-03-03
CA2172472C (en) 2000-01-18

Similar Documents

Publication Publication Date Title
PT736532E (pt) Pirido¬3,2-e|pirazinonas com actividade anti-asmatica e processos para a sua preparacao
PT874846E (pt) Derivados de purina e processos para a sua preparacao
BR9605919A (pt) Catalisadores e processos para sua preparação
LV11614A (lv) Alaninamidi ar antidiabetisku aktivitati
DE69623300D1 (de) 2,4 pentadiensaurederivate mit retinoidartigen biologischen aktivität
HUP9601555A2 (en) Microcapsule composition, preparation thereof, pesticidal composition and use thereof
NL300295I1 (nl) 3,3-Diarylpropylaminen, de toepassing en bereiding hiervan
LV11613A (lv) Aizvietoti glicinamidi ar antidiabetisku aktivitati
AU5772296A (en) 3,4-disubstituted-phenylsulphonamides and their therapeutic use
AU5772396A (en) 3,4-disubstituted-phenylsulphonamides and their therapeutic use
DE69618634D1 (de) 1,4-benzodioxin-derivate
ZA986421B (en) 2-[Pyrazolyl-and triazolyl-3'-oxymethylene]phenylisoxa zolones, -triazolones and - tetrazolones, their preparation and their use.
PT934319E (pt) Derivados de 1h-pirido¬3,4-b|indol-4-carboxamida processo para a sua preparacao e a sua aplicacao em terapeutica
AU7095296A (en) Phosphorylamides, their preparation and use
BR9609884A (pt) N-aril- 1,2,4-triazolin-5-onas
FI960529L (fi) Antineurodegeneratiivisesti vaikuttavat 10-aminoalifatyylidibents (b,f)oksepiinit
ES1031253Y (es) Construccion modular para juegos infantiles.
IL118644A (en) N-¬(1,4-diazabicyclo¬2.2.2¾oct-2-YL)methyl¾benzamide derivatives their preparation and their application in therapeutics
AU1301797A (en) Polypeptides with interleukin 16 activity, process for the preparation and use thereof
PT755985E (pt) Misturas de corantes, processos para a sua preparacao e sua utilizacao
HUP9600730A1 (en) 1,4-tetrazolinone-derivatives and use thereof as herbicides
GR3035493T3 (en) Benzenesulphonamide derivatives, preparation thereof and therapeutical uses thereof
BR9702116A (pt) Complexos 1:2 de cromo sua produção e utilização
GB9024796D0 (en) A hinge for bulky bodies,and a fish cage incorporating the hinge
HUP9600268A1 (en) Herbicidal [1,2,4] thiadiazoles, composition, producing and using them