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AR002015A1 - DERIVADOS DE ACIDO 8-OXO-5,8-DIHIDRO-6H-DIBENZO (a, g) QUINOLIZINA-13- PROPANOICO, PROCEDIMIENTO PARA SU PREPARACION Y MEDICAMENTO Y COMPOSICIONFARMACEUTICA QUE CONTIENEN A DICHOS DERIVADOS. - Google Patents

DERIVADOS DE ACIDO 8-OXO-5,8-DIHIDRO-6H-DIBENZO (a, g) QUINOLIZINA-13- PROPANOICO, PROCEDIMIENTO PARA SU PREPARACION Y MEDICAMENTO Y COMPOSICIONFARMACEUTICA QUE CONTIENEN A DICHOS DERIVADOS.

Info

Publication number
AR002015A1
AR002015A1 ARP950100766A AR10076695A AR002015A1 AR 002015 A1 AR002015 A1 AR 002015A1 AR P950100766 A ARP950100766 A AR P950100766A AR 10076695 A AR10076695 A AR 10076695A AR 002015 A1 AR002015 A1 AR 002015A1
Authority
AR
Argentina
Prior art keywords
derivatives
group
dibenzo
oxo
pharmaceutical composition
Prior art date
Application number
ARP950100766A
Other languages
English (en)
Inventor
Benoit Marabout
Mireille Sevrin
Jacques Froissant
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of AR002015A1 publication Critical patent/AR002015A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a derivados de ácido 8-oxo-5,8-dihidro-6H- dibenzo (a, g) quinolicina-13-propanoico que responden a la fórmula general (I)en la cual X representa un átomo de hidrógeno o de halógeno o un grupo alquilo, alcoxi o trifluorometilo; Y representa un átomo de hidrógeno o de halógeno, ungrupo alquilo o alcoxi; R representa un grupo hidroxi o metoxi o un grupo de fórmula general NR2R3 en la cual R2 y R3 representan cada uno un átomo dehidrógeno o un grupo alquilo, 2-metoxietilo, 2-aminoetilo, 3-aminopropilo, 2-(dimetilamino)etilo, 3-(dimetilamino)propilo o 2-piperidino-1-iletilo otambién R2 y R3 forman juntos un ciclo morfolinilo, pirrolidinilo o piperazinilo eventualmente sustituido en posición 4. Aplicación en terapéutica.Además, se refiere a un procedimiento para preparar dichos derivados y a un medicamento y a una composición farmacéutica que los contienen.
ARP950100766A 1994-12-29 1995-12-27 DERIVADOS DE ACIDO 8-OXO-5,8-DIHIDRO-6H-DIBENZO (a, g) QUINOLIZINA-13- PROPANOICO, PROCEDIMIENTO PARA SU PREPARACION Y MEDICAMENTO Y COMPOSICIONFARMACEUTICA QUE CONTIENEN A DICHOS DERIVADOS. AR002015A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9415836A FR2728902B1 (fr) 1994-12-29 1994-12-29 Derives d'acide 8-oxo-5,8-dihydro-6h-dibenzo(a,g)quinolizine-13-propanoique, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
AR002015A1 true AR002015A1 (es) 1998-01-07

Family

ID=9470389

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP950100766A AR002015A1 (es) 1994-12-29 1995-12-27 DERIVADOS DE ACIDO 8-OXO-5,8-DIHIDRO-6H-DIBENZO (a, g) QUINOLIZINA-13- PROPANOICO, PROCEDIMIENTO PARA SU PREPARACION Y MEDICAMENTO Y COMPOSICIONFARMACEUTICA QUE CONTIENEN A DICHOS DERIVADOS.

Country Status (26)

Country Link
US (1) US5614517A (es)
EP (1) EP0719776B1 (es)
JP (1) JPH08239383A (es)
KR (1) KR960022518A (es)
CN (1) CN1058009C (es)
AR (1) AR002015A1 (es)
AT (1) ATE172973T1 (es)
AU (1) AU697988B2 (es)
BR (1) BR9506105A (es)
CA (1) CA2166233A1 (es)
CO (1) CO4700297A1 (es)
CZ (1) CZ348895A3 (es)
DE (1) DE69505781T2 (es)
DK (1) DK0719776T3 (es)
ES (1) ES2126232T3 (es)
FI (1) FI956299L (es)
FR (1) FR2728902B1 (es)
HU (1) HU215393B (es)
IL (1) IL116596A (es)
NO (1) NO305084B1 (es)
NZ (1) NZ280766A (es)
PL (1) PL181811B1 (es)
RU (1) RU2155764C2 (es)
SK (1) SK280546B6 (es)
TW (1) TW385311B (es)
ZA (1) ZA9511035B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2806723B1 (fr) * 2000-03-23 2002-05-10 Sanofi Synthelabo DERIVES D'ACIDE 8-OXO-5,8-DIHYDRO-6H-DIBENZO [a,g] QUINOLIZINE-13-PROPANOIQUE , LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
US6686352B2 (en) * 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
CN104127414B (zh) * 2013-05-03 2018-04-13 中国科学院上海药物研究所 一种六氢二苯并[a,g]喹嗪类化合物的药物用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013616A (en) * 1971-11-22 1977-03-22 Wallace Richard A Mixed polymeric structural material and method
FR2537583B1 (fr) * 1982-12-14 1985-08-09 Urpha Enantiomeres levogyres des derives de la tetrahydro-5, 6, 13, 13a 8h-dibenzo (a,g-) quinolizine, procedes d'obtention, compositions pharmaceutiques les contenant et application
GB8429710D0 (en) * 1984-11-23 1985-01-03 Fujisawa Pharmaceutical Co Pharmaceutical composition
JPS61130289A (ja) * 1984-11-29 1986-06-18 Ss Pharmaceut Co Ltd １３−プロピルベルベリンの塩
HU195505B (en) * 1985-05-24 1988-05-30 Chinoin Gyogyszer Es Vegyeszet Process for producing 7,8-methylendioxy-14-hydroxy-berban derivatives and pharmaceuticals comprising the same

Also Published As

Publication number Publication date
ATE172973T1 (de) 1998-11-15
RU2155764C2 (ru) 2000-09-10
KR960022518A (ko) 1996-07-18
HUT74186A (en) 1996-11-28
DE69505781T2 (de) 1999-06-17
EP0719776A1 (fr) 1996-07-03
DE69505781D1 (de) 1998-12-10
PL312080A1 (en) 1996-07-08
NO955325L (no) 1996-07-01
HU215393B (hu) 1998-12-28
IL116596A0 (en) 1996-03-31
HU9503846D0 (en) 1996-02-28
AU4070895A (en) 1996-07-04
SK280546B6 (sk) 2000-03-13
CN1131154A (zh) 1996-09-18
CA2166233A1 (en) 1996-06-30
NO955325D0 (no) 1995-12-28
IL116596A (en) 1998-10-30
FI956299A7 (fi) 1996-06-30
TW385311B (en) 2000-03-21
CO4700297A1 (es) 1998-12-29
NO305084B1 (no) 1999-03-29
CZ348895A3 (en) 1996-07-17
US5614517A (en) 1997-03-25
BR9506105A (pt) 1997-12-23
ES2126232T3 (es) 1999-03-16
CN1058009C (zh) 2000-11-01
FI956299L (fi) 1996-06-30
NZ280766A (en) 1996-09-25
DK0719776T3 (da) 1999-07-19
FR2728902B1 (fr) 1997-01-31
EP0719776B1 (fr) 1998-11-04
FR2728902A1 (fr) 1996-07-05
ZA9511035B (en) 1996-07-01
FI956299A0 (fi) 1995-12-28
PL181811B1 (pl) 2001-09-28
AU697988B2 (en) 1998-10-22
SK165895A3 (en) 1996-07-03
JPH08239383A (ja) 1996-09-17

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