DE69505781D1 - 8-Oxo-5,8-dihydro-6H-dibenzo[a,g]chinolizin-13-propansäure-Derivate als Liganden der mit GABAA Rezeptoren verbundenen Benzodiazepine Rezeptoren - Google Patents

8-Oxo-5,8-dihydro-6H-dibenzo[a,g]chinolizin-13-propansäure-Derivate als Liganden der mit GABAA Rezeptoren verbundenen Benzodiazepine Rezeptoren

Info

Publication number: DE69505781D1
Authority: DE; Germany
Prior art keywords: receptors; quinolizine; dibenzo; dihydro; ligands
Prior art date: 1994-12-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69505781T

Other languages

English (en)

Other versions

DE69505781T2 (de

Inventor

Benoit Marabout

Mireille Sevrin

Jacques Froissant

Emmanuelle Dachary

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Aventis France

Original Assignee

Synthelabo SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-29

Filing date

1995-12-18

Publication date

1998-12-10

1995-12-18 Application filed by Synthelabo SA filed Critical Synthelabo SA

1998-12-10 Application granted granted Critical

1998-12-10 Publication of DE69505781D1 publication Critical patent/DE69505781D1/de

1999-06-17 Publication of DE69505781T2 publication Critical patent/DE69505781T2/de

2015-12-19 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Addiction (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

DE69505781T 1994-12-29 1995-12-18 8-Oxo-5,8-dihydro-6H-dibenzo[a,g]chinolizin-13-propansäure-Derivate als Liganden der mit GABAA Rezeptoren verbundenen Benzodiazepine Rezeptoren Expired - Fee Related DE69505781T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9415836A FR2728902B1 (fr)	1994-12-29	1994-12-29	Derives d'acide 8-oxo-5,8-dihydro-6h-dibenzo(a,g)quinolizine-13-propanoique, leur preparation et leur application en therapeutique

Publications (2)

Publication Number	Publication Date
DE69505781D1 true DE69505781D1 (de)	1998-12-10
DE69505781T2 DE69505781T2 (de)	1999-06-17

Family

ID=9470389

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69505781T Expired - Fee Related DE69505781T2 (de)	1994-12-29	1995-12-18	8-Oxo-5,8-dihydro-6H-dibenzo[a,g]chinolizin-13-propansäure-Derivate als Liganden der mit GABAA Rezeptoren verbundenen Benzodiazepine Rezeptoren

Country Status (26)

Country	Link
US (1)	US5614517A (de)
EP (1)	EP0719776B1 (de)
JP (1)	JPH08239383A (de)
KR (1)	KR960022518A (de)
CN (1)	CN1058009C (de)
AR (1)	AR002015A1 (de)
AT (1)	ATE172973T1 (de)
AU (1)	AU697988B2 (de)
BR (1)	BR9506105A (de)
CA (1)	CA2166233A1 (de)
CO (1)	CO4700297A1 (de)
CZ (1)	CZ348895A3 (de)
DE (1)	DE69505781T2 (de)
DK (1)	DK0719776T3 (de)
ES (1)	ES2126232T3 (de)
FI (1)	FI956299A7 (de)
FR (1)	FR2728902B1 (de)
HU (1)	HU215393B (de)
IL (1)	IL116596A (de)
NO (1)	NO305084B1 (de)
NZ (1)	NZ280766A (de)
PL (1)	PL181811B1 (de)
RU (1)	RU2155764C2 (de)
SK (1)	SK280546B6 (de)
TW (1)	TW385311B (de)
ZA (1)	ZA9511035B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2806723B1 (fr) *	2000-03-23	2002-05-10	Sanofi Synthelabo	DERIVES D'ACIDE 8-OXO-5,8-DIHYDRO-6H-DIBENZO [a,g] QUINOLIZINE-13-PROPANOIQUE , LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
US6686352B2 (en) *	2001-05-18	2004-02-03	Hoffmann-La Roche Inc.	Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
CN104127414B (zh) *	2013-05-03	2018-04-13	中国科学院上海药物研究所	一种六氢二苯并[a,g]喹嗪类化合物的药物用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4013616A (en) *	1971-11-22	1977-03-22	Wallace Richard A	Mixed polymeric structural material and method
FR2537583B1 (fr) *	1982-12-14	1985-08-09	Urpha	Enantiomeres levogyres des derives de la tetrahydro-5, 6, 13, 13a 8h-dibenzo (a,g-) quinolizine, procedes d'obtention, compositions pharmaceutiques les contenant et application
GB8429710D0 (en) *	1984-11-23	1985-01-03	Fujisawa Pharmaceutical Co	Pharmaceutical composition
JPS61130289A (ja) *	1984-11-29	1986-06-18	Ss Pharmaceut Co Ltd	１３−プロピルベルベリンの塩
HU195505B (en) *	1985-05-24	1988-05-30	Chinoin Gyogyszer Es Vegyeszet	Process for producing 7,8-methylendioxy-14-hydroxy-berban derivatives and pharmaceuticals comprising the same

1994
- 1994-12-29 FR FR9415836A patent/FR2728902B1/fr not_active Expired - Fee Related
1995
- 1995-12-18 DE DE69505781T patent/DE69505781T2/de not_active Expired - Fee Related
- 1995-12-18 DK DK95402841T patent/DK0719776T3/da active
- 1995-12-18 EP EP95402841A patent/EP0719776B1/de not_active Expired - Lifetime
- 1995-12-18 AT AT95402841T patent/ATE172973T1/de not_active IP Right Cessation
- 1995-12-18 ES ES95402841T patent/ES2126232T3/es not_active Expired - Lifetime
- 1995-12-21 NZ NZ280766A patent/NZ280766A/en unknown
- 1995-12-27 TW TW084113949A patent/TW385311B/zh not_active IP Right Cessation
- 1995-12-27 AR ARP950100766A patent/AR002015A1/es unknown
- 1995-12-28 CZ CZ953488A patent/CZ348895A3/cs unknown
- 1995-12-28 NO NO955325A patent/NO305084B1/no not_active IP Right Cessation
- 1995-12-28 CN CN95120636A patent/CN1058009C/zh not_active Expired - Fee Related
- 1995-12-28 RU RU95122601/04A patent/RU2155764C2/ru active
- 1995-12-28 CA CA002166233A patent/CA2166233A1/en not_active Abandoned
- 1995-12-28 PL PL95312080A patent/PL181811B1/pl unknown
- 1995-12-28 FI FI956299A patent/FI956299A7/fi unknown
- 1995-12-28 CO CO95062143A patent/CO4700297A1/es unknown
- 1995-12-28 KR KR1019950061342A patent/KR960022518A/ko not_active Ceased
- 1995-12-28 BR BR9506105A patent/BR9506105A/pt not_active Application Discontinuation
- 1995-12-28 IL IL11659695A patent/IL116596A/en not_active IP Right Cessation
- 1995-12-28 ZA ZA9511035A patent/ZA9511035B/xx unknown
- 1995-12-28 JP JP7342620A patent/JPH08239383A/ja not_active Withdrawn
- 1995-12-28 SK SK1658-95A patent/SK280546B6/sk unknown
- 1995-12-28 HU HU9503846A patent/HU215393B/hu not_active IP Right Cessation
- 1995-12-28 AU AU40708/95A patent/AU697988B2/en not_active Ceased
- 1995-12-28 US US08/580,295 patent/US5614517A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CO4700297A1 (es)	1998-12-29
FR2728902A1 (fr)	1996-07-05
ES2126232T3 (es)	1999-03-16
DK0719776T3 (da)	1999-07-19
HUT74186A (en)	1996-11-28
TW385311B (en)	2000-03-21
PL312080A1 (en)	1996-07-08
NO305084B1 (no)	1999-03-29
PL181811B1 (pl)	2001-09-28
CN1131154A (zh)	1996-09-18
HU9503846D0 (en)	1996-02-28
RU2155764C2 (ru)	2000-09-10
FI956299L (fi)	1996-06-30
ATE172973T1 (de)	1998-11-15
DE69505781T2 (de)	1999-06-17
HU215393B (hu)	1998-12-28
BR9506105A (pt)	1997-12-23
NO955325D0 (no)	1995-12-28
CZ348895A3 (en)	1996-07-17
KR960022518A (ko)	1996-07-18
EP0719776B1 (de)	1998-11-04
AU4070895A (en)	1996-07-04
IL116596A (en)	1998-10-30
AR002015A1 (es)	1998-01-07
FI956299A0 (fi)	1995-12-28
CA2166233A1 (en)	1996-06-30
NZ280766A (en)	1996-09-25
AU697988B2 (en)	1998-10-22
CN1058009C (zh)	2000-11-01
ZA9511035B (en)	1996-07-01
SK165895A3 (en)	1996-07-03
NO955325L (no)	1996-07-01
FI956299A7 (fi)	1996-06-30
FR2728902B1 (fr)	1997-01-31
EP0719776A1 (de)	1996-07-03
IL116596A0 (en)	1996-03-31
US5614517A (en)	1997-03-25
JPH08239383A (ja)	1996-09-17
SK280546B6 (sk)	2000-03-13

Publication	Publication Date	Title
NO954735D0 (no)	1995-11-23	Ligander for flt3-reseptorer
ATE264105T1 (de)	2004-04-15	Neue substituierte imidazolverbindungen
DE59501802D1 (de)	1998-05-14	Substituierte 1H-3-Aryl-pyrrolidin-2,4-dion-Derivate
FI953523L (fi)	1996-01-24	Fenyyli-3-dimetyyliamino-propaaniyhdisteet, joilla on farmakologista vaikutusta
PT738150E (pt)	2003-08-29	Antagonistas biciclicos de fibrinogenio
ATE290001T1 (de)	2005-03-15	Neue substituierte imidazolverbindungen
FI971234A7 (fi)	1997-05-23	Imidatsolijohdannainen
FI972970A7 (fi)	1997-09-11	Uusia yhdisteitä
FI960519L (fi)	1996-08-07	Uusia yhdisteitä
FI962749L (fi)	1996-09-04	Uusia heterosyklisiä yhdisteitä
DE69505780D1 (de)	1998-12-10	3-Phenylisochinolin-1(2H)-one-Derivate als Liganden der mit GABAA Rezeptoren verbundenen Benzodiazepine Rezeptoren
DK0820451T3 (da)	2003-05-12	Hidtil ukendte heterocykliske forbindelser
ITTO910865A0 (it)	1991-11-12	Nuovi composti tricicli
FI971674L (fi)	1997-04-18	Heterosyklisen ryhmän sisältämät di-tert-butyyli-fenoliyhdisteet, käyttökelpoisia tulehduksenvastaisina aineina
DE69505781D1 (de)	1998-12-10	8-Oxo-5,8-dihydro-6H-dibenzo[a,g]chinolizin-13-propansäure-Derivate als Liganden der mit GABAA Rezeptoren verbundenen Benzodiazepine Rezeptoren
FI943808A7 (fi)	1994-10-24	Triatsolopyrimidiinijohdannaisia angiotensiini II:n reseptoreiden vast avaikuttajina
KR970013921U (ko)	1997-04-28	건축용 다용도 브라켓
BR9507892A (pt)	1997-11-18	Novos derivados de diamino-metilideno
HUP9900377A2 (hu)	1999-05-28	Új eljárás 2,3-dihidro-benzofurán-származékok előállítására
ITTO910353A0 (it)	1991-05-13	Nuovi composti triciclici, procedimento per la loro preparazione
NO20000995D0 (no)	2000-02-28	Optisk rene camptotecin analoger, optisk rent mellomprodukt, fremgangsmõte for fremstilling av disse
TR199501356A2 (tr)	1996-06-21	Sübstitüe edilmis tetrasiklik azepin türevleri.
FI972862A7 (fi)	1997-09-03	Uudet stafylokinaasijohdannaiset
DE69527785D1 (de)	2002-09-19	Chinuclidin-n-oxidderivate als muscarin rezeptor liganden
FI903967A7 (fi)	1991-02-11	Uusia imidatsolijohdannaisia

Legal Events

Date	Code	Title	Description
1999-12-02	8364	No opposition during term of opposition
2000-12-28	8327	Change in the person/name/address of the patent owner	Owner name: SANOFI-SYNTHELABO, PARIS, FR
2002-11-07	8339	Ceased/non-payment of the annual fee