AR009484A1 - Un compuesto de acido n-sustituido-2-amino-4-fenil-4-oxo-butanoico, su utilizacion como inhibidor de la quinurenina-3-hidroxilasa y una composicionfarmaceutica que lo comprende. - Google Patents
Un compuesto de acido n-sustituido-2-amino-4-fenil-4-oxo-butanoico, su utilizacion como inhibidor de la quinurenina-3-hidroxilasa y una composicionfarmaceutica que lo comprende.Info
- Publication number
- AR009484A1 AR009484A1 ARP970103945A ARP970103945A AR009484A1 AR 009484 A1 AR009484 A1 AR 009484A1 AR P970103945 A ARP970103945 A AR P970103945A AR P970103945 A ARP970103945 A AR P970103945A AR 009484 A1 AR009484 A1 AR 009484A1
- Authority
- AR
- Argentina
- Prior art keywords
- phenyl
- alkyl
- alkenyl
- benzyl
- substituted
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- -1 N-SUBSTITUTED-2-AMINO-4-PHENYL-4-OXO-BUTANOIC ACID Chemical class 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 4
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000006528 (C2-C6) alkyl group Chemical group 0.000 abstract 1
- UTQNKKSJPHTPBS-UHFFFAOYSA-N 2,2,2-trichloroethanone Chemical group ClC(Cl)(Cl)[C]=O UTQNKKSJPHTPBS-UHFFFAOYSA-N 0.000 abstract 1
- 102100037652 Kynurenine 3-monooxygenase Human genes 0.000 abstract 1
- 108010033242 Kynurenine 3-monooxygenase Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 101150003374 sor2 gene Proteins 0.000 abstract 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Compuestos de ácido N-sustituido-2-amino-4-oxo butanoico de la formula (I) donde cada uno de los grupos X e Y son, de manera independiente, hidrogeno,halogeno, nitro, alquilo C1-C6; alquenilo C2-C4; alquinilo C2-C4; alcoxi C1-C6; alquiltio C1-C6; SOR2 o SO2R2, donde R2 es alquilo C2-C6, fenilo o bencilo; oSO2N(R3)2, donde cada uno de los grupos R3 son, de manera independiente, hidrogeno, alquilo C1-C6, alquenilo C2-C4, alquinilo C2-C4, fenilo o bencilo; Res hidroxi, -OR5, donde R5 es alquilo C1-C6, alquenilo C2-C4, alquinilo C2-C4 o bencilo; -N(R3)OR3, donde cada R3 es tal como se la definiera antes; W es-COOR4, -COR4 o -SO2R4, donde R4 es alquilo C1-C6, un alquenilo C2-C4 opcionalemente sustituido, un fenilo o bencilo opcionalmente sustituido;-CONHR5 o -CSNHR5, donde R5 es tal como se definiría antes; tricloroacetilo; o trifluoroacetilo; o las sales farmacéuticamente aceptables de ls mismos, parasu utilizacion como un medicamento, en particular como un inhibidor dela quinurenina 3-hidroxilasa, la utilizacion de tales compuestos; composicionesfarmacéuticas que los comprenden; un grupo de compuestos seleccionados de tales compuestos de formula (I), ya sea, en la forma de enantiomeros simples o comouna mezcla de enantiomeros o una sal farmacéuticamente aceptable de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9618349.6A GB9618349D0 (en) | 1996-09-03 | 1996-09-03 | N-substituted 2-amino-4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibitory activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR009484A1 true AR009484A1 (es) | 2000-04-26 |
Family
ID=10799321
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970103945A AR009484A1 (es) | 1996-09-03 | 1997-08-29 | Un compuesto de acido n-sustituido-2-amino-4-fenil-4-oxo-butanoico, su utilizacion como inhibidor de la quinurenina-3-hidroxilasa y una composicionfarmaceutica que lo comprende. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6207709B1 (es) |
| EP (1) | EP0931056A1 (es) |
| JP (1) | JP2001501179A (es) |
| AR (1) | AR009484A1 (es) |
| AU (1) | AU4117297A (es) |
| CA (1) | CA2263250A1 (es) |
| GB (1) | GB9618349D0 (es) |
| WO (1) | WO1998009938A1 (es) |
| ZA (1) | ZA977833B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9725055D0 (en) * | 1997-11-26 | 1998-01-28 | Pharmacia & Upjohn Spa | 1,3,4-thiadiazoles compounds |
| US6541521B1 (en) | 1999-07-12 | 2003-04-01 | Warner-Lambert Company | Benzene butyric acids and their derivatives as inhibitors of matrix metalloproteinases |
| IT1317049B1 (it) * | 2000-06-23 | 2003-05-26 | Sigma Tau Ind Farmaceuti | Composti utili per la preparazione di medicamenti ad attivita'inibitrice della fosfodiesterasi iv. |
| JP2005060311A (ja) * | 2003-08-13 | 2005-03-10 | Mochida Pharmaceut Co Ltd | Ｎ−（ベンゾイル）アミノ酸誘導体を有効成分とするニューロパシー性疼痛治療剤 |
| KR100560845B1 (ko) | 2003-10-09 | 2006-03-13 | 에스케이 텔레콤주식회사 | Ｍｍ-ｍｂ 단말기의 모뎀 간 절체 방법 |
| EP2054397B1 (en) * | 2006-08-16 | 2015-10-07 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Small molecule inhibitors of kynurenine-3-monooxygenase |
| DK2420494T3 (en) | 2006-08-16 | 2015-01-12 | J David Gladstone Inst A Testamentary Trust Established Under The Will Of J David Gladstone | Use of thiadiazole compounds as inhibitors of kynurenine 3-monooxygenase |
| US11229810B2 (en) * | 2017-05-17 | 2022-01-25 | University Of Virginia Patent Foundation | Methods and systems for producing neuronal lesions using magnetic resonance and acoustic energy |
| MX2020003811A (es) | 2017-10-05 | 2021-01-15 | Biogen Inc | Proceso para preparar derivados de alfa-carboxamida pirrolidina. |
| CN112236412B (zh) | 2018-02-09 | 2024-01-30 | 维斯塔津治疗公司 | 4-氯代犬尿氨酸及中间体的合成 |
| KR20210150528A (ko) * | 2019-04-10 | 2021-12-10 | 바이오젠 인크. | 알파-카르복스아미드 피롤리딘 유도체 제조 방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4758661A (en) * | 1986-06-24 | 1988-07-19 | Merck & Co., Inc. | Chiral synthesis of (+)-trans-1a,2,3,4a,5,6-hexahydro-9-hydroxy-4-propyl-4H-naphth[1,2-b]-1,4-oxazine |
| US5495044A (en) * | 1991-04-18 | 1996-02-27 | University Of Georgia Research Foundation, Inc. | Inhibitors of kynureninase |
| IT1265101B1 (it) * | 1993-07-23 | 1996-10-30 | Erba Carlo Spa | Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico |
| US5519055A (en) * | 1993-08-06 | 1996-05-21 | University Of Maryland At Baltimore | Substituted kynurenines and process for their preparation |
| GB9521486D0 (en) * | 1995-10-20 | 1995-12-20 | Pharmacia Spa | Fluoro-substituted benzoylpropionic acid derivatives |
-
1996
- 1996-09-03 GB GBGB9618349.6A patent/GB9618349D0/en active Pending
-
1997
- 1997-07-31 US US09/147,722 patent/US6207709B1/en not_active Expired - Fee Related
- 1997-07-31 WO PCT/EP1997/004271 patent/WO1998009938A1/en not_active Ceased
- 1997-07-31 EP EP97938879A patent/EP0931056A1/en not_active Ceased
- 1997-07-31 CA CA002263250A patent/CA2263250A1/en not_active Abandoned
- 1997-07-31 JP JP10512157A patent/JP2001501179A/ja not_active Withdrawn
- 1997-07-31 AU AU41172/97A patent/AU4117297A/en not_active Abandoned
- 1997-08-29 AR ARP970103945A patent/AR009484A1/es unknown
- 1997-09-01 ZA ZA9707833A patent/ZA977833B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB9618349D0 (en) | 1996-10-16 |
| AU4117297A (en) | 1998-03-26 |
| US6207709B1 (en) | 2001-03-27 |
| WO1998009938A1 (en) | 1998-03-12 |
| JP2001501179A (ja) | 2001-01-30 |
| EP0931056A1 (en) | 1999-07-28 |
| ZA977833B (en) | 1998-03-02 |
| CA2263250A1 (en) | 1998-03-12 |
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