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AR008829A1 - Derivados 6,6- o 6,7 biciclicos sustituidos que contienen pirido o pirimido como agentes antagonistas para el tratamiento de enfermedades gastrointestinales, inflamatorias y del snc, y composicion farmaceutica - Google Patents

Derivados 6,6- o 6,7 biciclicos sustituidos que contienen pirido o pirimido como agentes antagonistas para el tratamiento de enfermedades gastrointestinales, inflamatorias y del snc, y composicion farmaceutica

Info

Publication number
AR008829A1
AR008829A1 ARP970103560A ARP970103560A AR008829A1 AR 008829 A1 AR008829 A1 AR 008829A1 AR P970103560 A ARP970103560 A AR P970103560A AR P970103560 A ARP970103560 A AR P970103560A AR 008829 A1 AR008829 A1 AR 008829A1
Authority
AR
Argentina
Prior art keywords
nitrogen
sulfur
oxygen
atoms
cr6r12
Prior art date
Application number
ARP970103560A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of AR008829A1 publication Critical patent/AR008829A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • AIDS & HIV (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se refiere a un compuesto de formula (I) en la que las líneas de trazos representan dobles enlaces opcionales; A es nitrogeno o CR7; B es -NR1R2,CR1R2R10, - C(=CR2R11)R1, -NHCR1R2R10, OCR1R2R10, -SCR1R2R10, -CR2R10NHR1, -CR2R10OR1,CR2R10SR1 o -COR2, y está unido mediante un enlace sencillo a D;o B es -CR1R2 y está unido mediante un doble enlace a D, y D es carbono; D es nitrogeno o CR4 y está unido mediante un enlace sencillo a todos losátomos a los que se encuentraunido, o D es carbono y está unido mediante un doble enlace a E o mediante un doble enlace a B; E es oxígeno, nitrogeno,azufre, C=O, C=S, CR6R12, NR6 o CR6; o E es un separador de dos átomos, en el que uno de los átomos es oxígeno,nitrogeno, azufre, C=O, C=S, CR6R12,NR6 o E es oxígeno, nitrogeno, azufre, C=O, C=S, CR6R12, NR6 o CR6; o E es un separador de dos átomos, en el que uno de los átomos es oxígeno, nitrogeno,azufre, C=O, C=S, CR6R12, NR6 o CR6, y el otro esCR6R12 o CR9; K y G son cada uno, de forma independiente, C=O, C=S, azufre, oxígeno, CHR8 o NR8,cuando están unidos por medio de enlaces sencillos a los átomos adyacentes del anillo, o nitrogeno o CR8 cuando están unidos por medio de undobleenlace a un átomo adyacent e del anillo; el anillo de 6 o 7 eslabones que contiene D, E, K y G puede contener de uno a tres dobles enlaces, de cero ados heteroátomos seleccionados entre oxígeno, nitrogeno y azufre, y de cero a dosgrupos C=O o C=S, en los que los át omos de carbono de tales grupos formanparte del anillo y los átomos de oxígeno y azufre son sustituyentes del anillo; y R1, R2, R4, R6, R8, R9, R10, R11, R12 son como se describe en lamemoria. Dichoscompuestos son utiles como antagonistas pa ra el tratamiento de enfermedades gastrointestinales, inflamatorias y del SNC.
ARP970103560A 1996-08-06 1997-08-05 Derivados 6,6- o 6,7 biciclicos sustituidos que contienen pirido o pirimido como agentes antagonistas para el tratamiento de enfermedades gastrointestinales, inflamatorias y del snc, y composicion farmaceutica AR008829A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2345396P 1996-08-06 1996-08-06

Publications (1)

Publication Number Publication Date
AR008829A1 true AR008829A1 (es) 2000-02-23

Family

ID=21815208

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970103560A AR008829A1 (es) 1996-08-06 1997-08-05 Derivados 6,6- o 6,7 biciclicos sustituidos que contienen pirido o pirimido como agentes antagonistas para el tratamiento de enfermedades gastrointestinales, inflamatorias y del snc, y composicion farmaceutica

Country Status (40)

Country Link
US (1) US6492520B1 (es)
EP (1) EP0920429B1 (es)
JP (1) JP3345021B2 (es)
KR (1) KR20000029843A (es)
CN (1) CN1093130C (es)
AP (1) AP1096A (es)
AR (1) AR008829A1 (es)
AT (1) ATE232863T1 (es)
AU (1) AU709203B2 (es)
BG (1) BG103143A (es)
BR (1) BR9710808A (es)
CA (1) CA2262692C (es)
CO (1) CO4900060A1 (es)
CZ (1) CZ292806B6 (es)
DE (1) DE69719193T2 (es)
DK (1) DK0920429T3 (es)
DZ (1) DZ2289A1 (es)
EA (1) EA003188B1 (es)
ES (1) ES2191183T3 (es)
GT (1) GT199700089A (es)
HR (1) HRP970432B1 (es)
ID (1) ID17980A (es)
IL (1) IL128188A0 (es)
IS (1) IS4948A (es)
MA (1) MA24296A1 (es)
NO (1) NO313293B1 (es)
NZ (1) NZ333727A (es)
OA (1) OA10970A (es)
PA (1) PA8435201A1 (es)
PE (1) PE97098A1 (es)
PL (1) PL331602A1 (es)
SA (1) SA97180334A (es)
SK (1) SK14099A3 (es)
TN (1) TNSN97135A1 (es)
TR (1) TR199900228T2 (es)
TW (1) TW550265B (es)
UY (1) UY24655A1 (es)
WO (1) WO1998005661A1 (es)
YU (1) YU5399A (es)
ZA (1) ZA976954B (es)

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CN1227552A (zh) 1999-09-01
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US6492520B1 (en) 2002-12-10
ES2191183T3 (es) 2003-09-01
WO1998005661A1 (en) 1998-02-12
AP9701052A0 (en) 1997-10-31
MA24296A1 (fr) 1998-04-01
PE97098A1 (es) 1999-01-12
EA003188B1 (ru) 2003-02-27
DE69719193D1 (de) 2003-03-27
ID17980A (id) 1998-02-12
NO990544L (no) 1999-03-31
TR199900228T2 (xx) 1999-03-22
EP0920429A1 (en) 1999-06-09
NZ333727A (en) 2000-09-29
UY24655A1 (es) 2000-09-29
IL128188A0 (en) 1999-11-30
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IS4948A (is) 1999-01-19
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CA2262692C (en) 2002-06-11
YU5399A (sh) 2002-03-18
TW550265B (en) 2003-09-01
AP1096A (en) 2002-08-26
PA8435201A1 (es) 1999-12-27
CZ41199A3 (cs) 2000-01-12
HRP970432A2 (en) 1998-08-31
CO4900060A1 (es) 2000-03-27
EP0920429B1 (en) 2003-02-19
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