AR009413A1 - Un compuesto, el cual es un derivado de distamicina benzoheterociclico, su utilizacion, un procedimiento para producirlo y una composicionfarmaceutica que lo comprende - Google Patents
Un compuesto, el cual es un derivado de distamicina benzoheterociclico, su utilizacion, un procedimiento para producirlo y una composicionfarmaceutica que lo comprendeInfo
- Publication number
- AR009413A1 AR009413A1 ARP970105209A ARP970105209A AR009413A1 AR 009413 A1 AR009413 A1 AR 009413A1 AR P970105209 A ARP970105209 A AR P970105209A AR P970105209 A ARP970105209 A AR P970105209A AR 009413 A1 AR009413 A1 AR 009413A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivative
- alkyl
- pharmaceutical composition
- distamicina
- benzoheterociclico
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000118 anti-neoplastic effect Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- UPBAOYRENQEPJO-UHFFFAOYSA-N n-[5-[[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-formamido-1-methylpyrrole-2-carboxamide Chemical class CN1C=C(NC=O)C=C1C(=O)NC1=CN(C)C(C(=O)NC2=CN(C)C(C(=O)NCCC(N)=N)=C2)=C1 UPBAOYRENQEPJO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un derivado de distamicina benzoheterocíclico de la formula (I), donde: n es 2, 3 o 4; A es O, S o NR, donde R es hidrogeno o alquilo C1-C4; B es CH oN; R1 es hidrogeno o alquilo C1-C4; T se selecciona entre: (i) de ka formula (II), donde: p escero o 1; R2 y R3 se seleccionan, cada una de maneraindependiente, entre: hidrogeno, alquilo C1-C4 opcionalmente sustituido por uno o más átomos de fluor, y alcoxi C1-C4; R4 es alquilo C1-C4 o haloalquiloC1-C3; X1 es un átomo de halogeno; y (ii) de la formula (III), donde X2 es un átomo de halogeno; y las sales farmacéuticamente aceptables de los mismos,su utilizacion, un procedimiento para producir dicho derivado y una composicion farmacéutica que lo comprende. Los compuestos son utiles como agentesantineoplásicos y antivirales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9623522.1A GB9623522D0 (en) | 1996-11-11 | 1996-11-11 | Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR009413A1 true AR009413A1 (es) | 2000-04-12 |
Family
ID=10802813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970105209A AR009413A1 (es) | 1996-11-11 | 1997-11-10 | Un compuesto, el cual es un derivado de distamicina benzoheterociclico, su utilizacion, un procedimiento para producirlo y una composicionfarmaceutica que lo comprende |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6153642A (es) |
| EP (1) | EP0937070B1 (es) |
| JP (1) | JP2001504109A (es) |
| AR (1) | AR009413A1 (es) |
| AU (1) | AU5121698A (es) |
| CA (1) | CA2271299A1 (es) |
| DE (1) | DE69726593T2 (es) |
| ES (1) | ES2212138T3 (es) |
| GB (1) | GB9623522D0 (es) |
| WO (1) | WO1998021202A1 (es) |
| ZA (1) | ZA979997B (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9806692D0 (en) * | 1998-03-27 | 1998-05-27 | Pharmacia & Upjohn Spa | Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents |
| EP1146881B1 (de) * | 1999-02-04 | 2006-01-04 | Jörn Bullerdiek | Mittel zur prävention und/oder behandlung einer gewebeveränderung mesenchymalen ursprungs |
| US6559125B1 (en) | 2000-01-28 | 2003-05-06 | California Institute Of Technology | Polyamide-alkylator conjugates and related products and method |
| GB0011059D0 (en) * | 2000-05-08 | 2000-06-28 | Pharmacia & Upjohn Spa | Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione |
| GB0015446D0 (en) | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites |
| GB0015444D0 (en) | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors |
| GB0015447D0 (en) | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents |
| GB0016447D0 (en) | 2000-07-04 | 2000-08-23 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
| IT1318696B1 (it) | 2000-09-15 | 2003-08-27 | Pharmacia & Upjohn Spa | Coniugati di glutatione con derivati della distamicina ad attivita'antitumorale. |
| GB0029004D0 (en) | 2000-11-28 | 2001-01-10 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
| AU2002312371A1 (en) * | 2001-06-13 | 2002-12-23 | Roland W. Burli | Aryl-benzimidazole compounds having antiinfective activity |
| WO2002100852A1 (en) | 2001-06-13 | 2002-12-19 | Genesoft Pharmaceuticals, Inc. | Benzothiophene compounds having antiinfective activity |
| AU2002312370A1 (en) | 2001-06-13 | 2002-12-23 | Roland W. Burli | Antipathogenic benzamide compounds |
| ITTO20010633A1 (it) * | 2001-07-02 | 2003-01-02 | Univ Ferrara | Nuovo impiego di poliammidi eterocicliche e benzoeterocicliche strutturalmente correlate all'antibiotico naturale distamicina a. |
| US6969592B2 (en) | 2001-09-26 | 2005-11-29 | Pharmacia Italia S.P.A. | Method for predicting the sensitivity to chemotherapy |
| GB0130868D0 (en) | 2001-12-24 | 2002-02-06 | Univ Strathclyde | New compounds |
| US7498349B2 (en) | 2002-08-02 | 2009-03-03 | Genesoft Pharmaceuticals, Inc. | Biaryl compounds having anti-infective activity |
| WO2004026264A2 (en) | 2002-09-20 | 2004-04-01 | Genelabs Technologies, Inc. | Novel aromatic compounds possessing antifungal or antibacterial activity |
| US20050215614A1 (en) * | 2002-10-15 | 2005-09-29 | Rigel Pharmaceuticals, Inc. | Substituted indoles and their use as hcv inhibitors |
| WO2004039318A2 (en) * | 2002-10-25 | 2004-05-13 | Genesoft Pharmaceuticals, Inc. | Anti-infective biaryl compounds |
| US7129214B2 (en) | 2002-12-10 | 2006-10-31 | Oscient Pharmaceuticals Corporation | Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif |
| DE102006026764A1 (de) * | 2006-06-09 | 2007-12-13 | Comsort Gmbh | Verfahren zum Ausschleusen von auf einem Sortiertisch einer Fördervorrichtung angeordnetem Stückgut sowie Sortiertisch und Vorrichtung zum Transportieren und Vereinzeln von Stückgut |
| GB0619325D0 (en) | 2006-09-30 | 2006-11-08 | Univ Strathclyde | New compounds |
| CN102807540A (zh) * | 2012-09-06 | 2012-12-05 | 无锡万全医药技术有限公司 | 一种新的5-氨基苯并呋喃-2-甲酸的制备方法 |
| CN104845967B (zh) | 2015-04-15 | 2020-12-11 | 苏州新海生物科技股份有限公司 | 寡聚核苷酸片段及使用其的选择性扩增目标核酸序列变异体的方法及应用 |
| WO2018047148A1 (en) | 2016-09-12 | 2018-03-15 | Novartis Ag | Compounds for the inhibition of mirna |
| EP3963085A4 (en) * | 2019-05-01 | 2022-09-14 | The University of North Carolina at Chapel Hill | RNA-BINDING PROTEIN INHIBITORS, COMPOSITIONS THEREOF, AND THERAPEUTIC USES THEREOF |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8612218D0 (en) * | 1986-05-20 | 1986-06-25 | Erba Farmitalia | Site specific alkylating agents |
| IT1262921B (it) * | 1992-01-10 | 1996-07-22 | Federico Arcamone | Agenti antitumorali analoghi di oligopeptidi pirrol-amidinici retroversi processi di preparazione e prodotti farmaceutici che li contengono |
| IT1271456B (it) * | 1993-03-01 | 1997-05-28 | Menarini Farma Ind | Composti pirrol-amidinici, e loro sali farmaceuticamente accettabili, processi di preparazione e composizioni farmaceutiche che li contengono |
| GB9416005D0 (en) * | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Peptidic compounds analogous to distamycin a and process for their preparation |
| GB9514993D0 (en) * | 1995-07-21 | 1995-09-20 | Pharmacia Spa | Site specific phenyl nitrogen mustards |
-
1996
- 1996-11-11 GB GBGB9623522.1A patent/GB9623522D0/en active Pending
-
1997
- 1997-10-23 EP EP97945879A patent/EP0937070B1/en not_active Expired - Lifetime
- 1997-10-23 CA CA002271299A patent/CA2271299A1/en not_active Abandoned
- 1997-10-23 US US09/284,958 patent/US6153642A/en not_active Expired - Fee Related
- 1997-10-23 WO PCT/EP1997/005986 patent/WO1998021202A1/en not_active Ceased
- 1997-10-23 AU AU51216/98A patent/AU5121698A/en not_active Abandoned
- 1997-10-23 JP JP52210098A patent/JP2001504109A/ja not_active Ceased
- 1997-10-23 ES ES97945879T patent/ES2212138T3/es not_active Expired - Lifetime
- 1997-10-23 DE DE1997626593 patent/DE69726593T2/de not_active Expired - Fee Related
- 1997-11-06 ZA ZA9709997A patent/ZA979997B/xx unknown
- 1997-11-10 AR ARP970105209A patent/AR009413A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US6153642A (en) | 2000-11-28 |
| JP2001504109A (ja) | 2001-03-27 |
| GB9623522D0 (en) | 1997-01-08 |
| WO1998021202A1 (en) | 1998-05-22 |
| CA2271299A1 (en) | 1998-05-22 |
| ES2212138T3 (es) | 2004-07-16 |
| DE69726593T2 (de) | 2004-11-18 |
| EP0937070B1 (en) | 2003-12-03 |
| DE69726593D1 (de) | 2004-01-15 |
| EP0937070A1 (en) | 1999-08-25 |
| AU5121698A (en) | 1998-06-03 |
| ZA979997B (en) | 1998-05-25 |
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