YU5399A - Supstituisani pirido-ili pirimido-derivati koji sadrže 6,6- ili 6,7-biciklične prstenove - Google Patents
Supstituisani pirido-ili pirimido-derivati koji sadrže 6,6- ili 6,7-biciklične prstenoveInfo
- Publication number
- YU5399A YU5399A YU5399A YU5399A YU5399A YU 5399 A YU5399 A YU 5399A YU 5399 A YU5399 A YU 5399A YU 5399 A YU5399 A YU 5399A YU 5399 A YU5399 A YU 5399A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- pyrimido
- substituted pyrido
- bicyclic derivatives
- compounds
- bicyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Ovaj pronalazak se odnosi na jedinjenja formule (I) u kojoj su A, B, D, E, K, G, Z, R3 i R5 definisani kao u specifikaciji i za farmaceutski prihvatljive soli takvih jedinjenja. Jedinjenja formule (I) su antagonisti CRF (CRH) faktora otpuštanja kortikotropina (hormona).[This invention relates to compounds of formula (I), wherein A, B, D, E, K, G, Z, R3 and R5 are defined as in the specification, and to the pharmaceutically acceptable salts of such compounds. Compounds (I) are corticotropin releasing factor (hormone) CRF (CRH) antagonists.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2345396P | 1996-08-06 | 1996-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU5399A true YU5399A (sh) | 2002-03-18 |
Family
ID=21815208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU5399A YU5399A (sh) | 1996-08-06 | 1997-07-23 | Supstituisani pirido-ili pirimido-derivati koji sadrže 6,6- ili 6,7-biciklične prstenove |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US6492520B1 (sh) |
| EP (1) | EP0920429B1 (sh) |
| JP (1) | JP3345021B2 (sh) |
| KR (1) | KR20000029843A (sh) |
| CN (1) | CN1093130C (sh) |
| AP (1) | AP1096A (sh) |
| AR (1) | AR008829A1 (sh) |
| AT (1) | ATE232863T1 (sh) |
| AU (1) | AU709203B2 (sh) |
| BG (1) | BG103143A (sh) |
| BR (1) | BR9710808A (sh) |
| CA (1) | CA2262692C (sh) |
| CO (1) | CO4900060A1 (sh) |
| CZ (1) | CZ292806B6 (sh) |
| DE (1) | DE69719193T2 (sh) |
| DK (1) | DK0920429T3 (sh) |
| DZ (1) | DZ2289A1 (sh) |
| EA (1) | EA003188B1 (sh) |
| ES (1) | ES2191183T3 (sh) |
| GT (1) | GT199700089A (sh) |
| HR (1) | HRP970432B1 (sh) |
| ID (1) | ID17980A (sh) |
| IL (1) | IL128188A0 (sh) |
| IS (1) | IS4948A (sh) |
| MA (1) | MA24296A1 (sh) |
| NO (1) | NO313293B1 (sh) |
| NZ (1) | NZ333727A (sh) |
| OA (1) | OA10970A (sh) |
| PA (1) | PA8435201A1 (sh) |
| PE (1) | PE97098A1 (sh) |
| PL (1) | PL331602A1 (sh) |
| SA (1) | SA97180334A (sh) |
| SK (1) | SK14099A3 (sh) |
| TN (1) | TNSN97135A1 (sh) |
| TR (1) | TR199900228T2 (sh) |
| TW (1) | TW550265B (sh) |
| UY (1) | UY24655A1 (sh) |
| WO (1) | WO1998005661A1 (sh) |
| YU (1) | YU5399A (sh) |
| ZA (1) | ZA976954B (sh) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6187777B1 (en) | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
| ATE266399T1 (de) | 1998-08-20 | 2004-05-15 | Smithkline Beecham Corp | Neue substituierte triazolverbindungen |
| BR9915129A (pt) | 1998-11-12 | 2001-08-07 | Neurocrine Biosciences Inc | Antagonistas do receptor de crf e processos relacionados aos mesmos |
| US6514982B1 (en) | 1998-11-12 | 2003-02-04 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
| US6432989B1 (en) * | 1999-08-27 | 2002-08-13 | Pfizer Inc | Use of CRF antagonists to treat circadian rhythm disorders |
| IL139197A0 (en) * | 1999-10-29 | 2001-11-25 | Pfizer Prod Inc | Use of corticotropin releasing factor antagonists and related compositions |
| WO2001058489A1 (en) * | 2000-02-14 | 2001-08-16 | Japan Tobacco Inc. | Preventives/remedies for postoperative stress |
| AU2001234180A1 (en) * | 2000-02-25 | 2001-09-03 | Japan Tobacco Inc. | Benzamide derivative and use thereof |
| US7235551B2 (en) * | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
| AR030053A1 (es) * | 2000-03-02 | 2003-08-13 | Smithkline Beecham Corp | 1h-pirimido [4,5-d] pirimidin-2-onas y sales, composiciones farmaceuticas, uso para la fabricacion de un medicamento y procedimiento para producirlas |
| GB0011964D0 (en) | 2000-05-18 | 2000-07-05 | Suyal N | Thick glass films with controlled refractive indices and their applications |
| CN1847229B (zh) | 2000-10-23 | 2011-05-04 | 史密丝克莱恩比彻姆公司 | 2，4，8-三取代-8H-吡啶并[2，3-d]嘧啶-7-酮化合物 |
| GB0117396D0 (en) | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
| BR0212864A (pt) | 2001-09-26 | 2004-08-17 | Bayer Pharmaceuticals Corp | Derivados de 1,6-naftiridina como antidiabéticos |
| EP1499320B1 (en) | 2002-04-19 | 2007-08-22 | Smithkline Beecham Corporation | Novel compounds |
| FR2846657B1 (fr) * | 2002-11-05 | 2004-12-24 | Servier Lab | Nouveaux composes pyridopyrimidinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US7109337B2 (en) | 2002-12-20 | 2006-09-19 | Pfizer Inc | Pyrimidine derivatives for the treatment of abnormal cell growth |
| AU2003285614B2 (en) | 2002-12-20 | 2009-05-14 | Pfizer Products, Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| GB0308208D0 (en) | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
| AU2004253967B2 (en) | 2003-07-03 | 2010-02-18 | Cytovia, Inc. | 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis |
| US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| WO2005020910A2 (en) * | 2003-08-27 | 2005-03-10 | Pharmacia Corporation | Cyclooxygenase-2 selective inhibitor and corticotropin releasing factor antagonist compositions for treating ischemic mediated cns disorders or injuries |
| CA2562244A1 (en) * | 2004-04-07 | 2005-10-27 | Takeda Pharmaceutical Company Limited | Cyclic compounds |
| JP2007537238A (ja) | 2004-05-14 | 2007-12-20 | ファイザー・プロダクツ・インク | 異常細胞増殖の治療のためのピリミジン誘導体 |
| WO2005111024A1 (en) | 2004-05-14 | 2005-11-24 | Pfizer Products Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| JP2007537230A (ja) | 2004-05-14 | 2007-12-20 | ファイザー・プロダクツ・インク | 異常細胞増殖の処置用のピリミジン誘導体 |
| US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| CA2592900A1 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
| EP1868612A4 (en) * | 2005-03-25 | 2010-03-24 | Glaxo Group Ltd | NOVEL CONNECTIONS |
| UY29440A1 (es) * | 2005-03-25 | 2006-10-02 | Glaxo Group Ltd | Nuevos compuestos |
| CN101495475A (zh) * | 2005-03-25 | 2009-07-29 | 葛兰素集团有限公司 | 制备吡啶并[2,3-d]嘧啶-7-酮和3,4-二氢嘧啶并[4,5-d]嘧啶-2(1H)-酮衍生物的方法 |
| PE20061193A1 (es) | 2005-03-25 | 2006-12-02 | Glaxo Group Ltd | DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2-[1H]-0NA COMO INHIBIDORES DE QUINASA p38 |
| PT1888548E (pt) | 2005-05-26 | 2012-10-30 | Neuron Systems Inc | Derivado de quinolina para o tratamento de doenças da retina |
| ATE475660T1 (de) | 2005-12-21 | 2010-08-15 | Abbott Lab | Antivirale verbindungen |
| US7910595B2 (en) | 2005-12-21 | 2011-03-22 | Abbott Laboratories | Anti-viral compounds |
| EP2345652A1 (en) | 2005-12-21 | 2011-07-20 | Abbott Laboratories | Antiviral compounds |
| CN101384592A (zh) * | 2005-12-21 | 2009-03-11 | 艾博特公司 | 抗病毒化合物 |
| WO2007081517A2 (en) | 2005-12-21 | 2007-07-19 | Abbott Laboratories | Anti-viral compounds |
| EP2094276A4 (en) | 2006-12-20 | 2011-01-05 | Abbott Lab | ANTIVIRAL COMPOUNDS |
| SG172060A1 (en) | 2008-12-09 | 2011-07-28 | Gilead Sciences Inc | Modulators of toll-like receptors |
| US8551996B2 (en) * | 2009-02-20 | 2013-10-08 | Emory University | Compounds, compositions, methods of synthesis, and methods of treatment |
| AU2010292102B2 (en) | 2009-09-14 | 2015-04-09 | Gilead Sciences, Inc. | Modulators of Toll-like receptors |
| CA2782015C (en) | 2009-12-11 | 2020-08-25 | Neuron Systems, Inc. | Topical ophthalmic compositions and methods for the treatment of macular degeneration |
| US8754114B2 (en) | 2010-12-22 | 2014-06-17 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3 |
| CN107652289B (zh) | 2012-06-13 | 2020-07-21 | 因塞特控股公司 | 作为fgfr抑制剂的取代的三环化合物 |
| US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
| CA3195807A1 (en) | 2013-01-23 | 2014-07-31 | Aldeyra Therapeutics, Inc. | Toxic aldehyde related diseases and treatment |
| KR102269032B1 (ko) | 2013-04-19 | 2021-06-24 | 인사이트 홀딩스 코포레이션 | Fgfr 저해제로서 이환식 헤테로사이클 |
| US10882868B2 (en) | 2014-05-15 | 2021-01-05 | Hoffmann-La Roche Inc. | Compounds for treating spinal muscular atrophy |
| EA035068B1 (ru) * | 2014-05-15 | 2020-04-23 | Ф. Хоффманн-Ля Рош Аг | Соединения для лечения спинальной мышечной атрофии |
| CN113577081A (zh) | 2014-07-11 | 2021-11-02 | 吉利德科学公司 | 用于治疗hiv的toll样受体调节剂 |
| ES2845205T3 (es) | 2014-09-16 | 2021-07-26 | Gilead Sciences Inc | Métodos para preparar moduladores de receptores tipo Toll |
| UY36298A (es) | 2014-09-16 | 2016-04-29 | Gilead Science Inc | Formas sólidas de un modulador del receptor tipo toll |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
| PE20171514A1 (es) | 2015-02-20 | 2017-10-20 | Incyte Corp | Heterociclos biciclicos como inhibidores de fgfr |
| EP3317278B1 (en) | 2015-07-01 | 2021-04-14 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| MX2018002155A (es) | 2015-08-21 | 2018-06-08 | Aldeyra Therapeutics Inc | Compuestos deuterados y usos de los mismos. |
| MX379159B (es) | 2016-02-12 | 2025-03-10 | Astellas Pharma Inc | Derivados de tetrahidroisoquinolina. |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| EP3658560A4 (en) | 2017-07-25 | 2021-01-06 | Crinetics Pharmaceuticals, Inc. | SOMATOSTAT IN MODULATORS AND USES THEREOF |
| JP7311162B2 (ja) * | 2017-10-10 | 2023-07-19 | アルデイラ セラピューティクス， インコーポレイテッド | 炎症性障害の処置 |
| SG11202010636VA (en) | 2018-05-04 | 2020-11-27 | Incyte Corp | Solid forms of an fgfr inhibitor and processes for preparing the same |
| BR112020022373A2 (pt) | 2018-05-04 | 2021-02-02 | Incyte Corporation | sais de um inibidor de fgfr |
| US12006298B2 (en) | 2018-08-06 | 2024-06-11 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| CN113056353B (zh) | 2018-09-25 | 2022-11-01 | 奥尔德拉医疗公司 | 用于治疗干眼病的调配物 |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| US11786518B2 (en) | 2019-03-26 | 2023-10-17 | Aldeyra Therapeutics, Inc. | Ophthalmic formulations and uses thereof |
| CN113784954A (zh) | 2019-05-02 | 2021-12-10 | 奥尔德拉医疗公司 | 多晶型化合物和其用途 |
| WO2020223717A1 (en) | 2019-05-02 | 2020-11-05 | Aldeyra Therapeutics, Inc. | Process for preparation of aldehyde scavenger and intermediates |
| WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021067374A1 (en) | 2019-10-01 | 2021-04-08 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021076602A1 (en) | 2019-10-14 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| WO2021076728A1 (en) | 2019-10-16 | 2021-04-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| CN115151539A (zh) | 2019-12-04 | 2022-10-04 | 因赛特公司 | Fgfr抑制剂的衍生物 |
| JP7720840B2 (ja) | 2019-12-04 | 2025-08-08 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤としての三環式複素環 |
| WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
| JP2023526016A (ja) | 2020-05-13 | 2023-06-20 | アルデイラ セラピューティクス， インコーポレイテッド | 医薬製剤およびその使用 |
| US12065494B2 (en) | 2021-04-12 | 2024-08-20 | Incyte Corporation | Combination therapy comprising an FGFR inhibitor and a Nectin-4 targeting agent |
| AR126102A1 (es) | 2021-06-09 | 2023-09-13 | Incyte Corp | Heterociclos tricíclicos como inhibidores de fgfr |
| CA3220155A1 (en) | 2021-06-09 | 2022-12-15 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4605642A (en) | 1984-02-23 | 1986-08-12 | The Salk Institute For Biological Studies | CRF antagonists |
| US5063245A (en) | 1990-03-28 | 1991-11-05 | Nova Pharmaceutical Corporation | Corticotropin-releasing factor antagonism compounds |
| AU661533B2 (en) * | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
| PL176526B1 (pl) * | 1992-12-17 | 1999-06-30 | Pfizer | Pirolopirymidyny jako związki o działaniu antagonistów czynnika uwalniającego kortykotropinę |
| TW444018B (en) * | 1992-12-17 | 2001-07-01 | Pfizer | Pyrazolopyrimidines |
| IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
| TW574214B (en) * | 1994-06-08 | 2004-02-01 | Pfizer | Corticotropin releasing factor antagonists |
| JP2891544B2 (ja) * | 1994-06-16 | 1999-05-17 | ファイザー・インコーポレーテッド | ピラゾロおよびピロロピリジン類 |
| JP2898887B2 (ja) * | 1994-08-31 | 1999-06-02 | 沖電気工業株式会社 | Ｉｃカードの読み取り装置 |
| EP0729758A3 (en) * | 1995-03-02 | 1997-10-29 | Pfizer | Pyrazolopyrimidines and pyrrolopyrimidines for the treatment of neuronal and other diseases |
| AU716993B2 (en) * | 1995-05-12 | 2000-03-16 | Neurogen Corporation | Novel deazapurine derivatives; a new class of CRF1 specific ligands |
| US6403599B1 (en) * | 1995-11-08 | 2002-06-11 | Pfizer Inc | Corticotropin releasing factor antagonists |
| EP0778277B1 (en) * | 1995-12-08 | 2003-06-25 | Pfizer Inc. | Substituted heterocyclic derivatives as CRF antagonists |
| PT880523E (pt) | 1996-02-07 | 2007-01-31 | Neurocrine Biosciences Inc | Pirazolopirimidinas com antagonistas dos receptores de crf |
| TW477787B (en) | 1996-08-27 | 2002-03-01 | Pfizer | Pyrido six-membered nitrogen-containing cyclic ring derivatives having corticotropin releasing factor antagonist activity and pharmaceutical composition containing same |
-
1997
- 1997-07-23 PL PL97331602A patent/PL331602A1/xx unknown
- 1997-07-23 CZ CZ1999411A patent/CZ292806B6/cs not_active IP Right Cessation
- 1997-07-23 YU YU5399A patent/YU5399A/sh unknown
- 1997-07-23 DK DK97929472T patent/DK0920429T3/da active
- 1997-07-23 DE DE69719193T patent/DE69719193T2/de not_active Expired - Fee Related
- 1997-07-23 CN CN97197079A patent/CN1093130C/zh not_active Expired - Fee Related
- 1997-07-23 US US09/242,076 patent/US6492520B1/en not_active Expired - Fee Related
- 1997-07-23 CA CA002262692A patent/CA2262692C/en not_active Expired - Fee Related
- 1997-07-23 NZ NZ333727A patent/NZ333727A/xx unknown
- 1997-07-23 JP JP50775498A patent/JP3345021B2/ja not_active Expired - Fee Related
- 1997-07-23 TR TR1999/00228T patent/TR199900228T2/xx unknown
- 1997-07-23 EP EP97929472A patent/EP0920429B1/en not_active Expired - Lifetime
- 1997-07-23 IL IL12818897A patent/IL128188A0/xx unknown
- 1997-07-23 BR BR9710808A patent/BR9710808A/pt not_active Application Discontinuation
- 1997-07-23 AU AU33563/97A patent/AU709203B2/en not_active Ceased
- 1997-07-23 KR KR1019997001005A patent/KR20000029843A/ko not_active Abandoned
- 1997-07-23 WO PCT/IB1997/000918 patent/WO1998005661A1/en not_active Ceased
- 1997-07-23 ES ES97929472T patent/ES2191183T3/es not_active Expired - Lifetime
- 1997-07-23 EA EA199900083A patent/EA003188B1/ru not_active IP Right Cessation
- 1997-07-23 AT AT97929472T patent/ATE232863T1/de not_active IP Right Cessation
- 1997-07-23 SK SK140-99A patent/SK14099A3/sk unknown
- 1997-07-31 AP APAP/P/1997/001052A patent/AP1096A/en active
- 1997-08-04 GT GT199700089A patent/GT199700089A/es unknown
- 1997-08-04 TW TW086111115A patent/TW550265B/zh active
- 1997-08-05 CO CO97044966A patent/CO4900060A1/es unknown
- 1997-08-05 UY UY24655A patent/UY24655A1/es not_active IP Right Cessation
- 1997-08-05 PE PE1997000679A patent/PE97098A1/es not_active Application Discontinuation
- 1997-08-05 AR ARP970103560A patent/AR008829A1/es not_active Application Discontinuation
- 1997-08-05 ZA ZA976954A patent/ZA976954B/xx unknown
- 1997-08-05 PA PA19978435201A patent/PA8435201A1/es unknown
- 1997-08-05 ID IDP972708A patent/ID17980A/id unknown
- 1997-08-06 MA MA24755A patent/MA24296A1/fr unknown
- 1997-08-06 DZ DZ970139A patent/DZ2289A1/fr active
- 1997-08-06 TN TNTNSN97135A patent/TNSN97135A1/fr unknown
- 1997-08-06 HR HR970432A patent/HRP970432B1/xx not_active IP Right Cessation
- 1997-08-25 SA SA97180334A patent/SA97180334A/ar unknown
-
1999
- 1999-01-19 IS IS4948A patent/IS4948A/is unknown
- 1999-02-03 OA OA9900024A patent/OA10970A/en unknown
- 1999-02-03 BG BG103143A patent/BG103143A/xx unknown
- 1999-02-05 NO NO19990544A patent/NO313293B1/no not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| YU5399A (sh) | Supstituisani pirido-ili pirimido-derivati koji sadrže 6,6- ili 6,7-biciklične prstenove | |
| CA2263913A1 (en) | Substituted 6,6-hetero-bicyclic derivatives | |
| ES2160949T3 (es) | Derivados de fenilen-sulfonamida sustituidos en meta. | |
| PL327735A1 (en) | Novel substituted derivatives of imidazole | |
| PL327934A1 (en) | Novel substituted imidazole compounds | |
| AU1889392A (en) | Fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles | |
| MY115416A (en) | Quinolone-and naphthyridone-carboxylic acid derivatives | |
| HU9501738D0 (en) | Methods for administering crf antagonists | |
| HU9400623D0 (en) | Substituted 1h-imidazo(4,5-c)quinolin-4-amines, pharmaceutical compositions containing them as active components and intermediates for them | |
| BG103964A (en) | SUBSTITUTED PYRAZOLS AS p38 KINASE INHIBITORS | |
| AU4064597A (en) | Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof | |
| YU41199A (sh) | Hinoksalindioni | |
| ES2188984T3 (es) | Procedimiento de enriquecimiento en r de epimeros de derivados de 16,17-acetales de derivados de 21-aciloxi-pregnano-1,4-dieno-11-beta, 16alfa-triol-3,20-dionas. | |
| WO1992014696A3 (en) | SUBSTITUTED α-AMINOALDEHYDES AND DERIVATIVES | |
| TR199801268T2 (xx) | Ta�ikinin antagonistleri olarak 3-Azetidinilalkilpiperidinler veya pirolidinler. | |
| MD502G2 (ro) | Derivaţi noi ai adenozinei, procedee de preparare a lor, compoziţii farmaceutice ce le conţin | |
| MX9702203A (es) | Derivados de pirazolil-pirazol substituidos, procedimientos para su preparacion y su uso como agentes con accion herbicida. | |
| RU95106653A (ru) | Производные 2-имидазолин-5-онов и 2-имидазолин-5-тионов и фунгицидные композиции на их основе | |
| MX9801201A (es) | Mezclas fungicidas. | |
| TW344650B (en) | Fungicidal compositions and the process for the preparation thereof | |
| AU2639388A (en) | 2-cyano-2-aryl-1-(azole-1-yl)- ethane derivatives | |
| UA70975C2 (uk) | Похідні 1,4-діарил-2-фтор-1-бутен-3-олу, спосіб їх одержання та способи одержання похідних 1,4-діарил-2-фтор-1,3-бутадієну і 1,4-діарил-2-фтор-2-бутену | |
| MX9703899A (es) | Derivado de arilacrilamida. | |
| BG102613A (en) | New substituted imidazoles | |
| ES2151820A1 (es) | Herbicidas a base de derivados de 1,3-oxazin-4-ona, composiciones que los contienen y procedimiento para su preparacion. |