AR008483A1 - Una sustancia cristalina de cefditoren pivoxil y la produccion de la misma. - Google Patents
Una sustancia cristalina de cefditoren pivoxil y la produccion de la misma.Info
- Publication number
- AR008483A1 AR008483A1 ARP970104349A ARP970104349A AR008483A1 AR 008483 A1 AR008483 A1 AR 008483A1 AR P970104349 A ARP970104349 A AR P970104349A AR P970104349 A ARP970104349 A AR P970104349A AR 008483 A1 AR008483 A1 AR 008483A1
- Authority
- AR
- Argentina
- Prior art keywords
- crystalline substance
- cefditoren pivoxil
- pivoxil
- cefditoren
- substance
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Liquid Crystal Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Se revela una nueva sustancia cristalina de Cefditoren pivoxil, a saber, el pivaloilmetil éster del ácido 7-[(CZ)-2-(2-aminotiazol-4-ilo)-2metoxiiminoacetamido]-3-[(Z)-2-(4-metiltiazol-5-ilo)etenilo]-3-efem-4- carboxílico. Dicha sustancia cristalinade Cefditoren pivozil, de altapureza y estabilidad es de forma ortorombica y tiene un punto de fusion con descomposicion a una temperatura del rango de 206,2°C a 215,7°C como fueevaluado a partir del pico de absorcion térmica mostrand o en lacurva de flujo de calor de dicha sustancia determinada por medio de un calorímetrode escaneo diferencial, que un cristal unico de dicha sustancia cristalina tiene una densidad de 1,21 a 1,23 gm/cm3 y que contienen 4 moléculas deCe fditoren pivoxildentro de una unidad recticular del cristal unico, que dicha sustancia cristalina tiene una pureza del 97% al 98% para el componente deCefditoren pivoxil, tal como fue medido de una cromatografía líquida con la utilizacion de una fase reversade columna de gel de sílice y por medio dela deteccion de absorcion de rayos ultra-violeta, y que dicha sustancia cristalina tiene una más alta estabilidad térmica que la sustancia conocida deCefditoren pivoxil. Se describe a demás su procedimientode preparacion, que consiste esencialmente en disolver el Cefditoren pivoxil amorfo en un primersolvente orgánico anhidro, mezclar dicha solucion con un alcanol C1-C5 anhidro, concentrar a presion reducida, por deb ajo de 15°C, hastaunaconcentracion de 50 a 250 mg/ml de Cefditoren pivoxil y cristalizar completamente induciendo con agua y agitacion a temperatura igual, o pordebajo de, 10°C.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP24956196 | 1996-09-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR008483A1 true AR008483A1 (es) | 2000-01-19 |
Family
ID=17194838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970104349A AR008483A1 (es) | 1996-09-20 | 1997-09-22 | Una sustancia cristalina de cefditoren pivoxil y la produccion de la misma. |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US6294669B1 (es) |
| EP (1) | EP0937083B1 (es) |
| JP (1) | JP3403206B2 (es) |
| KR (1) | KR100441907B1 (es) |
| CN (1) | CN1116299C (es) |
| AR (1) | AR008483A1 (es) |
| AT (1) | ATE238310T1 (es) |
| AU (1) | AU714735B2 (es) |
| BR (1) | BR9712072A (es) |
| CA (1) | CA2265686C (es) |
| CZ (1) | CZ295199B6 (es) |
| DE (1) | DE69721290T2 (es) |
| EA (1) | EA001526B1 (es) |
| ES (1) | ES2198593T3 (es) |
| HU (1) | HU224196B1 (es) |
| ID (1) | ID22064A (es) |
| IL (1) | IL129016A (es) |
| NZ (1) | NZ334883A (es) |
| PL (1) | PL189548B1 (es) |
| PT (1) | PT937083E (es) |
| RO (1) | RO120196B1 (es) |
| SK (1) | SK284973B6 (es) |
| TR (1) | TR199900614T2 (es) |
| UA (1) | UA55426C2 (es) |
| WO (1) | WO1998012200A1 (es) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9712072A (pt) * | 1996-09-20 | 1999-08-24 | Meiji Seika Kaisha | Subst-ncia cristalina de defditoren pivoxil e a produ-Æo da mesma |
| IL137004A0 (en) | 1998-01-07 | 2001-06-14 | Meiji Seika Kaisha | Crystallographically stable amorphous cephalosporin compositions and process for producing the same |
| NZ517706A (en) * | 1999-10-08 | 2004-01-30 | Affinium Pharm Inc | Fab I inhibitors |
| HU226640B1 (en) * | 1999-10-18 | 2009-05-28 | Egis Gyogyszergyar Nyilvanosan | Process for producing amorphous atorvastatin calcium salt |
| JP2001131071A (ja) * | 1999-10-29 | 2001-05-15 | Meiji Seika Kaisha Ltd | 非晶質および非晶質を含有する医薬組成物 |
| DE60230934D1 (de) * | 2001-04-06 | 2009-03-05 | Affinium Pharm Inc | Fab-i-inhibitoren |
| ATE499116T1 (de) * | 2002-08-16 | 2011-03-15 | Immunogen Inc | Vernetzer mit hoher reaktivität und löslichkeit und ihre verwendung bei der herstellung von konjugaten für die gezielte abgabe von kleinmolekularen arzneimitteln |
| US8648065B2 (en) * | 2002-10-02 | 2014-02-11 | Meiji Seika Pharma Co., Ltd. | Antibacterial medicinal composition of enhanced oral absorptivity |
| US7244842B2 (en) * | 2002-11-15 | 2007-07-17 | Orchid Chemicals & Pharmaceuticals Ltd. | Amorphous hydrate of a cephalosporin antibiotic |
| ES2518316T3 (es) * | 2002-12-06 | 2014-11-05 | Debiopharm International Sa | Compuestos heterocíclicos, métodos de fabricación de los mismos y su uso en terapia |
| ATE409485T1 (de) * | 2003-03-17 | 2008-10-15 | Affinium Pharm Inc | Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend |
| JP5230934B2 (ja) * | 2003-03-27 | 2013-07-10 | バジリア ファルマスーチカ アーゲー | 結晶形態のセファロスポリン |
| US8088387B2 (en) * | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| WO2005016936A2 (en) * | 2003-08-14 | 2005-02-24 | Ranbaxy Laboratories Limited | Process for selective preparation of z-isomer of cefditoren and pharmaceutically acceptable salts and esters thereof |
| US20070053973A1 (en) * | 2003-10-08 | 2007-03-08 | Shigeru Chikase | Amorphous antibiotic composition comprising cefditoren pivoxil |
| JP2007510709A (ja) * | 2003-11-07 | 2007-04-26 | ランバクシー ラボラトリーズ リミテッド | 高純度３−（２−置換ビニル）セファロスポリンの製法 |
| JP2005162696A (ja) * | 2003-12-04 | 2005-06-23 | Nichiko Pharmaceutical Co Ltd | 溶出性に優れたセフジトレンピボキシル製剤 |
| SI1828167T1 (sl) * | 2004-06-04 | 2014-12-31 | Debiopharm International Sa Forum "Apres-Demain" | Akrilamidni derivati kot anitibiotična sredstva |
| WO2006024900A1 (en) * | 2004-08-31 | 2006-03-09 | Ranbaxy Laboratories Limited | Highly pure cefditoren pivoxil |
| EP1973902A2 (en) * | 2005-12-05 | 2008-10-01 | Affinium Pharmaceuticals, Inc. | 3-heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents |
| US20080069879A1 (en) * | 2006-05-02 | 2008-03-20 | Ravishekhar Bhiwgade | Stable solid dosage form containing amorphous cefditoren pivoxil and process for preparation thereof |
| EP2687533B1 (en) | 2006-07-20 | 2017-07-19 | Debiopharm International SA | Acrylamide derivatives as FAB I inhibitors |
| US8263613B2 (en) * | 2007-02-16 | 2012-09-11 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab I inhibitors |
| EP2520578A1 (en) | 2011-05-06 | 2012-11-07 | Lupin Limited | Process for purification of cephalosporins |
| CN103421025B (zh) * | 2012-05-21 | 2016-05-11 | 上海医药工业研究院 | 制备7α-甲氧基头孢菌素C的方法 |
| RS58898B1 (sr) | 2012-06-19 | 2019-08-30 | Debiopharm Int Sa | Prolek derivati (e)-n-metil-n-((3-metilbenzofuran-2-il)metil)-3-(7-okso-5,6,7,8-tetrahidro-1,8-naftiridin-3-il)akrilamida |
| KR101561963B1 (ko) * | 2013-05-23 | 2015-10-22 | 영진약품공업 주식회사 | 세프디토렌 피복실의 신규 결정 형태 및 이의 제조 방법 |
| CN103665002B (zh) * | 2013-12-18 | 2016-02-03 | 成都医路康医学技术服务有限公司 | 一种头孢妥仑匹酯的制备方法 |
| WO2016114727A1 (en) | 2015-01-16 | 2016-07-21 | Öğün Yusuf Toktamiş | Cefditoren pivoxil compositions with improved stability and production methods thereof |
| PT3419628T (pt) | 2016-02-26 | 2021-01-05 | Debiopharm Int Sa | Medicamento para o tratamento de infeções do pé diabético |
| CA3129508A1 (en) | 2019-02-14 | 2020-08-20 | Debiopharm International S.A. | Solid formulations of afabicin with histidine |
| CN113939306B (zh) | 2019-06-14 | 2024-07-19 | 德彪药业国际股份公司 | 用于治疗涉及生物膜的细菌感染的药物及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE58487B1 (en) * | 1984-09-07 | 1993-09-22 | Kaisha Maiji Seika | New cephalosporin compounds and the production thereof |
| DE69427365T2 (de) * | 1993-09-29 | 2002-02-28 | Meiji Seika Kaisha Ltd., Tokio/Tokyo | Neue cephalosporinderivate |
| DK0658558T3 (da) * | 1993-11-17 | 2001-04-17 | Biochemie Gmbh | Adskillelse af cephalosporinisomere |
| BR9712072A (pt) * | 1996-09-20 | 1999-08-24 | Meiji Seika Kaisha | Subst-ncia cristalina de defditoren pivoxil e a produ-Æo da mesma |
-
1997
- 1997-09-19 BR BR9712072A patent/BR9712072A/pt not_active Application Discontinuation
- 1997-09-19 PL PL97332314A patent/PL189548B1/pl unknown
- 1997-09-19 KR KR10-1999-7002385A patent/KR100441907B1/ko not_active Expired - Lifetime
- 1997-09-19 CZ CZ1999975A patent/CZ295199B6/cs not_active IP Right Cessation
- 1997-09-19 EP EP97940434A patent/EP0937083B1/en not_active Expired - Lifetime
- 1997-09-19 ES ES97940434T patent/ES2198593T3/es not_active Expired - Lifetime
- 1997-09-19 ID IDW990100A patent/ID22064A/id unknown
- 1997-09-19 CN CN97199098A patent/CN1116299C/zh not_active Expired - Lifetime
- 1997-09-19 AU AU42222/97A patent/AU714735B2/en not_active Expired
- 1997-09-19 EA EA199900311A patent/EA001526B1/ru not_active IP Right Cessation
- 1997-09-19 SK SK354-99A patent/SK284973B6/sk not_active IP Right Cessation
- 1997-09-19 NZ NZ334883A patent/NZ334883A/xx not_active IP Right Cessation
- 1997-09-19 RO RO99-00280A patent/RO120196B1/ro unknown
- 1997-09-19 AT AT97940434T patent/ATE238310T1/de active
- 1997-09-19 TR TR1999/00614T patent/TR199900614T2/xx unknown
- 1997-09-19 IL IL12901697A patent/IL129016A/xx not_active IP Right Cessation
- 1997-09-19 CA CA002265686A patent/CA2265686C/en not_active Expired - Lifetime
- 1997-09-19 UA UA99042171A patent/UA55426C2/uk unknown
- 1997-09-19 JP JP51452298A patent/JP3403206B2/ja not_active Expired - Lifetime
- 1997-09-19 HU HU9903454A patent/HU224196B1/hu active IP Right Grant
- 1997-09-19 PT PT97940434T patent/PT937083E/pt unknown
- 1997-09-19 DE DE69721290T patent/DE69721290T2/de not_active Expired - Lifetime
- 1997-09-19 WO PCT/JP1997/003340 patent/WO1998012200A1/en not_active Ceased
- 1997-09-19 US US09/269,109 patent/US6294669B1/en not_active Expired - Lifetime
- 1997-09-22 AR ARP970104349A patent/AR008483A1/es active IP Right Grant
-
2001
- 2001-05-15 US US09/854,462 patent/US6441162B2/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |