AR008294A1 - Lineas celulares inmortalizadas espontaneamente, y metodo para producir y usar dichas celulas para la produccion de virus - Google Patents
Lineas celulares inmortalizadas espontaneamente, y metodo para producir y usar dichas celulas para la produccion de virusInfo
- Publication number
- AR008294A1 AR008294A1 ARP970103696A ARP970103696A AR008294A1 AR 008294 A1 AR008294 A1 AR 008294A1 AR P970103696 A ARP970103696 A AR P970103696A AR P970103696 A ARP970103696 A AR P970103696A AR 008294 A1 AR008294 A1 AR 008294A1
- Authority
- AR
- Argentina
- Prior art keywords
- cell lines
- producing
- production
- viruses
- cells
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 241000287828 Gallus gallus Species 0.000 abstract 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000002950 fibroblast Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/867—Retroviral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/04—Immortalised cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16651—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12051—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Rheumatology (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Métodos para producir líneas celulares espontáneamente inmortalizadas de fibroblastos embriónicos de pollo, particularmente líneas celulares,cultivos y subclones de las mismas que tienen las características de UMNSAH-DF1, y que seus an en la propagación de virus, expresión de proteínasrecombinantes y producción de virus recombinantes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/696,200 US5672485A (en) | 1996-08-13 | 1996-08-13 | Immortalized cell lines for virus growth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR008294A1 true AR008294A1 (es) | 1999-12-29 |
Family
ID=24796108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970103696A AR008294A1 (es) | 1996-08-13 | 1997-08-13 | Lineas celulares inmortalizadas espontaneamente, y metodo para producir y usar dichas celulas para la produccion de virus |
Country Status (28)
| Country | Link |
|---|---|
| US (4) | US5672485A (es) |
| EP (1) | EP0920491B1 (es) |
| JP (3) | JP3754088B2 (es) |
| KR (1) | KR100375871B1 (es) |
| CN (1) | CN1228119B (es) |
| AR (1) | AR008294A1 (es) |
| AT (1) | ATE362524T1 (es) |
| AU (1) | AU726820B2 (es) |
| BR (1) | BR9711067A (es) |
| CA (1) | CA2263725C (es) |
| CO (1) | CO4700552A1 (es) |
| DE (1) | DE69737735T2 (es) |
| DK (1) | DK0920491T3 (es) |
| DZ (1) | DZ2291A1 (es) |
| ES (1) | ES2285738T3 (es) |
| GT (1) | GT199700091A (es) |
| HN (1) | HN1997000124A (es) |
| HU (1) | HU226658B1 (es) |
| IL (4) | IL128511A (es) |
| MA (1) | MA24303A1 (es) |
| MY (1) | MY125594A (es) |
| NZ (1) | NZ334147A (es) |
| PE (1) | PE108198A1 (es) |
| PT (1) | PT920491E (es) |
| SV (1) | SV1997000071A (es) |
| UY (1) | UY24668A1 (es) |
| WO (1) | WO1998006824A1 (es) |
| ZA (1) | ZA977216B (es) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5672485A (en) * | 1996-08-13 | 1997-09-30 | Regents Of The University Of Minnesota | Immortalized cell lines for virus growth |
| US6150505A (en) * | 1997-09-19 | 2000-11-21 | Hadasit Medical Research Services & Development Ltd. | Fibrin microbeads prepared from fibrinogen, thrombin and factor XIII |
| US6821741B1 (en) * | 2001-04-27 | 2004-11-23 | University Hospitals Of Cleveland | Cells for detection of enteroviruses |
| US6552172B2 (en) | 2001-08-30 | 2003-04-22 | Habto Biotech, Inc. | Fibrin nanoparticles and uses thereof |
| US20040210954A1 (en) * | 2003-03-07 | 2004-10-21 | Alex Harvey | Integrase mediated avian transgenesis |
| US20040023358A1 (en) * | 2001-12-21 | 2004-02-05 | Wyeth | Avian embryo particulate biomass for the production of virus antigens |
| FR2836924B1 (fr) | 2002-03-08 | 2005-01-14 | Vivalis | Lignees de cellules aviaires utiles pour la production de substances d'interet |
| US20090217404A1 (en) * | 2002-09-27 | 2009-08-27 | Lowe Scott W | Cell-based RNA interference and related methods and compositions |
| JPWO2004031450A1 (ja) * | 2002-09-30 | 2006-02-02 | 本田技研工業株式会社 | 水素活性化装置 |
| JP2006509526A (ja) * | 2002-12-13 | 2006-03-23 | アヴェンティス パストゥール インコーポレイテッド | トリ胚性幹細胞上におけるalvacの産生 |
| US20090186839A1 (en) * | 2003-02-17 | 2009-07-23 | Cold Spring Harbor Laboratory | Model for studying the role of genes in chemoresistance |
| EP1599573B1 (en) * | 2003-02-17 | 2013-06-19 | Cold Spring Harbor Laboratory | Model for studying the role of genes in tumor resistance to chemotherapy |
| US20050273873A1 (en) * | 2003-03-07 | 2005-12-08 | Avigenics, Inc. | Genomic modification |
| US20050198700A1 (en) * | 2003-03-07 | 2005-09-08 | Avigenics, Inc. | Genomic modification |
| US20040255345A1 (en) * | 2003-03-07 | 2004-12-16 | Rapp Jeffrey C. | Production of transgenic avians |
| US20050034186A1 (en) * | 2003-03-07 | 2005-02-10 | Harvey Alex J. | Site specific nucleic acid integration |
| PT1646715E (pt) | 2003-07-22 | 2010-08-09 | Vivalis | Produção de poxvírus com linhagem das células aviarias aderentes ou não aderentes |
| US20070275010A1 (en) * | 2003-09-18 | 2007-11-29 | Mark Feinberg | Mva Vaccines |
| EP1528101A1 (en) * | 2003-11-03 | 2005-05-04 | ProBioGen AG | Immortalized avian cell lines for virus production |
| US20060123504A1 (en) * | 2004-12-07 | 2006-06-08 | Avigenics, Inc. | Methods of producing polyclonal antibodies |
| US20060174364A1 (en) * | 2004-03-01 | 2006-08-03 | Avigenics, Inc. | Artificial chromosomes and transchromosomic avians |
| WO2006042214A1 (en) * | 2004-10-08 | 2006-04-20 | Avigenics, Inc. | Modified integrase and methods of use |
| US8137907B2 (en) * | 2005-01-03 | 2012-03-20 | Cold Spring Harbor Laboratory | Orthotopic and genetically tractable non-human animal model for liver cancer and the uses thereof |
| FR2884255B1 (fr) | 2005-04-11 | 2010-11-05 | Vivalis | Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe |
| US20070044164A1 (en) * | 2005-05-31 | 2007-02-22 | Cold Spring Harbor Laboratory | Methods for producing microRNAs |
| US7524626B2 (en) * | 2005-10-05 | 2009-04-28 | Synageva Biopharma Corp. | Rapid production of high titer virus |
| DK2029756T3 (en) | 2006-06-20 | 2017-02-13 | Transgene Sa | PROCEDURE FOR PREPARING POXVIRA AND POXVIRUS COMPOSITIONS |
| CN100443588C (zh) * | 2006-12-11 | 2008-12-17 | 中国农业科学院北京畜牧兽医研究所 | 静宁鸡胚成纤维细胞系及其培养方法 |
| US8213704B2 (en) * | 2007-05-09 | 2012-07-03 | Kla-Tencor Corp. | Methods and systems for detecting defects in a reticle design pattern |
| EP2014279A1 (en) * | 2007-06-22 | 2009-01-14 | Pevion Biotech AG | Virosomes comprising hemagglutinin derived from an influenza virus produced in a cell line, compositions, methods of manufacturing, use thereof |
| US8357531B2 (en) | 2007-07-03 | 2013-01-22 | Transgene S.A. | Immortalized avian cell lines |
| EP2176398B1 (en) | 2007-07-03 | 2016-12-28 | Transgene SA | Immortalized avian cell lines |
| WO2009055724A2 (en) * | 2007-10-26 | 2009-04-30 | Cold Spring Harbor Laboratory | High throughput methods for functionally determining rna interference efficiency |
| JP5653223B2 (ja) | 2008-02-25 | 2015-01-14 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | 連続細胞系の生成方法 |
| EP2429580A1 (en) * | 2009-05-12 | 2012-03-21 | Transgene SA | Method for orthopoxvirus production and purification |
| WO2010144797A2 (en) | 2009-06-12 | 2010-12-16 | Vaccine Technologies, Incorporated | Influenza vaccines with enhanced immunogenicity and uses thereof |
| AU2011281982B2 (en) | 2010-07-20 | 2015-12-17 | Bavarian Nordic A/S | Method for harvesting expression products |
| FR3008992A1 (fr) * | 2013-07-25 | 2015-01-30 | Agronomique Inst Nat Rech | Procede de selection d'une lignee cellulaire permissive pour la replication de virus aviaires |
| CN107206063B (zh) | 2014-12-01 | 2021-09-28 | 特兰斯吉恩股份有限公司 | 稳定的液体痘苗病毒制剂 |
| BR112017011582A2 (pt) * | 2014-12-04 | 2018-02-27 | Intervet Int Bv | fibroblasto de embrião de galinha imortalizado, cultura de célula, métodos para preparação de um cef importalizado, para a replicação de um vetor viral aviário e para a preparação de uma vacina, e, vacina. |
| WO2016128542A1 (en) | 2015-02-13 | 2016-08-18 | Transgene Sa | Immunotherapeutic vaccine and antibody combination therapy |
| KR101768581B1 (ko) * | 2015-08-13 | 2017-08-17 | 전북대학교 산학협력단 | 자발적 불멸화된 체세포의 단일 세포로부터 리프로그래밍 세포주의 제조방법 |
| EP3387113A1 (en) * | 2015-12-11 | 2018-10-17 | Intervet International B.V. | Immortalised chicken embryonic epithelial kidney cells |
| US20190134190A1 (en) | 2016-05-04 | 2019-05-09 | Transgene Sa | Combination therapy with cpg tlr9 ligand |
| IL320653A (en) * | 2016-07-11 | 2025-07-01 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Systems and methods for growing cells in vitro |
| EP3522920A2 (en) | 2016-10-10 | 2019-08-14 | Transgene SA | Immunotherapeutic product and mdsc modulator combination therapy |
| WO2018093903A1 (en) | 2016-11-17 | 2018-05-24 | Regents Of The University Of Minnesota | Immortalized cell lines and methods of use |
| KR20200003921A (ko) | 2017-05-15 | 2020-01-10 | 얀센 백신스 앤드 프리벤션 비.브이. | 안정한 바이러스-함유 조성물 |
| KR102658198B1 (ko) | 2017-05-15 | 2024-04-16 | 얀센 백신스 앤드 프리벤션 비.브이. | 안정한 바이러스 함유 조성물 |
| JP7334124B2 (ja) | 2017-06-21 | 2023-08-28 | トランジェーヌ | 個別化ワクチン |
| CN107858323B (zh) * | 2017-11-08 | 2020-10-09 | 广东省生物资源应用研究所 | 一种红耳龟胚胎成纤维细胞系及其构建方法 |
| CN109234239B (zh) * | 2018-07-13 | 2021-09-14 | 广东永顺生物制药股份有限公司 | 一种鸭瘟病毒的培养方法 |
| US12150988B2 (en) | 2018-09-06 | 2024-11-26 | Bavarian Nordic A/S | Storage improved poxvirus compositions |
| US12478571B2 (en) | 2018-12-17 | 2025-11-25 | Pontis Biologics, Inc. | Enzyme based compositions and methods for removing dental calculi |
| CN114828882A (zh) | 2019-12-20 | 2022-07-29 | 英特维特国际股份有限公司 | 多价hvt载体疫苗 |
| US20230114464A1 (en) | 2020-03-12 | 2023-04-13 | Bavarian Nordic A/S | Conditions Improving Poxvirus Stability |
| TW202217002A (zh) | 2020-07-13 | 2022-05-01 | 法商傳斯堅公司 | 免疫抑制之治療 |
| CN116528893A (zh) | 2020-09-07 | 2023-08-01 | 英特维特国际股份有限公司 | 用于ha抗体阳性靶标的ha茎疫苗 |
| EP4267179A1 (en) | 2020-12-24 | 2023-11-01 | Intervet International B.V. | Multivalent hvt vector vaccine |
| US20250009868A1 (en) | 2021-07-13 | 2025-01-09 | Intervet Inc. | Overcoming antibody-interference in avians |
| WO2023213764A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Fusion polypeptide comprising an anti-pd-l1 sdab and a member of the tnfsf |
| WO2023213763A1 (en) | 2022-05-02 | 2023-11-09 | Transgene | Poxvirus encoding a binding agent comprising an anti- pd-l1 sdab |
| EP4518893A1 (en) | 2022-05-05 | 2025-03-12 | Intervet International B.V. | New multivalent hvt vector vaccine |
| WO2025074921A1 (ja) * | 2023-10-06 | 2025-04-10 | 株式会社微生物化学研究所 | ウイルスの生産方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3058438B2 (ja) * | 1990-10-19 | 2000-07-04 | 財団法人化学及血清療法研究所 | ヒト肝臓組織特異的ウイルスの感染可能な霊長類の不死化肝細胞およびその調製方法 |
| US5672485A (en) * | 1996-08-13 | 1997-09-30 | Regents Of The University Of Minnesota | Immortalized cell lines for virus growth |
-
1996
- 1996-08-13 US US08/696,200 patent/US5672485A/en not_active Expired - Lifetime
-
1997
- 1997-08-12 MY MYPI97003686A patent/MY125594A/en unknown
- 1997-08-12 GT GT199700091A patent/GT199700091A/es unknown
- 1997-08-12 ZA ZA9707216A patent/ZA977216B/xx unknown
- 1997-08-12 MA MA24765A patent/MA24303A1/fr unknown
- 1997-08-13 SV SV1997000071A patent/SV1997000071A/es active IP Right Grant
- 1997-08-13 AU AU40691/97A patent/AU726820B2/en not_active Expired
- 1997-08-13 DK DK97938334T patent/DK0920491T3/da active
- 1997-08-13 CA CA002263725A patent/CA2263725C/en not_active Expired - Lifetime
- 1997-08-13 WO PCT/US1997/014384 patent/WO1998006824A1/en not_active Ceased
- 1997-08-13 IL IL12851197A patent/IL128511A/en not_active IP Right Cessation
- 1997-08-13 AR ARP970103696A patent/AR008294A1/es active IP Right Grant
- 1997-08-13 CO CO97046519A patent/CO4700552A1/es unknown
- 1997-08-13 UY UY24668A patent/UY24668A1/es not_active IP Right Cessation
- 1997-08-13 PT PT97938334T patent/PT920491E/pt unknown
- 1997-08-13 DZ DZ970141A patent/DZ2291A1/fr active
- 1997-08-13 IL IL15830297A patent/IL158302A0/xx not_active IP Right Cessation
- 1997-08-13 BR BR9711067A patent/BR9711067A/pt active Search and Examination
- 1997-08-13 NZ NZ334147A patent/NZ334147A/xx not_active IP Right Cessation
- 1997-08-13 CN CN971972818A patent/CN1228119B/zh not_active Expired - Lifetime
- 1997-08-13 DE DE69737735T patent/DE69737735T2/de not_active Expired - Lifetime
- 1997-08-13 JP JP51005398A patent/JP3754088B2/ja not_active Expired - Lifetime
- 1997-08-13 KR KR10-1999-7001214A patent/KR100375871B1/ko not_active Expired - Fee Related
- 1997-08-13 EP EP97938334A patent/EP0920491B1/en not_active Expired - Lifetime
- 1997-08-13 IL IL15830197A patent/IL158301A0/xx not_active IP Right Cessation
- 1997-08-13 ES ES97938334T patent/ES2285738T3/es not_active Expired - Lifetime
- 1997-08-13 IL IL15830397A patent/IL158303A0/xx not_active IP Right Cessation
- 1997-08-13 HU HU0000188A patent/HU226658B1/hu unknown
- 1997-08-13 AT AT97938334T patent/ATE362524T1/de active
- 1997-08-13 PE PE1997000704A patent/PE108198A1/es not_active Application Discontinuation
- 1997-08-26 HN HN1997000124A patent/HN1997000124A/es unknown
- 1997-09-30 US US08/941,849 patent/US5879924A/en not_active Expired - Lifetime
-
1998
- 1998-09-11 US US09/151,718 patent/US5985642A/en not_active Expired - Lifetime
-
1999
- 1999-09-30 US US09/409,521 patent/US6207415B1/en not_active Expired - Lifetime
-
2005
- 2005-01-19 JP JP2005011481A patent/JP2005118053A/ja active Pending
-
2006
- 2006-06-28 JP JP2006178683A patent/JP2006320328A/ja active Pending
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