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AR005706A1 - Inhibidores egfr de 4-aminoquinzolina, procedimiento para su obtencion, composicion farmaceutica que los contiene, uso de los mismos para lapreparacion de un medicamento util como agente antineoplasico - Google Patents

Inhibidores egfr de 4-aminoquinzolina, procedimiento para su obtencion, composicion farmaceutica que los contiene, uso de los mismos para lapreparacion de un medicamento util como agente antineoplasico

Info

Publication number
AR005706A1
AR005706A1 ARP970100442A ARP970100442A AR005706A1 AR 005706 A1 AR005706 A1 AR 005706A1 AR P970100442 A ARP970100442 A AR P970100442A AR P970100442 A ARP970100442 A AR P970100442A AR 005706 A1 AR005706 A1 AR 005706A1
Authority
AR
Argentina
Prior art keywords
procedure
obtaining
preparation
pharmaceutical composition
same
Prior art date
Application number
ARP970100442A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR005706A1 publication Critical patent/AR005706A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuesto que tiene la fórmula (I), donde: X es fenilo que está opcionalmente sustituido; R y R1 son cada uno independientemente, hidrógeno,halógeno, alquilo, alcoxi, hidroxi o trifluormetilo; R2 es hidrógeno, alquilo, alcoxi,trifluorme tilo; Y es un radical que está seleccionado del grupo (II),donde: R3 es independientemente hidrógeno, alquilo, carboxi, carboalcoxi, fenilo o carboalquilo; n = 2-4 o una sal farmaceuticamente aceptable del mismo,con la condición deque cada R3 de Y puede ser igual o diferente y que son útiles como agentes antineoplásicos. Además provee un uso de los compuestosde fórmula (I) para la preparación de medicamentos, una composición farmacéutica que contiene dichocompuesto, un p rocedimiento para su obtención.
ARP970100442A 1996-02-05 1997-02-04 Inhibidores egfr de 4-aminoquinzolina, procedimiento para su obtencion, composicion farmaceutica que los contiene, uso de los mismos para lapreparacion de un medicamento util como agente antineoplasico AR005706A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1112896P 1996-02-05 1996-02-05

Publications (1)

Publication Number Publication Date
AR005706A1 true AR005706A1 (es) 1999-07-14

Family

ID=21749003

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970100442A AR005706A1 (es) 1996-02-05 1997-02-04 Inhibidores egfr de 4-aminoquinzolina, procedimiento para su obtencion, composicion farmaceutica que los contiene, uso de los mismos para lapreparacion de un medicamento util como agente antineoplasico

Country Status (20)

Country Link
US (1) US5760041A (es)
EP (1) EP0787722A1 (es)
JP (1) JP3984319B2 (es)
KR (1) KR970061877A (es)
CN (1) CN1177833C (es)
AR (1) AR005706A1 (es)
AU (1) AU726320B2 (es)
BR (1) BR9700850A (es)
CA (1) CA2196640C (es)
CO (1) CO4770975A1 (es)
CZ (1) CZ293980B6 (es)
HU (1) HUP9700344A3 (es)
IL (1) IL120141A (es)
MX (1) MX9700883A (es)
NO (1) NO308298B1 (es)
NZ (1) NZ314184A (es)
RU (1) RU2195456C2 (es)
SK (1) SK14497A3 (es)
TW (1) TW402596B (es)
ZA (1) ZA97913B (es)

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