AP2014008179A0 - 3-Substituted estra-1,3,5(10), 16-tetraene derivativess, methods for the production thereof, pharmaceutical preparations containing same, and use thereof for the production of medicaments - Google Patents

3-Substituted estra-1,3,5(10), 16-tetraene derivativess, methods for the production thereof, pharmaceutical preparations containing same, and use thereof for the production of medicaments

Info

Publication number: AP2014008179A0
Authority: AP; ARIPO
Prior art keywords: production; derivativess; tetraene; medicaments; methods
Prior art date: 2012-07-10

Application number

AP2014008179A

Other languages

English (en)

Inventor

Christian Fischer Oliver Martin Stegmann

Matthias Busemann

Original Assignee

Bayer Pharma AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-07-10

Filing date

2013-07-05

Publication date

2014-12-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48748225&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2014008179(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2013-07-05 Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG

2014-12-31 Publication of AP2014008179A0 publication Critical patent/AP2014008179A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Reproductive Health (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pulmonology (AREA)
Gynecology & Obstetrics (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AP2014008179A 2012-07-10 2013-07-05 3-Substituted estra-1,3,5(10), 16-tetraene derivativess, methods for the production thereof, pharmaceutical preparations containing same, and use thereof for the production of medicaments AP2014008179A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE102012211970		2012-07-10
PCT/EP2013/064257 WO2014009274A1 (fr)	2012-07-10	2013-07-05	Dérivés d'oestra-1,3,5 (10), 16-tétraène substitués en position 3, leurs procédés de préparation, préparations pharmaceutiques les contenant, et leur utilisation pour la fabrication de médicaments

Publications (1)

Publication Number	Publication Date
AP2014008179A0 true AP2014008179A0 (en)	2014-12-31

Family

ID=48748225

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2014008179A AP2014008179A0 (en)	2012-07-10	2013-07-05	3-Substituted estra-1,3,5(10), 16-tetraene derivativess, methods for the production thereof, pharmaceutical preparations containing same, and use thereof for the production of medicaments

Country Status (27)

Country	Link
US (1)	US9512169B2 (fr)
EP (1)	EP2872524B1 (fr)
JP (1)	JP6196302B2 (fr)
KR (1)	KR20150036319A (fr)
CN (1)	CN104428309B (fr)
AP (1)	AP2014008179A0 (fr)
AR (1)	AR092025A1 (fr)
AU (1)	AU2013289344A1 (fr)
BR (1)	BR112015000443A2 (fr)
CA (1)	CA2878485A1 (fr)
CL (1)	CL2015000039A1 (fr)
CO (1)	CO7160008A2 (fr)
CR (1)	CR20150007A (fr)
DO (1)	DOP2015000005A (fr)
EA (1)	EA201500112A1 (fr)
EC (1)	ECSP15000868A (fr)
ES (1)	ES2603258T3 (fr)
IL (1)	IL236581A0 (fr)
MA (1)	MA37742B1 (fr)
MX (1)	MX2015000347A (fr)
PE (1)	PE20150353A1 (fr)
PH (1)	PH12015500062A1 (fr)
TN (1)	TN2015000007A1 (fr)
TW (1)	TW201402596A (fr)
UY (1)	UY34899A (fr)
WO (1)	WO2014009274A1 (fr)
ZA (1)	ZA201500920B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9714266B2 (en) *	2013-02-21	2017-07-25	Bayer Pharma Aktiengesellschaft	Estra-1,3,5(10),16-tetraene-3-carboxamides for inhibition of 17.beta.-hydroxysteroid dehydrogenase (AKR1C3)
JP6407415B2 (ja) *	2014-09-11	2018-10-17	バイエル・ファルマ・アクティエンゲゼルシャフト	３−窒素または硫黄置換エストラ−１，３，５（１０），１６−テトラエンａｋｒ１ｃ３阻害剤
US10167293B2 (en)	2016-05-26	2019-01-01	Bayer Pharma Aktiengesellschaft	[8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones
CZ307437B6 (cs)	2016-06-07	2018-08-22	Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i.	15β-substituované deriváty estronu jako selektivní inhibitory 17β-hydroxysteoiddehydrogenáz
EP3269373A1 (fr)	2016-07-11	2018-01-17	Bayer Pharma Aktiengesellschaft	Formes posologiques orales à faible dosage d'un inhibiteur de akr1c3 pour le traitement des maladies
TW201825478A (zh)	2016-12-19	2018-07-16	德商拜耳製藥公司	［４－（苯基磺醯基）哌嗪－１－-基］（１ｈ－１，２，３－三唑－４-基）甲酮
WO2018114672A1 (fr)	2016-12-19	2018-06-28	Bayer Pharma Aktiengesellschaft	[4-(phénylsulfonyl)pipérazin-1-yl](1h-1,2,3-triazol-4-yl)méthanones
CA3047196A1 (fr)	2016-12-19	2018-06-28	Bayer Pharma Aktiengesellschaft	[(phenylsulfonyl)octahydro-epiminoisoindol-yl](1h-1,2,3-triazol-5-yl)methanones
EP3421483A1 (fr)	2017-06-29	2019-01-02	Bayer Pharma Aktiengesellschaft	Nouveaux dérivés 17-beta-hétéroaryle des stéroïdes comme inhibiteurs de akr1c3
CN110693892A (zh) *	2018-07-09	2020-01-17	深圳艾欣达伟医药科技有限公司	化合物用于制备预防、治疗或改善疼痛的药物的用途
CN110272465A (zh) *	2019-07-15	2019-09-24	成都贝诺科成生物科技有限公司	阿比特龙衍生物、其制备方法与应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5604213A (en)	1992-03-31	1997-02-18	British Technology Group Limited	17-substituted steroids useful in cancer treatment
WO1993020097A1 (fr) *	1992-03-31	1993-10-14	British Technology Group Ltd.	Steroïdes substitues-17 utiles pour le traitement du cancer
IL122740A (en)	1997-01-15	2003-09-17	Akzo Nobel Nv	16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them
DK0973790T3 (da)	1997-04-07	2003-09-22	Wyeth Corp	Estra-5(10),7-diener med østrogen aktivitet
CA2323089A1 (fr) *	1998-03-11	1999-09-16	Endorecherche, Inc.	Inhibiteurs de la 17.beta.-hydroxysteroide deshydrogenase du type 5 et du type 3 et methodes d'utilisation associees
AU5144999A (en) *	1998-08-07	2000-02-28	Endorecherche Inc.	Inhibition of type 3 3alpha-hydroxysteroid dehydrogenase
JPWO2001081364A1 (ja) *	2000-04-24	2004-01-08	協和醗酵工業株式会社	エストラ−１，３，５（１０）−トリエン誘導体
JP2007529426A (ja)	2004-03-12	2007-10-25	エントレメッドインコーポレイテッド	抗血管新生薬
EP1990335A4 (fr)	2006-03-02	2009-11-11	Astellas Pharma Inc	Inhibiteur de la 17 beta hsd de type 5
AU2007327653B2 (en)	2006-11-30	2013-04-18	Solvay Pharmaceuticals Gmbh	Substituted estratrien derivatives as 17beta HSD inhibitors
WO2008077810A2 (fr)	2006-12-22	2008-07-03	F. Hoffmann-La Roche Ag	Dérivés de spiropipéridine
MX2010000918A (es)	2007-07-24	2010-03-15	Astellas Pharma Inc	Derivado de bencimidazol.
DE102011083725A1 (de)	2011-09-29	2013-04-04	Bayer Pharma AG	Estra-1,3,5(10),16-tetraen-3-carboxamid-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln

2013
- 2013-07-05 US US14/414,386 patent/US9512169B2/en not_active Expired - Fee Related
- 2013-07-05 CN CN201380036684.4A patent/CN104428309B/zh not_active Expired - Fee Related
- 2013-07-05 JP JP2015520927A patent/JP6196302B2/ja not_active Expired - Fee Related
- 2013-07-05 BR BR112015000443A patent/BR112015000443A2/pt not_active IP Right Cessation
- 2013-07-05 WO PCT/EP2013/064257 patent/WO2014009274A1/fr not_active Ceased
- 2013-07-05 AP AP2014008179A patent/AP2014008179A0/xx unknown
- 2013-07-05 ES ES13734744.9T patent/ES2603258T3/es active Active
- 2013-07-05 EA EA201500112A patent/EA201500112A1/ru unknown
- 2013-07-05 EP EP13734744.9A patent/EP2872524B1/fr active Active
- 2013-07-05 CA CA2878485A patent/CA2878485A1/fr not_active Abandoned
- 2013-07-05 AU AU2013289344A patent/AU2013289344A1/en not_active Abandoned
- 2013-07-05 MX MX2015000347A patent/MX2015000347A/es unknown
- 2013-07-05 KR KR20157002707A patent/KR20150036319A/ko not_active Withdrawn
- 2013-07-05 PE PE2015000018A patent/PE20150353A1/es not_active Application Discontinuation
- 2013-07-10 AR ARP130102438A patent/AR092025A1/es unknown
- 2013-07-10 TW TW102124795A patent/TW201402596A/zh unknown
- 2013-07-10 UY UY0001034899A patent/UY34899A/es not_active Application Discontinuation
2015
- 2015-01-05 IL IL236581A patent/IL236581A0/en unknown
- 2015-01-07 TN TNP2015000007A patent/TN2015000007A1/fr unknown
- 2015-01-07 MA MA37742A patent/MA37742B1/fr unknown
- 2015-01-08 CL CL2015000039A patent/CL2015000039A1/es unknown
- 2015-01-09 CR CR20150007A patent/CR20150007A/es unknown
- 2015-01-09 CO CO15004249A patent/CO7160008A2/es unknown
- 2015-01-09 PH PH12015500062A patent/PH12015500062A1/en unknown
- 2015-01-09 EC ECIEPI2015868A patent/ECSP15000868A/es unknown
- 2015-01-09 DO DO2015000005A patent/DOP2015000005A/es unknown
- 2015-02-09 ZA ZA2015/00920A patent/ZA201500920B/en unknown

Also Published As

Publication number	Publication date
BR112015000443A2 (pt)	2017-06-27
CN104428309B (zh)	2016-09-14
PE20150353A1 (es)	2015-03-28
CA2878485A1 (fr)	2014-01-16
HK1205743A1 (en)	2015-12-24
UY34899A (es)	2014-02-28
CN104428309A (zh)	2015-03-18
ZA201500920B (en)	2017-01-25
WO2014009274A1 (fr)	2014-01-16
EA201500112A1 (ru)	2015-07-30
MA37742A1 (fr)	2016-05-31
KR20150036319A (ko)	2015-04-07
TN2015000007A1 (en)	2016-06-29
MX2015000347A (es)	2015-04-14
ECSP15000868A (es)	2016-01-29
US9512169B2 (en)	2016-12-06
DOP2015000005A (es)	2015-02-15
IL236581A0 (en)	2015-02-26
CO7160008A2 (es)	2015-01-15
EP2872524A1 (fr)	2015-05-20
US20150210734A1 (en)	2015-07-30
ES2603258T3 (es)	2017-02-24
MA37742B1 (fr)	2016-12-30
EP2872524B1 (fr)	2016-08-24
PH12015500062A1 (en)	2015-03-02
JP2015522050A (ja)	2015-08-03
AR092025A1 (es)	2015-03-18
AU2013289344A1 (en)	2015-02-05
TW201402596A (zh)	2014-01-16
CR20150007A (es)	2015-03-13
CL2015000039A1 (es)	2015-03-27
JP6196302B2 (ja)	2017-09-13

Publication	Publication Date	Title
AP2014008179A0 (en)	2014-12-31	3-Substituted estra-1,3,5(10), 16-tetraene derivativess, methods for the production thereof, pharmaceutical preparations containing same, and use thereof for the production of medicaments
IL221160A (en)	2015-09-24	4,2,1-triazine-3-amine derivatives, a process for their preparation and use for drug preparation
IL246032A0 (en)	2016-08-02	New carboxamides, a method for their production, pharmaceutical preparations containing them and their use for the production of drugs
IL223795A (en)	2015-11-30	History of Tetrahydro-Pyrido-Pyrimidine
IL222120A (en)	2015-09-24	Annals (indole-1-yl) -carbonylalkyl, process for preparation, pharmaceutical preparations containing them and their use in the preparation of cancer drugs
IL230874A (en)	2016-07-31	History of dihydroquinoline-2-on-egg scallops, their preparation process, pharmaceutical preparations containing them and their use in the preparation of drugs
ZA201401568B (en)	2016-11-30	Estra-1,3,5(10),16-tetraene-3-carboxamide derivatives, process for preparation thereof, pharmaceutical preparations comprising them, and use thereof for production of medicaments
IL232325A0 (en)	2014-06-30	18-methyl-7,6-methylene-3-oxo-17-paragan-4-en-21, 17b-carbolactones, pharmaceutical preparations containing these compounds and their use for the treatment of endometrial disease
IL232771A0 (en)	2014-08-03	History of 7,6-dihydro-h5-benzo[7]anolane, methods for their production, pharmaceutical preparations containing these history of 7,6-dihydro-5h-benzo[7]anolane and their use for the production of drugs
IL223770A0 (en)	2013-03-05	6,7-dihydro-5h-benzo[7]annulene derivatives, methods of production thereof, pharmaceutical preparations containing them, and use thereof for the production of medicinal products
IL226205B (en)	2018-10-31	Fusion proteins, pharmaceutical preparations containing them and their use in the preparation of drugs for the treatment of cancer
IL239146A0 (en)	2015-07-30	Aminocyclobutane derivatives, methods for their preparation and their use as drugs
HUP1300647A2 (hu)	2015-05-28	Ciklosporin A és származékainak komplexei, elõállításuk és gyógyszerészeti kompozícióik
ZA201506675B (en)	2017-02-22	New stable pentadecapeptide salts, a process for preparation thereof, a use thereof in the manufacture of pharmaceutical preparations and a use thereof in therapy
IL225105A (en)	2016-12-29	Heterocyclic compounds, their process, their pharmaceutical preparations and their use in the preparation of drugs
EP2875814A4 (fr)	2016-05-25	Composition liquide contenant un principe actif à base de taxane, son procédé de fabrication et préparation médicinale liquide
PL2662382T3 (pl)	2016-10-31	Metoda przygotowywania pochodnych sterolu oraz zawierających je składów farmaceutycznych, a także stosowania ich w leczeniu licznych glejaków
ZA201209674B (en)	2013-09-25	Pharmaceutical compositions comprising paracetamol and process for preparing the same
PL398989A1 (pl)	2012-11-05	(Z)-6-O-ß-D-4'''-O-metylo-glukopiranozylo-4'-hydroksy-4-metoksy-7-prenyloauron i sposób jego wytwarzania
GB201202149D0 (en)	2012-03-21	Anti-aging mixtures, pure substance and drug called "laundrin"
PL398987A1 (pl)	2012-11-05	(Z)-6-siarczan-6,4'-dihydroksy-7-prenylo-4-metoksyauronu i sposób jego wytwarzania
HUP1300393A2 (en)	2014-12-29	Quinazoline derivatives, process for the preparation thereof and pharmaceutical compositions comprising the same