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MA37742A1 - Dérivés d'oestra-1,3,5 (10), 16-tétraène substitués en position 3, leurs procédés de préparation, préparations pharmaceutiques les contenant, et leur utilisation pour la fabrication de médicaments - Google Patents

Dérivés d'oestra-1,3,5 (10), 16-tétraène substitués en position 3, leurs procédés de préparation, préparations pharmaceutiques les contenant, et leur utilisation pour la fabrication de médicaments

Info

Publication number
MA37742A1
MA37742A1 MA37742A MA37742A MA37742A1 MA 37742 A1 MA37742 A1 MA 37742A1 MA 37742 A MA37742 A MA 37742A MA 37742 A MA37742 A MA 37742A MA 37742 A1 MA37742 A1 MA 37742A1
Authority
MA
Morocco
Prior art keywords
preparation
medicaments
tetraene
derivatives
manufacture
Prior art date
Application number
MA37742A
Other languages
Arabic (ar)
English (en)
Other versions
MA37742B1 (fr
Inventor
Ulrich Bothe
Naomi Barak
Matthias Busemann
Oliver Martin Fischer
Andrea Rotgeri
Tobias Marquardt
Christian Stegmann
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48748225&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA37742(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of MA37742A1 publication Critical patent/MA37742A1/fr
Publication of MA37742B1 publication Critical patent/MA37742B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J43/00Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/08Antiseborrheics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28Antiandrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32Antioestrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des inhibiteurs de akr1c3 et des procédés pour les préparer, ainsi que leur utilisation pour traiter et/ou prévenir des maladies et pour fabriquer des médicaments destinés à traiter et/ou à prévenir des maladies, en particulier les troubles hémorragiques et l'endométriose.
MA37742A 2012-07-10 2015-01-07 Dérivés d'oestra-1,3,5 (10), 16-tétraène substitués en position 3, leurs procédés de préparation, préparations pharmaceutiques les contenant, et leur utilisation pour la fabrication de médicaments MA37742B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102012211970 2012-07-10
PCT/EP2013/064257 WO2014009274A1 (fr) 2012-07-10 2013-07-05 Dérivés d'oestra-1,3,5 (10), 16-tétraène substitués en position 3, leurs procédés de préparation, préparations pharmaceutiques les contenant, et leur utilisation pour la fabrication de médicaments

Publications (2)

Publication Number Publication Date
MA37742A1 true MA37742A1 (fr) 2016-05-31
MA37742B1 MA37742B1 (fr) 2016-12-30

Family

ID=48748225

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37742A MA37742B1 (fr) 2012-07-10 2015-01-07 Dérivés d'oestra-1,3,5 (10), 16-tétraène substitués en position 3, leurs procédés de préparation, préparations pharmaceutiques les contenant, et leur utilisation pour la fabrication de médicaments

Country Status (27)

Country Link
US (1) US9512169B2 (fr)
EP (1) EP2872524B1 (fr)
JP (1) JP6196302B2 (fr)
KR (1) KR20150036319A (fr)
CN (1) CN104428309B (fr)
AP (1) AP2014008179A0 (fr)
AR (1) AR092025A1 (fr)
AU (1) AU2013289344A1 (fr)
BR (1) BR112015000443A2 (fr)
CA (1) CA2878485A1 (fr)
CL (1) CL2015000039A1 (fr)
CO (1) CO7160008A2 (fr)
CR (1) CR20150007A (fr)
DO (1) DOP2015000005A (fr)
EA (1) EA201500112A1 (fr)
EC (1) ECSP15000868A (fr)
ES (1) ES2603258T3 (fr)
IL (1) IL236581A0 (fr)
MA (1) MA37742B1 (fr)
MX (1) MX2015000347A (fr)
PE (1) PE20150353A1 (fr)
PH (1) PH12015500062A1 (fr)
TN (1) TN2015000007A1 (fr)
TW (1) TW201402596A (fr)
UY (1) UY34899A (fr)
WO (1) WO2014009274A1 (fr)
ZA (1) ZA201500920B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9714266B2 (en) * 2013-02-21 2017-07-25 Bayer Pharma Aktiengesellschaft Estra-1,3,5(10),16-tetraene-3-carboxamides for inhibition of 17.beta.-hydroxysteroid dehydrogenase (AKR1C3)
JP6407415B2 (ja) * 2014-09-11 2018-10-17 バイエル・ファルマ・アクティエンゲゼルシャフト 3−窒素または硫黄置換エストラ−1,3,5(10),16−テトラエンakr1c3阻害剤
US10167293B2 (en) 2016-05-26 2019-01-01 Bayer Pharma Aktiengesellschaft [8-(phenylsulfonyl)-3,8-diazabicyclo[3.2.1]oct-3-yl](1H-1,2,3-triazol-4-yl)methanones
CZ307437B6 (cs) 2016-06-07 2018-08-22 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. 15β-substituované deriváty estronu jako selektivní inhibitory 17β-hydroxysteoiddehydrogenáz
EP3269373A1 (fr) 2016-07-11 2018-01-17 Bayer Pharma Aktiengesellschaft Formes posologiques orales à faible dosage d'un inhibiteur de akr1c3 pour le traitement des maladies
TW201825478A (zh) 2016-12-19 2018-07-16 德商拜耳製藥公司 [4-(苯基磺醯基)哌嗪-1--基](1h-1,2,3-三唑-4-基)甲酮
WO2018114672A1 (fr) 2016-12-19 2018-06-28 Bayer Pharma Aktiengesellschaft [4-(phénylsulfonyl)pipérazin-1-yl](1h-1,2,3-triazol-4-yl)méthanones
CA3047196A1 (fr) 2016-12-19 2018-06-28 Bayer Pharma Aktiengesellschaft [(phenylsulfonyl)octahydro-epiminoisoindol-yl](1h-1,2,3-triazol-5-yl)methanones
EP3421483A1 (fr) 2017-06-29 2019-01-02 Bayer Pharma Aktiengesellschaft Nouveaux dérivés 17-beta-hétéroaryle des stéroïdes comme inhibiteurs de akr1c3
CN110693892A (zh) * 2018-07-09 2020-01-17 深圳艾欣达伟医药科技有限公司 化合物用于制备预防、治疗或改善疼痛的药物的用途
CN110272465A (zh) * 2019-07-15 2019-09-24 成都贝诺科成生物科技有限公司 阿比特龙衍生物、其制备方法与应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5604213A (en) 1992-03-31 1997-02-18 British Technology Group Limited 17-substituted steroids useful in cancer treatment
WO1993020097A1 (fr) * 1992-03-31 1993-10-14 British Technology Group Ltd. Steroïdes substitues-17 utiles pour le traitement du cancer
IL122740A (en) 1997-01-15 2003-09-17 Akzo Nobel Nv 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them
DK0973790T3 (da) 1997-04-07 2003-09-22 Wyeth Corp Estra-5(10),7-diener med østrogen aktivitet
CA2323089A1 (fr) * 1998-03-11 1999-09-16 Endorecherche, Inc. Inhibiteurs de la 17.beta.-hydroxysteroide deshydrogenase du type 5 et du type 3 et methodes d'utilisation associees
AU5144999A (en) * 1998-08-07 2000-02-28 Endorecherche Inc. Inhibition of type 3 3alpha-hydroxysteroid dehydrogenase
JPWO2001081364A1 (ja) * 2000-04-24 2004-01-08 協和醗酵工業株式会社 エストラ−1,3,5(10)−トリエン誘導体
JP2007529426A (ja) 2004-03-12 2007-10-25 エントレメッド インコーポレイテッド 抗血管新生薬
EP1990335A4 (fr) 2006-03-02 2009-11-11 Astellas Pharma Inc Inhibiteur de la 17 beta hsd de type 5
AU2007327653B2 (en) 2006-11-30 2013-04-18 Solvay Pharmaceuticals Gmbh Substituted estratrien derivatives as 17beta HSD inhibitors
WO2008077810A2 (fr) 2006-12-22 2008-07-03 F. Hoffmann-La Roche Ag Dérivés de spiropipéridine
MX2010000918A (es) 2007-07-24 2010-03-15 Astellas Pharma Inc Derivado de bencimidazol.
DE102011083725A1 (de) 2011-09-29 2013-04-04 Bayer Pharma AG Estra-1,3,5(10),16-tetraen-3-carboxamid-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate die diese enthalten, sowie deren Verwendung zur Herstellung von Arzneimitteln

Also Published As

Publication number Publication date
BR112015000443A2 (pt) 2017-06-27
CN104428309B (zh) 2016-09-14
PE20150353A1 (es) 2015-03-28
CA2878485A1 (fr) 2014-01-16
AP2014008179A0 (en) 2014-12-31
HK1205743A1 (en) 2015-12-24
UY34899A (es) 2014-02-28
CN104428309A (zh) 2015-03-18
ZA201500920B (en) 2017-01-25
WO2014009274A1 (fr) 2014-01-16
EA201500112A1 (ru) 2015-07-30
KR20150036319A (ko) 2015-04-07
TN2015000007A1 (en) 2016-06-29
MX2015000347A (es) 2015-04-14
ECSP15000868A (es) 2016-01-29
US9512169B2 (en) 2016-12-06
DOP2015000005A (es) 2015-02-15
IL236581A0 (en) 2015-02-26
CO7160008A2 (es) 2015-01-15
EP2872524A1 (fr) 2015-05-20
US20150210734A1 (en) 2015-07-30
ES2603258T3 (es) 2017-02-24
MA37742B1 (fr) 2016-12-30
EP2872524B1 (fr) 2016-08-24
PH12015500062A1 (en) 2015-03-02
JP2015522050A (ja) 2015-08-03
AR092025A1 (es) 2015-03-18
AU2013289344A1 (en) 2015-02-05
TW201402596A (zh) 2014-01-16
CR20150007A (es) 2015-03-13
CL2015000039A1 (es) 2015-03-27
JP6196302B2 (ja) 2017-09-13

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