AP2008004468A0 - Pyrazine derivatives as sodium channel modulators for the treatment of pain - Google Patents

Pyrazine derivatives as sodium channel modulators for the treatment of pain

Info

Publication number: AP2008004468A0
Authority: AP; ARIPO
Prior art keywords: pain; treatment; sodium channel; channel modulators; pyrazine derivatives
Prior art date: 2005-11-04

Application number

AP2008004468A

Other languages

English (en)

Inventor

Cedric Poinsard

Stephen Martin Denton

Karl Richard Et Al Gibson

Original Assignee

Pfizer Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-11-04

Filing date

2006-10-23

Publication date

2008-06-30

2006-10-23 Application filed by Pfizer Ltd filed Critical Pfizer Ltd

2008-06-30 Publication of AP2008004468A0 publication Critical patent/AP2008004468A0/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)
Medicines Containing Plant Substances (AREA)

AP2008004468A 2005-11-04 2006-10-23 Pyrazine derivatives as sodium channel modulators for the treatment of pain AP2008004468A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US73366205P	2005-11-04	2005-11-04
PCT/IB2006/003055 WO2007052123A2 (en)	2005-11-04	2006-10-23	Pyrazine derivatives as sodium channel modulators for the treatment of pain

Publications (1)

Publication Number	Publication Date
AP2008004468A0 true AP2008004468A0 (en)	2008-06-30

Family

ID=37890558

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2008004468A AP2008004468A0 (en)	2005-11-04	2006-10-23	Pyrazine derivatives as sodium channel modulators for the treatment of pain

Country Status (27)

Country	Link
US (1)	US7572797B2 (no)
EP (1)	EP1945630B1 (no)
JP (1)	JP2009514937A (no)
KR (1)	KR20080066073A (no)
CN (1)	CN101356169A (no)
AP (1)	AP2008004468A0 (no)
AR (1)	AR057855A1 (no)
AT (1)	ATE525372T1 (no)
AU (1)	AU2006310215A1 (no)
BR (1)	BRPI0618129A2 (no)
CA (1)	CA2624621C (no)
CR (1)	CR9954A (no)
DO (1)	DOP2006000243A (no)
EA (1)	EA200801011A1 (no)
EC (1)	ECSP088412A (no)
ES (1)	ES2371932T3 (no)
GT (1)	GT200600475A (no)
IL (1)	IL191059A0 (no)
MA (1)	MA29926B1 (no)
NL (1)	NL2000284C2 (no)
NO (1)	NO20082496L (no)
PE (1)	PE20070715A1 (no)
TN (1)	TNSN08196A1 (no)
TW (1)	TW200804353A (no)
UY (1)	UY29893A1 (no)
WO (1)	WO2007052123A2 (no)
ZA (1)	ZA200803671B (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0934061B3 (en)	1996-07-24	2015-01-21	Warner-Lambert Company LLC	Isobutylgaba and its derivatives for the treatment of pain
EP1741708A1 (en) *	2005-06-28	2007-01-10	Sanofi-Aventis Deutschland GmbH	Heteroaryl-substituted amides comprising an unsaturated or cyclic linker group, and their use as pharmaceuticals
GB2431927B (en)	2005-11-04	2010-03-17	Amira Pharmaceuticals Inc	5-Lipoxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en)	2005-11-04	2013-03-19	Panmira Pharmaceuticals, Llc	5-lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en)	2005-11-04	2011-07-12	Amira Pharmaceuticals, Inc.	5-lipdxygenase-activating protein (FLAP) inhibitors
US20100227872A1 (en) *	2007-05-03	2010-09-09	Mark Ian Kemp	Pyrazine derivatives
GEP20125379B (en)	2007-05-03	2012-01-10	Pfizer Ltd	2 -pyridine carboxamide derivatives as sodium channel modulators
US8614255B2 (en) *	2007-08-21	2013-12-24	Civitas Therapeutics, Inc.	Pulmonary pharmaceutical formulations
KR101578235B1 (ko)	2007-12-10	2015-12-16	노파르티스 아게	유기 화합물
RU2010137862A (ru)	2008-02-13	2012-03-20	ЭЙСАЙ Ар энд Ди МЕНЕДЖМЕНТ КО., ЛТД. (JP)	Производное бициклоамина
US20110160249A1 (en)	2008-05-23	2011-06-30	Schaab Kevin Murray	5-lipoxygenase-activating protein inhibitor
US8546431B2 (en)	2008-10-01	2013-10-01	Panmira Pharmaceuticals, Llc	5-lipoxygenase-activating protein (FLAP) inhibitors
US10703722B2 (en)	2010-04-27	2020-07-07	Calcimedica, Inc.	Compounds that modulate intracellular calcium
WO2013059677A1 (en) *	2011-10-19	2013-04-25	Calcimedica, Inc.	Compounds that modulate intracellular calcium
KR102090944B1 (ko) *	2012-04-25	2020-03-19	라퀄리아 파마 인코포레이티드	Ttx-s 차단제로서의 피롤로피리디논 유도체
EP3070085B1 (en)	2013-02-04	2019-01-09	Janssen Pharmaceutica NV	Flap modulators
TWI644899B (zh)	2013-02-04	2018-12-21	健生藥品公司	Ｆｌａｐ調節劑
US10428029B2 (en)	2014-09-10	2019-10-01	Epizyme, Inc.	Isoxazole carboxamide compounds
CA2978007A1 (en)	2015-02-27	2016-09-01	Calcimedica, Inc.	Pancreatitis treatment
JP6738575B2 (ja) *	2015-08-07	2020-08-12	カルシメディカ，インク．	脳卒中および外傷性脳損傷の処置のためのｃｒａｃチャネル阻害剤の使用
GB201801128D0 (en)	2018-01-24	2018-03-07	Univ Oxford Innovation Ltd	Compounds
EP4243813A4 (en)	2020-11-13	2024-07-17	Calcimedica, Inc.	IMPROVED SYNTHESIS OF CRAC CHANNEL INHIBITORS

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MA26473A1 (fr) *	1997-03-01	2004-12-20	Glaxo Group Ltd	Composes pharmacologiquement actifs.
MXPA04004714A (es) *	2001-11-21	2004-08-19	Upjohn Co	Derivados de aril 1,4-pirazina sustituidos.
US20030187026A1 (en)	2001-12-13	2003-10-02	Qun Li	Kinase inhibitors
KR20060123208A (ko) *	2003-10-27	2006-12-01	아스테라스 세이야쿠 가부시키가이샤	피라진 유도체 및 이의 약학적 용도
WO2006047504A1 (en) *	2004-10-22	2006-05-04	Janssen Pharmaceutica, N.V.	Aromatic amides as inhibitors of c-fms kinase

2006
- 2006-10-20 NL NL2000284A patent/NL2000284C2/nl not_active IP Right Cessation
- 2006-10-23 CN CNA2006800504914A patent/CN101356169A/zh active Pending
- 2006-10-23 JP JP2008539517A patent/JP2009514937A/ja not_active Ceased
- 2006-10-23 EP EP06809149A patent/EP1945630B1/en not_active Not-in-force
- 2006-10-23 AT AT06809149T patent/ATE525372T1/de not_active IP Right Cessation
- 2006-10-23 AU AU2006310215A patent/AU2006310215A1/en not_active Abandoned
- 2006-10-23 BR BRPI0618129-5A patent/BRPI0618129A2/pt not_active IP Right Cessation
- 2006-10-23 KR KR1020087013403A patent/KR20080066073A/ko not_active Ceased
- 2006-10-23 WO PCT/IB2006/003055 patent/WO2007052123A2/en not_active Ceased
- 2006-10-23 ES ES06809149T patent/ES2371932T3/es active Active
- 2006-10-23 AP AP2008004468A patent/AP2008004468A0/xx unknown
- 2006-10-23 CA CA2624621A patent/CA2624621C/en not_active Expired - Fee Related
- 2006-10-23 EA EA200801011A patent/EA200801011A1/ru unknown
- 2006-11-01 UY UY29893A patent/UY29893A1/es not_active Application Discontinuation
- 2006-11-02 AR ARP060104815A patent/AR057855A1/es unknown
- 2006-11-02 GT GT200600475A patent/GT200600475A/es unknown
- 2006-11-03 TW TW095140879A patent/TW200804353A/zh unknown
- 2006-11-03 PE PE2006001349A patent/PE20070715A1/es not_active Application Discontinuation
- 2006-11-03 US US11/556,354 patent/US7572797B2/en not_active Expired - Fee Related
- 2006-11-03 DO DO2006000243A patent/DOP2006000243A/es unknown
2008
- 2008-04-25 ZA ZA200803671A patent/ZA200803671B/xx unknown
- 2008-04-27 IL IL191059A patent/IL191059A0/en unknown
- 2008-04-29 EC EC2008008412A patent/ECSP088412A/es unknown
- 2008-05-02 MA MA30893A patent/MA29926B1/fr unknown
- 2008-05-02 TN TNP2008000196A patent/TNSN08196A1/fr unknown
- 2008-05-07 CR CR9954A patent/CR9954A/es not_active Application Discontinuation
- 2008-06-04 NO NO20082496A patent/NO20082496L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
UY29893A1 (es)	2007-06-29
NO20082496L (no)	2008-07-24
ZA200803671B (en)	2009-03-25
CA2624621A1 (en)	2007-05-10
ECSP088412A (es)	2008-05-30
ATE525372T1 (de)	2011-10-15
US7572797B2 (en)	2009-08-11
NL2000284A1 (nl)	2007-05-07
US20070105872A1 (en)	2007-05-10
CN101356169A (zh)	2009-01-28
TNSN08196A1 (fr)	2009-10-30
PE20070715A1 (es)	2007-08-11
DOP2006000243A (es)	2007-05-31
EA200801011A1 (ru)	2009-02-27
WO2007052123A3 (en)	2007-07-12
IL191059A0 (en)	2008-12-29
TW200804353A (en)	2008-01-16
AU2006310215A1 (en)	2007-05-10
BRPI0618129A2 (pt)	2011-08-16
ES2371932T3 (es)	2012-01-11
WO2007052123A2 (en)	2007-05-10
EP1945630A2 (en)	2008-07-23
GT200600475A (es)	2007-07-06
AR057855A1 (es)	2007-12-19
MA29926B1 (fr)	2008-11-03
CR9954A (es)	2008-05-28
JP2009514937A (ja)	2009-04-09
EP1945630B1 (en)	2011-09-21
NL2000284C2 (nl)	2007-09-28
KR20080066073A (ko)	2008-07-15
CA2624621C (en)	2010-11-30

Publication	Publication Date	Title
IL191059A0 (en)	2008-12-29	Pyrazine derivatives as sodium channel modulators for the treatment of pain
IL191832A0 (en)	2008-12-29	Pyridiazinone derivatives for the treatment of tumours
GB0522311D0 (en)	2005-12-07	Pharmaceutical compositions for the treatment of pain
SI2024368T1 (sl)	2014-08-29	Derivati 6,7,8,9-tetrahidro-5h-pirimido(4,5-d)azepin-4-il)-amina kot modulatorji trpv 1 za zdravljenje boleäśine
IL188430A0 (en)	2008-11-03	Treatment of tumors
IL192627A0 (en)	2011-08-01	Prolinamide derivatives as sodium channel modulators
AP2007004157A0 (en)	2007-10-31	N- (N-sulfonylaminomethyl) cyclo-propanecarboxamide derivatives useful for the treatment of pain
EP1727530A4 (en)	2009-10-21	TOPICAL FORMULATIONS FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS
IL184934A0 (en)	2007-12-03	4-oxoquinazoline-3-yl-benzamide derivatives for the treatment of cytokine diseases
EP1928452A4 (en)	2010-09-01	USE OF SODIUM CHANNEL BLOCKS FOR THE TREATMENT OF VISCERAL PAIN OR PAIN THROUGH CANCER TREATMENT
GB0909297D0 (en)	2009-07-15	Composition for the treatment of skin conditions
IL192933A0 (en)	2009-02-11	Benzoisoindole derivatives for the treatment of pain
EP1867640A4 (en)	2010-07-14	MEANS FOR TREATING SOLID TUMORS
PL1959957T3 (pl)	2012-12-31	Pochodne pirymidyloaminobenzamidu do leczenia neurowłókniakowatości
IL187792A0 (en)	2008-11-03	4-anilino-3-quinolinecarbonitriles for the treatment of cancer
EP1871372A4 (en)	2010-06-02	COMBINATION THERAPY WHICH INCLUDES AN AGENT BLOCKING CALCIUM CHANNELS OF TYPE N FOR THE RELIEF OF PAIN
GB0517387D0 (en)	2005-10-05	Combinations for the treatment of cancer
ZA200805522B (en)	2009-04-29	Dioxoiane dérivates for the treatment of cancer
EP1900363A4 (en)	2010-01-13	THERAPEUTIC AGENT AGAINST PAIN
GB0505203D0 (en)	2005-04-20	Skin composition treatment
HUP0500947A2 (en)	2007-08-28	Composition for treatment of paradontosis
HK1122032A (en)	2009-05-08	Benzoisoindole derivatives for the treatment of pain
ZA200806180B (en)	2009-07-29	Benzoisoindole derivatives for the treatment of pain
GB0517386D0 (en)	2005-10-05	Combinations for the treatment of cancer
HK1110796A (en)	2008-07-25	Treatment of tumors