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MA29926B1 - Derives de pyrazine - Google Patents

Derives de pyrazine

Info

Publication number
MA29926B1
MA29926B1 MA30893A MA30893A MA29926B1 MA 29926 B1 MA29926 B1 MA 29926B1 MA 30893 A MA30893 A MA 30893A MA 30893 A MA30893 A MA 30893A MA 29926 B1 MA29926 B1 MA 29926B1
Authority
MA
Morocco
Prior art keywords
compounds
pyrazine derivatives
preparation
solvates
pain
Prior art date
Application number
MA30893A
Other languages
English (en)
Inventor
Karl Richard Gibson
Cedric Poinsard
Melanie Susanne Glossop
Stephen Martin Denton
Mark Ian Kemp
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of MA29926B1 publication Critical patent/MA29926B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Dérivés de pyrazine La présente invention concerne les composés de formule (I) : et leurs sels et produits de solvatation pharmaceutiquement acceptables, les procédés pour la préparation de, les intermédiaires utilisés dans la préparation de, et les compositions contenant ces, composés et les utilisations de ces composés pour le traitement de la douleur.
MA30893A 2005-11-04 2008-05-02 Derives de pyrazine MA29926B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73366205P 2005-11-04 2005-11-04

Publications (1)

Publication Number Publication Date
MA29926B1 true MA29926B1 (fr) 2008-11-03

Family

ID=37890558

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30893A MA29926B1 (fr) 2005-11-04 2008-05-02 Derives de pyrazine

Country Status (27)

Country Link
US (1) US7572797B2 (fr)
EP (1) EP1945630B1 (fr)
JP (1) JP2009514937A (fr)
KR (1) KR20080066073A (fr)
CN (1) CN101356169A (fr)
AP (1) AP2008004468A0 (fr)
AR (1) AR057855A1 (fr)
AT (1) ATE525372T1 (fr)
AU (1) AU2006310215A1 (fr)
BR (1) BRPI0618129A2 (fr)
CA (1) CA2624621C (fr)
CR (1) CR9954A (fr)
DO (1) DOP2006000243A (fr)
EA (1) EA200801011A1 (fr)
EC (1) ECSP088412A (fr)
ES (1) ES2371932T3 (fr)
GT (1) GT200600475A (fr)
IL (1) IL191059A0 (fr)
MA (1) MA29926B1 (fr)
NL (1) NL2000284C2 (fr)
NO (1) NO20082496L (fr)
PE (1) PE20070715A1 (fr)
TN (1) TNSN08196A1 (fr)
TW (1) TW200804353A (fr)
UY (1) UY29893A1 (fr)
WO (1) WO2007052123A2 (fr)
ZA (1) ZA200803671B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1094757C (zh) 1996-07-24 2002-11-27 沃尼尔·朗伯公司 用于治疗疼痛的异丁基γ－氨基丁酸及其衍生物
EP1741708A1 (fr) * 2005-06-28 2007-01-10 Sanofi-Aventis Deutschland GmbH Amides heterocycliques substitués contenant un linker cyclique ou insaturé, et leur utilisation comme agent pharmaceutique
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
BRPI0810202A2 (pt) 2007-05-03 2014-10-21 Pfizer Ltd Derivados de piridina
US20100227872A1 (en) * 2007-05-03 2010-09-09 Mark Ian Kemp Pyrazine derivatives
WO2009026434A1 (fr) * 2007-08-21 2009-02-26 Alkermes, Inc. Formulations pharmaceutiques pulmonaires
AR069637A1 (es) 2007-12-10 2010-02-10 Novartis Ag Derivados de pirazinas
JPWO2009101917A1 (ja) 2008-02-13 2011-06-09 エーザイ・アール・アンド・ディー・マネジメント株式会社 ビシクロアミン誘導体
MX2010012814A (es) 2008-05-23 2010-12-20 Amira Pharmaceuticals Inc Inhibidor de proteina activadora de 5-lipoxigenasa.
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US10703722B2 (en) 2010-04-27 2020-07-07 Calcimedica, Inc. Compounds that modulate intracellular calcium
WO2013059677A1 (fr) * 2011-10-19 2013-04-25 Calcimedica, Inc. Composés qui modulent le calcium intracellulaire
RU2646754C2 (ru) * 2012-04-25 2018-03-07 Раквалиа Фарма Инк. Производные пирролопиридинона в качестве ttx-s блокаторов
TWI644899B (zh) * 2013-02-04 2018-12-21 健生藥品公司 Ｆｌａｐ調節劑
JP6424173B2 (ja) 2013-02-04 2018-11-14 ヤンセン ファーマシューティカ エヌ．ベー． Ｆｌａｐ調節因子
CA2960274A1 (fr) 2014-09-10 2016-03-17 Epizyme, Inc. Composes carboxamides isoxazoles
TWI835179B (zh) 2015-02-27 2024-03-11 美商鈣系醫藥公司 胰腺炎治療
DK3331525T3 (da) 2015-08-07 2020-12-14 Calcimedica Inc Anvendelse af CRAC-kanal-inhibitorer til behandling af slagtilfælde og traumatisk hjerneskade
GB201801128D0 (en) 2018-01-24 2018-03-07 Univ Oxford Innovation Ltd Compounds
EP4243813A4 (fr) 2020-11-13 2024-07-17 Calcimedica, Inc. Synthèse améliorée d'inhibiteurs de canal crac

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA26473A1 (fr) * 1997-03-01 2004-12-20 Glaxo Group Ltd Composes pharmacologiquement actifs.
AU2002343557A1 (en) * 2001-11-21 2003-06-10 Pharmacia And Upjohn Company Substituted aryl 1,4-pyrazine derivatives
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
CA2543644A1 (fr) * 2003-10-27 2005-05-06 Astellas Pharma Inc. Derives de pyrazine et utilisation pharmaceutique de ce derive
CN101084208A (zh) * 2004-10-22 2007-12-05 詹森药业有限公司 作为c－fms激酶抑制剂的芳族酰胺

Also Published As

Publication number Publication date
AP2008004468A0 (en) 2008-06-30
EA200801011A1 (ru) 2009-02-27
ES2371932T3 (es) 2012-01-11
GT200600475A (es) 2007-07-06
KR20080066073A (ko) 2008-07-15
WO2007052123A3 (fr) 2007-07-12
UY29893A1 (es) 2007-06-29
BRPI0618129A2 (pt) 2011-08-16
AR057855A1 (es) 2007-12-19
US7572797B2 (en) 2009-08-11
AU2006310215A1 (en) 2007-05-10
DOP2006000243A (es) 2007-05-31
CR9954A (es) 2008-05-28
ATE525372T1 (de) 2011-10-15
NL2000284C2 (nl) 2007-09-28
ECSP088412A (es) 2008-05-30
CN101356169A (zh) 2009-01-28
CA2624621A1 (fr) 2007-05-10
PE20070715A1 (es) 2007-08-11
JP2009514937A (ja) 2009-04-09
ZA200803671B (en) 2009-03-25
NL2000284A1 (nl) 2007-05-07
TW200804353A (en) 2008-01-16
CA2624621C (fr) 2010-11-30
IL191059A0 (en) 2008-12-29
WO2007052123A2 (fr) 2007-05-10
EP1945630B1 (fr) 2011-09-21
NO20082496L (no) 2008-07-24
EP1945630A2 (fr) 2008-07-23
US20070105872A1 (en) 2007-05-10
TNSN08196A1 (fr) 2009-10-30

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