AR057855A1 - Derivados de pirazina y composicion farmaceutica - Google Patents
Derivados de pirazina y composicion farmaceuticaInfo
- Publication number
- AR057855A1 AR057855A1 ARP060104815A ARP060104815A AR057855A1 AR 057855 A1 AR057855 A1 AR 057855A1 AR P060104815 A ARP060104815 A AR P060104815A AR P060104815 A ARP060104815 A AR P060104815A AR 057855 A1 AR057855 A1 AR 057855A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- compounds
- aminoalkyl
- haloalkyl
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 abstract 1
- 125000001376 1,2,4-triazolyl group Chemical group N1N=C(N=C1)* 0.000 abstract 1
- 125000006163 5-membered heteroaryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002971 oxazolyl group Chemical group 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
La presente se refiere a compuestos, a intermediarios utiles en su preparacion y a composiciones que contienen dichos compuestos. Estos compuestos resultan utiles para el tartamiento de dolor. Reivindicacion 1: Un compuesto de formula (1) o una sal o solvato farmacéuticamente aceptable del mismo, en a que R1 es un grupo heteroarilo de 5 miembros que comprende (a) de 1 a 4 átomos de N o (b) un átomo de O o S y 0, 1 o 2 átomos de N, opcionalmente sustituido con uno o más sustituyentes seleccioandos cada uno independientemente de alquilo C1-4, alcoxi C1-4, haloalquilo C1-4, alcoxi C1-4-alquilo C1-4, aminoalquilo C1-4, amino, alquil C1-4-amino, di(alquil C1-4)amino, alquil C1-4-aminoalquilo C1-4 y di(alquil C1-4)aminoalquilo C1-4; con la condicion de que R1 no sea imidazolilo, oxazolilo o 1,2,4-triazolilo; Ar es como en las formulas (2) en las que la flecha indica el punto de union al anillo de pirazina; y cada R2 se selecciona independientemente de H, alquilo C1-4, alcoxi C1- 4, haloalquilo C1-4, haloalcoxi C1-4, ciano y halo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73366205P | 2005-11-04 | 2005-11-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR057855A1 true AR057855A1 (es) | 2007-12-19 |
Family
ID=37890558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060104815A AR057855A1 (es) | 2005-11-04 | 2006-11-02 | Derivados de pirazina y composicion farmaceutica |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7572797B2 (es) |
| EP (1) | EP1945630B1 (es) |
| JP (1) | JP2009514937A (es) |
| KR (1) | KR20080066073A (es) |
| CN (1) | CN101356169A (es) |
| AP (1) | AP2008004468A0 (es) |
| AR (1) | AR057855A1 (es) |
| AT (1) | ATE525372T1 (es) |
| AU (1) | AU2006310215A1 (es) |
| BR (1) | BRPI0618129A2 (es) |
| CA (1) | CA2624621C (es) |
| CR (1) | CR9954A (es) |
| DO (1) | DOP2006000243A (es) |
| EA (1) | EA200801011A1 (es) |
| EC (1) | ECSP088412A (es) |
| ES (1) | ES2371932T3 (es) |
| GT (1) | GT200600475A (es) |
| IL (1) | IL191059A0 (es) |
| MA (1) | MA29926B1 (es) |
| NL (1) | NL2000284C2 (es) |
| NO (1) | NO20082496L (es) |
| PE (1) | PE20070715A1 (es) |
| TN (1) | TNSN08196A1 (es) |
| TW (1) | TW200804353A (es) |
| UY (1) | UY29893A1 (es) |
| WO (1) | WO2007052123A2 (es) |
| ZA (1) | ZA200803671B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0934061B3 (en) | 1996-07-24 | 2015-01-21 | Warner-Lambert Company LLC | Isobutylgaba and its derivatives for the treatment of pain |
| EP1741708A1 (en) * | 2005-06-28 | 2007-01-10 | Sanofi-Aventis Deutschland GmbH | Heteroaryl-substituted amides comprising an unsaturated or cyclic linker group, and their use as pharmaceuticals |
| GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| US20100227872A1 (en) * | 2007-05-03 | 2010-09-09 | Mark Ian Kemp | Pyrazine derivatives |
| GEP20125379B (en) | 2007-05-03 | 2012-01-10 | Pfizer Ltd | 2 -pyridine carboxamide derivatives as sodium channel modulators |
| US8614255B2 (en) * | 2007-08-21 | 2013-12-24 | Civitas Therapeutics, Inc. | Pulmonary pharmaceutical formulations |
| KR101578235B1 (ko) | 2007-12-10 | 2015-12-16 | 노파르티스 아게 | 유기 화합물 |
| RU2010137862A (ru) | 2008-02-13 | 2012-03-20 | ЭЙСАЙ Ар энд Ди МЕНЕДЖМЕНТ КО., ЛТД. (JP) | Производное бициклоамина |
| US20110160249A1 (en) | 2008-05-23 | 2011-06-30 | Schaab Kevin Murray | 5-lipoxygenase-activating protein inhibitor |
| US8546431B2 (en) | 2008-10-01 | 2013-10-01 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| US10703722B2 (en) | 2010-04-27 | 2020-07-07 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| WO2013059677A1 (en) * | 2011-10-19 | 2013-04-25 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| KR102090944B1 (ko) * | 2012-04-25 | 2020-03-19 | 라퀄리아 파마 인코포레이티드 | Ttx-s 차단제로서의 피롤로피리디논 유도체 |
| EP3070085B1 (en) | 2013-02-04 | 2019-01-09 | Janssen Pharmaceutica NV | Flap modulators |
| TWI644899B (zh) | 2013-02-04 | 2018-12-21 | 健生藥品公司 | Ｆｌａｐ調節劑 |
| US10428029B2 (en) | 2014-09-10 | 2019-10-01 | Epizyme, Inc. | Isoxazole carboxamide compounds |
| CA2978007A1 (en) | 2015-02-27 | 2016-09-01 | Calcimedica, Inc. | Pancreatitis treatment |
| JP6738575B2 (ja) * | 2015-08-07 | 2020-08-12 | カルシメディカ，インク． | 脳卒中および外傷性脳損傷の処置のためのｃｒａｃチャネル阻害剤の使用 |
| GB201801128D0 (en) | 2018-01-24 | 2018-03-07 | Univ Oxford Innovation Ltd | Compounds |
| EP4243813A4 (en) | 2020-11-13 | 2024-07-17 | Calcimedica, Inc. | IMPROVED SYNTHESIS OF CRAC CHANNEL INHIBITORS |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA26473A1 (fr) * | 1997-03-01 | 2004-12-20 | Glaxo Group Ltd | Composes pharmacologiquement actifs. |
| MXPA04004714A (es) * | 2001-11-21 | 2004-08-19 | Upjohn Co | Derivados de aril 1,4-pirazina sustituidos. |
| US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
| KR20060123208A (ko) * | 2003-10-27 | 2006-12-01 | 아스테라스 세이야쿠 가부시키가이샤 | 피라진 유도체 및 이의 약학적 용도 |
| WO2006047504A1 (en) * | 2004-10-22 | 2006-05-04 | Janssen Pharmaceutica, N.V. | Aromatic amides as inhibitors of c-fms kinase |
-
2006
- 2006-10-20 NL NL2000284A patent/NL2000284C2/nl not_active IP Right Cessation
- 2006-10-23 CN CNA2006800504914A patent/CN101356169A/zh active Pending
- 2006-10-23 JP JP2008539517A patent/JP2009514937A/ja not_active Ceased
- 2006-10-23 EP EP06809149A patent/EP1945630B1/en not_active Not-in-force
- 2006-10-23 AT AT06809149T patent/ATE525372T1/de not_active IP Right Cessation
- 2006-10-23 AU AU2006310215A patent/AU2006310215A1/en not_active Abandoned
- 2006-10-23 BR BRPI0618129-5A patent/BRPI0618129A2/pt not_active IP Right Cessation
- 2006-10-23 KR KR1020087013403A patent/KR20080066073A/ko not_active Ceased
- 2006-10-23 WO PCT/IB2006/003055 patent/WO2007052123A2/en not_active Ceased
- 2006-10-23 ES ES06809149T patent/ES2371932T3/es active Active
- 2006-10-23 AP AP2008004468A patent/AP2008004468A0/xx unknown
- 2006-10-23 CA CA2624621A patent/CA2624621C/en not_active Expired - Fee Related
- 2006-10-23 EA EA200801011A patent/EA200801011A1/ru unknown
- 2006-11-01 UY UY29893A patent/UY29893A1/es not_active Application Discontinuation
- 2006-11-02 AR ARP060104815A patent/AR057855A1/es unknown
- 2006-11-02 GT GT200600475A patent/GT200600475A/es unknown
- 2006-11-03 TW TW095140879A patent/TW200804353A/zh unknown
- 2006-11-03 PE PE2006001349A patent/PE20070715A1/es not_active Application Discontinuation
- 2006-11-03 US US11/556,354 patent/US7572797B2/en not_active Expired - Fee Related
- 2006-11-03 DO DO2006000243A patent/DOP2006000243A/es unknown
-
2008
- 2008-04-25 ZA ZA200803671A patent/ZA200803671B/xx unknown
- 2008-04-27 IL IL191059A patent/IL191059A0/en unknown
- 2008-04-29 EC EC2008008412A patent/ECSP088412A/es unknown
- 2008-05-02 MA MA30893A patent/MA29926B1/fr unknown
- 2008-05-02 TN TNP2008000196A patent/TNSN08196A1/fr unknown
- 2008-05-07 CR CR9954A patent/CR9954A/es not_active Application Discontinuation
- 2008-06-04 NO NO20082496A patent/NO20082496L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| UY29893A1 (es) | 2007-06-29 |
| NO20082496L (no) | 2008-07-24 |
| ZA200803671B (en) | 2009-03-25 |
| CA2624621A1 (en) | 2007-05-10 |
| ECSP088412A (es) | 2008-05-30 |
| ATE525372T1 (de) | 2011-10-15 |
| US7572797B2 (en) | 2009-08-11 |
| NL2000284A1 (nl) | 2007-05-07 |
| US20070105872A1 (en) | 2007-05-10 |
| CN101356169A (zh) | 2009-01-28 |
| TNSN08196A1 (fr) | 2009-10-30 |
| PE20070715A1 (es) | 2007-08-11 |
| DOP2006000243A (es) | 2007-05-31 |
| EA200801011A1 (ru) | 2009-02-27 |
| WO2007052123A3 (en) | 2007-07-12 |
| AP2008004468A0 (en) | 2008-06-30 |
| IL191059A0 (en) | 2008-12-29 |
| TW200804353A (en) | 2008-01-16 |
| AU2006310215A1 (en) | 2007-05-10 |
| BRPI0618129A2 (pt) | 2011-08-16 |
| ES2371932T3 (es) | 2012-01-11 |
| WO2007052123A2 (en) | 2007-05-10 |
| EP1945630A2 (en) | 2008-07-23 |
| GT200600475A (es) | 2007-07-06 |
| MA29926B1 (fr) | 2008-11-03 |
| CR9954A (es) | 2008-05-28 |
| JP2009514937A (ja) | 2009-04-09 |
| EP1945630B1 (en) | 2011-09-21 |
| NL2000284C2 (nl) | 2007-09-28 |
| KR20080066073A (ko) | 2008-07-15 |
| CA2624621C (en) | 2010-11-30 |
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Legal Events
| Date | Code | Title | Description |
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| FB | Suspension of granting procedure |