PE20020102A1 - Composicion topica oral que comprende un agente modulador de la respuesta del huesped frente a patogenos periodontales - Google Patents
Composicion topica oral que comprende un agente modulador de la respuesta del huesped frente a patogenos periodontalesInfo
- Publication number
- PE20020102A1 PE20020102A1 PE2001000646A PE2001000646A PE20020102A1 PE 20020102 A1 PE20020102 A1 PE 20020102A1 PE 2001000646 A PE2001000646 A PE 2001000646A PE 2001000646 A PE2001000646 A PE 2001000646A PE 20020102 A1 PE20020102 A1 PE 20020102A1
- Authority
- PE
- Peru
- Prior art keywords
- agents
- host
- oral
- present
- oral cavity
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 244000052769 pathogen Species 0.000 title abstract 2
- 230000000699 topical effect Effects 0.000 title abstract 2
- 230000003239 periodontal effect Effects 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 4
- 210000000214 mouth Anatomy 0.000 abstract 3
- 241000894006 Bacteria Species 0.000 abstract 2
- 244000052616 bacterial pathogen Species 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 101710170181 Metalloproteinase inhibitor Proteins 0.000 abstract 1
- 102000003945 NF-kappa B Human genes 0.000 abstract 1
- 108010057466 NF-kappa B Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 230000002882 anti-plaque Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 235000006708 antioxidants Nutrition 0.000 abstract 1
- 239000003975 dentin desensitizing agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000002158 endotoxin Substances 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000003589 local anesthetic agent Substances 0.000 abstract 1
- 238000012423 maintenance Methods 0.000 abstract 1
- 230000000873 masking effect Effects 0.000 abstract 1
- 229940126170 metalloproteinase inhibitor Drugs 0.000 abstract 1
- 239000003475 metalloproteinase inhibitor Substances 0.000 abstract 1
- 239000003607 modifier Substances 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 108700012359 toxins Proteins 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Birds (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Finger-Pressure Massage (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
SE REFIERE A UNA COMPOSICION TOPICA ORAL QUE COMPRENDE: a) UNA CANTIDAD DE UN AGENTE MODULADOR DE LA RESPUESTA AL HUESPED COMO: i) UN ANTAGONISTA H2 TAL COMO CIMETIDINA, ETINTIDINA, RANITIDINA, ROXATIDINA, ENTRE OTROS, ii) UN AGENTE ANTIINFLAMATORIO TAL COMO ASPIRINA, KETOROLACO, IBUPROFENO, NAPROXENO, ENTRE OTROS, iii) UN MODIFICADOR DEL ESTADO REDOX TAL COMO VITAMINA C, VITAMINA E, ENTRE OTROS, iv) INHIBIDOR DE METALOPROTEINASA, v) UN AGENTE ANTIOXIDANTE, ENTRE OTROS; Y b) UN AGENTE PORTADOR ORAL FARMACEUTICAMENTE ACEPTABLE. LA COMPOSICION PUEDE SER ADMINISTRADA JUNTO A UN AGENTE ANTIMICROBIANO, ANTIBIOTICO, ANALGESICO, DESENSIBILIZADORES DE LA DENTINA Y ES CLAVE PARA EL MANTENIMIENTO DE UN EQUILIBRIO DE LA RESPUESTA DEL HUESPED FRENTE A PATOGENOS PERIODONTALES EN LA CAVIDAD BUCAL ASI COMO TOXINAS Y ENDOTOXINAS LIBERADAS POR ESTOS GENTES PATOGENOS Y LA CITOQUINAS Y MEDIADORES INFLAMATORIOS INDUCIDOS POR ESTOS AGENTES PATOGENOS BUCALES. LA COMPOSICION SE ENCUENTRA EN FORMA ENJUAGUE BUCAL, PASTA DENTRIFICA, AEROSOL BUCAL, PASTILLA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60760200A | 2000-06-30 | 2000-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020102A1 true PE20020102A1 (es) | 2002-03-06 |
Family
ID=24432968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000646A PE20020102A1 (es) | 2000-06-30 | 2001-06-28 | Composicion topica oral que comprende un agente modulador de la respuesta del huesped frente a patogenos periodontales |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8277782B2 (es) |
| EP (1) | EP1294367B1 (es) |
| JP (1) | JP4754155B2 (es) |
| CN (1) | CN1536989A (es) |
| AT (1) | ATE401065T1 (es) |
| AU (1) | AU2001271544A1 (es) |
| CA (1) | CA2415065C (es) |
| DE (1) | DE60134854D1 (es) |
| ES (1) | ES2309076T3 (es) |
| MX (1) | MXPA03000043A (es) |
| PE (1) | PE20020102A1 (es) |
| WO (1) | WO2002002096A2 (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8283135B2 (en) * | 2000-06-30 | 2012-10-09 | The Procter & Gamble Company | Oral care compositions containing combinations of anti-bacterial and host-response modulating agents |
| US20040101494A1 (en) | 2002-11-26 | 2004-05-27 | Scott Douglas Craig | Chewable solid unit dosage forms and methods for delivery of active agents into occlusal surfaces of teeth |
| KR20060121866A (ko) | 2003-09-09 | 2006-11-29 | 디에스엠 아이피 어셋츠 비.브이. | 산화에 민감한 물질 하나 이상을 함유하는 경구 활성을갖는 본질적으로 무수성의 국소 작용제 |
| WO2005046363A2 (en) | 2003-11-07 | 2005-05-26 | U.S. Smokeless Tobacco Company | Tobacco compositions |
| US8627828B2 (en) | 2003-11-07 | 2014-01-14 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
| WO2005117849A1 (en) | 2004-05-28 | 2005-12-15 | Unigen Pharmaceuticals, Inc. | Diarylalkanes as potent inhibitors of binuclear enzymes |
| US8168161B2 (en) * | 2004-12-22 | 2012-05-01 | Hill's Pet Nutrition, Inc. | Method to promote oral health in companion animals |
| JP2006182662A (ja) * | 2004-12-27 | 2006-07-13 | Lion Corp | 歯磨剤組成物 |
| US20080045575A1 (en) * | 2004-12-29 | 2008-02-21 | Van Dyke Thomas E | Delivery of H2 Antagonists |
| RU2381769C2 (ru) | 2005-11-04 | 2010-02-20 | Дзе Проктер Энд Гэмбл Компани | Электрическое устройство для ухода за полостью рта |
| US20070140990A1 (en) * | 2005-12-21 | 2007-06-21 | Nataly Fetissova | Oral Compositions Comprising Propolis |
| CA2660894C (en) | 2006-07-20 | 2018-12-04 | Izun Pharmaceuticals Corporation | Film-delivering rinse |
| US8858995B2 (en) | 2008-03-10 | 2014-10-14 | University Of Louisville Research Foundation, Inc. | Methods and compositions for controlled delivery of phytochemical agents |
| AU2009223653B2 (en) * | 2008-03-10 | 2014-07-31 | University Of Louisville Research Foundation, Inc. | Methods and compositions for controlled delivery of phytochemical agents |
| KR101849695B1 (ko) | 2008-07-21 | 2018-04-17 | 유니젠, 인크. | 일련의 피부-화이트닝(라이트닝) 화합물 |
| WO2011106089A1 (en) * | 2010-02-24 | 2011-09-01 | Bisco, Inc. | Benzalkonium chloride compositions for inhibiting the hydrolytic activity of endogenous matrix metalloproteinases in dental restorations |
| CN109896935A (zh) | 2011-03-24 | 2019-06-18 | 尤尼根公司 | 用于制备二芳基丙烷的化合物和方法 |
| US8731747B2 (en) | 2011-04-28 | 2014-05-20 | General Electric Company | Communication systems and method for a rail vehicle or other powered system |
| US8798807B2 (en) | 2011-06-13 | 2014-08-05 | General Electric Company | Data distribution system and method for distributing data in a vehicle |
| US8510026B2 (en) | 2011-06-13 | 2013-08-13 | General Electric Company | Data conversion system and method for converting data that is distributed in a vehicle |
| US8620552B2 (en) | 2011-06-13 | 2013-12-31 | General Electric Company | Data communication system and method for communicating data in a vehicle |
| WO2013049507A1 (en) | 2011-09-30 | 2013-04-04 | Perio Sciences, Llc | Antioxidant compositions for treatment of inflammation or oxidative damage |
| US20130274650A1 (en) * | 2012-04-17 | 2013-10-17 | Luitpold Pharmaceuticals, Inc. | Stabilized ketorolac compositions |
| US20150210964A1 (en) | 2014-01-24 | 2015-07-30 | The Procter & Gamble Company | Consumer Product Compositions |
| CN110024726B (zh) * | 2019-04-03 | 2022-03-08 | 中国水产科学研究院长江水产研究所 | 天然产物在激活斑点叉尾鮰核受体ahr1和ahr2活性中的应用 |
| CA3136620C (en) * | 2019-04-10 | 2023-12-05 | Black Tulip Management, Inc. | Oral rinse compositions for reducing pathogens underlying tooth decay, periodontitis and oral malodor |
| JP2022526682A (ja) * | 2019-04-10 | 2022-05-25 | ブラック チューリップ マネージメント、インコーポレイテッド | イヌにおける歯周病及び口臭の基礎をなす病原菌を低減し、歯周病及び口臭を治療するための口すすぎ用組成物 |
| CN112494483B (zh) * | 2020-11-13 | 2022-09-02 | 兰州大学 | 一种二硫杂环戊烯硫酮类化合物在抗菌方面的用途 |
| CN115024355B (zh) * | 2022-06-09 | 2023-06-09 | 宁波大学科学技术学院 | 对冷鲜肉保鲜的基于大蒜素的复合载体涂层的制备方法 |
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| KR20000052736A (ko) | 1996-10-22 | 2000-08-25 | 데이비드 엠 모이어 | 제1주석 글루코네이트를 함유하는 구강용 조성물 |
| NZ335780A (en) | 1996-10-23 | 2001-01-26 | Univ New York State Res Found | Compositions to control oral microbial oxidation-reduction (Eh) levels and treat gingivitis-periodontitis |
| US5906811A (en) * | 1997-06-27 | 1999-05-25 | Thione International, Inc. | Intra-oral antioxidant preparations |
| EP1009737A2 (en) | 1997-07-31 | 2000-06-21 | The Procter & Gamble Company | Sulfonylamino substituted hydroxamic acid derivatives as metalloprotease inhibitors |
| US5875799A (en) * | 1997-09-23 | 1999-03-02 | Advanced Medical Instruments, Inc. | Therapeutic dental floss for treating systemic diseases |
| US5875798A (en) * | 1997-09-23 | 1999-03-02 | Advanced Medical Instruments, Inc. | Therapeutic toothpick for treating oral and systemic diseases |
| CN1213534A (zh) | 1997-10-06 | 1999-04-14 | 陈创 | 口体舒治疗保健系统牙膏 |
| JPH11139947A (ja) | 1997-11-11 | 1999-05-25 | Sunstar Inc | マトリックスメタロプロテアーゼ阻害剤含有口腔用組成物 |
| US6228347B1 (en) * | 1997-12-01 | 2001-05-08 | Thione International, Inc. | Antioxidant gel for gingival conditions |
| US6350438B1 (en) * | 1998-02-27 | 2002-02-26 | The Procter & Gamble Company | Oral care compositions comprising chlorite and methods |
| US6132702A (en) * | 1998-02-27 | 2000-10-17 | The Procter & Gamble Company | Oral care compositions comprising chlorite and methods |
| JP3763075B2 (ja) * | 1998-04-24 | 2006-04-05 | サンスター株式会社 | 歯周病の予防又は治療用の食品組成物、口腔用組成物及び医薬組成物 |
| WO2007079331A2 (en) * | 2005-12-13 | 2007-07-12 | Richard Paul Bonfiglio | Antibacterial oral rinse formulation for preventing coronary artery disease |
-
2001
- 2001-06-28 DE DE60134854T patent/DE60134854D1/de not_active Expired - Lifetime
- 2001-06-28 AT AT01950569T patent/ATE401065T1/de not_active IP Right Cessation
- 2001-06-28 CN CNA018118607A patent/CN1536989A/zh active Pending
- 2001-06-28 EP EP01950569A patent/EP1294367B1/en not_active Revoked
- 2001-06-28 AU AU2001271544A patent/AU2001271544A1/en not_active Abandoned
- 2001-06-28 MX MXPA03000043A patent/MXPA03000043A/es active IP Right Grant
- 2001-06-28 WO PCT/US2001/020515 patent/WO2002002096A2/en not_active Ceased
- 2001-06-28 CA CA002415065A patent/CA2415065C/en not_active Expired - Fee Related
- 2001-06-28 JP JP2002506718A patent/JP4754155B2/ja not_active Expired - Fee Related
- 2001-06-28 ES ES01950569T patent/ES2309076T3/es not_active Expired - Lifetime
- 2001-06-28 PE PE2001000646A patent/PE20020102A1/es not_active Application Discontinuation
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2006
- 2006-04-24 US US11/409,850 patent/US8277782B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001271544A1 (en) | 2002-01-14 |
| WO2002002096A3 (en) | 2002-09-12 |
| CN1536989A (zh) | 2004-10-13 |
| WO2002002096A2 (en) | 2002-01-10 |
| DE60134854D1 (de) | 2008-08-28 |
| ATE401065T1 (de) | 2008-08-15 |
| CA2415065A1 (en) | 2002-01-10 |
| CA2415065C (en) | 2009-09-15 |
| JP4754155B2 (ja) | 2011-08-24 |
| ES2309076T3 (es) | 2008-12-16 |
| EP1294367B1 (en) | 2008-07-16 |
| JP2004501966A (ja) | 2004-01-22 |
| MXPA03000043A (es) | 2003-10-15 |
| EP1294367A2 (en) | 2003-03-26 |
| US20060193790A1 (en) | 2006-08-31 |
| US8277782B2 (en) | 2012-10-02 |
| WO2002002096A8 (en) | 2003-11-06 |
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| FD | Application declared void or lapsed |