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NO982072L - Amidin- og isotioureaderivater som inhibitorer av nitrogenoksydsyntase - Google Patents

Amidin- og isotioureaderivater som inhibitorer av nitrogenoksydsyntase

Info

Publication number
NO982072L
NO982072L NO982072A NO982072A NO982072L NO 982072 L NO982072 L NO 982072L NO 982072 A NO982072 A NO 982072A NO 982072 A NO982072 A NO 982072A NO 982072 L NO982072 L NO 982072L
Authority
NO
Norway
Prior art keywords
amidine
inhibitors
nitric oxide
oxide synthase
isothiourea derivatives
Prior art date
Application number
NO982072A
Other languages
English (en)
Other versions
NO982072D0 (no
Inventor
James Macdonald
James Matz
William Shakespeare
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9600275A external-priority patent/SE9600275D0/xx
Priority claimed from SE9603301A external-priority patent/SE9603301D0/xx
Priority claimed from SE9603300A external-priority patent/SE9603300D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Publication of NO982072D0 publication Critical patent/NO982072D0/no
Publication of NO982072L publication Critical patent/NO982072L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Exhaust Gas Treatment By Means Of Catalyst (AREA)
  • Treating Waste Gases (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Gas Separation By Absorption (AREA)

Abstract

Nye forbindelser av formel (I) hvor X, R , R , R , R4 og R5 er som definert heri, og optiske isomerer og racemater derav og farmasøytisk akseptable salter derav; samt fremgangsmåter for deres frem- stilling, preparater inneholdende disse forbindelsene og deres anvendelse i terapi.
NO982072A 1995-11-07 1998-05-06 Amidin- og isotioureaderivater som inhibitorer av nitrogenoksydsyntase NO982072L (no)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US625395P 1995-11-07 1995-11-07
US627695P 1995-11-07 1995-11-07
SE9600275A SE9600275D0 (sv) 1996-01-25 1996-01-25 Compounds
SE9603301A SE9603301D0 (sv) 1996-09-11 1996-09-11 Compounds and compositions
SE9603300A SE9603300D0 (sv) 1996-09-11 1996-09-11 Compounds
PCT/SE1996/001425 WO1997017344A1 (en) 1995-11-07 1996-11-06 Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase

Publications (2)

Publication Number Publication Date
NO982072D0 NO982072D0 (no) 1998-05-06
NO982072L true NO982072L (no) 1998-07-03

Family

ID=27532790

Family Applications (1)

Application Number Title Priority Date Filing Date
NO982072A NO982072L (no) 1995-11-07 1998-05-06 Amidin- og isotioureaderivater som inhibitorer av nitrogenoksydsyntase

Country Status (24)

Country Link
EP (1) EP0861250B1 (no)
JP (1) JP2000500132A (no)
KR (1) KR19990067349A (no)
AT (1) ATE213241T1 (no)
AU (1) AU701329B2 (no)
BR (1) BR9611276A (no)
CA (1) CA2235301A1 (no)
CZ (1) CZ139298A3 (no)
DE (1) DE69619259T2 (no)
DK (1) DK0861250T3 (no)
EE (1) EE9800141A (no)
ES (1) ES2171743T3 (no)
HU (1) HUP9900142A3 (no)
IL (1) IL124296A0 (no)
IS (1) IS4725A (no)
NO (1) NO982072L (no)
NZ (1) NZ322227A (no)
PL (1) PL326554A1 (no)
PT (1) PT861250E (no)
SI (1) SI0861250T1 (no)
SK (1) SK61098A3 (no)
TR (1) TR199800813T2 (no)
TW (1) TW458978B (no)
WO (1) WO1997017344A1 (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016526A1 (en) * 1996-10-16 1998-04-23 Glaxo Group Limited Tetrahydro-6h-pyrazino[1,2-b]isoquinoline 1,4-diones as apoprotein b-100 inhibitors
SE9701681D0 (sv) 1997-05-05 1997-05-05 Astra Ab New compounds
SE9901901D0 (sv) * 1999-05-26 1999-05-26 Astra Ab Compounds
US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
CN100509805C (zh) 2001-12-19 2009-07-08 H.隆德贝克有限公司 3,4-二氢-1h-异喹啉-2-基-衍生物
US6608193B2 (en) * 2001-12-21 2003-08-19 The Procter & Gamble Company Methods for synthesis of amino-tetrahydroisoquinoline ring compounds
WO2004014885A1 (en) * 2002-08-07 2004-02-19 Neuraxon Inc. Amino benzothiazole compounds with nos inhibitory activity
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
EP1603450A4 (en) 2003-03-07 2009-07-29 Univ Columbia PROCEDURE BASED ON TYPE 1 RYANODIN RECEPTOR
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
JP2009501705A (ja) * 2005-07-05 2009-01-22 アストラゼネカ・アクチエボラーグ 新規化合物、その製造方法、中間体、医薬組成物、並びにアルツハイマー病、認知障害、統合失調症に伴う認識機能障害、肥満及びパーキンソン病のような５−ｈｔ６介在疾患の治療におけるそれらの使用
US8247403B2 (en) 2007-03-07 2012-08-21 Takeda Pharmaceutical Company Limited Benzoxazepine derivatives and use thereof
ES2960374T3 (es) 2016-12-23 2024-03-04 Daiichi Sankyo Co Ltd Compuestos de sulfonamida con actividad inhibidora de la TNAP

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0690851B1 (en) * 1993-03-23 1999-05-19 Astra Aktiebolag Guanidine derivatives useful in therapy
EP0713483B1 (en) * 1993-08-12 2003-01-15 AstraZeneca AB Amidine derivatives with nitric oxide synthetase activities
AU7705694A (en) * 1993-10-04 1995-05-01 Glaxo Wellcome House Substituted urea and isothiourea derivatives as no synthase inhibitors
TW397812B (en) * 1995-02-11 2000-07-11 Astra Ab Bicyclic isothiourea derivatives useful in therapy

Also Published As

Publication number Publication date
NZ322227A (en) 1999-11-29
NO982072D0 (no) 1998-05-06
DK0861250T3 (da) 2002-04-29
EE9800141A (et) 1998-10-15
MX9803453A (es) 1998-09-30
TR199800813T2 (xx) 1998-07-21
CZ139298A3 (cs) 1998-09-16
DE69619259D1 (de) 2002-03-21
TW458978B (en) 2001-10-11
PL326554A1 (en) 1998-09-28
AU7592796A (en) 1997-05-29
JP2000500132A (ja) 2000-01-11
SI0861250T1 (en) 2002-06-30
PT861250E (pt) 2002-07-31
EP0861250B1 (en) 2002-02-13
DE69619259T2 (de) 2002-09-19
BR9611276A (pt) 1999-01-26
HUP9900142A2 (hu) 1999-05-28
EP0861250A1 (en) 1998-09-02
ES2171743T3 (es) 2002-09-16
HUP9900142A3 (en) 2001-08-28
SK61098A3 (en) 1999-01-11
AU701329B2 (en) 1999-01-28
IL124296A0 (en) 1998-12-06
KR19990067349A (ko) 1999-08-16
CA2235301A1 (en) 1997-05-15
IS4725A (is) 1998-04-24
WO1997017344A1 (en) 1997-05-15
ATE213241T1 (de) 2002-02-15

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