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HUP9900142A3 - Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase - Google Patents

Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase

Info

Publication number
HUP9900142A3
HUP9900142A3 HU9900142A HUP9900142A HUP9900142A3 HU P9900142 A3 HUP9900142 A3 HU P9900142A3 HU 9900142 A HU9900142 A HU 9900142A HU P9900142 A HUP9900142 A HU P9900142A HU P9900142 A3 HUP9900142 A3 HU P9900142A3
Authority
HU
Hungary
Prior art keywords
amidine
inhibitors
nitric oxide
oxide synthase
isothiourea derivatives
Prior art date
Application number
HU9900142A
Other languages
English (en)
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9600275A external-priority patent/SE9600275D0/xx
Priority claimed from SE9603300A external-priority patent/SE9603300D0/xx
Priority claimed from SE9603301A external-priority patent/SE9603301D0/xx
Application filed by Astra Ab filed Critical Astra Ab
Publication of HUP9900142A2 publication Critical patent/HUP9900142A2/hu
Publication of HUP9900142A3 publication Critical patent/HUP9900142A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Treating Waste Gases (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Exhaust Gas Treatment By Means Of Catalyst (AREA)
  • Gas Separation By Absorption (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HU9900142A 1995-11-07 1996-11-06 Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase HUP9900142A3 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US627695P 1995-11-07 1995-11-07
US625395P 1995-11-07 1995-11-07
SE9600275A SE9600275D0 (sv) 1996-01-25 1996-01-25 Compounds
SE9603300A SE9603300D0 (sv) 1996-09-11 1996-09-11 Compounds
SE9603301A SE9603301D0 (sv) 1996-09-11 1996-09-11 Compounds and compositions

Publications (2)

Publication Number Publication Date
HUP9900142A2 HUP9900142A2 (hu) 1999-05-28
HUP9900142A3 true HUP9900142A3 (en) 2001-08-28

Family

ID=27532790

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9900142A HUP9900142A3 (en) 1995-11-07 1996-11-06 Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase

Country Status (24)

Country Link
EP (1) EP0861250B1 (hu)
JP (1) JP2000500132A (hu)
KR (1) KR19990067349A (hu)
AT (1) ATE213241T1 (hu)
AU (1) AU701329B2 (hu)
BR (1) BR9611276A (hu)
CA (1) CA2235301A1 (hu)
CZ (1) CZ139298A3 (hu)
DE (1) DE69619259T2 (hu)
DK (1) DK0861250T3 (hu)
EE (1) EE9800141A (hu)
ES (1) ES2171743T3 (hu)
HU (1) HUP9900142A3 (hu)
IL (1) IL124296A0 (hu)
IS (1) IS4725A (hu)
NO (1) NO982072L (hu)
NZ (1) NZ322227A (hu)
PL (1) PL326554A1 (hu)
PT (1) PT861250E (hu)
SI (1) SI0861250T1 (hu)
SK (1) SK61098A3 (hu)
TR (1) TR199800813T2 (hu)
TW (1) TW458978B (hu)
WO (1) WO1997017344A1 (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016526A1 (en) * 1996-10-16 1998-04-23 Glaxo Group Limited Tetrahydro-6h-pyrazino[1,2-b]isoquinoline 1,4-diones as apoprotein b-100 inhibitors
SE9701681D0 (sv) * 1997-05-05 1997-05-05 Astra Ab New compounds
SE9901901D0 (sv) * 1999-05-26 1999-05-26 Astra Ab Compounds
US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
CN100509805C (zh) 2001-12-19 2009-07-08 H.隆德贝克有限公司 3,4-二氢-1h-异喹啉-2-基-衍生物
US6608193B2 (en) * 2001-12-21 2003-08-19 The Procter & Gamble Company Methods for synthesis of amino-tetrahydroisoquinoline ring compounds
ATE375333T1 (de) * 2002-08-07 2007-10-15 Neuraxon Inc Aminobenzothiazolverbindungen mit nos-hemmender wirkung
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
EP1603450A4 (en) 2003-03-07 2009-07-29 Univ Columbia PROCEDURE BASED ON TYPE 1 RYANODIN RECEPTOR
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
CN101258135A (zh) * 2005-07-05 2008-09-03 阿斯利康(瑞典)有限公司 新化合物、其制备方法、中间体、药物组合物和其在治疗5－ht6介导的疾病例如阿尔茨海默病、认知障碍、精神分裂症相关的认知缺损、肥胖和帕金森病中的用途
JP5497429B2 (ja) 2007-03-07 2014-05-21 武田薬品工業株式会社 ベンゾオキサゼピン誘導体およびその用途
CA3045492C (en) 2016-12-23 2021-10-19 Daiichi Sankyo Company, Limited Sulfonamide compounds having tnap inhibitory activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995009619A2 (en) * 1993-10-04 1995-04-13 The Wellcome Foundation Limited Substituted urea and isothiourea derivatives as no synthase inhibitors
EP0690851B1 (en) * 1993-03-23 1999-05-19 Astra Aktiebolag Guanidine derivatives useful in therapy
JPH09501918A (ja) * 1993-08-12 1997-02-25 アストラ・アクチエボラーグ 酸化窒素合成酵素活性を有するアミジン誘導体
TW397812B (en) * 1995-02-11 2000-07-11 Astra Ab Bicyclic isothiourea derivatives useful in therapy

Also Published As

Publication number Publication date
NO982072L (no) 1998-07-03
BR9611276A (pt) 1999-01-26
SI0861250T1 (en) 2002-06-30
JP2000500132A (ja) 2000-01-11
DE69619259T2 (de) 2002-09-19
PT861250E (pt) 2002-07-31
AU7592796A (en) 1997-05-29
TR199800813T2 (xx) 1998-07-21
KR19990067349A (ko) 1999-08-16
CA2235301A1 (en) 1997-05-15
NZ322227A (en) 1999-11-29
ATE213241T1 (de) 2002-02-15
WO1997017344A1 (en) 1997-05-15
DE69619259D1 (de) 2002-03-21
SK61098A3 (en) 1999-01-11
TW458978B (en) 2001-10-11
CZ139298A3 (cs) 1998-09-16
ES2171743T3 (es) 2002-09-16
AU701329B2 (en) 1999-01-28
HUP9900142A2 (hu) 1999-05-28
EE9800141A (et) 1998-10-15
PL326554A1 (en) 1998-09-28
EP0861250A1 (en) 1998-09-02
DK0861250T3 (da) 2002-04-29
MX9803453A (es) 1998-09-30
NO982072D0 (no) 1998-05-06
IS4725A (is) 1998-04-24
IL124296A0 (en) 1998-12-06
EP0861250B1 (en) 2002-02-13

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