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NO961812L - Humanproteaseinhibitorer av Kunitz-type - Google Patents

Humanproteaseinhibitorer av Kunitz-type

Info

Publication number
NO961812L
NO961812L NO961812A NO961812A NO961812L NO 961812 L NO961812 L NO 961812L NO 961812 A NO961812 A NO 961812A NO 961812 A NO961812 A NO 961812A NO 961812 L NO961812 L NO 961812L
Authority
NO
Norway
Prior art keywords
dna
kunitz
type human
protease inhibitors
dna segment
Prior art date
Application number
NO961812A
Other languages
English (en)
Other versions
NO961812D0 (no
Inventor
Cindy A Sprecher
Walter Kisiel
Donald C Foster
Original Assignee
Zymogenetics Inc
Univ New Mexico
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc, Univ New Mexico filed Critical Zymogenetics Inc
Publication of NO961812D0 publication Critical patent/NO961812D0/no
Publication of NO961812L publication Critical patent/NO961812L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Foreliggende oppfinnelse til- veiebringer isolerte DNA-molekyler som omfatter et DNA-segment som koder for nye humaninhibitorer av Kunitz-type. Det er også tilveiebrakt DNA-konstruk- sjoner som omfatter et første DNA-seg- ment som koder for en ny humaninhibitor av Kunitz-type, hvor det første DNA- segment er operativt bundet til ytter- ligere DNA-segmenter som er påkrevet for ekspresjonen av det første DNA-seg- ment, samt vertsceller som inneholder slike DNA-konstruksjoner, og fremgangs- måter for fremstilling av proteiner fra vertscellene.
NO961812A 1993-11-05 1996-05-03 Humanproteaseinhibitorer av Kunitz-type NO961812L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/147,710 US5455338A (en) 1993-11-05 1993-11-05 DNA encoding novel human kunitz-type inhibitors and methods relating thereto
PCT/US1994/012609 WO1995012674A1 (en) 1993-11-05 1994-11-02 Human kunitz-type protease inhibitors

Publications (2)

Publication Number Publication Date
NO961812D0 NO961812D0 (no) 1996-05-03
NO961812L true NO961812L (no) 1996-07-05

Family

ID=22522614

Family Applications (1)

Application Number Title Priority Date Filing Date
NO961812A NO961812L (no) 1993-11-05 1996-05-03 Humanproteaseinhibitorer av Kunitz-type

Country Status (12)

Country Link
US (7) US5455338A (no)
EP (1) EP0726953B1 (no)
JP (1) JP3201527B2 (no)
KR (1) KR100243989B1 (no)
CN (1) CN1073159C (no)
AT (1) ATE262587T1 (no)
AU (1) AU685190B2 (no)
CA (1) CA2175797C (no)
DE (1) DE69433647T2 (no)
FI (1) FI961886A7 (no)
NO (1) NO961812L (no)
WO (1) WO1995012674A1 (no)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455338A (en) * 1993-11-05 1995-10-03 Zymogenetics, Inc. DNA encoding novel human kunitz-type inhibitors and methods relating thereto
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
CA2202131A1 (en) * 1995-08-09 1997-02-20 Jun Utsumi Therapeutic agent for ophthalmic diseases
ES2263174T3 (es) * 1996-03-11 2006-12-01 Bayer Corporation Bikunina humana.
EP1374891B1 (en) * 1998-12-22 2008-09-10 Bayer Aktiengesellschaft Method for accelerating the rate of mucociliary clearance
US20070140979A1 (en) * 1998-12-22 2007-06-21 Bayer Aktiengesellschaft Method for accelerating the rate of mucociliary clearance
WO2001009360A1 (en) * 1999-08-02 2001-02-08 Avigen, Inc. USE OF RECOMBINANT ADENO-ASSOCIATED VIRUS VECTOR (rAAV) FOR THE PREVENTION OF SMOOTH MUSCLE CELL PROLIFERATION IN A VASCULAR GRAFT
US6180607B1 (en) 1999-08-05 2001-01-30 Christopher Davies Protein having proteinase inhibitor activity
US20040235715A1 (en) * 1999-11-12 2004-11-25 Bayer Corporation Method of producing glycosylated bikunin
US6964764B2 (en) 1999-11-13 2005-11-15 Talecris Biotherapeutics, Inc. Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
US6355243B1 (en) * 1999-11-13 2002-03-12 Bayer Corporation Method of thrombolysis by local delivery of active plasmin
US7544500B2 (en) * 1999-11-13 2009-06-09 Talecris Biotherapeutics, Inc. Process for the production of a reversibly inactive acidified plasmin composition
US20020132978A1 (en) * 2000-03-21 2002-09-19 Hans-Peter Gerber VEGF-modulated genes and methods employing them
AU2001296470A1 (en) 2000-10-02 2002-04-15 Marc D. Andelman Fringe-field capacitor electrode for electrochemical device
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
EP2298278B1 (en) * 2002-06-07 2015-11-11 Dyax Corp. Prevention and reduction of blood loss and inflammatory response
US7244616B2 (en) 2003-06-27 2007-07-17 Bayer Pharmaceuticals Corporation Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells
US7910550B2 (en) * 2004-04-16 2011-03-22 Stc.Unm Human kunitz-type inhibitor with enhanced antifibrinolytic activity
US7432238B2 (en) * 2004-04-16 2008-10-07 Stc.Unm Human Kunitz-type inhibitor with enhanced antifibrinolytic activity
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
RU2007137489A (ru) * 2005-03-10 2009-04-20 Дженентек, Инк. (Us) Способы и композиции для модуляции целостности сосудов
PL1981519T3 (pl) 2005-12-29 2018-07-31 Dyax Corp. Hamowanie proteaz
US8993719B2 (en) 2005-12-29 2015-03-31 The Regents Of The University Of California Methods and compositions related to mutant Kunitz domain I of TFPI-2
US20070278239A1 (en) * 2006-05-17 2007-12-06 Michele Vogt Sipping lid closure device and method of use
JP2010536870A (ja) * 2007-08-21 2010-12-02 ジェンザイム・コーポレーション カリクレイン阻害剤を用いた治療
DE102007056231A1 (de) 2007-09-08 2009-03-12 Bayer Healthcare Ag Herstellung und Verwendung von Varianten humander Kunitz-Typ Protease-Inhibitoren (hKTPI)
EP3078743B1 (en) 2007-09-28 2020-06-24 Portola Pharmaceuticals, Inc. Antidotes for factor xa inhibitors and methods of using the same
NZ589557A (en) * 2008-06-04 2012-08-31 Talecris Biotherapeutics Inc Immobilised streptokinase, method and kit for preparing plasmin
CN104984319B (zh) 2008-12-19 2025-05-09 武田药品工业株式会社 Tfpi抑制剂和使用方法
WO2010072691A1 (en) * 2008-12-22 2010-07-01 Novo Nordisk A/S Antibodies against tissue factor pathway inhibitor
AU2010203712A1 (en) * 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
EP2403865B9 (en) 2009-03-03 2015-12-09 Grifols Therapeutics Inc. Methods for preparing plasminogen
FI3604510T3 (fi) 2009-03-30 2025-06-26 Alexion Pharma Inc Vastalääkkeitä tekijä xa:n estäjille ja menetelmiä niiden käyttämiseksi
CN101588509B (zh) * 2009-06-23 2011-08-24 硅谷数模半导体（北京）有限公司 视频图像编码和解码方法
WO2011008885A1 (en) 2009-07-15 2011-01-20 Portola Pharmaceuticals, Inc. Unit dose formulation of antidotes for factor xa inhibitors and methods of using the same
RS57870B1 (sr) 2010-01-06 2018-12-31 Dyax Corp Proteini koji vezuju kalikrein plazme
SG10201502587SA (en) 2010-03-01 2015-06-29 Bayer Healthcare Llc Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi)
BR112012023559A2 (pt) 2010-03-19 2017-10-17 Baxter Healthcare Sa inibidores tfpi e métodos de uso
KR102320178B1 (ko) 2011-01-06 2021-11-02 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 결합 단백질
US11448657B2 (en) * 2011-01-18 2022-09-20 Rambam Med-Tech Methods and kits for assessing Heparanase procoagulant activity, compositions comprising Heparanase, and methods for the treatment of coagulation-related disorders
WO2013016449A2 (en) 2011-07-26 2013-01-31 Indicator Systems International, Inc. Assays for the detection of microbes
AU2013234046B2 (en) 2012-03-16 2017-09-07 University Health Network Methods and compositions for modulating Toso activity
CA2867363C (en) 2012-03-21 2023-02-28 Baxter International Inc. Tfpi inhibitors and methods of use
CN105377888A (zh) * 2013-03-15 2016-03-02 加利福尼亚大学董事会 纤维蛋白溶解的双反应性的有效的Kunitz抑制剂
US20150250853A1 (en) 2014-03-07 2015-09-10 University Health Network Methods and compositions for modifying the immune response
KR102555955B1 (ko) 2014-03-27 2023-07-18 다케다 파머수티컬 컴패니 리미티드 당뇨병성 황반 부종의 치료를 위한 조성물 및 방법
WO2017011275A1 (en) 2015-07-10 2017-01-19 Nersissian Aram M Factor viii protein compositions and methods of treating hemophilia a
WO2017023863A1 (en) 2015-07-31 2017-02-09 Research Institute At Nationwide Children's Hospital Peptides and antibodies for the removal of biofilms
WO2017066719A2 (en) 2015-10-14 2017-04-20 Research Institute At Nationwide Children's Hospital Hu specific interfering agents
EA201891388A1 (ru) 2015-12-11 2018-11-30 Дайэкс Корп. Ингибиторы калликреина плазмы и их применение для лечения обострения наследственного ангионевротического отека
US12098188B2 (en) 2017-01-04 2024-09-24 Research Institute At Nationwide Children's Hospital Antibody fragments for the treatment of biofilm-related disorders
JP7514621B2 (ja) 2017-01-04 2024-07-11 リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル Ｄｎａｂｉｉワクチンおよび強化された活性を有する抗体
AU2018236271B2 (en) 2017-03-15 2023-12-21 Research Institute At Nationwide Children's Hospital Composition and methods for disruption of bacterial biofilms without accompanying inflammation
US12209118B2 (en) 2019-07-08 2025-01-28 Research Institute At Nationwide Children's Hospital Antibody compositions for disrupting biofilms
US12528880B2 (en) 2020-01-13 2026-01-20 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack
CN112206310B (zh) * 2020-09-23 2022-10-21 湖北医药学院 一组用于抑制补体的寄生绦虫多肽

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1244763A (en) * 1984-09-21 1988-11-15 Christian P.M. Reutelingsperger Blood coagulation inhibiting proteins, processes for preparing them and their uses
US5011912A (en) * 1986-12-19 1991-04-30 Immunex Corporation Hybridoma and monoclonal antibody for use in an immunoaffinity purification system
US5106833A (en) * 1987-07-23 1992-04-21 Washington University Coagulation inhibitors
IL87171A (en) * 1987-11-23 1995-08-31 Monsanto Co cDNA of human tissue factor inhibitor
DK408089D0 (da) * 1989-08-18 1989-08-18 Novo Nordisk As Proteiner
US5557518A (en) * 1994-04-28 1996-09-17 Citibank, N.A. Trusted agents for open electronic commerce
IL104325A (en) * 1992-01-07 2000-10-31 Novo Nordisk As Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above
IL104324A0 (en) * 1992-01-07 1993-05-13 Novo Nordisk As Variant of human kunitz-type protease inhibitor
US5276015A (en) * 1992-03-18 1994-01-04 Washington University Method of inhibiting microvascular thrombosis
US5884292A (en) * 1993-05-06 1999-03-16 Pitney Bowes Inc. System for smart card funds refill
US5455338A (en) * 1993-11-05 1995-10-03 Zymogenetics, Inc. DNA encoding novel human kunitz-type inhibitors and methods relating thereto
US5578808A (en) * 1993-12-22 1996-11-26 Datamark Services, Inc. Data card that can be used for transactions involving separate card issuers
US5854975A (en) * 1994-12-23 1998-12-29 Freedom Wireless, Inc. Prepaid security cellular telecommunications system
US5722067A (en) * 1994-12-23 1998-02-24 Freedom Wireless, Inc. Security cellular telecommunications system
US5903633A (en) * 1995-03-27 1999-05-11 Smarttalk Teleservices, Inc. Method and apparatus for prepaid phone card activation and billing
US5684291A (en) * 1995-06-01 1997-11-04 American Express Trs Refundable prepaid telephone card
US5778313A (en) * 1995-12-08 1998-07-07 Cellexis International, Inc. Pre-paid cellular telephone system
US5892827A (en) * 1996-06-14 1999-04-06 Catalina Marketing International, Inc. Method and apparatus for generating personal identification numbers for use in consumer transactions
US5845259A (en) * 1996-06-27 1998-12-01 Electronic Consumer Concepts, L.L.C. Electronic coupon dispensing system
US5991749A (en) * 1996-09-11 1999-11-23 Morrill, Jr.; Paul H. Wireless telephony for collecting tolls, conducting financial transactions, and authorizing other activities
US5828740A (en) * 1996-11-14 1998-10-27 Sprint Communications Co., L.P. Prepaid calling card external/adjunct database processor
US5991380A (en) * 1997-10-21 1999-11-23 At&T Corp. Universal telecommunications services account
US6035025A (en) * 1998-01-07 2000-03-07 National Telemanagement Corporation System and method for a prepaid bundled telecommunications account
US7249054B2 (en) * 1998-06-18 2007-07-24 Keil Dean S System and method for debit account transactions
EP1105813A4 (en) * 1998-08-25 2001-10-10 Mobshop Inc ON-LINE MARKETING SYSTEM AND METHOD
US20030163425A1 (en) * 2002-02-26 2003-08-28 Cannon Thomas Calvin System for executing high-volume electronic bill payments

Also Published As

Publication number Publication date
EP0726953A1 (en) 1996-08-21
US6656746B2 (en) 2003-12-02
CA2175797C (en) 2000-07-18
US20070092948A1 (en) 2007-04-26
FI961886L (fi) 1996-07-03
AU685190B2 (en) 1998-01-15
US5455338A (en) 1995-10-03
KR100243989B1 (ko) 2000-02-01
FI961886A0 (fi) 1996-05-03
ATE262587T1 (de) 2004-04-15
US7541449B2 (en) 2009-06-02
KR960705850A (ko) 1996-11-08
DE69433647D1 (de) 2004-04-29
CN1139955A (zh) 1997-01-08
CA2175797A1 (en) 1995-05-11
NO961812D0 (no) 1996-05-03
FI961886A7 (fi) 1996-07-03
JPH09504696A (ja) 1997-05-13
EP0726953B1 (en) 2004-03-24
WO1995012674A1 (en) 1995-05-11
US20020098560A1 (en) 2002-07-25
US5728674A (en) 1998-03-17
AU8131294A (en) 1995-05-23
JP3201527B2 (ja) 2001-08-20
US20040253686A1 (en) 2004-12-16
US5914315A (en) 1999-06-22
CN1073159C (zh) 2001-10-17
DE69433647T2 (de) 2004-08-05
US20050004021A1 (en) 2005-01-06

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