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FI961886A7 - Ihmisen Kunitz-tyyppiset proteaasi-inhibiittorit - Google Patents

Ihmisen Kunitz-tyyppiset proteaasi-inhibiittorit Download PDF

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Publication number
FI961886A7
FI961886A7 FI961886A FI961886A FI961886A7 FI 961886 A7 FI961886 A7 FI 961886A7 FI 961886 A FI961886 A FI 961886A FI 961886 A FI961886 A FI 961886A FI 961886 A7 FI961886 A7 FI 961886A7
Authority
FI
Finland
Prior art keywords
protease inhibitors
type protease
human kunitz
kunitz
human
Prior art date
Application number
FI961886A
Other languages
English (en)
Swedish (sv)
Other versions
FI961886L (fi
FI961886A0 (fi
Inventor
Cindy A Sprecher
Walter Kisiel
Donald C Foster
Original Assignee
Zymogenetics Inc
Univ Of New Mexico
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc, Univ Of New Mexico filed Critical Zymogenetics Inc
Publication of FI961886A0 publication Critical patent/FI961886A0/fi
Publication of FI961886A7 publication Critical patent/FI961886A7/fi
Publication of FI961886L publication Critical patent/FI961886L/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FI961886A 1993-11-05 1994-11-02 Ihmisen Kunitz-tyyppiset proteaasi-inhibiittorit FI961886L (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/147,710 US5455338A (en) 1993-11-05 1993-11-05 DNA encoding novel human kunitz-type inhibitors and methods relating thereto
PCT/US1994/012609 WO1995012674A1 (en) 1993-11-05 1994-11-02 Human kunitz-type protease inhibitors

Publications (3)

Publication Number Publication Date
FI961886A0 FI961886A0 (fi) 1996-05-03
FI961886A7 true FI961886A7 (fi) 1996-07-03
FI961886L FI961886L (fi) 1996-07-03

Family

ID=22522614

Family Applications (1)

Application Number Title Priority Date Filing Date
FI961886A FI961886L (fi) 1993-11-05 1994-11-02 Ihmisen Kunitz-tyyppiset proteaasi-inhibiittorit

Country Status (12)

Country Link
US (7) US5455338A (fi)
EP (1) EP0726953B1 (fi)
JP (1) JP3201527B2 (fi)
KR (1) KR100243989B1 (fi)
CN (1) CN1073159C (fi)
AT (1) ATE262587T1 (fi)
AU (1) AU685190B2 (fi)
CA (1) CA2175797C (fi)
DE (1) DE69433647T2 (fi)
FI (1) FI961886L (fi)
NO (1) NO961812L (fi)
WO (1) WO1995012674A1 (fi)

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US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
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US20070140979A1 (en) * 1998-12-22 2007-06-21 Bayer Aktiengesellschaft Method for accelerating the rate of mucociliary clearance
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US6180607B1 (en) 1999-08-05 2001-01-30 Christopher Davies Protein having proteinase inhibitor activity
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US6964764B2 (en) 1999-11-13 2005-11-15 Talecris Biotherapeutics, Inc. Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin
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US6781817B2 (en) 2000-10-02 2004-08-24 Biosource, Inc. Fringe-field capacitor electrode for electrochemical device
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DK2298278T3 (en) 2002-06-07 2016-02-01 Dyax Corp Prevention and reduction of blood loss and inflammatory response
US7244616B2 (en) 2003-06-27 2007-07-17 Bayer Pharmaceuticals Corporation Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells
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KR101792032B1 (ko) 2008-12-19 2017-11-02 백스터 인터내셔널 인코포레이티드 Ｔｆｐｉ 억제제 및 사용 방법
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WO2010080833A1 (en) * 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
US9206410B2 (en) 2009-03-03 2015-12-08 Grifols Therapeutics Inc. Compositions, methods and kits for preparing plasminogen and plasmin prepared therefrom
DK3604510T3 (da) 2009-03-30 2025-06-30 Alexion Pharma Inc Antidoter til faktor-Xa-hæmmere og fremgangsmåder til anvendelse deraf
CN101588509B (zh) * 2009-06-23 2011-08-24 硅谷数模半导体（北京）有限公司 视频图像编码和解码方法
CN102625712B (zh) 2009-07-15 2017-07-25 博尔托拉制药公司 用于因子xa抑制剂的解毒剂的单位剂量制剂及其使用方法
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ES2765418T3 (es) 2010-03-01 2020-06-09 Bayer Healthcare Llc Anticuerpos monoclonales optimizados contra el inhibidor de la ruta del factor tisular (TFPI)
CA2793465C (en) 2010-03-19 2022-06-14 Baxter International Inc. Tfpi inhibitors and methods of use
CN105713092B (zh) 2011-01-06 2019-09-10 戴埃克斯有限公司 血浆前激肽释放酶结合蛋白
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WO2014144658A1 (en) * 2013-03-15 2014-09-18 The Regents Of The University Of California Dual reactivity potent kunitz inhibitor of fibrinolysis
EP3113798B1 (en) 2014-03-07 2019-06-05 University Health Network Methods and compositions for modifying the immune response
JP6719384B2 (ja) 2014-03-27 2020-07-15 ダイアックス コーポレーション 糖尿病黄斑浮腫の治療のための組成物および方法
WO2017011275A1 (en) 2015-07-10 2017-01-19 Nersissian Aram M Factor viii protein compositions and methods of treating hemophilia a
JP2018528763A (ja) 2015-07-31 2018-10-04 リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル バイオフィルムの除去のためのペプチドおよび抗体
EP3365027B1 (en) 2015-10-14 2022-03-30 Research Institute at Nationwide Children's Hospital Hu specific antibodies and their use in inhibiting biofilm
KR102857973B1 (ko) 2015-12-11 2025-09-10 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 저해제 및 유전성 혈관부종 발작을 치료하기 위한 이의 용도
US12098188B2 (en) 2017-01-04 2024-09-24 Research Institute At Nationwide Children's Hospital Antibody fragments for the treatment of biofilm-related disorders
JP7514621B2 (ja) 2017-01-04 2024-07-11 リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル Ｄｎａｂｉｉワクチンおよび強化された活性を有する抗体
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Also Published As

Publication number Publication date
CA2175797A1 (en) 1995-05-11
AU685190B2 (en) 1998-01-15
US20070092948A1 (en) 2007-04-26
EP0726953A1 (en) 1996-08-21
JP3201527B2 (ja) 2001-08-20
FI961886L (fi) 1996-07-03
ATE262587T1 (de) 2004-04-15
US7541449B2 (en) 2009-06-02
CN1139955A (zh) 1997-01-08
CA2175797C (en) 2000-07-18
US20040253686A1 (en) 2004-12-16
EP0726953B1 (en) 2004-03-24
KR100243989B1 (ko) 2000-02-01
KR960705850A (ko) 1996-11-08
NO961812L (no) 1996-07-05
FI961886A0 (fi) 1996-05-03
US20050004021A1 (en) 2005-01-06
WO1995012674A1 (en) 1995-05-11
DE69433647D1 (de) 2004-04-29
DE69433647T2 (de) 2004-08-05
AU8131294A (en) 1995-05-23
US5455338A (en) 1995-10-03
US5914315A (en) 1999-06-22
JPH09504696A (ja) 1997-05-13
US20020098560A1 (en) 2002-07-25
US6656746B2 (en) 2003-12-02
US5728674A (en) 1998-03-17
NO961812D0 (no) 1996-05-03
CN1073159C (zh) 2001-10-17

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