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IL104324A0 - Variant of human kunitz-type protease inhibitor - Google Patents

Variant of human kunitz-type protease inhibitor

Info

Publication number
IL104324A0
IL104324A0 IL104324A IL10432493A IL104324A0 IL 104324 A0 IL104324 A0 IL 104324A0 IL 104324 A IL104324 A IL 104324A IL 10432493 A IL10432493 A IL 10432493A IL 104324 A0 IL104324 A0 IL 104324A0
Authority
IL
Israel
Prior art keywords
variant
protease inhibitor
type protease
human kunitz
kunitz
Prior art date
Application number
IL104324A
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of IL104324A0 publication Critical patent/IL104324A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL104324A 1992-01-07 1993-01-06 Variant of human kunitz-type protease inhibitor IL104324A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK9200002 1992-01-07
DK9200340 1992-11-16

Publications (1)

Publication Number Publication Date
IL104324A0 true IL104324A0 (en) 1993-05-13

Family

ID=26068350

Family Applications (1)

Application Number Title Priority Date Filing Date
IL104324A IL104324A0 (en) 1992-01-07 1993-01-06 Variant of human kunitz-type protease inhibitor

Country Status (13)

Country Link
EP (1) EP0621872A1 (en)
JP (1) JPH07504891A (en)
AU (1) AU675926B2 (en)
CA (1) CA2127246A1 (en)
CZ (1) CZ164494A3 (en)
FI (1) FI943234A7 (en)
HU (1) HUT70293A (en)
IL (1) IL104324A0 (en)
NO (1) NO942549L (en)
NZ (1) NZ246570A (en)
RU (1) RU94036773A (en)
WO (1) WO1993014122A1 (en)
ZA (1) ZA9396B (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455338A (en) 1993-11-05 1995-10-03 Zymogenetics, Inc. DNA encoding novel human kunitz-type inhibitors and methods relating thereto
US6057287A (en) * 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
EP0737207B1 (en) 1994-01-11 2004-09-22 Dyax Corporation Inhibitors of human plasmin derived from the kunitz domains
DE69533472T2 (en) * 1994-01-11 2006-01-12 Dyax Corp., Cambridge KALLIKER INHIBITING "KUNITZ DOMAIN" PROTEINS AND DERIVATIVES THEREOF
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
DE69528591T2 (en) * 1994-08-05 2003-02-20 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville PRODUCTION OF THE INHIBITOR FOR THE COMPLEX FORMATION OF THE TISSUE FACTOR
US5589359A (en) * 1994-08-05 1996-12-31 Chiron Corporation Chimeric proteins
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
US5780265A (en) * 1995-06-05 1998-07-14 Genentech, Inc. Kunitz type plasma kallikrein inhibitors
US6242414B1 (en) 1995-06-07 2001-06-05 Chiron Corporation Regulation of cytokine synthesis and release
CA2221601A1 (en) * 1995-06-07 1996-12-19 Chiron Corporation Regulation of cytokine synthesis and release
EP1105423B1 (en) * 1998-08-25 2004-06-16 Kleesiek, Knut, Prof. Dr. A mutant of tissue factor pathway inhibitor, dna sequence and use for detecting thrombotic disorders
CN1325889A (en) * 2000-05-26 2001-12-12 上海博德基因开发有限公司 Polypeptide-human kazal-type inhibitor 11 and polynucleotide for coding it
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
DK2298278T3 (en) 2002-06-07 2016-02-01 Dyax Corp Prevention and reduction of blood loss and inflammatory response
JP2005537006A (en) * 2002-08-28 2005-12-08 ダイアックス、コープ Organ and tissue preservation method
US6989369B2 (en) 2003-02-07 2006-01-24 Dyax Corp. Kunitz domain peptides
PT1663281E (en) 2003-08-29 2014-03-17 Dyax Corp Poly-pegylated protease inhibitors
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
US7276480B1 (en) 2005-12-30 2007-10-02 Dyax Corp. Prevention and reduction of blood loss
KR101792032B1 (en) 2008-12-19 2017-11-02 백스터 인터내셔널 인코포레이티드 Tfpi inhibitors and methods of use
WO2010080833A1 (en) 2009-01-06 2010-07-15 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
WO2011085103A2 (en) 2010-01-06 2011-07-14 Dyax Corp. Plasma kallikrein binding proteins
CA2793465C (en) 2010-03-19 2022-06-14 Baxter International Inc. Tfpi inhibitors and methods of use
CN105713092B (en) 2011-01-06 2019-09-10 戴埃克斯有限公司 Blood plasma prekallikrein binding protein
WO2013141965A1 (en) 2012-03-21 2013-09-26 Baxter International Inc. Tfpi inhibitors and methods of use
KR102857973B1 (en) 2015-12-11 2025-09-10 다케다 파머수티컬 컴패니 리미티드 Plasma kallikrein inhibitors and their use in the treatment of hereditary angioedema attacks
EP4090427A1 (en) 2020-01-13 2022-11-23 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5106833A (en) * 1987-07-23 1992-04-21 Washington University Coagulation inhibitors
DK408089D0 (en) * 1989-08-18 1989-08-18 Novo Nordisk As PROTEINS

Also Published As

Publication number Publication date
FI943234A0 (en) 1994-07-06
NZ246570A (en) 1996-09-25
JPH07504891A (en) 1995-06-01
FI943234L (en) 1994-07-06
NO942549L (en) 1994-09-07
CA2127246A1 (en) 1993-07-22
WO1993014122A1 (en) 1993-07-22
NO942549D0 (en) 1994-07-06
RU94036773A (en) 1996-09-27
CZ164494A3 (en) 1994-12-15
AU3346093A (en) 1993-08-03
ZA9396B (en) 1993-08-10
HU9401990D0 (en) 1994-09-28
EP0621872A1 (en) 1994-11-02
HUT70293A (en) 1995-09-28
FI943234A7 (en) 1994-07-06
AU675926B2 (en) 1997-02-27

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