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NO951813D0 - Bicyklisk heterocyklisk sulfonamid og sulfonester-derivater - Google Patents

Bicyklisk heterocyklisk sulfonamid og sulfonester-derivater

Info

Publication number
NO951813D0
NO951813D0 NO951813A NO951813A NO951813D0 NO 951813 D0 NO951813 D0 NO 951813D0 NO 951813 A NO951813 A NO 951813A NO 951813 A NO951813 A NO 951813A NO 951813 D0 NO951813 D0 NO 951813D0
Authority
NO
Norway
Prior art keywords
ring
nitrogen
optionally substituted
ester derivatives
bicyclic heterocyclic
Prior art date
Application number
NO951813A
Other languages
English (en)
Other versions
NO303778B1 (no
NO951813L (no
Inventor
Hiroshi Yoshino
Takashi Owa
Tatsuo Okauchi
Kentaro Yoshimatsu
Naoko Sugi
Takeshi Nagasu
Yoichi Ozawa
Nozomu Koyonagi
Kyosuke Kito
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of NO951813L publication Critical patent/NO951813L/no
Publication of NO951813D0 publication Critical patent/NO951813D0/no
Publication of NO303778B1 publication Critical patent/NO303778B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/08Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/34Oxygen atoms in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO19951813A 1993-09-10 1995-05-09 Sulfonamid-derivat eller sulfonester-derivat, middel og preparat omfattende et slikt derivat, anvendelse derav samt mellomprodukt NO303778B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP24861493 1993-09-10
PCT/JP1994/001487 WO1995007276A1 (en) 1993-09-10 1994-09-08 Bicyclic heterocyclic sulfonamide and sulfonic ester derivatives

Publications (3)

Publication Number Publication Date
NO951813L NO951813L (no) 1995-05-09
NO951813D0 true NO951813D0 (no) 1995-05-09
NO303778B1 NO303778B1 (no) 1998-08-31

Family

ID=17180741

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19951813A NO303778B1 (no) 1993-09-10 1995-05-09 Sulfonamid-derivat eller sulfonester-derivat, middel og preparat omfattende et slikt derivat, anvendelse derav samt mellomprodukt

Country Status (16)

Country Link
US (1) US5767283A (no)
EP (1) EP0673937B1 (no)
KR (2) KR0174752B1 (no)
CN (2) CN1079097C (no)
AT (1) ATE255106T1 (no)
AU (2) AU683492B2 (no)
CA (1) CA2146961C (no)
DE (1) DE69433353T2 (no)
DK (1) DK0673937T3 (no)
ES (1) ES2206469T3 (no)
HU (1) HU224069B1 (no)
NO (1) NO303778B1 (no)
NZ (1) NZ273073A (no)
PT (1) PT673937E (no)
RU (2) RU2121997C1 (no)
WO (1) WO1995007276A1 (no)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2122290T3 (es) * 1993-06-25 1998-12-16 Kumiai Chemical Industry Co Derivado de indazolsulfonilurea, su utilizacion e intermediario para su produccion.
WO1996034866A1 (en) * 1995-05-01 1996-11-07 Fujisawa Pharmaceutical Co., Ltd. Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivatives and their use as bone resorption inhibitors
US6060498A (en) * 1996-02-26 2000-05-09 Eisai Co., Ltd. Composition containing antitumor agent
DE69738815D1 (de) * 1996-10-15 2008-08-14 Searle Llc Verwendung von Cyclooxygenase-2 Inhibitoren zur Behandlung und Vorbeugung von Neoplasia
JP2000247949A (ja) 1999-02-26 2000-09-12 Eisai Co Ltd スルホンアミド含有インドール化合物
JP4516942B2 (ja) * 1999-02-26 2010-08-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 スルホンアミド含有インドール化合物
US6653309B1 (en) 1999-04-26 2003-11-25 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme technical field of the invention
US6521658B1 (en) 1999-05-28 2003-02-18 Abbott Laboratories Cell proliferation inhibitors
AU776933B2 (en) * 1999-12-28 2004-09-23 Eisai R&D Management Co., Ltd. Heterocyclic compounds having sulfonamide groups
RU2240826C2 (ru) 2000-02-03 2004-11-27 Эйсай Ко., Лтд. Ингибитор экспрессии интегрина
KR100767002B1 (ko) * 2000-02-03 2007-10-15 에자이 알앤드디 매니지먼트 가부시키가이샤 인테그린 발현 저해제
TWI283575B (en) * 2000-10-31 2007-07-11 Eisai Co Ltd Medicinal compositions for concomitant use as anticancer agent
WO2002042493A1 (en) * 2000-11-24 2002-05-30 Eisai C0. Ltd. Method of testing anticancer agent-sensitivity of tumor cells
ES2280502T3 (es) * 2001-02-21 2007-09-16 EISAI R&D MANAGEMENT CO., LTD. Metodo para evaluar el efecto de un inhibidor de la angiogenesis a traves de la inhibicion de la expresion de integrinas.
US7186745B2 (en) 2001-03-06 2007-03-06 Astrazeneca Ab Indolone derivatives having vascular damaging activity
WO2003022271A1 (fr) * 2001-09-05 2003-03-20 Eisai C0. Ltd. Inhibiteur d'activation lymphocytaire et remede pour maladie auto-immune
CN100549011C (zh) * 2002-09-19 2009-10-14 先灵公司 用作细胞周期蛋白依赖性激酶抑制剂的新颖咪唑并吡啶
US8772269B2 (en) 2004-09-13 2014-07-08 Eisai R&D Management Co., Ltd. Use of sulfonamide-including compounds in combination with angiogenesis inhibitors
WO2006030947A1 (ja) 2004-09-13 2006-03-23 Eisai R & D Management Co., Ltd. スルホンアミド含有化合物の血管新生阻害物質との併用
CA2582276C (en) * 2004-10-04 2011-09-13 F. Hoffmann-La Roche Ag Alkil-pyridines as 11-beta inhibitors for diabetes
WO2006054456A1 (ja) 2004-11-17 2006-05-26 Eisai R & D Management Co., Ltd. 二環式へテロ環含有スルホンアミド化合物の結晶
DE602006021401D1 (de) * 2005-02-28 2011-06-01 Eisai R&D Man Co Ltd Neue kombinierte anwendung einer sulfonamid-verbindung zur behandlung von krebs
WO2006112549A1 (ja) * 2005-04-20 2006-10-26 Takeda Pharmaceutical Company Limited 縮合複素環化合物
NZ561609A (en) * 2005-05-12 2010-03-26 Abbott Lab 3-((trifluoromethyl)sulfonyl)benzenesulfonamide and 3-((chloro(difluoro)methyl)sulfonyl)benzenesulfonamide apoptosis promoters
EP2015070A4 (en) 2006-04-20 2010-04-21 Eisai R&D Man Co Ltd Novel marker for sensitivity against sulfonamide compound
WO2008050821A1 (en) 2006-10-19 2008-05-02 Takeda Pharmaceutical Company Limited Indole compound
EP3243814B1 (en) 2007-04-16 2018-10-17 AbbVie Inc. 7-substituted indole as mcl-1 inhibitors
SI2178870T1 (sl) * 2007-08-17 2018-11-30 Lg Chem, Ltd. Indolne in indazolne spojine kot inhibitor celične nekroze
RU2460525C2 (ru) 2008-01-04 2012-09-10 Эл Джи Лайф Сайенсиз Лтд. Производные индола и индазола, обладающие консервирующим действием по отношению к клеткам, тканям и органам
EP2229929B1 (en) 2009-03-18 2017-06-14 DENTSPLY DETREY GmbH Temporary root canal sealer dispersion
TWI410408B (zh) * 2010-03-16 2013-10-01 Purzer Pharmaceutical Co Ltd 苯磺醯胺衍生物及其醫藥組合物
CN102199148A (zh) * 2010-03-25 2011-09-28 瑞安大药厂股份有限公司 苯磺酰胺衍生物及其医药组合物
WO2012056319A1 (en) * 2010-10-27 2012-05-03 Dynamix Pharmaceuticals Ltd. Sulfonamides for the modulation of pkm2
CN102875549B (zh) * 2012-09-14 2015-11-04 浙江大学 7-芳(甲)胺基-5-胺基-6-氮杂吲哚衍生物及制备与用途
CN105636956B (zh) 2013-08-22 2019-07-09 株式会社Lg化学 作为细胞坏死阻碍剂的吲哚化合物
CN105658625B (zh) 2013-08-22 2019-05-03 株式会社Lg化学 作为细胞坏死阻碍剂的吲哚酰胺化合物
EP3953331B1 (en) * 2019-04-10 2024-11-20 Peloton Therapeutics, Inc. Pyrazolesulfonamides as antitumor agents
WO2020256430A1 (ko) 2019-06-19 2020-12-24 주식회사 엘지화학 인돌 또는 인다졸 화합물의 제조방법
KR102389717B1 (ko) 2019-06-19 2022-04-25 주식회사 엘지화학 인돌 또는 인다졸 화합물의 제조방법
KR102397752B1 (ko) 2019-06-19 2022-05-16 주식회사 엘지화학 인돌 또는 인다졸 화합물의 제조방법
CN114080382B (zh) 2019-06-19 2024-05-24 株式会社Lg化学 制备吲哚或吲唑化合物的方法
EP4404929A2 (en) * 2021-09-21 2024-07-31 The Trustees of Princeton University Inhibitors of the mtdh-snd1 protein complex for cancer therapy
MA54773B1 (fr) * 2021-10-29 2023-10-31 Univ Euro Mediterraneenne De Fes Uemf Nouvelles familles de composés à base de sulfonamides pour le traitement du cancer du sein triple négatif
AU2023324686A1 (en) * 2022-08-15 2025-01-23 Recursion Pharmaceuticals, Inc. Heterocycle rbm39 modulators

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU509046A1 (ru) * 1975-02-21 1984-06-23 Всесоюзный научно-исследовательский химико-фармацевтический институт им.Серго Орджоникидзе Производные 2-карбэтокси-3-аминоиндола,про вл ющие противовоспалительную активность, и способ их получени
JPS539256A (en) * 1976-07-14 1978-01-27 Hitachi Kiden Kogyo Kk Two hook type club
DE3105850A1 (de) * 1981-02-18 1982-08-19 Horst, Hans Jörg, Priv.Doz.Dr., 2057 Reinbek Mittel zum behandeln von tumoren
DE3247615A1 (de) * 1982-12-23 1984-07-05 Hoechst Ag, 6230 Frankfurt Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4610981A (en) * 1985-02-11 1986-09-09 American Cyanamid Company N-[(1H-imidazol-1-yl) and (1H-1,2,4-triazol-1-yl)-alkyl]benzenesulfonamides and thromboxane synthetase/antihypertensive compositions
EP0215200B1 (en) * 1985-06-24 1992-09-09 Merck & Co. Inc. Use of sulfanilamido quinoxalines in the treatment of neoplastic diseases
US4849563A (en) * 1986-01-21 1989-07-18 Yale University Novel 1-alkyl-1-arenesulfonyl-2-alkoxycarbonylsulfenylhydrazines having antineoplastic activity
US4942263A (en) * 1989-04-13 1990-07-17 Eastman Kodak Company Preparation of aldehydes
JP2790926B2 (ja) * 1990-08-20 1998-08-27 エーザイ株式会社 スルホンアミド誘導体
ATE167473T1 (de) * 1990-08-20 1998-07-15 Eisai Co Ltd Sulfonamid-derivate
LU87814A1 (fr) * 1990-09-27 1992-05-25 Oreal Composition cosmetique comportant une dispersion de vesicules lipidiques ainsi que des pigments melaniques,et son utilisation

Also Published As

Publication number Publication date
WO1995007276A1 (en) 1995-03-16
NO303778B1 (no) 1998-08-31
CA2146961A1 (en) 1995-03-16
AU711438B2 (en) 1999-10-14
KR100188846B1 (en) 1999-06-01
RU2121997C1 (ru) 1998-11-20
HU9501363D0 (en) 1995-06-28
DK0673937T3 (da) 2004-03-22
CN1491941A (zh) 2004-04-28
US5767283A (en) 1998-06-16
NO951813L (no) 1995-05-09
NZ273073A (en) 1996-09-25
CN1079097C (zh) 2002-02-13
EP0673937B1 (en) 2003-11-26
KR950704304A (ko) 1995-11-17
DE69433353D1 (de) 2004-01-08
HU224069B1 (hu) 2005-05-30
CA2146961C (en) 2006-11-07
EP0673937A1 (en) 1995-09-27
PT673937E (pt) 2004-04-30
ATE255106T1 (de) 2003-12-15
AU7623794A (en) 1995-03-27
RU2128648C1 (ru) 1999-04-10
AU1778597A (en) 1997-08-14
CN1221533C (zh) 2005-10-05
HUT71551A (en) 1995-12-28
EP0673937A4 (en) 1996-01-17
RU95112848A (ru) 1997-03-20
DE69433353T2 (de) 2004-09-09
AU683492B2 (en) 1997-11-13
CN1114506A (zh) 1996-01-03
KR0174752B1 (ko) 1999-02-01
ES2206469T3 (es) 2004-05-16

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