[go: up one dir, main page]

NO932954L - 2,4-diaminokinazolin-derivater for aa oppnaa oeket antitumoraktivitet - Google Patents

2,4-diaminokinazolin-derivater for aa oppnaa oeket antitumoraktivitet

Info

Publication number
NO932954L
NO932954L NO93932954A NO932954A NO932954L NO 932954 L NO932954 L NO 932954L NO 93932954 A NO93932954 A NO 93932954A NO 932954 A NO932954 A NO 932954A NO 932954 L NO932954 L NO 932954L
Authority
NO
Norway
Prior art keywords
derivatives
diaminokinazoline
antitumor activity
increased antitumor
increase increased
Prior art date
Application number
NO93932954A
Other languages
English (en)
Norwegian (no)
Other versions
NO932954D0 (no
Inventor
Jotham W Coe
Anton F J Fliri
Takushi Kaneko
Eric R Larson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO932954D0 publication Critical patent/NO932954D0/no
Publication of NO932954L publication Critical patent/NO932954L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO93932954A 1991-02-20 1993-08-19 2,4-diaminokinazolin-derivater for aa oppnaa oeket antitumoraktivitet NO932954L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65792291A 1991-02-20 1991-02-20
PCT/US1992/000028 WO1992014716A1 (fr) 1991-02-20 1992-01-08 Derives de 2,4-diaminoquinazolines stimulant l'activite anti-tumorale

Publications (2)

Publication Number Publication Date
NO932954D0 NO932954D0 (no) 1993-08-19
NO932954L true NO932954L (no) 1993-08-19

Family

ID=24639196

Family Applications (1)

Application Number Title Priority Date Filing Date
NO93932954A NO932954L (no) 1991-02-20 1993-08-19 2,4-diaminokinazolin-derivater for aa oppnaa oeket antitumoraktivitet

Country Status (23)

Country Link
EP (1) EP0572437B1 (fr)
JP (1) JPH06500117A (fr)
KR (1) KR930703270A (fr)
CN (1) CN1064271A (fr)
AT (1) ATE121735T1 (fr)
AU (1) AU655798B2 (fr)
BR (1) BR9205645A (fr)
CA (1) CA2101542A1 (fr)
CZ (1) CZ387292A3 (fr)
DE (2) DE69202243T2 (fr)
DK (1) DK0572437T3 (fr)
ES (1) ES2071484T3 (fr)
FI (1) FI933656L (fr)
HU (1) HUT64755A (fr)
IE (1) IE920522A1 (fr)
IL (1) IL100942A0 (fr)
MX (1) MX9200675A (fr)
NO (1) NO932954L (fr)
NZ (1) NZ241627A (fr)
PT (1) PT100132A (fr)
WO (1) WO1992014716A1 (fr)
YU (1) YU17092A (fr)
ZA (1) ZA921911B (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU661533B2 (en) * 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
ES2049659B1 (es) * 1992-10-08 1994-10-16 Ici Plc Una composicion farmaceutica a base de derivados de quinazolina con actividad anti-cancerigena.
GB9323290D0 (en) * 1992-12-10 1994-01-05 Zeneca Ltd Quinazoline derivatives
GB9314893D0 (en) * 1993-07-19 1993-09-01 Zeneca Ltd Quinazoline derivatives
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
IL112248A0 (en) 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
DE4429026C2 (de) * 1994-08-16 1995-11-16 Mueller Wolfgang Inlay-Entfernungsinstrumentarium für Totalendoprothese
GB9424233D0 (en) * 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
GB9508537D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
WO1996033977A1 (fr) * 1995-04-27 1996-10-31 Zeneca Limited Derives de quinazoline
GB9508535D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivative
GB9508565D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
AU7692896A (en) * 1995-12-01 1997-06-27 Novartis Ag Quinazolin-2,4-diazirines as NPY receptor antagonist
GB9624482D0 (en) * 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
BR9707495A (pt) 1996-02-13 1999-07-27 Zeneca Ltd Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente
GB9603097D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
AU719327B2 (en) 1996-03-05 2000-05-04 Astrazeneca Ab 4-anilinoquinazoline derivatives
GB9607729D0 (en) * 1996-04-13 1996-06-19 Zeneca Ltd Quinazoline derivatives
GB9707800D0 (en) 1996-05-06 1997-06-04 Zeneca Ltd Chemical compounds
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
PL203782B1 (pl) 1999-11-05 2009-11-30 Astrazeneca Ab Pochodne chinazoliny,sposoby ich wytwarzania,ich kompozycje farmaceutyczne oraz ich zastosowania
WO2001068615A1 (fr) * 2000-03-13 2001-09-20 Chemrx Advanced Technologies, Inc. Synthese de la quinazoline
CA2403365A1 (fr) 2000-04-07 2001-10-18 Astrazeneca Ab Composes a base de quinazoline
AU2002361846A1 (en) * 2001-12-21 2003-07-15 Bayer Pharmaceuticals Corporation Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
CN1984660B (zh) * 2003-07-03 2010-12-15 美瑞德生物工程公司 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉
US8309562B2 (en) 2003-07-03 2012-11-13 Myrexis, Inc. Compounds and therapeutical use thereof
JP2007269629A (ja) * 2004-06-21 2007-10-18 Astellas Pharma Inc キナゾリン誘導体
CA2573103A1 (fr) * 2004-07-06 2006-02-09 Angion Biomedica Corporation Modulateurs quinazoline d'activite de facteur de croissance hepatocyte/c-met permettant de traiter le cancer
CA2592900A1 (fr) * 2005-01-03 2006-07-13 Myriad Genetics Inc. Composes et utilisation therapeutique associee
US8258145B2 (en) 2005-01-03 2012-09-04 Myrexis, Inc. Method of treating brain cancer
CN101287369A (zh) * 2005-01-03 2008-10-15 美瑞德生物工程公司 治疗脑癌的方法
EP1963284A1 (fr) * 2005-12-07 2008-09-03 NeuroSearch A/S Derives innovants de la quinazoline-2,4-diamine et leur utilisation en tant que modulateurs de canaux potassiques de faible conductance actives par le calcium
CN101100466B (zh) 2006-07-05 2013-12-25 天津和美生物技术有限公司 不可逆蛋白质酪氨酸磷酰化酶抑制剂及其制备和应用
US20090004185A1 (en) * 2007-01-11 2009-01-01 Wyeth Amino-substituted quinazoline derivatives as inhibitors of beta-catenin/tcf-4 pathway and cancer treatment agents
CA2691932A1 (fr) * 2007-06-27 2008-12-31 Summit Corporation Plc Utilisation de composes pour la preparation d'agents anti-tuberculose
CN103068393A (zh) 2010-05-07 2013-04-24 加州理工学院 用于抑制过渡型内质网atp酶的方法和组合物
WO2018212774A1 (fr) * 2017-05-17 2018-11-22 Vanderbilt University Composés de quinazoline utilisés en tant que modulateurs de signalisation ras

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3635979A (en) * 1969-09-29 1972-01-18 Pfizer Certain 6- and/or 7-alkoxy-substituted-2 4-bis(disubstituted amino) quinazolines
AU610328B2 (en) * 1987-12-03 1991-05-16 Smithkline Beckman Intercredit B.V. 2,4- diaminoquinazoline derivatives
IL88507A (en) * 1987-12-03 1993-02-21 Smithkline Beckman Intercredit 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
WO1992014716A1 (fr) 1992-09-03
AU1184892A (en) 1992-09-15
PT100132A (pt) 1993-05-31
KR930703270A (ko) 1993-11-29
BR9205645A (pt) 1994-06-07
CZ387292A3 (en) 1994-04-13
DK0572437T3 (da) 1995-07-03
EP0572437A1 (fr) 1993-12-08
DE69202243T2 (de) 1995-08-31
JPH06500117A (ja) 1994-01-06
FI933656A0 (fi) 1993-08-19
HUT64755A (en) 1994-02-28
YU17092A (sh) 1994-12-28
AU655798B2 (en) 1995-01-12
CA2101542A1 (fr) 1992-08-21
ZA921911B (en) 1993-08-19
HU9302384D0 (en) 1993-11-29
DE9290018U1 (de) 1993-10-14
NZ241627A (en) 1993-06-25
EP0572437B1 (fr) 1995-04-26
CN1064271A (zh) 1992-09-09
IL100942A0 (en) 1992-11-15
ES2071484T3 (es) 1995-06-16
FI933656A7 (fi) 1993-08-19
FI933656L (fi) 1993-08-19
ATE121735T1 (de) 1995-05-15
NO932954D0 (no) 1993-08-19
IE920522A1 (en) 1992-08-26
DE69202243D1 (de) 1995-06-01
MX9200675A (es) 1992-08-01

Similar Documents

Publication Publication Date Title
NO932954D0 (no) 2,4-diaminokinazolin-derivater for aa oppnaa oeket antitumoraktivitet
FI932032A0 (fi) Kinazolinderivat foer oekande av antitumoeraktivitet
IN170909B (fr)
UA29466C2 (uk) Фармацевтична композиція з антипухлинною активністю
MX9201763A (es) Derivados de pirimidina para aumentar la actividad antitumores.
DE68912818D1 (de) Antitumormittel.
CA1265159C (fr) Gem-dihalogeno-1,8-diamino-4-aza-octanes
ES2061775T3 (es) Derivados de estrobirulina, su obtencion y empleo.
FI950101A7 (fi) 4-oksa-1-atsabisyklo 3,2,0 -7heptanoni-johdannaiset kasvainten vastaisina aineina
RU95118900A (ru) Противоопухолевое средство
RU93054001A (ru) 2,4-диаминохиназолиновые производные, способ их получения фармацевтическая композиция, способ ингибирования р-гликопротеина
RU93034452A (ru) Производные хиназолинов для усиления противоопухолевой активности, способ их получения, способ лечения и фармацевтическая композиция
ITPR920022U1 (it) Macchina agricola operatrice per la lavorazione del terreno.
NO904154D0 (no) Terapeutisk anvendbare tetralinderivater.