BR9205645A - Derivados de 2,4-diaminoquinazolinas para aumentar a atividade antitumoral - Google Patents

Derivados de 2,4-diaminoquinazolinas para aumentar a atividade antitumoral

Info

Publication number: BR9205645A
Authority: BR; Brazil
Prior art keywords: antitumor activity; increase antitumor; diaminoquinazoline derivatives; diaminoquinazoline; derivatives
Prior art date: 1991-02-20

Application number

BR9205645A

Other languages

English (en)

Inventor

Jotham W Coe

Anton F J Fliri

Takushi Kaneko

Eric R Larson

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-20

Filing date

1992-01-08

Publication date

1994-06-07

1992-01-08 Application filed by Pfizer filed Critical Pfizer

1994-06-07 Publication of BR9205645A publication Critical patent/BR9205645A/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

BR9205645A 1991-02-20 1992-01-08 Derivados de 2,4-diaminoquinazolinas para aumentar a atividade antitumoral BR9205645A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US65792291A	1991-02-20	1991-02-20
PCT/US1992/000028 WO1992014716A1 (en)	1991-02-20	1992-01-08	2,4-diaminoquinazolines derivatives for enhancing antitumor activity

Publications (1)

Publication Number	Publication Date
BR9205645A true BR9205645A (pt)	1994-06-07

Family

ID=24639196

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9205645A BR9205645A (pt)	1991-02-20	1992-01-08	Derivados de 2,4-diaminoquinazolinas para aumentar a atividade antitumoral

Country Status (23)

Country	Link
EP (1)	EP0572437B1 (pt)
JP (1)	JPH06500117A (pt)
KR (1)	KR930703270A (pt)
CN (1)	CN1064271A (pt)
AT (1)	ATE121735T1 (pt)
AU (1)	AU655798B2 (pt)
BR (1)	BR9205645A (pt)
CA (1)	CA2101542A1 (pt)
CZ (1)	CZ387292A3 (pt)
DE (2)	DE69202243T2 (pt)
DK (1)	DK0572437T3 (pt)
ES (1)	ES2071484T3 (pt)
FI (1)	FI933656L (pt)
HU (1)	HUT64755A (pt)
IE (1)	IE920522A1 (pt)
IL (1)	IL100942A0 (pt)
MX (1)	MX9200675A (pt)
NO (1)	NO932954L (pt)
NZ (1)	NZ241627A (pt)
PT (1)	PT100132A (pt)
WO (1)	WO1992014716A1 (pt)
YU (1)	YU17092A (pt)
ZA (1)	ZA921911B (pt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU661533B2 (en) *	1992-01-20	1995-07-27	Astrazeneca Ab	Quinazoline derivatives
ES2049659B1 (es) *	1992-10-08	1994-10-16	Ici Plc	Una composicion farmaceutica a base de derivados de quinazolina con actividad anti-cancerigena.
GB9323290D0 (en) *	1992-12-10	1994-01-05	Zeneca Ltd	Quinazoline derivatives
GB9314893D0 (en) *	1993-07-19	1993-09-01	Zeneca Ltd	Quinazoline derivatives
IL112249A (en)	1994-01-25	2001-11-25	Warner Lambert Co	Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
IL112248A0 (en)	1994-01-25	1995-03-30	Warner Lambert Co	Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
DE4429026C2 (de) *	1994-08-16	1995-11-16	Mueller Wolfgang	Inlay-Entfernungsinstrumentarium für Totalendoprothese
GB9424233D0 (en) *	1994-11-30	1995-01-18	Zeneca Ltd	Quinazoline derivatives
GB9508537D0 (en) *	1995-04-27	1995-06-14	Zeneca Ltd	Quinazoline derivatives
WO1996033977A1 (en) *	1995-04-27	1996-10-31	Zeneca Limited	Quinazoline derivatives
GB9508535D0 (en) *	1995-04-27	1995-06-14	Zeneca Ltd	Quinazoline derivative
GB9508565D0 (en) *	1995-04-27	1995-06-14	Zeneca Ltd	Quiazoline derivative
GB9508538D0 (en) *	1995-04-27	1995-06-14	Zeneca Ltd	Quinazoline derivatives
AU7692896A (en) *	1995-12-01	1997-06-27	Novartis Ag	Quinazolin-2,4-diazirines as NPY receptor antagonist
GB9624482D0 (en) *	1995-12-18	1997-01-15	Zeneca Phaema S A	Chemical compounds
BR9707495A (pt)	1996-02-13	1999-07-27	Zeneca Ltd	Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente
GB9603097D0 (en) *	1996-02-14	1996-04-10	Zeneca Ltd	Quinazoline compounds
GB9603095D0 (en) *	1996-02-14	1996-04-10	Zeneca Ltd	Quinazoline derivatives
AU719327B2 (en)	1996-03-05	2000-05-04	Astrazeneca Ab	4-anilinoquinazoline derivatives
GB9607729D0 (en) *	1996-04-13	1996-06-19	Zeneca Ltd	Quinazoline derivatives
GB9707800D0 (en)	1996-05-06	1997-06-04	Zeneca Ltd	Chemical compounds
GB9718972D0 (en)	1996-09-25	1997-11-12	Zeneca Ltd	Chemical compounds
PL203782B1 (pl)	1999-11-05	2009-11-30	Astrazeneca Ab	Pochodne chinazoliny,sposoby ich wytwarzania,ich kompozycje farmaceutyczne oraz ich zastosowania
WO2001068615A1 (en) *	2000-03-13	2001-09-20	Chemrx Advanced Technologies, Inc.	Quinazoline synthesis
CA2403365A1 (en)	2000-04-07	2001-10-18	Astrazeneca Ab	Quinazoline compounds
AU2002361846A1 (en) *	2001-12-21	2003-07-15	Bayer Pharmaceuticals Corporation	Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
CN1984660B (zh) *	2003-07-03	2010-12-15	美瑞德生物工程公司	作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉
US8309562B2 (en)	2003-07-03	2012-11-13	Myrexis, Inc.	Compounds and therapeutical use thereof
JP2007269629A (ja) *	2004-06-21	2007-10-18	Astellas Pharma Inc	キナゾリン誘導体
CA2573103A1 (en) *	2004-07-06	2006-02-09	Angion Biomedica Corporation	Quinazoline modulators of hepatocyte growth factor / c-met activity for the treatment of cancer
CA2592900A1 (en) *	2005-01-03	2006-07-13	Myriad Genetics Inc.	Nitrogen containing bicyclic compounds and therapeutical use thereof
US8258145B2 (en)	2005-01-03	2012-09-04	Myrexis, Inc.	Method of treating brain cancer
CN101287369A (zh) *	2005-01-03	2008-10-15	美瑞德生物工程公司	治疗脑癌的方法
EP1963284A1 (en) *	2005-12-07	2008-09-03	NeuroSearch A/S	Novel quinazoline-2,4-diamine derivatives and their use as modulators of small-conductance calcium-activated potassium channels
CN101100466B (zh)	2006-07-05	2013-12-25	天津和美生物技术有限公司	不可逆蛋白质酪氨酸磷酰化酶抑制剂及其制备和应用
US20090004185A1 (en) *	2007-01-11	2009-01-01	Wyeth	Amino-substituted quinazoline derivatives as inhibitors of beta-catenin/tcf-4 pathway and cancer treatment agents
CA2691932A1 (en) *	2007-06-27	2008-12-31	Summit Corporation Plc	Use of compounds for preparing anti-tuberculosis agents
CN103068393A (zh)	2010-05-07	2013-04-24	加州理工学院	用于抑制过渡型内质网atp酶的方法和组合物
WO2018212774A1 (en) *	2017-05-17	2018-11-22	Vanderbilt University	Quinazoline compounds as modulators of ras signaling

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3635979A (en) *	1969-09-29	1972-01-18	Pfizer	Certain 6- and/or 7-alkoxy-substituted-2 4-bis(disubstituted amino) quinazolines
AU610328B2 (en) *	1987-12-03	1991-05-16	Smithkline Beckman Intercredit B.V.	2,4- diaminoquinazoline derivatives
IL88507A (en) *	1987-12-03	1993-02-21	Smithkline Beckman Intercredit	2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them

1992
- 1992-01-08 JP JP4503777A patent/JPH06500117A/ja active Pending
- 1992-01-08 KR KR1019930702481A patent/KR930703270A/ko not_active Withdrawn
- 1992-01-08 CZ CS923872A patent/CZ387292A3/cs unknown
- 1992-01-08 CA CA002101542A patent/CA2101542A1/en not_active Abandoned
- 1992-01-08 DK DK92903632.5T patent/DK0572437T3/da active
- 1992-01-08 BR BR9205645A patent/BR9205645A/pt not_active Application Discontinuation
- 1992-01-08 HU HU9302384A patent/HUT64755A/hu unknown
- 1992-01-08 DE DE69202243T patent/DE69202243T2/de not_active Expired - Fee Related
- 1992-01-08 FI FI933656A patent/FI933656L/fi not_active Application Discontinuation
- 1992-01-08 ES ES92903632T patent/ES2071484T3/es not_active Expired - Lifetime
- 1992-01-08 WO PCT/US1992/000028 patent/WO1992014716A1/en not_active Ceased
- 1992-01-08 EP EP92903632A patent/EP0572437B1/en not_active Expired - Lifetime
- 1992-01-08 DE DE9290018U patent/DE9290018U1/de not_active Expired - Lifetime
- 1992-01-08 AU AU11848/92A patent/AU655798B2/en not_active Expired - Fee Related
- 1992-01-08 AT AT92903632T patent/ATE121735T1/de not_active IP Right Cessation
- 1992-02-13 IL IL100942A patent/IL100942A0/xx unknown
- 1992-02-17 NZ NZ241627A patent/NZ241627A/xx unknown
- 1992-02-18 MX MX9200675A patent/MX9200675A/es unknown
- 1992-02-18 PT PT100132A patent/PT100132A/pt not_active Application Discontinuation
- 1992-02-19 IE IE052292A patent/IE920522A1/en not_active Application Discontinuation
- 1992-02-19 ZA ZA921191A patent/ZA921911B/xx unknown
- 1992-02-19 CN CN92101113A patent/CN1064271A/zh active Pending
- 1992-02-19 YU YU17092A patent/YU17092A/sh unknown
1993
- 1993-08-19 NO NO93932954A patent/NO932954L/no unknown

Also Published As

Publication number	Publication date
WO1992014716A1 (en)	1992-09-03
AU1184892A (en)	1992-09-15
PT100132A (pt)	1993-05-31
KR930703270A (ko)	1993-11-29
CZ387292A3 (en)	1994-04-13
DK0572437T3 (da)	1995-07-03
EP0572437A1 (en)	1993-12-08
DE69202243T2 (de)	1995-08-31
JPH06500117A (ja)	1994-01-06
FI933656A0 (fi)	1993-08-19
HUT64755A (en)	1994-02-28
YU17092A (sh)	1994-12-28
AU655798B2 (en)	1995-01-12
CA2101542A1 (en)	1992-08-21
ZA921911B (en)	1993-08-19
HU9302384D0 (en)	1993-11-29
DE9290018U1 (de)	1993-10-14
NZ241627A (en)	1993-06-25
EP0572437B1 (en)	1995-04-26
CN1064271A (zh)	1992-09-09
IL100942A0 (en)	1992-11-15
ES2071484T3 (es)	1995-06-16
FI933656A7 (fi)	1993-08-19
FI933656L (fi)	1993-08-19
ATE121735T1 (de)	1995-05-15
NO932954D0 (no)	1993-08-19
NO932954L (no)	1993-08-19
IE920522A1 (en)	1992-08-26
DE69202243D1 (de)	1995-06-01
MX9200675A (es)	1992-08-01

Publication	Publication Date	Title
BR9205645A (pt)	1994-06-07	Derivados de 2,4-diaminoquinazolinas para aumentar a atividade antitumoral
BR9107070A (pt)	1994-05-31	Processo para a preparação de derivados de quinazolina uteis para melhorar a atividade antitumoral.
IN170909B (pt)	1992-06-13
DE3773711D1 (de)	1991-11-21	Luftkissengelagerter gleitkoerper.
ES2054778T3 (es)	1994-08-16	Complejos de 1,2-bis (aminometil) ciclobutano-platino.
DK267885A (da)	1986-12-14	Maebel, saasom sidde- eller liggemaebel
BR9205906A (pt)	1994-07-05	Derivados de pirimidina para aumento da atividade antitumoral
FI880944A7 (fi)	1988-09-03	Yhdistelmäterapia, jossa käytetään antituumori-immunotoksiineja yhdessä tuumorin nekroositekijän kanssa.
ATE311399T1 (de)	2005-12-15	2'-deoxy-4'-thioribonucleoside als antivirale und antikrebsmittel
FI950101A7 (fi)	1995-03-07	4-oksa-1-atsabisyklo 3,2,0 -7heptanoni-johdannaiset kasvainten vastaisina aineina
CA1265160C (en)	1990-01-30	GEM-DIHALOGENO- AND GEM-TETRAHALOGENO-1,12-DIAMINO-4,9-DIAZA-DODECANE
IE862894L (en)	1987-05-05	Pharmaceutical compositions
ES1003783Y (es)	1989-04-01	Camara hiperbarica.
NO904154L (no)	1990-09-24	Terapeutisk anvendbare tetralinderivater.
NO904235D0 (no)	1990-09-28	Forbedret cytotoksisk terapi.

Legal Events

Date	Code	Title
1999-01-26	EG	Technical examination (opinion): publication of technical examination (opinion)
1999-08-17	FC	Decision: refusal
2000-03-14	FC	Decision: refusal