MX9200675A - Derivados de 2,4-diaminoquinazolinas para mejorar la actividad antitumoral. - Google Patents

Derivados de 2,4-diaminoquinazolinas para mejorar la actividad antitumoral.

Info

Publication number: MX9200675A
Authority: MX; Mexico
Prior art keywords: derivatives; diaminoquinazolines; improve; antitumoral activity; antitumoral
Prior art date: 1991-02-20

Application number

MX9200675A

Other languages

English (en)

Inventor

Jotham W Coe

Anton F J Fliri

Takushi Kaneko

Eric R Larson

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-20

Filing date

1992-02-18

Publication date

1992-08-01

1992-02-18 Application filed by Pfizer filed Critical Pfizer

1992-08-01 Publication of MX9200675A publication Critical patent/MX9200675A/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

MX9200675A 1991-02-20 1992-02-18 Derivados de 2,4-diaminoquinazolinas para mejorar la actividad antitumoral. MX9200675A (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US65792291A	1991-02-20	1991-02-20

Publications (1)

Publication Number	Publication Date
MX9200675A true MX9200675A (es)	1992-08-01

Family

ID=24639196

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MX9200675A MX9200675A (es)	1991-02-20	1992-02-18	Derivados de 2,4-diaminoquinazolinas para mejorar la actividad antitumoral.

Country Status (23)

Country	Link
EP (1)	EP0572437B1 (es)
JP (1)	JPH06500117A (es)
KR (1)	KR930703270A (es)
CN (1)	CN1064271A (es)
AT (1)	ATE121735T1 (es)
AU (1)	AU655798B2 (es)
BR (1)	BR9205645A (es)
CA (1)	CA2101542A1 (es)
CZ (1)	CZ387292A3 (es)
DE (2)	DE9290018U1 (es)
DK (1)	DK0572437T3 (es)
ES (1)	ES2071484T3 (es)
FI (1)	FI933656A7 (es)
HU (1)	HUT64755A (es)
IE (1)	IE920522A1 (es)
IL (1)	IL100942A0 (es)
MX (1)	MX9200675A (es)
NO (1)	NO932954L (es)
NZ (1)	NZ241627A (es)
PT (1)	PT100132A (es)
WO (1)	WO1992014716A1 (es)
YU (1)	YU17092A (es)
ZA (1)	ZA921911B (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU661533B2 (en) *	1992-01-20	1995-07-27	Astrazeneca Ab	Quinazoline derivatives
ES2049659B1 (es) *	1992-10-08	1994-10-16	Ici Plc	Una composicion farmaceutica a base de derivados de quinazolina con actividad anti-cancerigena.
GB9323290D0 (en) *	1992-12-10	1994-01-05	Zeneca Ltd	Quinazoline derivatives
GB9314893D0 (en) *	1993-07-19	1993-09-01	Zeneca Ltd	Quinazoline derivatives
IL112248A0 (en)	1994-01-25	1995-03-30	Warner Lambert Co	Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
IL112249A (en)	1994-01-25	2001-11-25	Warner Lambert Co	Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
DE4429026C2 (de) *	1994-08-16	1995-11-16	Mueller Wolfgang	Inlay-Entfernungsinstrumentarium für Totalendoprothese
GB9424233D0 (en) *	1994-11-30	1995-01-18	Zeneca Ltd	Quinazoline derivatives
GB9508538D0 (en) *	1995-04-27	1995-06-14	Zeneca Ltd	Quinazoline derivatives
GB9508537D0 (en) *	1995-04-27	1995-06-14	Zeneca Ltd	Quinazoline derivatives
GB9508565D0 (en) *	1995-04-27	1995-06-14	Zeneca Ltd	Quiazoline derivative
GB9508535D0 (en) *	1995-04-27	1995-06-14	Zeneca Ltd	Quinazoline derivative
US5932574A (en) *	1995-04-27	1999-08-03	Zeneca Limited	Quinazoline derivatives
WO1997020822A1 (en) *	1995-12-01	1997-06-12	Novartis Ag	Quinazolin-2,4-diazirines as npy receptor antagonist
GB9624482D0 (en)	1995-12-18	1997-01-15	Zeneca Phaema S A	Chemical compounds
AU719434B2 (en)	1996-02-13	2000-05-11	Astrazeneca Ab	Quinazoline derivatives as VEGF inhibitors
GB9603097D0 (en) *	1996-02-14	1996-04-10	Zeneca Ltd	Quinazoline compounds
GB9603095D0 (en)	1996-02-14	1996-04-10	Zeneca Ltd	Quinazoline derivatives
ES2169355T3 (es)	1996-03-05	2002-07-01	Astrazeneca Ab	Derivados de 4-anilinoquinazolina.
GB9607729D0 (en) *	1996-04-13	1996-06-19	Zeneca Ltd	Quinazoline derivatives
GB9707800D0 (en)	1996-05-06	1997-06-04	Zeneca Ltd	Chemical compounds
GB9718972D0 (en)	1996-09-25	1997-11-12	Zeneca Ltd	Chemical compounds
EP1676845B1 (en)	1999-11-05	2008-06-11	AstraZeneca AB	New quinazoline derivatives
AU2001240150A1 (en) *	2000-03-13	2001-09-24	Chemrx Advanced Technologies, Inc.	Quinazoline synthesis
DK1274692T3 (da)	2000-04-07	2006-10-30	Astrazeneca Ab	Quinazolinforbindelser
WO2003055866A1 (en) *	2001-12-21	2003-07-10	Bayer Pharmaceuticals Corporation	Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents
US8309562B2 (en)	2003-07-03	2012-11-13	Myrexis, Inc.	Compounds and therapeutical use thereof
AU2004253967B2 (en) *	2003-07-03	2010-02-18	Cytovia, Inc.	4-arylamino-quinazolines as activators of caspases and inducers of apoptosis
JP2007269629A (ja) *	2004-06-21	2007-10-18	Astellas Pharma Inc	キナゾリン誘導体
EP1768964A1 (en) *	2004-07-06	2007-04-04	Angion Biomedica Corporation	Quinazoline modulators of hepatocyte growth factor / c-met activity for the treatment of cancer
CA2592900A1 (en) *	2005-01-03	2006-07-13	Myriad Genetics Inc.	Nitrogen containing bicyclic compounds and therapeutical use thereof
WO2006074187A2 (en) *	2005-01-03	2006-07-13	Myriad Genetics, Inc.	Method of treating brain cancer
US8258145B2 (en)	2005-01-03	2012-09-04	Myrexis, Inc.	Method of treating brain cancer
WO2007065913A1 (en) *	2005-12-07	2007-06-14	Neurosearch A/S	Novel quinazoline-2,4-diamine derivatives and their use as modulators of small-conductance calcium-activated potassium channels
CN101100466B (zh)	2006-07-05	2013-12-25	天津和美生物技术有限公司	不可逆蛋白质酪氨酸磷酰化酶抑制剂及其制备和应用
US20090004185A1 (en) *	2007-01-11	2009-01-01	Wyeth	Amino-substituted quinazoline derivatives as inhibitors of beta-catenin/tcf-4 pathway and cancer treatment agents
CA2691932A1 (en) *	2007-06-27	2008-12-31	Summit Corporation Plc	Use of compounds for preparing anti-tuberculosis agents
CA2798698A1 (en)	2010-05-07	2011-11-10	Cleave Biosciences, Inc. (Cleave)	Methods and compositions for inhibition of the transitional endoplasmic reticulum atpase
US11318137B2 (en) *	2017-05-17	2022-05-03	Vanderbilt University	Quinazoline compounds as modulators of Ras signaling

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3663706A (en) *	1969-09-29	1972-05-16	Pfizer	Use of 2,4-diaminoquinazolines as hypotensive agents
AU610328B2 (en) *	1987-12-03	1991-05-16	Smithkline Beckman Intercredit B.V.	2,4- diaminoquinazoline derivatives
IL88507A (en) *	1987-12-03	1993-02-21	Smithkline Beckman Intercredit	2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them

1992
- 1992-01-08 DE DE9290018U patent/DE9290018U1/de not_active Expired - Lifetime
- 1992-01-08 CA CA002101542A patent/CA2101542A1/en not_active Abandoned
- 1992-01-08 AT AT92903632T patent/ATE121735T1/de not_active IP Right Cessation
- 1992-01-08 ES ES92903632T patent/ES2071484T3/es not_active Expired - Lifetime
- 1992-01-08 FI FI933656A patent/FI933656A7/fi not_active Application Discontinuation
- 1992-01-08 DK DK92903632.5T patent/DK0572437T3/da active
- 1992-01-08 DE DE69202243T patent/DE69202243T2/de not_active Expired - Fee Related
- 1992-01-08 KR KR1019930702481A patent/KR930703270A/ko not_active Withdrawn
- 1992-01-08 AU AU11848/92A patent/AU655798B2/en not_active Expired - Fee Related
- 1992-01-08 BR BR9205645A patent/BR9205645A/pt not_active Application Discontinuation
- 1992-01-08 CZ CS923872A patent/CZ387292A3/cs unknown
- 1992-01-08 HU HU9302384A patent/HUT64755A/hu unknown
- 1992-01-08 JP JP4503777A patent/JPH06500117A/ja active Pending
- 1992-01-08 EP EP92903632A patent/EP0572437B1/en not_active Expired - Lifetime
- 1992-01-08 WO PCT/US1992/000028 patent/WO1992014716A1/en not_active Ceased
- 1992-02-13 IL IL100942A patent/IL100942A0/xx unknown
- 1992-02-17 NZ NZ241627A patent/NZ241627A/xx unknown
- 1992-02-18 MX MX9200675A patent/MX9200675A/es unknown
- 1992-02-18 PT PT100132A patent/PT100132A/pt not_active Application Discontinuation
- 1992-02-19 YU YU17092A patent/YU17092A/sh unknown
- 1992-02-19 ZA ZA921191A patent/ZA921911B/xx unknown
- 1992-02-19 CN CN92101113A patent/CN1064271A/zh active Pending
- 1992-02-19 IE IE052292A patent/IE920522A1/en not_active Application Discontinuation
1993
- 1993-08-19 NO NO93932954A patent/NO932954L/no unknown

Also Published As

Publication number	Publication date
YU17092A (sh)	1994-12-28
FI933656A0 (fi)	1993-08-19
NO932954D0 (no)	1993-08-19
ZA921911B (en)	1993-08-19
EP0572437A1 (en)	1993-12-08
ES2071484T3 (es)	1995-06-16
FI933656L (fi)	1993-08-19
AU1184892A (en)	1992-09-15
DE69202243T2 (de)	1995-08-31
BR9205645A (pt)	1994-06-07
NO932954L (no)	1993-08-19
WO1992014716A1 (en)	1992-09-03
CZ387292A3 (en)	1994-04-13
KR930703270A (ko)	1993-11-29
AU655798B2 (en)	1995-01-12
CA2101542A1 (en)	1992-08-21
IE920522A1 (en)	1992-08-26
JPH06500117A (ja)	1994-01-06
DK0572437T3 (da)	1995-07-03
EP0572437B1 (en)	1995-04-26
DE9290018U1 (de)	1993-10-14
ATE121735T1 (de)	1995-05-15
CN1064271A (zh)	1992-09-09
IL100942A0 (en)	1992-11-15
FI933656A7 (fi)	1993-08-19
HUT64755A (en)	1994-02-28
NZ241627A (en)	1993-06-25
HU9302384D0 (en)	1993-11-29
PT100132A (pt)	1993-05-31
DE69202243D1 (de)	1995-06-01

Publication	Publication Date	Title
MX9200675A (es)	1992-08-01	Derivados de 2,4-diaminoquinazolinas para mejorar la actividad antitumoral.
MX9101913A (es)	1992-07-08	Derivados de quinazolinas para potenciar la actividad antitumoral
ATE81505T1 (de)	1992-10-15	Azacycloalkanderivate, absorptionspromotoren, die die derivate als effektiven inhaltsstoff enthalten und aeusserlich anzuwendende praeparate, die absorptionspromotoren enthalten.
DE3563533D1 (en)	1988-08-04	Derivatives of glycerophosphocholine and of glycerophosphoethanol amine, their preparation and use
DK267885A (da)	1986-12-14	Maebel, saasom sidde- eller liggemaebel
MX9201763A (es)	1992-10-01	Derivados de pirimidina para aumentar la actividad antitumores.
EP0325129A3 (en)	1990-12-19	Disubstituted pyridines
DE3462688D1 (en)	1987-04-23	1,7-diphenyl-3-methylaza-7-cyano-8-methylnonane useful in combating diseases
ATE311399T1 (de)	2005-12-15	2'-deoxy-4'-thioribonucleoside als antivirale und antikrebsmittel
CA1265159C (en)	1990-01-30	GEM-DIHALOGENO-1,8-DIAMINO-4-AZA-OCTANES
ZA893310B (en)	1991-01-30	Novel strobilurine derivatives,their preparation and their use
DE3669497D1 (de)	1990-04-19	Cycloalkan-1-ol derivate und duftstoff-zusammensetzungen, die diese enthalten.
IE862894L (en)	1987-05-05	Pharmaceutical compositions
MX9203715A (es)	1992-07-01	Preparciones para el tratamiento del tejido aloinjertado.
IT1236394B (it)	1993-02-26	Agente anti psoriasi a base di salicilato di papaverina